LOCUS       NM_017801               3307 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens CKLF like MARVEL transmembrane domain containing 6
            (CMTM6), mRNA.
ACCESSION   NM_017801
VERSION     NM_017801.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3307)
  AUTHORS   Shaha,A., Wang,Y., Wang,X., Wang,D., Guinovart,D., Liu,B. and
            Kang,N.
  TITLE     CMTM6 mediates the Warburg effect and promotes the liver metastasis
            of colorectal cancer
  JOURNAL   Exp Mol Med 56 (9), 2002-2015 (2024)
   PUBMED   39218981
  REMARK    GeneRIF: CMTM6 mediates the Warburg effect and promotes the liver
            metastasis of colorectal cancer.
REFERENCE   2  (bases 1 to 3307)
  AUTHORS   Dai,L., Xiao,J., Li,X., Tao,Y., Zhou,P., Lyu,L., Shi,Z., Liang,X.,
            Jia,Z. and Jiang,S.
  TITLE     Autophagy-related CMTM6 promotes glioblastoma progression by
            activating Wnt/beta-catenin pathway and acts as an
            onco-immunological biomarker
  JOURNAL   J Gene Med 26 (5), e3685 (2024)
   PUBMED   38686653
  REMARK    GeneRIF: Autophagy-related CMTM6 promotes glioblastoma progression
            by activating Wnt/beta-catenin pathway and acts as an
            onco-immunological biomarker.
REFERENCE   3  (bases 1 to 3307)
  AUTHORS   Xu,Y., Li,Q. and Lin,H.
  TITLE     Bioinformatics analysis of CMTM family in pan-cancer and
            preliminary exploration of CMTM6 in bladder cancer
  JOURNAL   Cell Signal 115, 111012 (2024)
   PUBMED   38113979
  REMARK    GeneRIF: Bioinformatics analysis of CMTM family in pan-cancer and
            preliminary exploration of CMTM6 in bladder cancer.
REFERENCE   4  (bases 1 to 3307)
  AUTHORS   Chen,X., Shen,H., Liu,H., Tan,L. and Zhang,N.
  TITLE     CMTM 6 promotes the development of thyroid cancer by inhibiting NIS
            activity through activating the MAPK signaling pathway
  JOURNAL   Funct Integr Genomics 24 (1), 10 (2024)
   PUBMED   38221563
  REMARK    GeneRIF: CMTM 6 promotes the development of thyroid cancer by
            inhibiting NIS activity through activating the MAPK signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3307)
  AUTHORS   Zhou,Y., Ma,B., Liu,Q., Duan,H., Huo,Y., Zhao,L., Chen,J., Han,W.
            and Qi,H.
  TITLE     Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory Response
            and Improves Corneal Epithelial Barrier Function in Experimental
            Dry Eye
  JOURNAL   Invest Ophthalmol Vis Sci 65 (1), 4 (2024)
   PUBMED   38165704
  REMARK    GeneRIF: Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory
            Response and Improves Corneal Epithelial Barrier Function in
            Experimental Dry Eye.
REFERENCE   6  (bases 1 to 3307)
  AUTHORS   Burr,M.L., Sparbier,C.E., Chan,Y.C., Williamson,J.C., Woods,K.,
            Beavis,P.A., Lam,E.Y.N., Henderson,M.A., Bell,C.C., Stolzenburg,S.,
            Gilan,O., Bloor,S., Noori,T., Morgens,D.W., Bassik,M.C.,
            Neeson,P.J., Behren,A., Darcy,P.K., Dawson,S.J., Voskoboinik,I.,
            Trapani,J.A., Cebon,J., Lehner,P.J. and Dawson,M.A.
  TITLE     CMTM6 maintains the expression of PD-L1 and regulates anti-tumour
            immunity
  JOURNAL   Nature 549 (7670), 101-105 (2017)
   PUBMED   28813417
  REMARK    GeneRIF: CMTM6 depletion, via the reduction of PD-L1, significantly
            alleviates the suppression of tumour-specific T cell activity in
            vitro and in vivo; findings provide insights into the biology of
            PD-L1 regulation, identify a previously unrecognized master
            regulator of this critical immune checkpoint and highlight a
            potential therapeutic target to overcome immune evasion by tumour
            cells
REFERENCE   7  (bases 1 to 3307)
  AUTHORS   Mezzadra,R., Sun,C., Jae,L.T., Gomez-Eerland,R., de Vries,E.,
            Wu,W., Logtenberg,M.E.W., Slagter,M., Rozeman,E.A., Hofland,I.,
            Broeks,A., Horlings,H.M., Wessels,L.F.A., Blank,C.U., Xiao,Y.,
            Heck,A.J.R., Borst,J., Brummelkamp,T.R. and Schumacher,T.N.M.
  TITLE     Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
  JOURNAL   Nature 549 (7670), 106-110 (2017)
   PUBMED   28813410
  REMARK    GeneRIF: CMTM6 is present at the cell surface, associates with the
            PD-L1 protein, reduces its ubiquitination and increases PD-L1
            protein half-life; CMTM6 enhances the ability of PD-L1-expressing
            tumour cells to inhibit T cells; collectively, our data reveal that
            PD-L1 relies on CMTM6/4 to efficiently carry out its inhibitory
            function, and suggest potential new avenues to block this pathway
REFERENCE   8  (bases 1 to 3307)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   9  (bases 1 to 3307)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   10 (bases 1 to 3307)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
  REMARK    GeneRIF: Bioinformatics based on CKLF2 cDNA and protein sequences
            in combination with experimental validation identified CKLFSF1-8
            gene clusters, between the SCY and the TM4SF gene families. The 8
            family members were cloned and characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104306.2.
            
            On Nov 26, 2018 this sequence version replaced NM_017801.2.
            
            Summary: This gene belongs to the chemokine-like factor gene
            superfamily, a novel family that is similar to the chemokine and
            transmembrane 4 superfamilies. This gene is one of several
            chemokine-like factor genes located in a cluster on chromosome 3.
            This gene is widely expressed in many tissues, but the exact
            function of the encoded protein is unknown. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF479261.1, SRR1660809.9855.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000205636.4/ ENSP00000205636.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AC104306.2         131494-131738
            246-422             AC104306.2         142460-142636
            423-521             AC104306.2         146310-146408
            522-3307            AC104306.2         150249-153034
FEATURES             Location/Qualifiers
     source          1..3307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..3307
                     /gene="CMTM6"
                     /gene_synonym="CKLFSF6; PRO2219"
                     /note="CKLF like MARVEL transmembrane domain containing 6"
                     /db_xref="GeneID:54918"
                     /db_xref="HGNC:HGNC:19177"
                     /db_xref="MIM:607889"
     exon            1..245
                     /gene="CMTM6"
                     /gene_synonym="CKLFSF6; PRO2219"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..659
                     /gene="CMTM6"
                     /gene_synonym="CKLFSF6; PRO2219"
                     /note="chemokine-like factor super family 6;
                     chemokine-like factor superfamily 6; chemokine-like factor
                     superfamily member 6"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 6"
                     /protein_id="NP_060271.1"
                     /db_xref="CCDS:CCDS2653.1"
                     /db_xref="GeneID:54918"
                     /db_xref="HGNC:HGNC:19177"
                     /db_xref="MIM:607889"
                     /translation="MENGAVYSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRVLKGL
                     QLLLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKV
                     KSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKR
                     QESQLRKPENTTRAEALTEPLNA"
     exon            246..422
                     /gene="CMTM6"
                     /gene_synonym="CKLFSF6; PRO2219"
                     /inference="alignment:Splign:2.1.0"
     exon            423..521
                     /gene="CMTM6"
                     /gene_synonym="CKLFSF6; PRO2219"
                     /inference="alignment:Splign:2.1.0"
     exon            522..3307
                     /gene="CMTM6"
                     /gene_synonym="CKLFSF6; PRO2219"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3283..3288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMTM6"
                     /gene_synonym="CKLFSF6; PRO2219"
                     /note="hexamer: AATAAA"
     polyA_site      3307
                     /gene="CMTM6"
                     /gene_synonym="CKLFSF6; PRO2219"
                     /note="major polyA site"
ORIGIN      
        1 gagaaggccc aggaagtgac ggccgcctcc cggctaccgg ggacttctgg agtccgagaa
       61 gtcaacggcg cggttgctgc ggccgccgcg ctccccggcc cgaggcgatg gagaacggag
      121 cggtgtacag ccccactacg gaggaggacc cgggccccgc cagaggcccc cggagcggcc
      181 tcgctgccta ctttttcatg ggccggctcc cattgctccg gcgcgttctc aagggcttgc
      241 agctgttgct gtctctgctg gccttcatct gtgaagaagt tgtatcacaa tgtactttat
      301 gtggaggact ttattttttt gagtttgtaa gctgcagtgc ctttcttctg agtctcctta
      361 tactgattgt gtattgcact ccattttatg agagagttga taccacaaaa gtaaaatcat
      421 cggattttta tattactttg ggaacaggat gtgtgttttt gttggcatcc atcatttttg
      481 tttccacaca tgacaggact tcagctgaga ttgctgcaat tgtgtttgga tttatagcaa
      541 gttttatgtt cctacttgac tttatcacta tgctgtatga aaaacgacag gagtcccagc
      601 tgagaaaacc tgaaaatacc actagggctg aagccctcac tgagccactt aatgcctaaa
      661 gactctgggg agcagatgtt acctaaggta gtgaccctgc attgtggtgc ctgagccctg
      721 gcagaagctc ttgtaaaatt tgttaattgt ttaaaccact tcttttggag agcaagggga
      781 aggtcaagaa ggcagtttta tcaatattgt gtcagtcacc acaaagtagg ccagataagt
      841 taaaaaaaat ttttttttaa ataataattg aaacttatct caaatggaga ttttggtggg
      901 aggaggagaa aacaattgtt tttaaatcac acagctcaac ggttgataaa tgattctgtc
      961 attctgttac aggtcattct tttactaggc ttagcttcca aattatgctt tatagctgta
     1021 taaacatcgt gattatattc atctacttag aaattgtttt atttttaaat taatttgctt
     1081 agctgtttgt tttgatgctt agattatgtt ctgttaatgg gaatttaaca tatttaagaa
     1141 accaatattt aaaatgttgg tctaggtttt tttccttaac atatattacc aggctttact
     1201 gtatttcact cagccttaaa tgttataata tttttggata acggttatta attctttgag
     1261 accttcgtat agcctataaa atgtatggga gatgttggta ttttatgtgt ataaaagcaa
     1321 caatatcagc aacttcgtgt ttatactgca ccttggttgt tgatgtcaag taaaaaaaag
     1381 attgttttgt aacacataaa aaaatggaag aaactgatac cacacctaag gaccaaagat
     1441 aagaaagact ttttgcccaa gacagtgaaa gtaattataa aaacaagctt tgaccactta
     1501 ccaagtatct gaagagatga gttcatacta tgatttagaa agtggttcaa ttcccctgtt
     1561 ggcatatgat tatttttact aaaattaata cagctctgtg ggtcttcctt agtgttttct
     1621 ttgaagccaa tctgtttttt ttaggacacc agcctttggt ttttcatctg ttcgagatgc
     1681 ctcttctctg tctccttatc agatagaaat ggagtcatgt gctgctgctt catctagcag
     1741 aggttggcct ctggctctga cactttttgt cagttgtctt taggtggtcc tgaatcttgg
     1801 gcccttttga ttgtgaatac tgtgtagcag gatcttgaga gtccttgttc ttacataggc
     1861 attgctctag tttgtctttg gcaaaaaaaa aaaaaaaaaa aagtaaatat ccagggaacc
     1921 ctgcccagac taatactgtt ggtggcataa gagaatcaag ccattctcaa gagataactt
     1981 cataaccaga attgtctgtt ggctagcagc tgtcacagat aggcagggca cttgggatat
     2041 gacctttctg tccaggtgat tcacagacta gacctttctt atcctcctcc tagagttttg
     2101 acttgggact ctagtgttaa gatgatgagc ccgtgcatca ggtccttctg cactttggtg
     2161 gaagtctccc agggtaggtt tcctatttga aacagtggaa tcatgtttcc agtgataaag
     2221 tttaatgacc tcatcctttt ttttttttct catctgccat ttgtgtgtct tagatgggtt
     2281 ttaattgcat gaatgtggct aatgtggttc tcagaaattg gtcagtatgg cccaacatag
     2341 cttctgctct gtcttactga ctcaatacct ttaggatttg tatcagagtt tggatactag
     2401 tgttagtggt ggtgtcacca ctacttaatt gggagataat gaaaccaatc atggatgctg
     2461 tttttattgg gcatgtcatc taagagagga gaaatagctg ggttttgggt ctaattatga
     2521 ataaggactg attcagaaaa cgagtttatg gtaggtagac taaagtttca catcagactg
     2581 taccattgtg atttagacct atctaaaatt cagagcatat catctgggct acctcagggt
     2641 caccacccat gtattgggct tagtcaggat tgacagatac attctcagct ggcctgtcat
     2701 ataaaacata ctgtcattga gcttaagctc cgcttgttct gaggtttcac ctccatgtgt
     2761 ttcattggtg caaaagtgga tctcttagtt ggtcacttaa ttctttcttt ttcagaaaga
     2821 tagtatgttc actggtatat ttggtcactc ttagaacctt ccttcacatt gttttttatg
     2881 ggacccatga atggttagcc tttcttttct attgtagaag gaaataaata ggagtaaaaa
     2941 gaccattgta gtaaataagt tcaaggggaa cttgggacca gaaaccactg ttatgtacaa
     3001 aaaaatggca aattcaataa actcaaattt aaaataattt ttaaattaac agttatgata
     3061 aattttatat tttatacaaa tagattgctt agaatggttc tcaagaatta taagagaaat
     3121 gaactcacag tacaaaaatt ttataattac tatacttgtg ttttgtttgg gggctgggaa
     3181 atgtattttt acattgtagc caatcatttt atatttgtca atttaaatct tatgggtctt
     3241 ttttttttat ctctcttgat gtcagatttt atagtctttt taaataaatc catttaatta
     3301 aaacgtt
//
