LOCUS       NP_060271                183 aa            linear   PRI 15-OCT-2024
DEFINITION  CKLF-like MARVEL transmembrane domain-containing protein 6 [Homo
            sapiens].
ACCESSION   NP_060271
VERSION     NP_060271.1
DBSOURCE    REFSEQ: accession NM_017801.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 183)
  AUTHORS   Shaha,A., Wang,Y., Wang,X., Wang,D., Guinovart,D., Liu,B. and
            Kang,N.
  TITLE     CMTM6 mediates the Warburg effect and promotes the liver metastasis
            of colorectal cancer
  JOURNAL   Exp Mol Med 56 (9), 2002-2015 (2024)
   PUBMED   39218981
  REMARK    GeneRIF: CMTM6 mediates the Warburg effect and promotes the liver
            metastasis of colorectal cancer.
REFERENCE   2  (residues 1 to 183)
  AUTHORS   Dai,L., Xiao,J., Li,X., Tao,Y., Zhou,P., Lyu,L., Shi,Z., Liang,X.,
            Jia,Z. and Jiang,S.
  TITLE     Autophagy-related CMTM6 promotes glioblastoma progression by
            activating Wnt/beta-catenin pathway and acts as an
            onco-immunological biomarker
  JOURNAL   J Gene Med 26 (5), e3685 (2024)
   PUBMED   38686653
  REMARK    GeneRIF: Autophagy-related CMTM6 promotes glioblastoma progression
            by activating Wnt/beta-catenin pathway and acts as an
            onco-immunological biomarker.
REFERENCE   3  (residues 1 to 183)
  AUTHORS   Xu,Y., Li,Q. and Lin,H.
  TITLE     Bioinformatics analysis of CMTM family in pan-cancer and
            preliminary exploration of CMTM6 in bladder cancer
  JOURNAL   Cell Signal 115, 111012 (2024)
   PUBMED   38113979
  REMARK    GeneRIF: Bioinformatics analysis of CMTM family in pan-cancer and
            preliminary exploration of CMTM6 in bladder cancer.
REFERENCE   4  (residues 1 to 183)
  AUTHORS   Chen,X., Shen,H., Liu,H., Tan,L. and Zhang,N.
  TITLE     CMTM 6 promotes the development of thyroid cancer by inhibiting NIS
            activity through activating the MAPK signaling pathway
  JOURNAL   Funct Integr Genomics 24 (1), 10 (2024)
   PUBMED   38221563
  REMARK    GeneRIF: CMTM 6 promotes the development of thyroid cancer by
            inhibiting NIS activity through activating the MAPK signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 183)
  AUTHORS   Zhou,Y., Ma,B., Liu,Q., Duan,H., Huo,Y., Zhao,L., Chen,J., Han,W.
            and Qi,H.
  TITLE     Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory Response
            and Improves Corneal Epithelial Barrier Function in Experimental
            Dry Eye
  JOURNAL   Invest Ophthalmol Vis Sci 65 (1), 4 (2024)
   PUBMED   38165704
  REMARK    GeneRIF: Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory
            Response and Improves Corneal Epithelial Barrier Function in
            Experimental Dry Eye.
REFERENCE   6  (residues 1 to 183)
  AUTHORS   Burr,M.L., Sparbier,C.E., Chan,Y.C., Williamson,J.C., Woods,K.,
            Beavis,P.A., Lam,E.Y.N., Henderson,M.A., Bell,C.C., Stolzenburg,S.,
            Gilan,O., Bloor,S., Noori,T., Morgens,D.W., Bassik,M.C.,
            Neeson,P.J., Behren,A., Darcy,P.K., Dawson,S.J., Voskoboinik,I.,
            Trapani,J.A., Cebon,J., Lehner,P.J. and Dawson,M.A.
  TITLE     CMTM6 maintains the expression of PD-L1 and regulates anti-tumour
            immunity
  JOURNAL   Nature 549 (7670), 101-105 (2017)
   PUBMED   28813417
  REMARK    GeneRIF: CMTM6 depletion, via the reduction of PD-L1, significantly
            alleviates the suppression of tumour-specific T cell activity in
            vitro and in vivo; findings provide insights into the biology of
            PD-L1 regulation, identify a previously unrecognized master
            regulator of this critical immune checkpoint and highlight a
            potential therapeutic target to overcome immune evasion by tumour
            cells
REFERENCE   7  (residues 1 to 183)
  AUTHORS   Mezzadra,R., Sun,C., Jae,L.T., Gomez-Eerland,R., de Vries,E.,
            Wu,W., Logtenberg,M.E.W., Slagter,M., Rozeman,E.A., Hofland,I.,
            Broeks,A., Horlings,H.M., Wessels,L.F.A., Blank,C.U., Xiao,Y.,
            Heck,A.J.R., Borst,J., Brummelkamp,T.R. and Schumacher,T.N.M.
  TITLE     Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
  JOURNAL   Nature 549 (7670), 106-110 (2017)
   PUBMED   28813410
  REMARK    GeneRIF: CMTM6 is present at the cell surface, associates with the
            PD-L1 protein, reduces its ubiquitination and increases PD-L1
            protein half-life; CMTM6 enhances the ability of PD-L1-expressing
            tumour cells to inhibit T cells; collectively, our data reveal that
            PD-L1 relies on CMTM6/4 to efficiently carry out its inhibitory
            function, and suggest potential new avenues to block this pathway
REFERENCE   8  (residues 1 to 183)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   9  (residues 1 to 183)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   10 (residues 1 to 183)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
  REMARK    GeneRIF: Bioinformatics based on CKLF2 cDNA and protein sequences
            in combination with experimental validation identified CKLFSF1-8
            gene clusters, between the SCY and the TM4SF gene families. The 8
            family members were cloned and characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104306.2.
            
            Summary: This gene belongs to the chemokine-like factor gene
            superfamily, a novel family that is similar to the chemokine and
            transmembrane 4 superfamilies. This gene is one of several
            chemokine-like factor genes located in a cluster on chromosome 3.
            This gene is widely expressed in many tissues, but the exact
            function of the encoded protein is unknown. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF479261.1, SRR1660809.9855.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000205636.4/ ENSP00000205636.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     Protein         1..183
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 6"
                     /note="chemokine-like factor super family 6;
                     chemokine-like factor superfamily 6; chemokine-like factor
                     superfamily member 6"
                     /calculated_mol_wt=20288
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine. /evidence=ECO:0000269|Ref.6,
                     ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378;
                     propagated from UniProtKB/Swiss-Prot (Q9NX76.1)"
     Site            8
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q9NX76.1)"
     Site            40..60
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NX76.1)"
     Region          <61..153
                     /region_name="MARVEL"
                     /note="Membrane-associating domain; pfam01284"
                     /db_xref="CDD:366555"
     Site            68..88
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NX76.1)"
     Site            107..127
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NX76.1)"
     Site            135..155
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NX76.1)"
     Site            171
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9NX76.1)"
     CDS             1..183
                     /gene="CMTM6"
                     /gene_synonym="CKLFSF6; PRO2219"
                     /coded_by="NM_017801.3:108..659"
                     /db_xref="CCDS:CCDS2653.1"
                     /db_xref="GeneID:54918"
                     /db_xref="HGNC:HGNC:19177"
                     /db_xref="MIM:607889"
ORIGIN      
        1 mengavyspt teedpgparg prsglaayff mgrlpllrrv lkglqlllsl laficeevvs
       61 qctlcgglyf fefvscsafl lsllilivyc tpfyervdtt kvkssdfyit lgtgcvflla
      121 siifvsthdr tsaeiaaivf gfiasfmfll dfitmlyekr qesqlrkpen ttraealtep
      181 lna
//
