LOCUS       NM_001288746            1163 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens CKLF like MARVEL transmembrane domain containing 5
            (CMTM5), transcript variant 6, mRNA.
ACCESSION   NM_001288746 XM_005267303
VERSION     NM_001288746.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1163)
  AUTHORS   Fan,Y. and Zou,H.Q.
  TITLE     CMTM5 influences Hippo/YAP axis to promote ferroptosis in glioma
            through regulating WWP2-mediated LATS2 ubiquitination
  JOURNAL   Kaohsiung J Med Sci 40 (10), 890-902 (2024)
   PUBMED   39166861
  REMARK    GeneRIF: CMTM5 influences Hippo/YAP axis to promote ferroptosis in
            glioma through regulating WWP2-mediated LATS2 ubiquitination.
REFERENCE   2  (bases 1 to 1163)
  AUTHORS   Li,L., Hu,Y., Chen,D., Zhu,J., Bao,W., Xu,X., Chen,H., Chen,W. and
            Feng,R.
  TITLE     CMTM5 inhibits the development of prostate cancer via the
            EGFR/PI3K/AKT signaling pathway
  JOURNAL   Mol Med Rep 25 (1) (2022)
   PUBMED   34791506
  REMARK    GeneRIF: CMTM5 inhibits the development of prostate cancer via the
            EGFR/PI3K/AKT signaling pathway.
REFERENCE   3  (bases 1 to 1163)
  AUTHORS   Liu,T.F., Lin,T., Ren,L.H., Li,G.P. and Peng,J.J.
  TITLE     [Association between CMTM5 gene and coronary artery disease and the
            relative mechanism]
  JOURNAL   Beijing Da Xue Xue Bao Yi Xue Ban 52 (6), 1082-1087 (2020)
   PUBMED   33331317
  REMARK    GeneRIF: [Association between CMTM5 gene and coronary artery
            disease and the relative mechanism].
REFERENCE   4  (bases 1 to 1163)
  AUTHORS   Liu,T.F., Lin,T., Ren,L.H., Li,G.P. and Peng,J.J.
  TITLE     [Association of CMTM5 gene expression with the risk of in-stent
            restenosis in patients with coronary artery disease after
            drug-eluting stent implantation and the effects and mechanisms of
            CMTM5 on human vascular endothelial cells]
  JOURNAL   Beijing Da Xue Xue Bao Yi Xue Ban 52 (5), 856-862 (2020)
   PUBMED   33047719
  REMARK    GeneRIF: [Association of CMTM5 gene expression with the risk of
            in-stent restenosis in patients with coronary artery disease after
            drug-eluting stent implantation and the effects and mechanisms of
            CMTM5 on human vascular endothelial cells].
REFERENCE   5  (bases 1 to 1163)
  AUTHORS   Wu,J.
  TITLE     CMTM5/7 are biomarkers and prognostic factors in human breast
            carcinoma
  JOURNAL   Cancer Biomark 29 (1), 89-99 (2020)
   PUBMED   32568178
  REMARK    GeneRIF: CMTM5/7 are biomarkers and prognostic factors in human
            breast carcinoma.
REFERENCE   6  (bases 1 to 1163)
  AUTHORS   Li,H., Guo,X., Shao,L., Plate,M., Mo,X., Wang,Y. and Han,W.
  TITLE     CMTM5-v1, a four-transmembrane protein, presents a secreted form
            released via a vesicle-mediated secretory pathway
  JOURNAL   BMB Rep 43 (3), 182-187 (2010)
   PUBMED   20356458
  REMARK    GeneRIF: CMTM5-v1 might be secreted via a different
            vesicle-mediated secretory pathway, which will be helpful for the
            studies of vesicle-mediated secretion and MARVEL domain-containing
            proteins.
REFERENCE   7  (bases 1 to 1163)
  AUTHORS   Guo,X., Li,T., Wang,Y., Shao,L., Zhang,Y., Ma,D. and Han,W.
  TITLE     CMTM5 induces apoptosis of pancreatic cancer cells and has
            synergistic effects with TNF-alpha
  JOURNAL   Biochem Biophys Res Commun 387 (1), 139-142 (2009)
   PUBMED   19577543
  REMARK    GeneRIF: CMTM5 may play a role in the pancreatic cancer.
REFERENCE   8  (bases 1 to 1163)
  AUTHORS   Shao,L., Guo,X., Plate,M., Li,T., Wang,Y., Ma,D. and Han,W.
  TITLE     CMTM5-v1 induces apoptosis in cervical carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 379 (4), 866-871 (2009)
   PUBMED   19124004
  REMARK    GeneRIF: These findings verify that CMTM5-v1 inhibits the growth of
            CC cell lines via inducing apoptosis.
REFERENCE   9  (bases 1 to 1163)
  AUTHORS   Shao,L., Cui,Y., Li,H., Liu,Y., Zhao,H., Wang,Y., Zhang,Y.,
            Ng,K.M., Han,W., Ma,D. and Tao,Q.
  TITLE     CMTM5 exhibits tumor suppressor activities and is frequently
            silenced by methylation in carcinoma cell lines
  JOURNAL   Clin Cancer Res 13 (19), 5756-5762 (2007)
   PUBMED   17908965
  REMARK    GeneRIF: CMTM5 exhibits tumor suppressor activities, but with
            frequent epigenetic inactivation in carcinoma cell lines
            Erratum:[Clin Cancer Res. 2007 Nov 1;13(21):6543]
REFERENCE   10 (bases 1 to 1163)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
  REMARK    GeneRIF: Bioinformatics based on CKLF2 cDNA and protein sequences
            in combination with experimental validation identified CKLFSF1-8
            gene clusters, between the SCY and the TM4SF gene families. The 8
            family members were cloned and characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF527413.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001288746.1.
            
            Summary: This gene encodes a member of the chemokine-like factor
            superfamily. This family of genes encodes multi-pass membrane
            proteins that are similar to both the chemokine and the
            transmembrane 4 superfamilies of signaling molecules. The encoded
            protein may exhibit tumor suppressor activity. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2014].
            
            Transcript Variant: This variant (6) includes an alternate in-frame
            exon in the central coding region, compared to variant 1. The
            encoded isoform (f) is longer, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF527413.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2154665,
                                           SAMN03465405 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339180.9/ ENSP00000344819.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1163              AF527413.1         22-1184
FEATURES             Location/Qualifiers
     source          1..1163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1163
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /note="CKLF like MARVEL transmembrane domain containing 5"
                     /db_xref="GeneID:116173"
                     /db_xref="HGNC:HGNC:19176"
                     /db_xref="MIM:607888"
     exon            1..332
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..878
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /note="isoform f is encoded by transcript variant 6;
                     chemokine-like factor super family 5; chemokine-like
                     factor superfamily member 5"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 5 isoform f"
                     /protein_id="NP_001275675.1"
                     /db_xref="CCDS:CCDS73617.1"
                     /db_xref="GeneID:116173"
                     /db_xref="HGNC:HGNC:19176"
                     /db_xref="MIM:607888"
                     /translation="MLSARDRRDRHPEEGVVAELQGFAVDKAFLTSHKGILLETELAL
                     TLIIFICFTASISAYMAAALLEFFITLAFLFLYATQYYQRFDRINWPCLLQGHGQSGG
                     PHPLDLLSHSAKVQPQPWPGLTPPGWHTPAAVPWVPAPAPGFWSWLLWFICFHSLGSS
                     DFLRCVSAIIIFLVVSFAAVTSRDGAAIAAFVFGIILVSIFAYDAFKIYRTEMAPGAS
                     QGDQQ"
     exon            333..485
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            486..686
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            687..779
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            780..864
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1163
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1144..1149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /note="hexamer: ATTAAA"
     polyA_site      1163
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /note="major polyA site"
ORIGIN      
        1 actctgggca gctgggtgag ggcccatctg ggcaaggccc ccagcgcctg ccttctctcc
       61 cggggccctg tgggcaagcc tcctgcttca ctttcaggtt tctcgaagtg ccttcttgct
      121 cctgtctgtt tccccatcct gccagatttc tgtttctctt gctgggcttt tggcagtagg
      181 gggctgtgtt ggtgggccct acgaagatgc tcagtgctcg agatcgccgg gaccggcacc
      241 ctgaggaggg ggtagttgca gagctccagg gcttcgcggt ggacaaggcc ttcctcacct
      301 cccacaaggg catcctgctg gaaaccgagc tggccctgac cctcatcatc ttcatctgct
      361 tcacggcctc catctctgcc tacatggccg cggcgctact ggagttcttc atcacacttg
      421 ccttcctctt cctctatgcc acccagtact accagcgctt cgaccgaatt aactggccct
      481 gtctgctgca gggccacggg caatcaggag gaccacatcc gctagatcta ctctcccact
      541 cagcaaaggt ccagccccag ccctggcctg gcttgacccc cccgggctgg catactccag
      601 ccgctgtccc ctgggttcca gccccagcgc ctggcttctg gtcctggttg ctctggttca
      661 tctgcttcca ctccctgggt agcagtgact tcctgcgctg tgtcagtgcc atcatcatct
      721 tcctggtggt ctcctttgca gctgtgacct cccgggacgg agctgccatt gctgcttttg
      781 tttttggcat catcctggtt tccatctttg cctatgatgc cttcaagatc taccggactg
      841 agatggcacc cggggccagc cagggggacc agcagtgact ctggggctac ctggctccta
      901 ggcccagcca gccagagagg acagtggagc ccagacacgt ctccttggga ttcactagcc
      961 cccagcccgc caaaccccac cccagcccta cacagcagtc tggcctgaga cgtcactggg
     1021 gacttatctg tggagcctgg tgctccagga tgtggcttct catgaagctc tggccagagg
     1081 aggggaactt attgggggag ggggggtgga ggggaggaat ctggacctct aagtcattcc
     1141 caaattaaaa tattcaaatt cta
//
