LOCUS       NM_181521               8153 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens CKLF like MARVEL transmembrane domain containing 4
            (CMTM4), transcript variant 2, mRNA.
ACCESSION   NM_181521
VERSION     NM_181521.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8153)
  AUTHORS   Luo,T., Xu,T., Ou,Y., Ci,H. and Sun,J.
  TITLE     Prognostic significance of RKIP, TGM2, and CMTM4 expression in oral
            squamous cell carcinoma
  JOURNAL   Medicine (Baltimore) 103 (7), e37278 (2024)
   PUBMED   38363884
  REMARK    GeneRIF: Prognostic significance of RKIP, TGM2, and CMTM4
            expression in oral squamous cell carcinoma.
REFERENCE   2  (bases 1 to 8153)
  AUTHORS   Knizkova,D., Pribikova,M., Draberova,H., Semberova,T., Trivic,T.,
            Synackova,A., Ujevic,A., Stefanovic,J., Drobek,A., Huranova,M.,
            Niederlova,V., Tsyklauri,O., Neuwirth,A., Tureckova,J., Stepanek,O.
            and Draber,P.
  TITLE     CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune
            pathology
  JOURNAL   Nat Immunol 23 (11), 1644-1652 (2022)
   PUBMED   36271145
  REMARK    GeneRIF: CMTM4 is a subunit of the IL-17 receptor and mediates
            autoimmune pathology.
REFERENCE   3  (bases 1 to 8153)
  AUTHORS   Xue,H., Qiu,B., Wang,H., Jiang,P., Zhang,W., Xue,L. and Wang,J.
  TITLE     Analysis of CMTM6 and CMTM4 expression as potential regulators of
            the PD-L1 protein and its association with prognosis in glioma
            cancer
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (8), 1193-1196 (2022)
   PUBMED   35983975
  REMARK    GeneRIF: Analysis of CMTM6 and CMTM4 expression as potential
            regulators of the PD-L1 protein and its association with prognosis
            in glioma cancer.
REFERENCE   4  (bases 1 to 8153)
  AUTHORS   Tan,S., Guo,X., Bei,C., Zhang,H., Li,D., Zhu,X. and Tan,H.
  TITLE     Prognostic significance and immune characteristics of CMTM4 in
            hepatocellular carcinoma
  JOURNAL   BMC Cancer 22 (1), 905 (2022)
   PUBMED   35986302
  REMARK    GeneRIF: Prognostic significance and immune characteristics of
            CMTM4 in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8153)
  AUTHORS   Zhang,T., Yu,H., Dai,X. and Zhang,X.
  TITLE     CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate the tumor
            microenvironment
  JOURNAL   Front Immunol 13, 971428 (2022)
   PUBMED   35958549
  REMARK    GeneRIF: CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate
            the tumor microenvironment.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8153)
  AUTHORS   Burr,M.L., Sparbier,C.E., Chan,Y.C., Williamson,J.C., Woods,K.,
            Beavis,P.A., Lam,E.Y.N., Henderson,M.A., Bell,C.C., Stolzenburg,S.,
            Gilan,O., Bloor,S., Noori,T., Morgens,D.W., Bassik,M.C.,
            Neeson,P.J., Behren,A., Darcy,P.K., Dawson,S.J., Voskoboinik,I.,
            Trapani,J.A., Cebon,J., Lehner,P.J. and Dawson,M.A.
  TITLE     CMTM6 maintains the expression of PD-L1 and regulates anti-tumour
            immunity
  JOURNAL   Nature 549 (7670), 101-105 (2017)
   PUBMED   28813417
REFERENCE   7  (bases 1 to 8153)
  AUTHORS   Mezzadra,R., Sun,C., Jae,L.T., Gomez-Eerland,R., de Vries,E.,
            Wu,W., Logtenberg,M.E.W., Slagter,M., Rozeman,E.A., Hofland,I.,
            Broeks,A., Horlings,H.M., Wessels,L.F.A., Blank,C.U., Xiao,Y.,
            Heck,A.J.R., Borst,J., Brummelkamp,T.R. and Schumacher,T.N.M.
  TITLE     Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
  JOURNAL   Nature 549 (7670), 106-110 (2017)
   PUBMED   28813410
  REMARK    GeneRIF: CMTM6 is present at the cell surface, associates with the
            PD-L1 protein, reduces its ubiquitination and increases PD-L1
            protein half-life; CMTM6 enhances the ability of PD-L1-expressing
            tumour cells to inhibit T cells; collectively, our data reveal that
            PD-L1 relies on CMTM6/4 to efficiently carry out its inhibitory
            function, and suggest potential new avenues to block this pathway
REFERENCE   8  (bases 1 to 8153)
  AUTHORS   Li,T., Cheng,Y., Wang,P., Wang,W., Hu,F., Mo,X., Lv,H., Xu,T. and
            Han,W.
  TITLE     CMTM4 is frequently downregulated and functions as a tumour
            suppressor in clear cell renal cell carcinoma
  JOURNAL   J Exp Clin Cancer Res 34, 122 (2015)
   PUBMED   26474560
  REMARK    GeneRIF: CMTM4 is downregulated and exhibits tumour-suppressor
            activities in clear cell renal cell carcinoma, and could be
            exploited as a target for clear cell renal cell carcinoma
            treatment.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8153)
  AUTHORS   Plate,M., Li,T., Wang,Y., Mo,X., Zhang,Y., Ma,D. and Han,W.
  TITLE     Identification and characterization of CMTM4, a novel gene with
            inhibitory effects on HeLa cell growth through Inducing G2/M phase
            accumulation
  JOURNAL   Mol Cells 29 (4), 355-361 (2010)
   PUBMED   20213316
  REMARK    GeneRIF: Data show that CMTM4 might be an important gene involved
            in cell growth and cell cycle regulation.
REFERENCE   10 (bases 1 to 8153)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
  REMARK    GeneRIF: Bioinformatics based on CKLF2 cDNA and protein sequences
            in combination with experimental validation identified CKLFSF1-8
            gene clusters, between the SCY and the TM4SF gene families. The 8
            family members were cloned and characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018557.9, AF479814.1 and
            AW207043.1.
            
            On Jun 3, 2019 this sequence version replaced NM_181521.2.
            
            Summary: This gene belongs to the chemokine-like factor gene
            superfamily, a novel family that is similar to the chemokine and
            the transmembrane 4 superfamilies of signaling molecules. This gene
            is one of several chemokine-like factor genes located in a cluster
            on chromosome 16. Alternatively spliced transcript variants
            encoding different isoforms have been identified. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) includes an additional segment
            in the 3' coding region that leads to an upstream stop codon,
            compared to variant 1. The encoded protein (isoform 2) has a
            shorter C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138516.66279.1,
                                           DRR138528.1108492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394106.7/ ENSP00000377666.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC018557.9         135365-135400       c
            37-1138             AF479814.1         1-1102
            1139-7733           AC018557.9         53827-60421         c
            7734-8153           AW207043.1         17-436              c
FEATURES             Location/Qualifiers
     source          1..8153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21-q22.1"
     gene            1..8153
                     /gene="CMTM4"
                     /gene_synonym="CKLFSF4"
                     /note="CKLF like MARVEL transmembrane domain containing 4"
                     /db_xref="GeneID:146223"
                     /db_xref="HGNC:HGNC:19175"
                     /db_xref="MIM:607887"
     exon            1..404
                     /gene="CMTM4"
                     /gene_synonym="CKLFSF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..845
                     /gene="CMTM4"
                     /gene_synonym="CKLFSF4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     chemokine-like factor super family 4; CKLF-like MARVEL
                     transmembrane domain-containing protein 4; chemokine-like
                     factor superfamily member 4"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 4 isoform 2"
                     /protein_id="NP_852662.1"
                     /db_xref="CCDS:CCDS42170.1"
                     /db_xref="GeneID:146223"
                     /db_xref="HGNC:HGNC:19175"
                     /db_xref="MIM:607887"
                     /translation="MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLR
                     CDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLL
                     IMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLA
                     TAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDT"
     exon            405..581
                     /gene="CMTM4"
                     /gene_synonym="CKLFSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            582..680
                     /gene="CMTM4"
                     /gene_synonym="CKLFSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            681..8153
                     /gene="CMTM4"
                     /gene_synonym="CKLFSF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8134..8139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMTM4"
                     /gene_synonym="CKLFSF4"
                     /note="hexamer: AATAAA"
     polyA_site      8153
                     /gene="CMTM4"
                     /gene_synonym="CKLFSF4"
                     /note="major polyA site"
ORIGIN      
        1 ccctttccgc tgccgaggcg gcgggagccg agcccgagcg gaccgagccg cagccgcagc
       61 cgggcggcgg gcgagaggcg gcggcggcgg gcgggccgcg ggcagtcagt cgggcggcgg
      121 cggcggcggc ggcggcggcg atgcggcggc cccgctgagt ccgcccgctc ctggcgccgg
      181 gagccagccg cgcgaggcgg cccgggccgg gcggcagcat gcggagcggc gaggagctgg
      241 acggcttcga gggcgaggcc tcgagcacct ccatgatctc gggcgccagc agcccgtacc
      301 agcccaccac cgagccggtg agccagcgcc gcgggctggc cggcctgcgc tgcgaccccg
      361 actacctgcg cggcgcgctc ggccgcctca aggtcgccca agtgatcttg gccctgattg
      421 cattcatctg catagagacc atcatggcat gctccccgtg tgaaggcctc tacttttttg
      481 agtttgtgag ctgcagtgcg tttgtggtga ctggcgtctt gctgattatg ttcagtctca
      541 acctgcacat gaggatcccc cagatcaact ggaatctgac agatttggtc aacactggac
      601 tcagcgcttt ccttttcttt attgcttcaa tcgtactggc tgctttaaac catagagccg
      661 gagcagaaat tgctgccgtg atatttggct tcttggcgac tgcggcatat gcagtgaaca
      721 cattcctggc agtgcagaaa tggagagtca gcgtccgcca gcagagcacc aatgactaca
      781 tccgagcccg cacggagtcc agggatgtgg acagtcgccc tgagatccag cgcctggaca
      841 cgtgaggacc tgcctggatc ctcctccctc ccgtcctcgt gcctgtctct cagtcaagtt
      901 ttctttccct tgtcctgtca gatttccatg tgattcagtt gaattttgtc ctctttggta
      961 aaagttcatt ttgggaaagg gtttcccgag tggcccagtg ggcgggtccg cggtggagtt
     1021 gggaggccca cgttcctcag cgtttggggc tgtggagcag ccggcgtcac tgcccaggtc
     1081 cacttgaggt cttacctgcc ctgaagcaca ggcttccttt gactctgagc caccttgtcg
     1141 tgtgtatttg taacaagact ttggattaaa tggggctgct aagagggggg aaatatgaag
     1201 gaatgaaggg acagcattgg aacggtcagt cggcagtggt tctcaggcag ccttaggcac
     1261 cacctgctcc aagtcagtgt tgagtctgcg tgctgggatc cagcccactc ctcatcttcc
     1321 atgccagggc ccccaggcag ccagcaccag cccaaaggcc acagggctgg ggaaagctga
     1381 tgtcctgtta ggatggctcc cagggacctc tgactcaagg aagggtgacc ttttgtttcc
     1441 tactctgctg agaaatcact tgattcttcc tcaaatgaat caccttcctg aaccccagat
     1501 tcttctccag gaatatgggg gccatcttgt tatggggact atcttgtttt ccagtttcct
     1561 gcctacccta aatactttga ggctgaattg cagattttca gtcattttac cttctcaggt
     1621 aaaagccatg aaagaaacaa gcctactcca ccagccaaag cacttgccca tttgctggct
     1681 tcatgaaccg caggtgggag gtgtttgtgt taaaaaacag catgcacacg cgtgcgcgca
     1741 cacatgcaca cacacacccc tctattttag ggatgtgtgc taattttcta aatgcctgca
     1801 aagagttcta aaatgattct gagcagattc gtctaggatt tgaaaatact tgaatttgca
     1861 ccagaacaca cccttccacc catgtttcag aaggcactaa ttgtcgcttt gggcgcctca
     1921 gtgtcataac tgtagacatc attcttggga gttgttgggg ggaaaaatcc tagctactta
     1981 aggtttctga ttgattcttg ataaagtgaa gattattgtg tgtggtgaat gagttcagtg
     2041 agtccccatg atgcagtagt ttttttaaaa aattagagag taattatatc ttttatggaa
     2101 aaaagttgtt ttagtttgtc aggttttccc tctttgaact gtttttaatg tttacaaacc
     2161 tcactttagc tctaacattt tgtgtttagc cctcaccaaa aagcacttac tgtggcagga
     2221 agattttgca gtaacatgga gaaatcccca agatcaagtg ctgacaaatg ttgacagctt
     2281 tagcagcgta ctgtgtaata aataactccg agggggcggc ggggggtctg tgcaagaaag
     2341 cgtcacctta tggacatgtg gcgtctcatt ccccagaaaa ggacagcatc tgagctcaca
     2401 gtgttgatca ggcaacactg ctgggctggg ggtcggagtt ggggttagct tcctgcacca
     2461 acaccttcag tacgatctga gttgggagca gtgtcccagg ctatgtggct gagcaccacg
     2521 tctgcctcag gggctgaccc tgctagcctg ttaacaactc gtctcccctc tgctcccaca
     2581 gagagggcag ccaggccagc tcacagctgg gtgtgctgcc tgtcaggtct gttgagtgtg
     2641 tttgcaaagt caaaattggg cttatctctc tttgagagtt ccttttaaaa tagggccaca
     2701 aaggctcagc cttgcattaa atggggccca cttggaagga ccatcctgag ctttatcaga
     2761 aatctcctgc tgggaatcat gttacttggc ccccaaaaaa ggccatcttt gaagtgagat
     2821 tgaaaacaag aacaccattc aggtgggctt gttgcccaag ttttcccagc tcacttcagt
     2881 aaaaccactt gatcatctgg tgaaagaggg gggcaggtgg ttggcctcct gaggatatgt
     2941 tgtcagctgc aagaaatagt tctgaagtca ctgaaactaa atgcagatga atgaccaaaa
     3001 aggatgacac gccagagagt gacttaggag ttaatttgca tcttcgtgat agactcttca
     3061 gaattattta tgtccctgta actatttaat atcctttgtg ccgtgaggct cctcggtggt
     3121 tttgtaaatg ttctccttgt atttaattaa ctcccactag aaccggaagt ggtgctatgg
     3181 acgctttcta gttgatgtaa tgtgtggttg cacatgtcat catgtataga ccacgtggtg
     3241 acgaaagttc tggagggaat agggttatcc aaggtgaata tgaagacgcc tatatttttc
     3301 ttatattgcc tctatatgca aacagaagac aatcgatatc tgggggcctt aaaatgacct
     3361 cttggcaaat tgaaggaagc gtttttgcgt ttaatagttt caatagggac caatatcagt
     3421 ttggtttggg gcatttgaag gctgagcgac cttagttttt ctcagtgttc tggtgggacg
     3481 atattggttt tcacatttaa agcaaaactt gaagaaactg cagttgctgt gtgcatttgg
     3541 gttttttcct ggacactgta cagctgaaac cctcaagcat ttggtggaac ctctggtggt
     3601 tttagatgga tgcaaacact gatgtcctca gagaaagttt attttggcac tgattgggtg
     3661 gatttggtat tttttccctc tgattctctt tgatatcctt ctttcacact gctgaaggca
     3721 tgggagggaa atatgttttc cctgccttaa agagggatta cagtcatgaa aggctggaga
     3781 tacttgttgg ccccacataa agctgggaag aacagatgca gtttcagatt aaaatctcgt
     3841 cagagaagtt tgatttgaag taaacagcca tccgagggag gtgacttttg tctacagaaa
     3901 aagcaagaat gtggcagcct gcacagcccc aatacacatc ttccttggca atgtgagctg
     3961 aagccagcat gggcaagtcc ggcccagctc tgagcgcttg gccctgggaa gccagcggca
     4021 cccccagccc ttcgggccct gttactgtcc cctggcagga aggctcacgc ctgtgggcag
     4081 ccagggaatg tgtctgacct ccaccctatg tcgggtgctt ctgggacagc ttcgtgactc
     4141 agttgaaaac attctgactc tcttcaagtt tgcagttaca tctgtggttc ttggaagctg
     4201 tcctagtgag tcagccttgg gttaagcctg aggagaccaa gctccaacac ctttgtgcac
     4261 tcatgtacgt gaattcttgc ttgcagtgaa tgagacctga acaaccctag tgggtgccat
     4321 gtcctgcgtg tggcccaggc gtaccttttc ttgtagattc acatgagaaa cccgtcacct
     4381 atccatgtgc tctgagaggt ggactgaggt ctaatccctt tctgtgccag attttctgtg
     4441 ggttggtctt agcacctagg agatgaatag agcatggaga cacctgaaca atttagtgat
     4501 tctgcaaggc agtgatgatt taagggttcc tattgtctca tctgtgttca aaacaaaaca
     4561 gtcatgaagt ctttgtgcca ctgcctgact gtcatcttct ccagatcttg tttacagagt
     4621 aataatgacg ttaaacaggt atcagaaagg ggaaaaagtt tctaggccaa gagctgctgg
     4681 tggattctct tgagcagaat aacaagttgc ttcctgctcc agggactgcc attagcttgt
     4741 gaagtctcta ggtgccttgt tatttcctag tgaagttgca gaatccaggg ttttttccag
     4801 gtttgtctta ttttatcagc acccacgtcc aggcccaaca gcttggtagg ctggtgaggt
     4861 ccacacacgg ccaggtctgg gagataaggg aggaagcagt ggcctggaac accccacctg
     4921 tctgctatca gcactagaca gctcaggctg tcttggaaac gtgtactttg ttaactgcct
     4981 tcctgtcctc ttgtctttga aagctgtctc gcgttccaca gtcagcttga gggcaagagt
     5041 gggatgctgg ggacaggtct ttcccgtcct gtgggtgagc tcctggcatc tggctcagga
     5101 acatgtgggt ccagcaggtg actctgaagc tggcttggct gccatctcag acaggacgca
     5161 ggcctgacac cctcagcttt tagctttgta aacttccctg gcgctttgta gaatcttgtg
     5221 tttcttctct tctcagcaga tatcattcaa gtcacaagaa ctgtctggtt gagaaagtaa
     5281 tttaaaatat ttgacctttt atgtttcttt tatttagaaa ctgtgagaga aaataccgtc
     5341 aatatctgtt aggtctagaa aaattttctt ccgaaagtga atgttctgtt taattcttct
     5401 tcatgcaagt gagtggcatt ttgtacactc tttagcttga agcggagtgg gtcctattgt
     5461 attttccctt cttttgtctg gaatatattc tttttccatt tggatacagt ttttcaacct
     5521 ttgggatttt tttttccttt ctagtttttc ctactccaca aacgtaacag taaggaaaaa
     5581 atcacccaca aacctgctga gtttgaatca ctggcaactt gcctagaaaa gttcagatga
     5641 tgggtccttg aactgtgtat ctatttcata gggtaagttt gttgtctatg tttgtttttt
     5701 tatgctgagg ctttaattca ggtgacttgc tatctagaca cctggggtgg cgtgttttct
     5761 ttgggatgca taatacacaa aggccaggga gcctttggct tggaccccca gggagctatt
     5821 gaaactttta aagtttgagt ttaggagtaa gaacatatct cagaccacct tagtcagctt
     5881 tgctgatggg atttagggcc aggtcagagt ttcttttcat aactgcctga aaagagagat
     5941 ggtgtgaaac aagattctga taatggtttg tgtgagattt gatcatagtc taaaactatc
     6001 acgtctgagt tgccttagga tgacagtgct gacacccagt aggaagtatc ccatttttat
     6061 caggaaagtc agtcacgcgt agggatggtg aggagacgcg tagggatggt gaggagggga
     6121 gaggagggag acctgctggt gcccttgcac cagggtgagg cctgactcac gctgcttccc
     6181 cccacaggcc ctgctttgct tgcctgcttt ttccagaatc gattttgcaa gcttcaagat
     6241 tctgttcccc tcttcgcaga agtgaggaag gcaaatactc agggtttgaa gggagacctg
     6301 gccggcctga gggctggcag atgtgagggc aggacacctg ggatggactc gtaggctgac
     6361 ccaggcccaa agggggctgc ctgttcccaa ctctttcact ctgtaaccca ttttaaaatg
     6421 agtttttgaa tcttgcctca aattgaccta cttggataaa atcagtgctt ttcctaactt
     6481 gattttgttt gacgtggttc cctctaagag aatggtagga attgaaacta tttgtatatg
     6541 ttgaaatttg taggggttca ggaacccatg gcagaaacac taaactattt atttacaagt
     6601 atgactattt ttttttcaaa gtaggcaatt ctttgtatat tttaaggcaa ataatcactt
     6661 cacctctggt gccttccatg cgtcgcataa gcactcttgt caatcatgga attggaaaaa
     6721 aagatgtaca tttagttaaa caagataaca ctatttttgt agcatgattt tagattgtgt
     6781 ccttttaata ttgttttcaa caatggtagt tttgaggttt tggccatttt ctctttacac
     6841 ttcgtatgta ttttaaagaa gaaaaaaaac aaaaaaaatt ccctggctat tcctctttcc
     6901 tctctgctgc tgcttctcct gcatcttgtt cctgcttatt taaatagtct gagagtaaga
     6961 gtatatttct gtgaaataat tataagtcag tataattgca tttggcattt tttaaccact
     7021 tgctcagttt ggagccactg ctcacctcaa acagtacaaa gaaagtggtt ccatatttta
     7081 caaacagaag agtagcatca gagccctgac ctcctgtctt tgggtgtaaa atggtgagag
     7141 gccggtgtcc ggctccttcc cctgtggttt gggctggtga actgagccca agtgtattct
     7201 ctggcctggg ccccttccag aatcagtgcg agcgtcctgc agaggcatgg ccttcctgcc
     7261 actgcagagt gggaagcttc ctgggggacc tcagccagct ccggggctct catcttccac
     7321 tcggatctca gattggttcg ttgtggatgc tctggctagg ctcggcggcc ttttccaggc
     7381 ttcaggcctg aacaaaacag gctgtttgct gtgaggagct agatgacacc aagacacaga
     7441 cacgtactct tcaccggctc cttttgcttc tccttcctgc aggacgtgag ttatgtctgg
     7501 tcccaaaacc cttgagtaaa ctagctgagc cattgcaaat gaaggtacag atggattgaa
     7561 acataaaatt gtagcttttg gtgtccttct gaagggtcag aatatgtaat tatttgataa
     7621 ccaaggaagt caagtcagat ggctaagtag taactttcca atatgatttc tccgtggtac
     7681 ttcacctggt ggcacttttg gggggcaatg ttaacaacta tcacatttta ctcatcaagt
     7741 ctctttcatt tcggcagttt aaagacacaa ctgtgggctt tctgaggcga tgcccgttgg
     7801 gcaaacttag gtttatgtgt ttggtttttc agctgacgtg gaagccctgg gtgggcgtcc
     7861 cctggctggc ctggcttttg ggttcaagtc tgtatgtatg gagtgggttg gggccccaaa
     7921 gctttgctgc tattgatttg tccccgacag caggcaaagc ctcacattgc cctcaatttt
     7981 ccccctttca tttgaaggac cagtttttca tggtacttgt cttgatcttt ttcatagtgt
     8041 tcaaatctgt atttttgtat gtagagggaa ataattttct caacactaat cgttaataac
     8101 tattgtatta aattgtcatg aaggaacttg tttaataaat ggacgtgtaa gga
//
