LOCUS       NP_852662                208 aa            linear   PRI 29-APR-2025
DEFINITION  CKLF-like MARVEL transmembrane domain-containing protein 4 isoform
            2 [Homo sapiens].
ACCESSION   NP_852662
VERSION     NP_852662.1
DBSOURCE    REFSEQ: accession NM_181521.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 208)
  AUTHORS   Luo,T., Xu,T., Ou,Y., Ci,H. and Sun,J.
  TITLE     Prognostic significance of RKIP, TGM2, and CMTM4 expression in oral
            squamous cell carcinoma
  JOURNAL   Medicine (Baltimore) 103 (7), e37278 (2024)
   PUBMED   38363884
  REMARK    GeneRIF: Prognostic significance of RKIP, TGM2, and CMTM4
            expression in oral squamous cell carcinoma.
REFERENCE   2  (residues 1 to 208)
  AUTHORS   Knizkova,D., Pribikova,M., Draberova,H., Semberova,T., Trivic,T.,
            Synackova,A., Ujevic,A., Stefanovic,J., Drobek,A., Huranova,M.,
            Niederlova,V., Tsyklauri,O., Neuwirth,A., Tureckova,J., Stepanek,O.
            and Draber,P.
  TITLE     CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune
            pathology
  JOURNAL   Nat Immunol 23 (11), 1644-1652 (2022)
   PUBMED   36271145
  REMARK    GeneRIF: CMTM4 is a subunit of the IL-17 receptor and mediates
            autoimmune pathology.
REFERENCE   3  (residues 1 to 208)
  AUTHORS   Xue,H., Qiu,B., Wang,H., Jiang,P., Zhang,W., Xue,L. and Wang,J.
  TITLE     Analysis of CMTM6 and CMTM4 expression as potential regulators of
            the PD-L1 protein and its association with prognosis in glioma
            cancer
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (8), 1193-1196 (2022)
   PUBMED   35983975
  REMARK    GeneRIF: Analysis of CMTM6 and CMTM4 expression as potential
            regulators of the PD-L1 protein and its association with prognosis
            in glioma cancer.
REFERENCE   4  (residues 1 to 208)
  AUTHORS   Tan,S., Guo,X., Bei,C., Zhang,H., Li,D., Zhu,X. and Tan,H.
  TITLE     Prognostic significance and immune characteristics of CMTM4 in
            hepatocellular carcinoma
  JOURNAL   BMC Cancer 22 (1), 905 (2022)
   PUBMED   35986302
  REMARK    GeneRIF: Prognostic significance and immune characteristics of
            CMTM4 in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 208)
  AUTHORS   Zhang,T., Yu,H., Dai,X. and Zhang,X.
  TITLE     CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate the tumor
            microenvironment
  JOURNAL   Front Immunol 13, 971428 (2022)
   PUBMED   35958549
  REMARK    GeneRIF: CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate
            the tumor microenvironment.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 208)
  AUTHORS   Burr,M.L., Sparbier,C.E., Chan,Y.C., Williamson,J.C., Woods,K.,
            Beavis,P.A., Lam,E.Y.N., Henderson,M.A., Bell,C.C., Stolzenburg,S.,
            Gilan,O., Bloor,S., Noori,T., Morgens,D.W., Bassik,M.C.,
            Neeson,P.J., Behren,A., Darcy,P.K., Dawson,S.J., Voskoboinik,I.,
            Trapani,J.A., Cebon,J., Lehner,P.J. and Dawson,M.A.
  TITLE     CMTM6 maintains the expression of PD-L1 and regulates anti-tumour
            immunity
  JOURNAL   Nature 549 (7670), 101-105 (2017)
   PUBMED   28813417
REFERENCE   7  (residues 1 to 208)
  AUTHORS   Mezzadra,R., Sun,C., Jae,L.T., Gomez-Eerland,R., de Vries,E.,
            Wu,W., Logtenberg,M.E.W., Slagter,M., Rozeman,E.A., Hofland,I.,
            Broeks,A., Horlings,H.M., Wessels,L.F.A., Blank,C.U., Xiao,Y.,
            Heck,A.J.R., Borst,J., Brummelkamp,T.R. and Schumacher,T.N.M.
  TITLE     Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
  JOURNAL   Nature 549 (7670), 106-110 (2017)
   PUBMED   28813410
  REMARK    GeneRIF: CMTM6 is present at the cell surface, associates with the
            PD-L1 protein, reduces its ubiquitination and increases PD-L1
            protein half-life; CMTM6 enhances the ability of PD-L1-expressing
            tumour cells to inhibit T cells; collectively, our data reveal that
            PD-L1 relies on CMTM6/4 to efficiently carry out its inhibitory
            function, and suggest potential new avenues to block this pathway
REFERENCE   8  (residues 1 to 208)
  AUTHORS   Li,T., Cheng,Y., Wang,P., Wang,W., Hu,F., Mo,X., Lv,H., Xu,T. and
            Han,W.
  TITLE     CMTM4 is frequently downregulated and functions as a tumour
            suppressor in clear cell renal cell carcinoma
  JOURNAL   J Exp Clin Cancer Res 34, 122 (2015)
   PUBMED   26474560
  REMARK    GeneRIF: CMTM4 is downregulated and exhibits tumour-suppressor
            activities in clear cell renal cell carcinoma, and could be
            exploited as a target for clear cell renal cell carcinoma
            treatment.
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 208)
  AUTHORS   Plate,M., Li,T., Wang,Y., Mo,X., Zhang,Y., Ma,D. and Han,W.
  TITLE     Identification and characterization of CMTM4, a novel gene with
            inhibitory effects on HeLa cell growth through Inducing G2/M phase
            accumulation
  JOURNAL   Mol Cells 29 (4), 355-361 (2010)
   PUBMED   20213316
  REMARK    GeneRIF: Data show that CMTM4 might be an important gene involved
            in cell growth and cell cycle regulation.
REFERENCE   10 (residues 1 to 208)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
  REMARK    GeneRIF: Bioinformatics based on CKLF2 cDNA and protein sequences
            in combination with experimental validation identified CKLFSF1-8
            gene clusters, between the SCY and the TM4SF gene families. The 8
            family members were cloned and characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018557.9, AF479814.1 and
            AW207043.1.
            
            Summary: This gene belongs to the chemokine-like factor gene
            superfamily, a novel family that is similar to the chemokine and
            the transmembrane 4 superfamilies of signaling molecules. This gene
            is one of several chemokine-like factor genes located in a cluster
            on chromosome 16. Alternatively spliced transcript variants
            encoding different isoforms have been identified. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) includes an additional segment
            in the 3' coding region that leads to an upstream stop codon,
            compared to variant 1. The encoded protein (isoform 2) has a
            shorter C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138516.66279.1,
                                           DRR138528.1108492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394106.7/ ENSP00000377666.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21-q22.1"
     Protein         1..208
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 4 isoform 2"
                     /note="chemokine-like factor super family 4; CKLF-like
                     MARVEL transmembrane domain-containing protein 4;
                     chemokine-like factor superfamily member 4"
                     /calculated_mol_wt=22709
     Region          1..38
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IZR5.1)"
     Region          49..170
                     /region_name="MARVEL"
                     /note="Membrane-associating domain; pfam01284"
                     /db_xref="CDD:366555"
     Site            59..79
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IZR5.1)"
     Site            85..105
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IZR5.1)"
     Site            123..143
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IZR5.1)"
     Site            151..171
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IZR5.1)"
     Site            194
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8IZR5.1)"
     CDS             1..208
                     /gene="CMTM4"
                     /gene_synonym="CKLFSF4"
                     /coded_by="NM_181521.3:219..845"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS42170.1"
                     /db_xref="GeneID:146223"
                     /db_xref="HGNC:HGNC:19175"
                     /db_xref="MIM:607887"
ORIGIN      
        1 mrsgeeldgf egeasstsmi sgasspyqpt tepvsqrrgl aglrcdpdyl rgalgrlkva
       61 qvilaliafi cietimacsp ceglyffefv scsafvvtgv llimfslnlh mripqinwnl
      121 tdlvntglsa flffiasivl aalnhragae iaavifgfla taayavntfl avqkwrvsvr
      181 qqstndyira rtesrdvdsr peiqrldt
//
