LOCUS       NM_181553               1901 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens CKLF like MARVEL transmembrane domain containing 3
            (CMTM3), transcript variant 2, mRNA.
ACCESSION   NM_181553
VERSION     NM_181553.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   Wardlaw,A.J., Barwell,J., Hitchman,C., Shrine,N., Bennett,N.,
            Adewoye,A., Ozturk,H., Ntereke,T., Wurm,P., Tobin,M., Gooptu,B.,
            Hollox,E. and Wain,L.V.
  TITLE     Familial hypereosinophilia associated with eosinophilic
            gastrointestinal symptoms in individuals with a missense mutation
            in CKLF-like MARVEL transmembrane domain containing 3
  JOURNAL   Clin Exp Allergy 51 (11), 1501-1504 (2021)
   PUBMED   34048099
  REMARK    GeneRIF: Familial hypereosinophilia associated with eosinophilic
            gastrointestinal symptoms in individuals with a missense mutation
            in CKLF-like MARVEL transmembrane domain containing 3.
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1901)
  AUTHORS   Lu,M., Huang,Y., Sun,W., Li,P., Li,L. and Li,L.
  TITLE     miR-135b-5p promotes gastric cancer progression by targeting CMTM3
  JOURNAL   Int J Oncol 52 (2), 589-598 (2018)
   PUBMED   29345297
  REMARK    GeneRIF: CMTM3 exhibited a lower expression pattern in gastric
            cancer tissues.MiR-135b-5p promotes gastric cancer progression by
            targeting CMTM3.
REFERENCE   5  (bases 1 to 1901)
  AUTHORS   Li,J., Chen,C., Bi,X., Zhou,C., Huang,T., Ni,C., Yang,P., Chen,S.,
            Ye,M. and Duan,S.
  TITLE     DNA methylation of CMTM3, SSTR2, and MDFI genes in colorectal
            cancer
  JOURNAL   Gene 630, 1-7 (2017)
   PUBMED   28782576
  REMARK    GeneRIF: CMTM3 was significantly hypermethylated in colorectal
            cancer tissues when compared with adjacent normal colorectal
            tissues.
REFERENCE   6  (bases 1 to 1901)
  AUTHORS   Wang,Y., Li,J., Cui,Y., Li,T., Ng,K.M., Geng,H., Li,H., Shu,X.S.,
            Li,H., Liu,W., Luo,B., Zhang,Q., Mok,T.S., Zheng,W., Qiu,X.,
            Srivastava,G., Yu,J., Sung,J.J., Chan,A.T., Ma,D., Tao,Q. and
            Han,W.
  TITLE     CMTM3, located at the critical tumor suppressor locus 16q22.1, is
            silenced by CpG methylation in carcinomas and inhibits tumor cell
            growth through inducing apoptosis
  JOURNAL   Cancer Res 69 (12), 5194-5201 (2009)
   PUBMED   19509237
REFERENCE   7  (bases 1 to 1901)
  AUTHORS   Wang,Y., Li,T., Qiu,X., Mo,X., Zhang,Y., Song,Q., Ma,D. and Han,W.
  TITLE     CMTM3 can affect the transcription activity of androgen receptor
            and inhibit the expression level of PSA in LNCaP cells
  JOURNAL   Biochem Biophys Res Commun 371 (1), 54-58 (2008)
   PUBMED   18402773
  REMARK    GeneRIF: CMTM3 inhibits prostate-specific antigen expression at
            both mRNA and protein levels with no obvious influence on androgen
            receptor expression.
REFERENCE   8  (bases 1 to 1901)
  AUTHORS   Zhong,J., Wang,Y., Qiu,X., Mo,X., Liu,Y., Li,T., Song,Q., Ma,D. and
            Han,W.
  TITLE     Characterization and expression profile of CMTM3/CKLFSF3
  JOURNAL   J Biochem Mol Biol 39 (5), 537-545 (2006)
   PUBMED   17002874
  REMARK    GeneRIF: CMTM3/CKLFSF3 is an evolutionarily conserved gene that may
            have important roles in the male reproductive system and immune
            system.
REFERENCE   9  (bases 1 to 1901)
  AUTHORS   Imamura,Y., Katahira,T. and Kitamura,D.
  TITLE     Identification and characterization of a novel BASH N
            terminus-associated protein, BNAS2
  JOURNAL   J Biol Chem 279 (25), 26425-26432 (2004)
   PUBMED   15087455
REFERENCE   10 (bases 1 to 1901)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
  REMARK    GeneRIF: Bioinformatics based on CKLF2 cDNA and protein sequences
            in combination with experimental validation identified CKLFSF1-8
            gene clusters, between the SCY and the TM4SF gene families. The 8
            family members were cloned and characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC047701.1 and AF479813.1.
            
            On Nov 22, 2018 this sequence version replaced NM_181553.3.
            
            Summary: This gene belongs to the chemokine-like factor gene
            superfamily, a novel family that is similar to the chemokine and
            the transmembrane 4 superfamilies of signaling molecules. This gene
            is one of several chemokine-like factor genes located in a cluster
            on chromosome 16. Alternatively spliced transcript variants
            containing different 5' UTRs, but encoding the same protein, have
            been identified. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.448790.1, BC047701.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000567572.6/ ENSP00000455851.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1895              BC047701.1         41-1935
            1896-1901           AF479813.1         2074-2079
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1901
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /note="CKLF like MARVEL transmembrane domain containing 3"
                     /db_xref="GeneID:123920"
                     /db_xref="HGNC:HGNC:19174"
                     /db_xref="MIM:607886"
     exon            1..249
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..651
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /note="chemokine-like factor superfamily member 3"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 3"
                     /protein_id="NP_853531.1"
                     /db_xref="CCDS:CCDS10815.1"
                     /db_xref="GeneID:123920"
                     /db_xref="HGNC:HGNC:19174"
                     /db_xref="MIM:607886"
                     /translation="MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRL
                     LLAESGLSFITFICYVASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMD
                     FLRCVTAALIYFAISITAIAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQ
                     GDSADETTAHKTEEENSDSDSD"
     exon            250..405
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            406..501
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            502..622
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..1901
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /note="hexamer: AATGAA"
     polyA_site      1759
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /note="major polyA site"
     regulatory      1878..1883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /note="hexamer: AATACA"
     polyA_site      1901
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
ORIGIN      
        1 agtgtcgcct gccctccttc cgcacagccc gggtttccgc ttccctccgg gcgcgagaag
       61 aggggagcca ggccgagccc cggccctacc gccgccgccg ccatgtggcc cccagacccc
      121 gaccccgacc cggaccccga gcctgccggc ggctcccgtc ccggccccgc ggtccccggg
      181 ctccgcgccc tgctgccggc gcgggctttc ctctgctctc tcaaaggccg cctcctgctg
      241 gccgagtcgg gtctctcatt catcactttt atctgctatg tggcgtcctc agcatctgcc
      301 ttcctcacag cgcctctgct ggagttcctg ctggccttgt acttcctctt tgctgatgcc
      361 atgcagctga atgacaagtg gcagggcttg tgctggccca tgatggactt cctgcgctgt
      421 gtcaccgcgg ccctcatcta ctttgctatc tccatcacgg ccatcgccaa gtactcggat
      481 ggggcttcca aagccgctgg ggtgtttggc ttctttgcta ccatcgtgtt tgcaactgat
      541 ttctacctga tctttaacga cgtggccaaa ttcctcaaac aaggggactc tgcagatgag
      601 accacagccc acaagacaga agaagagaat tccgactcgg actctgactg aaggcctggc
      661 gggtgccttg gcaacctgag ccacacaggc ctccacccct gcgcctcaca ggggtcgctg
      721 gcgttggagc ggaggcctgg acttctgagt tgcagagggg gctgcggaca cagcaggccc
      781 cctacagcct caggttctgc ctgagcccag cctaccaggc ttgcccctca gctcagcact
      841 gttgaccacg ctgcgtatga gggcatcttg ggtatcccac tccttctccc catttctgtc
      901 ccacaggcct tcagcccttt aacgtctctg ccaaaaacca gcacaaggag acaaagcaga
      961 gccttgtctg tatctgggca gcaggtgttc catgctgcta ggtggcgggg gtcgggggtc
     1021 ttctgtttca ctaacaggaa caaagacaga aaccatgaca gggctgcccc gccaggcccc
     1081 ggtgggtttg tctgcacttg gtgctcctgc ccacaccagc cactttggtg acaatgaccc
     1141 ttccaagaat ctttggttca aggagcacca gttccctctt cattcttgaa gcagggagaa
     1201 attgaccttt gccttgtcgc ccaggaagtg gggctcggca cccataacta acacctccca
     1261 cccttggaaa ccatgtcttc tgggggtgag atgaccattc tgggtctaag actgtttcaa
     1321 agaagagctc atagactgac tggtccagaa gacagagggt acaacagtgg catcacagtg
     1381 acagtgtcat ggggagctgg gcgggcccag ccaaaccctc cttcttccta gagcccagcc
     1441 agcaggcagg agttcctgga ccctcaggac agtgaacttc cagacctcag ggcaggtcta
     1501 tgggccactg caggagatga gaccagcctt ctgtgttcac ctaacgattt atactgtgta
     1561 tctgtctttg atggaatttt gtaacttttt atattttttt atgcaaaagc agcttcttaa
     1621 cagatggcat tttctgtgac tctaggcctc acaaaagagc cagagttctg gacccatgtt
     1681 tggagcattt gtagccttat tctcttgcgt gtgaatctct taccctgaaa aaaagccata
     1741 atgaattaag ccagactgac cacttgcttg gagtgtgtgc ttgaaaaaac cagagcaata
     1801 ctgttgggta ttgtatcagg cttcagtaca aactggtaac accaatgtgg atcctgacag
     1861 ctttcagttt tagcaaaaat acacgtgaaa tctgactacc a
//
