LOCUS       NM_001363918            2328 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens CKLF like MARVEL transmembrane domain containing 3
            (CMTM3), transcript variant 8, mRNA.
ACCESSION   NM_001363918 XM_006721131
VERSION     NM_001363918.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2328)
  AUTHORS   Wardlaw,A.J., Barwell,J., Hitchman,C., Shrine,N., Bennett,N.,
            Adewoye,A., Ozturk,H., Ntereke,T., Wurm,P., Tobin,M., Gooptu,B.,
            Hollox,E. and Wain,L.V.
  TITLE     Familial hypereosinophilia associated with eosinophilic
            gastrointestinal symptoms in individuals with a missense mutation
            in CKLF-like MARVEL transmembrane domain containing 3
  JOURNAL   Clin Exp Allergy 51 (11), 1501-1504 (2021)
   PUBMED   34048099
  REMARK    GeneRIF: Familial hypereosinophilia associated with eosinophilic
            gastrointestinal symptoms in individuals with a missense mutation
            in CKLF-like MARVEL transmembrane domain containing 3.
REFERENCE   2  (bases 1 to 2328)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2328)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2328)
  AUTHORS   Lu,M., Huang,Y., Sun,W., Li,P., Li,L. and Li,L.
  TITLE     miR-135b-5p promotes gastric cancer progression by targeting CMTM3
  JOURNAL   Int J Oncol 52 (2), 589-598 (2018)
   PUBMED   29345297
  REMARK    GeneRIF: CMTM3 exhibited a lower expression pattern in gastric
            cancer tissues.MiR-135b-5p promotes gastric cancer progression by
            targeting CMTM3.
REFERENCE   5  (bases 1 to 2328)
  AUTHORS   Li,J., Chen,C., Bi,X., Zhou,C., Huang,T., Ni,C., Yang,P., Chen,S.,
            Ye,M. and Duan,S.
  TITLE     DNA methylation of CMTM3, SSTR2, and MDFI genes in colorectal
            cancer
  JOURNAL   Gene 630, 1-7 (2017)
   PUBMED   28782576
  REMARK    GeneRIF: CMTM3 was significantly hypermethylated in colorectal
            cancer tissues when compared with adjacent normal colorectal
            tissues.
REFERENCE   6  (bases 1 to 2328)
  AUTHORS   Wang,Y., Li,J., Cui,Y., Li,T., Ng,K.M., Geng,H., Li,H., Shu,X.S.,
            Li,H., Liu,W., Luo,B., Zhang,Q., Mok,T.S., Zheng,W., Qiu,X.,
            Srivastava,G., Yu,J., Sung,J.J., Chan,A.T., Ma,D., Tao,Q. and
            Han,W.
  TITLE     CMTM3, located at the critical tumor suppressor locus 16q22.1, is
            silenced by CpG methylation in carcinomas and inhibits tumor cell
            growth through inducing apoptosis
  JOURNAL   Cancer Res 69 (12), 5194-5201 (2009)
   PUBMED   19509237
REFERENCE   7  (bases 1 to 2328)
  AUTHORS   Wang,Y., Li,T., Qiu,X., Mo,X., Zhang,Y., Song,Q., Ma,D. and Han,W.
  TITLE     CMTM3 can affect the transcription activity of androgen receptor
            and inhibit the expression level of PSA in LNCaP cells
  JOURNAL   Biochem Biophys Res Commun 371 (1), 54-58 (2008)
   PUBMED   18402773
  REMARK    GeneRIF: CMTM3 inhibits prostate-specific antigen expression at
            both mRNA and protein levels with no obvious influence on androgen
            receptor expression.
REFERENCE   8  (bases 1 to 2328)
  AUTHORS   Zhong,J., Wang,Y., Qiu,X., Mo,X., Liu,Y., Li,T., Song,Q., Ma,D. and
            Han,W.
  TITLE     Characterization and expression profile of CMTM3/CKLFSF3
  JOURNAL   J Biochem Mol Biol 39 (5), 537-545 (2006)
   PUBMED   17002874
  REMARK    GeneRIF: CMTM3/CKLFSF3 is an evolutionarily conserved gene that may
            have important roles in the male reproductive system and immune
            system.
REFERENCE   9  (bases 1 to 2328)
  AUTHORS   Imamura,Y., Katahira,T. and Kitamura,D.
  TITLE     Identification and characterization of a novel BASH N
            terminus-associated protein, BNAS2
  JOURNAL   J Biol Chem 279 (25), 26425-26432 (2004)
   PUBMED   15087455
REFERENCE   10 (bases 1 to 2328)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
  REMARK    GeneRIF: Bioinformatics based on CKLF2 cDNA and protein sequences
            in combination with experimental validation identified CKLFSF1-8
            gene clusters, between the SCY and the TM4SF gene families. The 8
            family members were cloned and characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018557.9.
            
            On Aug 13, 2020 this sequence version replaced NM_001363918.1.
            
            Summary: This gene belongs to the chemokine-like factor gene
            superfamily, a novel family that is similar to the chemokine and
            the transmembrane 4 superfamilies of signaling molecules. This gene
            is one of several chemokine-like factor genes located in a cluster
            on chromosome 16. Alternatively spliced transcript variants
            containing different 5' UTRs, but encoding the same protein, have
            been identified. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1845200.1,
                                           SRR14038196.1545161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-454               AC018557.9         42653-43106
            455-676             AC018557.9         43388-43609
            677-832             AC018557.9         46966-47121
            833-928             AC018557.9         48092-48187
            929-1049            AC018557.9         48540-48660
            1050-2328           AC018557.9         51266-52544
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2328
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /note="CKLF like MARVEL transmembrane domain containing 3"
                     /db_xref="GeneID:123920"
                     /db_xref="HGNC:HGNC:19174"
                     /db_xref="MIM:607886"
     exon            1..454
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..676
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             530..1078
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /note="chemokine-like factor superfamily member 3"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 3"
                     /protein_id="NP_001350847.1"
                     /db_xref="CCDS:CCDS10815.1"
                     /db_xref="GeneID:123920"
                     /db_xref="HGNC:HGNC:19174"
                     /db_xref="MIM:607886"
                     /translation="MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRL
                     LLAESGLSFITFICYVASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMD
                     FLRCVTAALIYFAISITAIAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQ
                     GDSADETTAHKTEEENSDSDSD"
     exon            677..832
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..928
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1049
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..2328
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2167..2172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /note="hexamer: AATGAA"
     polyA_site      2186
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /note="major polyA site"
     regulatory      2305..2310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
                     /note="hexamer: AATACA"
     polyA_site      2328
                     /gene="CMTM3"
                     /gene_synonym="BNAS2; CKLFSF3"
ORIGIN      
        1 agacgctctc tagatgtgca cgcatgtgcg tgtggagtgt gtgtgtgtgt gtgtgtgaga
       61 gagagagatg tgttggggtg gggggactgc aggtcaggaa gtcctgcaga tgtgcgtgcc
      121 tgtgtgtgtt tgcgcgcgcg cgcgcgtgtg tgtgtgtctg tgtgtgtgcc tggagctgcg
      181 cttgcaggtc tgagagtcct ctgagaatgg gttgggggag gcgggtgcag gaccgaggcc
      241 tggaacagcc aacaaagagg ccctggagga gggtggggct ggccggggac aggaggggtg
      301 gccaagaaag tcgcaagaaa actccggccc ccaagaaaaa gagagggcat gggttgcgga
      361 gccgacatca cggccggggt ctttgctgtt tagacgcctg ggttcccgga tcccagacac
      421 gcgcacgggc aggaagttag accggagaca gcgacccggg tttccgcttc cctccgggcg
      481 cgagaagagg ggagccaggc cgagccccgg ccctaccgcc gccgccgcca tgtggccccc
      541 agaccccgac cccgacccgg accccgagcc tgccggcggc tcccgtcccg gccccgcggt
      601 ccccgggctc cgcgccctgc tgccggcgcg ggctttcctc tgctctctca aaggccgcct
      661 cctgctggcc gagtcgggtc tctcattcat cacttttatc tgctatgtgg cgtcctcagc
      721 atctgccttc ctcacagcgc ctctgctgga gttcctgctg gccttgtact tcctctttgc
      781 tgatgccatg cagctgaatg acaagtggca gggcttgtgc tggcccatga tggacttcct
      841 gcgctgtgtc accgcggccc tcatctactt tgctatctcc atcacggcca tcgccaagta
      901 ctcggatggg gcttccaaag ccgctggggt gtttggcttc tttgctacca tcgtgtttgc
      961 aactgatttc tacctgatct ttaacgacgt ggccaaattc ctcaaacaag gggactctgc
     1021 agatgagacc acagcccaca agacagaaga agagaattcc gactcggact ctgactgaag
     1081 gcctggcggg tgccttggca acctgagcca cacaggcctc cacccctgcg cctcacaggg
     1141 gtcgctggcg ttggagcgga ggcctggact tctgagttgc agagggggct gcggacacag
     1201 caggccccct acagcctcag gttctgcctg agcccagcct accaggcttg cccctcagct
     1261 cagcactgtt gaccacgctg cgtatgaggg catcttgggt atcccactcc ttctccccat
     1321 ttctgtccca caggccttca gccctttaac gtctctgcca aaaaccagca caaggagaca
     1381 aagcagagcc ttgtctgtat ctgggcagca ggtgttccat gctgctaggt ggcgggggtc
     1441 gggggtcttc tgtttcacta acaggaacaa agacagaaac catgacaggg ctgccccgcc
     1501 aggccccggt gggtttgtct gcacttggtg ctcctgccca caccagccac tttggtgaca
     1561 atgacccttc caagaatctt tggttcaagg agcaccagtt ccctcttcat tcttgaagca
     1621 gggagaaatt gacctttgcc ttgtcgccca ggaagtgggg ctcggcaccc ataactaaca
     1681 cctcccaccc ttggaaacca tgtcttctgg gggtgagatg accattctgg gtctaagact
     1741 gtttcaaaga agagctcata gactgactgg tccagaagac agagggtaca acagtggcat
     1801 cacagtgaca gtgtcatggg gagctgggcg ggcccagcca aaccctcctt cttcctagag
     1861 cccagccagc aggcaggagt tcctggaccc tcaggacagt gaacttccag acctcagggc
     1921 aggtctatgg gccactgcag gagatgagac cagccttctg tgttcaccta acgatttata
     1981 ctgtgtatct gtctttgatg gaattttgta actttttata tttttttatg caaaagcagc
     2041 ttcttaacag atggcatttt ctgtgactct aggcctcaca aaagagccag agttctggac
     2101 ccatgtttgg agcatttgta gccttattct cttgcgtgtg aatctcttac cctgaaaaaa
     2161 agccataatg aattaagcca gactgaccac ttgcttggag tgtgtgcttg aaaaaaccag
     2221 agcaatactg ttgggtattg tatcaggctt cagtacaaac tggtaacacc aatgtggatc
     2281 ctgacagctt tcagttttag caaaaataca cgtgaaatct gactacca
//
