LOCUS       NM_144673               1048 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens CKLF like MARVEL transmembrane domain containing 2
            (CMTM2), transcript variant 1, mRNA.
ACCESSION   NM_144673
VERSION     NM_144673.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1048)
  AUTHORS   Chen,S., Hu,Q., Chen,H., Zhang,F.F., Duan,L., Wang,B., Li,D.D.,
            Zhang,J. and Chen,W.X.
  TITLE     Identification of Serum CMTM2 as a Potential Biomarker for
            HBV-Related Disorders
  JOURNAL   Dis Markers 2020, 2032056 (2020)
   PUBMED   33101541
  REMARK    GeneRIF: Identification of Serum CMTM2 as a Potential Biomarker for
            HBV-Related Disorders.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1048)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1048)
  AUTHORS   Guo,X., Zhang,S., Tan,S., Bei,C., Zhang,H., Zhu,X. and Qiu,X.
  TITLE     Downregulated CMTM2 Poses Potential Clinical Significance in
            Hepatocellular Carcinoma
  JOURNAL   DNA Cell Biol 39 (4), 683-689 (2020)
   PUBMED   31990600
  REMARK    GeneRIF: CMTM2 is downregulated in hepatocellular carcinoma tissues
            and correlated with the prognosis of hepatocellular carcinoma
            patients, suggesting a potential tumor suppressor role of CMTM2 in
            hepatocellular carcinoma progression.
REFERENCE   4  (bases 1 to 1048)
  AUTHORS   Zhang,X.W., Lan,K., Yang,W.B., Li,Q., Zhao,Y.P., Yin,H.Q., Kite,B.,
            Bai,W.J. and Xu,T.
  TITLE     [Expression and localization of transmembrane protein CMTM2 in
            human testis and sperm]
  JOURNAL   Beijing Da Xue Xue Bao Yi Xue Ban 49 (4), 575-579 (2017)
   PUBMED   28816268
  REMARK    GeneRIF: he expression of CMTM2 in the male reproductive system of
            the adult human exhibits cell- and region-specific patterns, which
            suggests that they may play an important role in spermatogenesis
            and sperm-egg fusion
REFERENCE   5  (bases 1 to 1048)
  AUTHORS   Fang,W.J., Zheng,Y., Wu,L.M., Ke,Q.H., Shen,H., Yuan,Y. and
            Zheng,S.S.
  TITLE     Genome-wide analysis of aberrant DNA methylation for identification
            of potential biomarkers in colorectal cancer patients
  JOURNAL   Asian Pac J Cancer Prev 13 (5), 1917-1921 (2012)
   PUBMED   22901147
  REMARK    GeneRIF: Aberrant DNA methylation of CMTM2 gene is associated with
            colorectal cancer.
REFERENCE   6  (bases 1 to 1048)
  AUTHORS   Song,H.S., Shi,S., Lu,X.Z., Gao,F., Yan,L., Wang,Y. and Zhuang,H.
  TITLE     Intracellular CMTM2 negatively regulates human immunodeficiency
            virus type-1 transcription through targeting the transcription
            factors AP-1 and CREB
  JOURNAL   Chin Med J (Engl) 123 (17), 2440-2445 (2010)
   PUBMED   21034562
  REMARK    GeneRIF: Intracellular CMTM2 can negatively regulate HIV-1
            transcription, at least in part, by targeting the AP-1 and CREB
            pathways.
REFERENCE   7  (bases 1 to 1048)
  AUTHORS   Liu,G., Xin,Z.C., Chen,L., Tian,L., Yuan,Y.M., Song,W.D.,
            Jiang,X.J. and Guo,Y.L.
  TITLE     Expression and localization of CKLFSF2 in human spermatogenesis
  JOURNAL   Asian J Androl 9 (2), 189-198 (2007)
   PUBMED   17334588
  REMARK    GeneRIF: CKLFSF2 was specifically expressed in meiotic and
            post-meiotic germ cells, which were localized to the endoplasmic
            reticulum (ER) near the Golgi apparatus.
REFERENCE   8  (bases 1 to 1048)
  AUTHORS   Shi,S., Rui,M., Han,W., Wang,Y., Qiu,X., Ding,P., Zhang,P., Zhu,X.,
            Zhang,Y., Gan,Q. and Ma,D.
  TITLE     CKLFSF2 is highly expressed in testis and can be secreted into the
            seminiferous tubules
  JOURNAL   Int J Biochem Cell Biol 37 (8), 1633-1640 (2005)
   PUBMED   15896670
REFERENCE   9  (bases 1 to 1048)
  AUTHORS   Xu,M., Yang,S., Gao,Y., Shi,S. and Ma,D.
  TITLE     A functional promoter region of the CKLFSF2 gene is located in the
            last intron/exon region of the upstream CKLFSF1 gene
  JOURNAL   Int J Biochem Cell Biol 37 (6), 1296-1307 (2005)
   PUBMED   15778092
  REMARK    GeneRIF: novel evidence that the final intron/exon region of the
            CKLFSF1 gene contains a novel eukaryotic promoter capable of
            directing expression of the downstream gene, CKLFSF2
REFERENCE   10 (bases 1 to 1048)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
  REMARK    GeneRIF: Bioinformatics based on CKLF2 cDNA and protein sequences
            in combination with experimental validation identified CKLFSF1-8
            gene clusters, between the SCY and the TM4SF gene families. The 8
            family members were cloned and characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC025354.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144673.2.
            
            Summary: This gene belongs to the chemokine-like factor gene
            superfamily, a novel family that links the chemokine and the
            transmembrane 4 superfamilies of signaling molecules. The protein
            encoded by this gene may play an important role in testicular
            development. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025354.1, AF479260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268595.3/ ENSP00000268595.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1048              BC025354.1         7-1054
FEATURES             Location/Qualifiers
     source          1..1048
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..1048
                     /gene="CMTM2"
                     /gene_synonym="CKLFSF2"
                     /note="CKLF like MARVEL transmembrane domain containing 2"
                     /db_xref="GeneID:146225"
                     /db_xref="HGNC:HGNC:19173"
                     /db_xref="MIM:607885"
     exon            1..430
                     /gene="CMTM2"
                     /gene_synonym="CKLFSF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..892
                     /gene="CMTM2"
                     /gene_synonym="CKLFSF2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chemokine-like factor superfamily 2; CKLF-like MARVEL
                     transmembrane domain-containing protein 2; chemokine-like
                     factor superfamily member 2"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 2 isoform 1"
                     /protein_id="NP_653274.1"
                     /db_xref="CCDS:CCDS10814.1"
                     /db_xref="GeneID:146225"
                     /db_xref="HGNC:HGNC:19173"
                     /db_xref="MIM:607885"
                     /translation="MAPKAAKGAKPEPAPAPPPPGAKPEEDKKDGKEPSDKPQKAVQD
                     HKEPSDKPQKAVQPKHEVGTRRGCRRYRWELKDSNKEFWLLGHAEIKIRSLGCLIAAM
                     ILLSSLTVHPILRLIITMEISFFSFFILLYSFAIHRYIPFILWPISDLFNDLIACAFL
                     VGAVVFAVRSRRSMNLHYLLAVILIGAAGVFAFIDVCLQRNHFRGKKAKKHMLVPPPG
                     KEKGPQQGKGPEPAKPPEPGKPPGPAKGKK"
     exon            431..589
                     /gene="CMTM2"
                     /gene_synonym="CKLFSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..691
                     /gene="CMTM2"
                     /gene_synonym="CKLFSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..1048
                     /gene="CMTM2"
                     /gene_synonym="CKLFSF2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1048
                     /gene="CMTM2"
                     /gene_synonym="CKLFSF2"
                     /note="major polyA site"
ORIGIN      
        1 attcggtggt cctggcagtt agctgagcac gccctctgag ccgctcggtg gacaccaggc
       61 actctagtag gcctggccta cccagaaaca gcaggagaga gaagaaacag gccagctgtg
      121 agaagccaag gacaccgagt cagtcatggc acctaaggcg gcaaaggggg ccaagccaga
      181 gccagcacca gctccacctc cacccggggc caaacccgag gaagacaaga aggacggtaa
      241 ggagccatcg gacaaacctc aaaaggcggt gcaggaccat aaggagccat cggacaaacc
      301 tcaaaaggcg gtgcagccca agcacgaagt gggcacgagg agggggtgtc gccgctaccg
      361 gtgggaatta aaagacagca ataaagagtt ctggctcttg gggcacgctg agatcaagat
      421 tcggagtttg ggctgcctaa tagctgcaat gatactgttg tcctcactca ccgtgcaccc
      481 catcttgagg cttatcatca ccatggagat atccttcttc agcttcttca tcttactgta
      541 cagctttgcc attcatagat acataccctt catcctgtgg cccatttctg acctcttcaa
      601 cgacctgatt gcttgtgcgt tccttgtggg agccgtggtc tttgctgtga gaagtcggcg
      661 atccatgaat ctccactact tacttgctgt gatccttatt ggtgcggctg gagtttttgc
      721 ttttatcgat gtgtgtcttc aaagaaacca cttcagaggc aagaaggcca aaaagcatat
      781 gctggttcct cctccaggaa aggaaaaagg accccagcag ggcaagggac cagaacccgc
      841 caagccacca gaacctggca agccaccagg gccagcaaag ggaaagaaat gacttggagg
      901 aggctcctgg tgtctgaaac ggcagtgtat tttacagcaa tatgtttcca ctctcttcct
      961 tgtcttcttt ctggaatggt tttcttttcc attttcatta ccacctttgc ttggaaaaga
     1021 atggattaat ggattctaaa agcctaaa
//
