LOCUS       NM_052999               1070 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens CKLF like MARVEL transmembrane domain containing 1
            (CMTM1), transcript variant 17, mRNA.
ACCESSION   NM_052999
VERSION     NM_052999.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1070)
  AUTHORS   Si,J., Zhang,P., Tian,D., Wang,X., Ma,Y., Zhang,J., Wang,L. and
            Yang,Y.
  TITLE     CMTM1_v17 is associated with chemotherapy resistance and poor
            prognosis in non-small cell lung cancer
  JOURNAL   World J Surg Oncol 15 (1), 34 (2017)
   PUBMED   28129775
  REMARK    GeneRIF: High CMTM1_v17 expression was associated with chemotherapy
            resistance in lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1070)
  AUTHORS   Delic,S., Thuy,A., Schulze,M., Proescholdt,M.A., Dietrich,P.,
            Bosserhoff,A.K. and Riemenschneider,M.J.
  TITLE     Systematic investigation of CMTM family genes suggests relevance to
            glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets
  JOURNAL   Genes Chromosomes Cancer 54 (7), 433-443 (2015)
   PUBMED   25931111
  REMARK    GeneRIF: CMTM1 and 3 are priority targets in glioblastomas. First
            insights into signalling of these two genes that might be conveyed
            by growth factor receptor, Src family kinase and WNT activation was
            presented.
REFERENCE   3  (bases 1 to 1070)
  AUTHORS   Wang,J., Zhang,G., Zhang,Y., Luo,Y., Song,Q., Qiu,X., Mo,X. and
            Wang,L.
  TITLE     CMTM1_v17 is a novel potential therapeutic target in breast cancer
  JOURNAL   Oncol Rep 32 (5), 1829-1836 (2014)
   PUBMED   25175386
  REMARK    GeneRIF: Study shows that CMTM1_v17 is highly expressed in human
            testis and many human tumor tissues and cell lines and seems to
            enhance cell proliferation and resistance to tumor necrosis
            factor-alpha (TNF-alpha)-induced apoptosis in MDA-MB-231 breast
            cancer cells.
REFERENCE   4  (bases 1 to 1070)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1070)
  AUTHORS   Xu,M., Yang,S., Gao,Y., Shi,S. and Ma,D.
  TITLE     A functional promoter region of the CKLFSF2 gene is located in the
            last intron/exon region of the upstream CKLFSF1 gene
  JOURNAL   Int J Biochem Cell Biol 37 (6), 1296-1307 (2005)
   PUBMED   15778092
  REMARK    GeneRIF: novel evidence that the final intron/exon region of the
            CKLFSF1 gene contains a novel eukaryotic promoter capable of
            directing expression of the downstream gene, CKLFSF2
REFERENCE   6  (bases 1 to 1070)
  AUTHORS   Wang,L., Wu,C., Zheng,Y., Qiu,X., Wang,L., Fan,H., Han,W., Lv,B.,
            Wang,Y., Zhu,X., Xu,M., Ding,P., Cheng,S., Zhang,Y., Song,Q. and
            Ma,D.
  TITLE     Molecular cloning and characterization of chemokine-like factor
            super family member 1 (CKLFSF1), a novel human gene with at least
            23 alternative splicing isoforms in testis tissue
  JOURNAL   Int J Biochem Cell Biol 36 (8), 1492-1501 (2004)
   PUBMED   15147728
  REMARK    GeneRIF: gene structure, mapping to chromsome 16, identification of
            altenative transcription start sites, expression in spermatocyte
            and testes
REFERENCE   7  (bases 1 to 1070)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
  REMARK    GeneRIF: Bioinformatics based on CKLF2 cDNA and protein sequences
            in combination with experimental validation identified CKLFSF1-8
            gene clusters, between the SCY and the TM4SF gene families. The 8
            family members were cloned and characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010542.7, DN992496.1,
            BC057852.1 and AY174119.1.
            
            On Jun 2, 2019 this sequence version replaced NM_052999.3.
            
            Summary: This gene belongs to the chemokine-like factor gene
            superfamily, a novel family that is similar to the chemokine and
            the transmembrane 4 superfamilies of signaling molecules. The
            protein encoded by this gene may play an important role in
            testicular development. Alternatively spliced transcript variants
            encoding different isoforms have been identified. Naturally
            occurring read-through transcription occurs between this locus and
            the neighboring locus CKLF (chemokine-like factor).[provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (17) encodes the longest isoform
            (13).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057852.1, AF278577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379500.7/ ENSP00000368814.2
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC010542.7         88423-88430
            9-138               DN992496.1         203-332
            139-958             BC057852.1         131-950
            959-1070            AY174119.1         644-755
FEATURES             Location/Qualifiers
     source          1..1070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..1070
                     /gene="CMTM1"
                     /gene_synonym="CKLFH; CKLFH1; CKLFSF1"
                     /note="CKLF like MARVEL transmembrane domain containing 1"
                     /db_xref="GeneID:113540"
                     /db_xref="HGNC:HGNC:19172"
                     /db_xref="MIM:607884"
     exon            1..507
                     /gene="CMTM1"
                     /gene_synonym="CKLFH; CKLFH1; CKLFSF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..936
                     /gene="CMTM1"
                     /gene_synonym="CKLFH; CKLFH1; CKLFSF1"
                     /note="isoform 13 is encoded by transcript variant 17;
                     chemokine-like factor-like protein CKLFH1; chemokine-like
                     factor super family 1; CKLF-like MARVEL transmembrane
                     domain-containing protein 1; chemokine-like factor
                     superfamily 1; chemokine-like factor superfamily member 1"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 1 isoform 13"
                     /protein_id="NP_443725.3"
                     /db_xref="CCDS:CCDS10812.2"
                     /db_xref="GeneID:113540"
                     /db_xref="HGNC:HGNC:19172"
                     /db_xref="MIM:607884"
                     /translation="MDPEHAKPESSEAPSGNLKQPETAAALASSGSVVSSVPKAQRNI
                     SAKTAPRKHPAVSIRSAQSAAAARPQGSEGTAPSRKATTRPPPKPTLPPPTPSAHTES
                     KLLNEMAIKERVEGRAKVPYKFRDSLKRFSFSPTGMLKILRLSLILGALACFIITQAN
                     ESFITITSLEICIVVFFILIYVLTLHHLLTYLHWPLLDLTNSIITAVFLSVVAILAMQ
                     EKKRRHLLYVGGSLCLTAVIVCCIDAFVVTTKMRTNLKRFLGVEVERKLSPAKDAYPE
                     TGPDAPQRPA"
     exon            508..666
                     /gene="CMTM1"
                     /gene_synonym="CKLFH; CKLFH1; CKLFSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..765
                     /gene="CMTM1"
                     /gene_synonym="CKLFH; CKLFH1; CKLFSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..1070
                     /gene="CMTM1"
                     /gene_synonym="CKLFH; CKLFH1; CKLFSF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1039..1044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMTM1"
                     /gene_synonym="CKLFH; CKLFH1; CKLFSF1"
                     /note="hexamer: CATAAA"
     polyA_site      1070
                     /gene="CMTM1"
                     /gene_synonym="CKLFH; CKLFH1; CKLFSF1"
                     /note="major polyA site"
ORIGIN      
        1 gcgacgctgg ttcccagggg agagccagcc gctgccgcgg cactggttca gacggccagg
       61 ccctagggac ccaccatgga tcctgaacac gccaaacctg agtcatccga ggcaccttca
      121 gggaacttga aacaaccgga gactgccgca gccctggcaa gtagcggcag cgtagtgagt
      181 tctgtaccca aggcacagcg caacatctca gcgaagaccg caccccggaa gcaccccgca
      241 gtctcaattc gcagtgcgca gtccgcagcc gccgcacgtc cccaaggcag tgagggcacc
      301 gcaccctcaa ggaaagccac cacacgccca cccccaaagc ccacactccc accccccacg
      361 ccctctgcac acactgaatc caaactctta aatgagatgg cgatcaaaga gcgcgtggag
      421 ggccgagcca aagtcccgta caaattcagg gacagcctca aacgtttctc cttctcgccc
      481 actggaatgt tgaagatcct gagactgagt cttatcttag gagcattagc ttgtttcatc
      541 atcacccaag ccaatgagtc atttataaca atcacaagtc tggaaatctg cattgtcgtt
      601 ttttttattc taatatatgt gctaaccctt caccacttgc tgacctattt acattggccc
      661 ttacttgatc ttaccaacag tatcattaca gctgtgttcc tttcagtagt tgccatcttg
      721 gccatgcaag aaaagaaaag aaggcattta ctctatgtcg gggggtccct gtgtctcaca
      781 gcggtaatcg tgtgttgcat cgatgcgttt gtggtcacca cgaagatgag gaccaacttg
      841 aaaagattcc tgggagtcga agttgaaagg aagctttccc ccgccaagga cgcctacccc
      901 gaaaccggcc ccgacgcccc gcagaggccc gcctgaagcc agcccggcgc cctagcagat
      961 gcacgtgtct gtcgaatcgc tgcctccgag cccacccccg agctcgcatg ctgtcaccca
     1021 ttccagccta aatgtgacca taaaattagg gctgctgctt ttatcgagaa
//
