LOCUS       NM_032359               4302 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cms1 ribosomal small subunit homolog (CMSS1),
            transcript variant 1, mRNA.
ACCESSION   NM_032359
VERSION     NM_032359.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4302)
  AUTHORS   Lau,B., Beine-Golovchuk,O., Kornprobst,M., Cheng,J., Kressler,D.,
            Jady,B., Kiss,T., Beckmann,R. and Hurt,E.
  TITLE     Cms1 coordinates stepwise local 90S pre-ribosome assembly with
            timely snR83 release
  JOURNAL   Cell Rep 41 (8), 111684 (2022)
   PUBMED   36417864
REFERENCE   2  (bases 1 to 4302)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4302)
  AUTHORS   Cheng,C.Y., Schache,M., Ikram,M.K., Young,T.L., Guggenheim,J.A.,
            Vitart,V., MacGregor,S., Verhoeven,V.J., Barathi,V.A., Liao,J.,
            Hysi,P.G., Bailey-Wilson,J.E., St Pourcain,B., Kemp,J.P.,
            McMahon,G., Timpson,N.J., Evans,D.M., Montgomery,G.W., Mishra,A.,
            Wang,Y.X., Wang,J.J., Rochtchina,E., Polasek,O., Wright,A.F.,
            Amin,N., van Leeuwen,E.M., Wilson,J.F., Pennell,C.E., van
            Duijn,C.M., de Jong,P.T., Vingerling,J.R., Zhou,X., Chen,P., Li,R.,
            Tay,W.T., Zheng,Y., Chew,M., Burdon,K.P., Craig,J.E., Iyengar,S.K.,
            Igo,R.P. Jr., Lass,J.H. Jr., Chew,E.Y., Haller,T., Mihailov,E.,
            Metspalu,A., Wedenoja,J., Simpson,C.L., Wojciechowski,R., Hohn,R.,
            Mirshahi,A., Zeller,T., Pfeiffer,N., Lackner,K.J., Bettecken,T.,
            Meitinger,T., Oexle,K., Pirastu,M., Portas,L., Nag,A.,
            Williams,K.M., Yonova-Doing,E., Klein,R., Klein,B.E.,
            Hosseini,S.M., Paterson,A.D., Makela,K.M., Lehtimaki,T.,
            Kahonen,M., Raitakari,O., Yoshimura,N., Matsuda,F., Chen,L.J.,
            Pang,C.P., Yip,S.P., Yap,M.K., Meguro,A., Mizuki,N., Inoko,H.,
            Foster,P.J., Zhao,J.H., Vithana,E., Tai,E.S., Fan,Q., Xu,L.,
            Campbell,H., Fleck,B., Rudan,I., Aung,T., Hofman,A.,
            Uitterlinden,A.G., Bencic,G., Khor,C.C., Forward,H., Parssinen,O.,
            Mitchell,P., Rivadeneira,F., Hewitt,A.W., Williams,C., Oostra,B.A.,
            Teo,Y.Y., Hammond,C.J., Stambolian,D., Mackey,D.A., Klaver,C.C.,
            Wong,T.Y., Saw,S.M. and Baird,P.N.
  CONSRTM   Consortium for Refractive Error and Myopia; Fuchs' Genetics
            Multi-Center Study Group; Wellcome Trust Case Control Consortium 2;
            Diabetes Control and Complications Trial/Epidemiology of Diabetes
            Interventions, and Complications Research Group
  TITLE     Nine loci for ocular axial length identified through genome-wide
            association studies, including shared loci with refractive error
  JOURNAL   Am J Hum Genet 93 (2), 264-277 (2013)
   PUBMED   24144296
REFERENCE   4  (bases 1 to 4302)
  AUTHORS   Ludwig,K.U., Mangold,E., Herms,S., Nowak,S., Reutter,H., Paul,A.,
            Becker,J., Herberz,R., AlChawa,T., Nasser,E., Bohmer,A.C.,
            Mattheisen,M., Alblas,M.A., Barth,S., Kluck,N., Lauster,C.,
            Braumann,B., Reich,R.H., Hemprich,A., Potzsch,S., Blaumeiser,B.,
            Daratsianos,N., Kreusch,T., Murray,J.C., Marazita,M.L.,
            Ruczinski,I., Scott,A.F., Beaty,T.H., Kramer,F.J., Wienker,T.F.,
            Steegers-Theunissen,R.P., Rubini,M., Mossey,P.A., Hoffmann,P.,
            Lange,C., Cichon,S., Propping,P., Knapp,M. and Nothen,M.M.
  TITLE     Genome-wide meta-analyses of nonsyndromic cleft lip with or without
            cleft palate identify six new risk loci
  JOURNAL   Nat Genet 44 (9), 968-971 (2012)
   PUBMED   22863734
REFERENCE   5  (bases 1 to 4302)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 4302)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 4302)
  AUTHORS   Jung,H.M., Choi,S.J. and Kim,J.K.
  TITLE     Expression profiles of SV40-immortalization-associated genes
            upregulated in various human cancers
  JOURNAL   J Cell Biochem 106 (4), 703-713 (2009)
   PUBMED   19160420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK312483.1, AC069222.23, BC006512.2 and AC129803.3.
            
            On Nov 23, 2018 this sequence version replaced NM_032359.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291392.1, SRR1660807.113871.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421999.8/ ENSP00000410396.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AK312483.1         29-67
            40-40               AC069222.23        49929-49929         c
            41-958              AK312483.1         69-986
            959-1173            BC006512.2         984-1198
            1174-4302           AC129803.3         65671-68799         c
FEATURES             Location/Qualifiers
     source          1..4302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.1"
     gene            1..4302
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /note="cms1 ribosomal small subunit homolog"
                     /db_xref="GeneID:84319"
                     /db_xref="HGNC:HGNC:28666"
     exon            1..182
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..958
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein CMSS1"
                     /codon_start=1
                     /product="protein CMSS1 isoform 1"
                     /protein_id="NP_115735.2"
                     /db_xref="CCDS:CCDS2935.1"
                     /db_xref="GeneID:84319"
                     /db_xref="HGNC:HGNC:28666"
                     /translation="MADDLGDEWWENQPTGAGSSPEASDGEGEGDTEVMQQETVPVPV
                     PSEKTKQPKECFLIQPKERKENTTKTRKRRKKKITDVLAKSEPKPGLPEDLQKLMKDY
                     YSSRRLVIELEELNLPDSCFLKANDLTHSLSSYLKEICPKWVKLRKNHSEKKSVLMLI
                     ICSSAVRALELIRSMTAFRGDGKVIKLFAKHIKVQAQVKLLEKRVVHLGVGTPGRIKE
                     LVKQGGLNLSPLKFLVFDWNWRDQKLRRMMDIPEIRKEVFELLEMGVLSLCKSESLKL
                     GLF"
     exon            183..271
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            272..343
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            344..473
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            474..533
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            534..636
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            637..697
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            698..785
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            786..874
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            875..4302
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1147..1152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /note="hexamer: AATAAA"
     polyA_site      1173
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /note="major polyA site"
     regulatory      4275..4280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
                     /note="hexamer: ATTAAA"
     polyA_site      4302
                     /gene="CMSS1"
                     /gene_synonym="C3orf26"
ORIGIN      
        1 agtgtctagc gggagctccg cgtgtagcta cgccggccgc ctggctttga gacaacgtga
       61 ttctccgcag ctggtcgcct acccgtgatg ttctgcccac gtcgagacct gagctgaaat
      121 ggcagacgat ctcggagacg agtggtggga gaaccagccg actggagcag gcagcagccc
      181 agaagcatca gatggtgaag gagaaggaga cacagaagtg atgcagcagg agacagttcc
      241 agttcctgta ccttcagaga aaaccaaaca gcctaaagaa tgttttttga tacaaccaaa
      301 ggaaagaaaa gagaatacca ccaagaccag gaaaagaaga aagaagaaaa ttactgatgt
      361 tcttgcaaaa tcagaaccaa aaccagggtt acctgaagac ctacagaagc tgatgaagga
      421 ctattatagc agcagacgct tggtgattga attagaagaa ctgaacctgc cagactcctg
      481 tttcctcaag gccaatgatt tgactcacag tctttcctca tacctaaaag aaatttgtcc
      541 taagtgggta aaacttagga agaaccacag tgagaagaaa tcggtcctga tgctgatcat
      601 ctgcagctcg gccgtccgag ccctggagct cattaggtcg atgacagcat tcagaggaga
      661 cggcaaagtt ataaaattat ttgcaaagca cataaaggtc caggcgcagg taaagttgct
      721 ggagaagcgt gtggtgcacc tgggtgtagg aactccgggg agaattaaag aacttgttaa
      781 acaaggtggc cttaatttga gccccttaaa atttctggtt tttgactgga actggagaga
      841 tcagaagttg aggagaatga tggacattcc cgagataaga aaggaggtat tcgaacttct
      901 ggaaatggga gtgctcagtc tgtgcaagtc agaatccttg aaactgggcc ttttctaagt
      961 ctgtgtccta atgaagattc cagttttcac agtagaagtt gcatcttatt taatgactct
     1021 gatacattgc aagcactcag taaatatcag caaatagttt atgttaattg tgtcaacaga
     1081 tggatcactg gaatgtgggg attctgaaac agaaatgaaa ctgtcctttt gacaactctc
     1141 ttatataata aagtatcacc ggcttgtgta tgatccttgt tgagcggacc gtgtttttct
     1201 gtcaccaact ggcttctgat gtaactgtgc aggagaaagg aaagagcagc tgggtgacct
     1261 taggcaagcg taaggtcttg cctctctgag ccccatctta tcaactcaaa gtgggaatgt
     1321 ctcacagcat tgttgaggat tccaggagat agtacatggg gagcagattt gtaaactctg
     1381 aggcatggtc ccagcaaaaa gggtggcagg tatattaatc cattctcaca ttgctataaa
     1441 gaactacccg agactgggta gattataaag aaaagaggtt taattgactc acagtttcac
     1501 aggctgtaca ggaggcatgg ctgagaggcc tcaggaaact tggcagaagg tgaaggggaa
     1561 gcaagcacat cttcacatgg cgacaagaga gcaagagagt gaagggagaa atgccacaca
     1621 cttttaaacg actagatctt gtgagaactc actccctatc atgagaacag cagaacagca
     1681 aggggaaaat ctgtccctat gatccagtca ccttccacca ggtccctccc ccaacattgg
     1741 gaattataat tcaacataag attcgggtgg agacacagag ccaaaccatg tcaattccac
     1801 cccggcctct tccaaatttc atgttcttct cacatttcaa aacacaatca tgccttctca
     1861 acagtccccc aaagtcttaa ctcattccag cattaactga aaagtccaac tccaaagtct
     1921 gatctgagac aaggcaactt ccttccacct atgagcctgt aaaataaaaa acaagttagt
     1981 catttccaag atacaatgga ggtacaggca ttgggtaaat gctcccattc caagtgggag
     2041 aaactggccc aaaggagcta aaggcctcat gccagtttga aacccagcag ggcactcttt
     2101 gaatcttaaa gctccaaaat aatctttgac tccatgtctc acatccaggc cactctgatg
     2161 caaggagtgg gctcccaagg ccttaggcag ctctgcccct gtggctctgc agggtacagt
     2221 ccccatggtt gctttcacag gctggtgttg agtgcctaca gcatatccag gtacacagtg
     2281 taagctgtca gtggatctac cattctgggg tctggaggat gatggctctc ttctcacagc
     2341 tccactaggc agtgccccag tggggactct gtgtagggtc tccaacccca catttcccct
     2401 ctgcactgcc ctagtagagg ctctccatga gggcttcacc cctgtagcag acttctgcct
     2461 ggacatccag gcgtttccat acatcctctg aaattgaggc agaggctccc aaacctcagc
     2521 tcttgccttc tgcacaccca taagcccaac agcacgtgga agctgccaag gcttggggct
     2581 tgcaccctct gaagcaatgg ttcagctgta ccttggcccc ttttagtcac agctggagct
     2641 ggggcagctg ggaattaggc tgccatgtcc taaggctgca cagagcagct gggcccaggg
     2701 cctagcccac gaaaccattt ttttcctcct aggcctctgg gcctgtttgg tggggctggg
     2761 gagggctgcc acgaaggtct ctgaagtgcc ctggaggcat tttatccatt gttttggcta
     2821 ttaacatttg gctcctcttg tgcaaacttc tgcagtgagc ttgaatttct ccccagaaaa
     2881 tggcttttct tttctaccac atggtcaggc tgcaaatttt caagctttta tactctgctt
     2941 tgcttttaaa tataagttat ctctgcttat gcaaatgagc ataggctttt agaagcaacc
     3001 aggccacctc ttgaacactt tgctgcttag aaatttctgc cggataccct aagtcatctc
     3061 tcccaagttc aaagttacac agatccctaa agcaggggca caatgccacc agtctctgct
     3121 aaagcatagc aagagtgacc tttgctccag ttcctgataa gttcctcatc tccatttgag
     3181 accacctcag cctggacttc attgtccata tcactatcag cattttggtc aaaactgttc
     3241 aacaagtctc taggaggttc caaacatccc tcatattcct gtcttcttct gatccttcca
     3301 aactgttgca acttctcccc gttacccagt ttcaaagttg cttccacatt ttttaggtat
     3361 ctttatagaa atgtcccact tctctggtac caattttttg tattcttcca tttttacact
     3421 gctatgaaga actacctgag actgggtagt ttataatgaa aagaggttta attgacttcc
     3481 agttccacag actgtacagg aggatggctg gggaggcctc aggaaattta caatcatggc
     3541 agaagatgaa agggatgcaa ccacatcttg tggcaacaag agagcaagag agtgaagggg
     3601 gaagtgctat acacttttaa acaatcagat ctcttgagaa ctcactatca tgagaacagc
     3661 aagggggaaa tctgccccca tgatctaatc acctcccacc agatccctcc cccaacactg
     3721 ggaattacaa ttcgacatga aacttgggtg gggacacagc caaaccacat cagcagggta
     3781 gtggtagaaa gagcatcaag tgaatttggc cctttgtaaa cgtataaaaa gacaacaata
     3841 taattacagc tgtcttatta actttttttt aaaaactttc tattttgaaa cttcaggctt
     3901 aatagaaaag tttaaaaaat agagaattcc catatcccct tccctgagct ttccctgtgt
     3961 taaattcttg tataaccata atagagttat caaaactaag aagtcatcac tggtactgta
     4021 taattaacta aactacagag tttatttgga tttctccaat ttttccacta atgtccttgt
     4081 tctattccag gattcactgc aggatcccac attgcactta cttagttgtt gtatcttttt
     4141 ggtttcttca gaccagtgac agttcctcag tatttccctg tctttcatga ccttcacact
     4201 tttgaacagt atccatcgtg tattttgtag aatgtccttc aatttggatt tgtctgtaat
     4261 gttctcatga tttgattaaa gttatgcatt ttttgaccag aa
//
