LOCUS       NM_207315               3095 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens cytidine/uridine monophosphate kinase 2 (CMPK2),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_207315
VERSION     NM_207315.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3095)
  AUTHORS   Guan,X., Zhu,S., Song,J., Liu,K., Liu,M., Xie,L., Wang,Y., Wu,J.,
            Xu,X. and Pang,T.
  TITLE     Microglial CMPK2 promotes neuroinflammation and brain injury after
            ischemic stroke
  JOURNAL   Cell Rep Med 5 (5), 101522 (2024)
   PUBMED   38701781
  REMARK    GeneRIF: Microglial CMPK2 promotes neuroinflammation and brain
            injury after ischemic stroke.
REFERENCE   2  (bases 1 to 3095)
  AUTHORS   Pawlak,J.B., Hsu,J.C., Xia,H., Han,P., Suh,H.W., Grove,T.L.,
            Morrison,J., Shi,P.Y., Cresswell,P. and Laurent-Rolle,M.
  TITLE     CMPK2 restricts Zika virus replication by inhibiting viral
            translation
  JOURNAL   PLoS Pathog 19 (4), e1011286 (2023)
   PUBMED   37075076
  REMARK    GeneRIF: CMPK2 restricts Zika virus replication by inhibiting viral
            translation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3095)
  AUTHORS   Zhao,M., Su,H.Z., Zeng,Y.H., Sun,Y., Guo,X.X., Li,Y.L., Wang,C.,
            Zhao,Z.Y., Huang,X.J., Lin,K.J., Ye,Z.L., Lin,B.W., Hong,S.,
            Zheng,J., Liu,Y.B., Yao,X.P., Yang,D., Lu,Y.Q., Chen,H.Z., Zuo,E.,
            Yang,G., Wang,H.T., Huang,C.W., Lin,X.H., Cen,Z., Lai,L.L.,
            Zhang,Y.K., Li,X., Lai,T., Lin,J., Zuo,D.D., Lin,M.T., Liou,C.W.,
            Kong,Q.X., Yan,C.Z., Xiong,Z.Q., Wang,N., Luo,W., Zhao,C.P.,
            Cheng,X. and Chen,W.J.
  TITLE     Loss of function of CMPK2 causes mitochondria deficiency and brain
            calcification
  JOURNAL   Cell Discov 8 (1), 128 (2022)
   PUBMED   36443312
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3095)
  AUTHORS   Arumugam,P., Chauhan,M., Rajeev,T., Chakraborty,R., Bisht,K.,
            Madan,M., Shankaran,D., Ramalingam,S., Gandotra,S. and Rao,V.
  TITLE     The mitochondrial gene-CMPK2 functions as a rheostat for macrophage
            homeostasis
  JOURNAL   Front Immunol 13, 935710 (2022)
   PUBMED   36451821
  REMARK    GeneRIF: The mitochondrial gene-CMPK2 functions as a rheostat for
            macrophage homeostasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3095)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 3095)
  AUTHORS   Lai,J.H., Hung,L.F., Huang,C.Y., Wu,D.W., Wu,C.H. and Ho,L.J.
  TITLE     Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell
            formation, potentially contributing to premature atherosclerosis in
            SLE
  JOURNAL   Arthritis Res Ther 23 (1), 120 (2021)
   PUBMED   33874983
  REMARK    GeneRIF: Mitochondrial protein CMPK2 regulates IFN alpha-enhanced
            foam cell formation, potentially contributing to premature
            atherosclerosis in SLE.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3095)
  AUTHORS   Amiri,M., Conserva,F., Panayiotou,C., Karlsson,A. and Solaroli,N.
  TITLE     The human adenylate kinase 9 is a nucleoside mono- and diphosphate
            kinase
  JOURNAL   Int J Biochem Cell Biol 45 (5), 925-931 (2013)
   PUBMED   23416111
REFERENCE   8  (bases 1 to 3095)
  AUTHORS   Chen,Y.L., Lin,D.W. and Chang,Z.F.
  TITLE     Identification of a putative human mitochondrial thymidine
            monophosphate kinase associated with monocytic/macrophage terminal
            differentiation
  JOURNAL   Genes Cells 13 (7), 679-689 (2008)
   PUBMED   18498354
  REMARK    GeneRIF: Upregulated in monocyte/macrophage differentiating cells,
            suggesting coordinated regulation with the terminal differentiation
            program.
REFERENCE   9  (bases 1 to 3095)
  AUTHORS   Xu,Y., Johansson,M. and Karlsson,A.
  TITLE     Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase
            localized in mitochondria
  JOURNAL   J Biol Chem 283 (3), 1563-1571 (2008)
   PUBMED   17999954
  REMARK    GeneRIF: a human mitochondrial UMP-CMP kinase (UMP-CMPK, cytidylate
            kinase; EC 2.7.4.14), designated as UMP-CMP kinase 2 (UMP-CMPK2),
            is identified.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC017076.14.
            
            On Aug 6, 2020 this sequence version replaced NM_207315.3.
            
            Summary: This gene encodes one of the enzymes in the nucleotide
            synthesis salvage pathway that may participate in terminal
            differentiation of monocytic cells. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089425.1, SRR14038195.1863294.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000256722.10/
                                                  ENSP00000256722.5
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-886               AC017076.14        64455-65340         c
            887-1001            AC017076.14        62897-63011         c
            1002-1203           AC017076.14        60617-60818         c
            1204-1437           AC017076.14        50883-51116         c
            1438-3095           AC017076.14        47749-49406         c
FEATURES             Location/Qualifiers
     source          1..3095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.2"
     gene            1..3095
                     /gene="CMPK2"
                     /gene_synonym="IBGC10; NDK; TMPK2; TYKi; UMP-CMPK2"
                     /note="cytidine/uridine monophosphate kinase 2"
                     /db_xref="GeneID:129607"
                     /db_xref="HGNC:HGNC:27015"
                     /db_xref="MIM:611787"
     exon            1..886
                     /gene="CMPK2"
                     /gene_synonym="IBGC10; NDK; TMPK2; TYKi; UMP-CMPK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1561
                     /gene="CMPK2"
                     /gene_synonym="IBGC10; NDK; TMPK2; TYKi; UMP-CMPK2"
                     /EC_number="2.7.4.6"
                     /EC_number="2.7.4.14"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mitochondrial UMP-CMP kinase; cytidylate kinase
                     2; cytidine monophosphate (UMP-CMP) kinase 2,
                     mitochondrial; UMP/CMP kinase; thymidylate kinase family
                     LPS-inducible member; UMP-CMP kinase 2, mitochondrial;
                     thymidine monophosphate kinase 2; nucleoside-diphosphate
                     kinase"
                     /codon_start=1
                     /product="UMP-CMP kinase 2, mitochondrial isoform 1
                     precursor"
                     /protein_id="NP_997198.2"
                     /db_xref="CCDS:CCDS42648.1"
                     /db_xref="GeneID:129607"
                     /db_xref="HGNC:HGNC:27015"
                     /db_xref="MIM:611787"
                     /translation="MAFARRLLRGPLSGPLLGRRGVCAGAMAPPRRFVLELPDCTLAH
                     FALGADAPGDADAPDPRLAALLGPPERSYSLCVPVTPDAGCGARVRAARLHQRLLHQL
                     RRGPFQRCQLLRLLCYCPGGQAGGAQQGFLLRDPLDDPDTRQALLELLGACQEAPRPH
                     LGEFEADPRGQLWQRLWEVQDGRRLQVGCAQVVPVPEPPLHPVVPDLPSSVVFPDREA
                     ARAVLEECTSFIPEARAVLDLVDQCPKQIQKGKFQVVAIEGLDATGKTTVTQSVADSL
                     KAVLLKSPPSCIGQWRKIFDDEPTIIRRAFYSLGNYIVASEIAKESAKSPVIVDRYWH
                     STATYAIATEVSGGLQHLPPAHHPVYQWPEDLLKPDLILLLTVSPEERLQRLQGRGME
                     KTREEAELEANSVFRQKVEMSYQRMENPGCHVVDASPSREKVLQTVLSLIQNSFSEP"
     exon            887..1001
                     /gene="CMPK2"
                     /gene_synonym="IBGC10; NDK; TMPK2; TYKi; UMP-CMPK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1203
                     /gene="CMPK2"
                     /gene_synonym="IBGC10; NDK; TMPK2; TYKi; UMP-CMPK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1437
                     /gene="CMPK2"
                     /gene_synonym="IBGC10; NDK; TMPK2; TYKi; UMP-CMPK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..3095
                     /gene="CMPK2"
                     /gene_synonym="IBGC10; NDK; TMPK2; TYKi; UMP-CMPK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3067..3072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMPK2"
                     /gene_synonym="IBGC10; NDK; TMPK2; TYKi; UMP-CMPK2"
                     /note="hexamer: AATAAA"
     polyA_site      3095
                     /gene="CMPK2"
                     /gene_synonym="IBGC10; NDK; TMPK2; TYKi; UMP-CMPK2"
                     /note="major polyA site"
ORIGIN      
        1 acatctcgcg gcgaggagga gaggccggaa gggcgcccca gccccagggc tcctgccccg
       61 cctgggcctc cggctttcgt ttccccgcaa cgcttcgctt tcgtttcccg ctggcgcctg
      121 gctccctccg ggtttcgttt cccgccggcg cctggctccc gccaggtttc gtttccgagg
      181 cggggccgag ggcggcgtcg ctgaggcgcc catggccttc gcccgccggc tcctgcgcgg
      241 gccactgtcg gggccgctgc tcgggcggcg cggggtctgc gctggggcca tggctccgcc
      301 gcgccgcttc gtcctggagc ttcccgactg caccctggct cacttcgccc taggcgccga
      361 cgcccccggc gacgcagacg cccccgaccc ccgcctggcg gcgctgctgg ggcccccgga
      421 gcgcagctac tcgctgtgcg tgcccgtgac cccggacgcc ggctgcgggg cccgggtccg
      481 ggcggcgcgg ctgcaccagc gcctgctgca ccagctgcgc cgcggcccct tccagcggtg
      541 ccagctgctc aggctgctct gctactgccc gggcggccag gccggcggcg cacagcaagg
      601 cttcctgctg cgcgaccccc tggatgaccc tgacacccgg caagcgctgc tcgagctgct
      661 gggcgcctgt caggaggcac cacgcccgca cttgggcgag ttcgaggccg acccgcgcgg
      721 ccagctgtgg cagcgcctct gggaggtgca agacggcagg cggctgcagg tgggctgcgc
      781 acaggtcgtg cccgtcccgg agcccccgct gcacccggtg gtgccagact tgcccagttc
      841 cgtggtcttc ccggaccggg aagccgcccg ggccgttttg gaggagtgta cctcctttat
      901 tcctgaagcc cgggcagtgc ttgacctggt cgaccagtgc ccaaaacaga tccagaaagg
      961 aaagttccag gttgttgcca tcgaaggact ggatgccacg ggtaaaacca cggtgaccca
     1021 gtcagtggca gattcactta aggctgtcct cttaaagtca ccaccctctt gcattggcca
     1081 gtggaggaag atctttgatg atgaaccaac tatcattaga agagcttttt actctttggg
     1141 caattatatt gtggcctccg aaatagctaa agaatctgcc aaatctcctg tgattgtaga
     1201 caggtactgg cacagcacgg ccacctatgc catagccact gaggtgagtg ggggtctcca
     1261 gcacctgccc ccagcccatc accctgtgta ccagtggcca gaggacctgc tcaaacctga
     1321 ccttatcctg ctgctcactg tgagtcctga ggagaggttg cagaggctgc agggccgggg
     1381 catggagaag accagggaag aagcagaact tgaggccaac agtgtgtttc gtcaaaaggt
     1441 agaaatgtcc taccagcgga tggagaatcc tggctgccat gtggttgatg ccagcccctc
     1501 cagagaaaag gtcctgcaga cggtattaag cctaatccag aatagtttta gtgaaccgta
     1561 gttactctgg ccaggtgcca cgtctaacta gattagatgt tgtttgaaac atctacatcc
     1621 accatttgtt atgcagtgtt cccaaatttc tgttctacaa gcatgttgtg tggcagaaaa
     1681 ctggagacca ggcatcttaa ttttacttca gccatcgtac cctcttctga ctgatggacc
     1741 cgtcatcaca aaggtccctc tcatcatgtt ccagtgagag gccagcgatt gctttcttcc
     1801 tggcatagta aacattttct tggaacatat gtttcactta atcactacca aatatctgga
     1861 agacctgtct tactcagaca gcaccaggtg tacagaagca gcagacaaga tcttccagat
     1921 cagcagggag accccggagc ctctgcttct cctacactgg catgctgatg agatcgtgac
     1981 atgcccacat tggcttcttc cacatctggt tgcactcgtc atgatgggct cgctgcatct
     2041 ccctcagtcc caaattctag agccaagtgt tcctgcagag gctgtctatg tgtcctggct
     2101 gcccaaggac actcctgcag agccattttt gggtaaggaa cacttacaaa gaaggcattg
     2161 atcttgtgtc tgaggctcag agcccttttg ataggcttct gagtcatata taaagacatt
     2221 caagccaaga tgctccaact gcaaatatac caaccttctc tgaattatat tttgcttatt
     2281 tatatttctt ttcttttttt ctaaagtatg gctctgaata gaatgcacat tttccattga
     2341 actggatgca tttcatttag ccaatccagt aatttattta tattaatcta tacataatat
     2401 gtttcctcag cataggagct atgattcatt aattaaaagt ggagtcaaaa cgctaaatgc
     2461 aatgtttgtt gtgtattttc attacacaaa cttaatttgt cttgttaaat aagtacagtg
     2521 gatcttggag tgggatttct tggtaaatta tcttgcactt gaatgtctca tgattacata
     2581 tgaaatcgct ttgacatatc tttagacaga aaaaagtagc tgagtgaggg ggaaattata
     2641 gagctgtgtg actttaggga gtaggttgaa ccaggtgatt acctaaaatt ccttccagtt
     2701 caaaggcaga taaatctgta aattatttta tcctatctac catttcttaa gaagacatta
     2761 ctccaaaata attaaattta aggctttatc aggtctgcat atagaatctt aaattctaat
     2821 aaagtttcat gttaatgtca taggattttt aaaagagcta taggtaattt ctatataata
     2881 tgtgtatatt aaaatgtaat tgatttcagt tgaaagtatt ttaaagctga taaatagcat
     2941 tagggttctt tgcaatgtgg tatctagctg tattattggt tttatttact ttaaacattt
     3001 tgaaaagctt atactggcag cctagaaaaa caaacaatta atgtatcttt atgtccctgg
     3061 cacatgaata aactttgctg tggtttacta atcta
//
