LOCUS       NM_016308               2937 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cytidine/uridine monophosphate kinase 1 (CMPK1),
            transcript variant 1, mRNA.
ACCESSION   NM_016308
VERSION     NM_016308.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2937)
  AUTHORS   Christison,K.S., Sol,J.A., Gurney,S.C. and Dumke,C.L.
  TITLE     Twenty-Four Percent of Wildland Firefighters Reach Critical Levels
            of Serum Creatine Kinase During 80-Hour Critical Training
  JOURNAL   Wilderness Environ Med 34 (3), 334-340 (2023)
   PUBMED   37258394
  REMARK    GeneRIF: Twenty-Four Percent of Wildland Firefighters Reach
            Critical Levels of Serum Creatine Kinase During 80-Hour Critical
            Training.
REFERENCE   2  (bases 1 to 2937)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2937)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2937)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2937)
  AUTHORS   Van Rompay,A.R., Johansson,M. and Karlsson,A.
  TITLE     Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP
            kinase: molecular characterization of the human enzyme
  JOURNAL   Mol Pharmacol 56 (3), 562-569 (1999)
   PUBMED   10462544
REFERENCE   6  (bases 1 to 2937)
  AUTHORS   Hochstrasser,D.F., Frutiger,S., Paquet,N., Bairoch,A., Ravier,F.,
            Pasquali,C., Sanchez,J.C., Tissot,J.D., Bjellqvist,B., Vargas,R. et
            al.
  TITLE     Human liver protein map: a reference database established by
            microsequencing and gel comparison
  JOURNAL   Electrophoresis 13 (12), 992-1001 (1992)
   PUBMED   1286669
REFERENCE   7  (bases 1 to 2937)
  AUTHORS   Komatsu,N., Kimura,Y., Kido,A. and Oya,M.
  TITLE     Polymorphism of uridine monophosphate kinase: population study in
            Japanese and phenotyping in bloodstains
  JOURNAL   Int J Legal Med 104 (1), 13-16 (1990)
   PUBMED   11453085
REFERENCE   8  (bases 1 to 2937)
  AUTHORS   Scott,E.M. and Wright,R.C.
  TITLE     Kinetics and equilibria of pyrimidine nucleoside monophosphate
            kinase from human erythrocytes
  JOURNAL   Biochim Biophys Acta 571 (1), 45-54 (1979)
   PUBMED   40615
REFERENCE   9  (bases 1 to 2937)
  AUTHORS   Jamil,T.P., Swallow,D.M. and Povey,S.
  TITLE     A comparative study of the age-related patterns of decay of some
            nucleoside monophosphate kinases in human red cells
  JOURNAL   Biochem Genet 16 (11-12), 1219-1232 (1978)
   PUBMED   220950
REFERENCE   10 (bases 1 to 2937)
  AUTHORS   Satlin,A., Kucherlapati,R. and Ruddle,F.H.
  TITLE     Assignment of the gene for human uridine monophosphate kinase to
            chromosome 1 using somatic cell hybrid clone panels
  JOURNAL   Cytogenet Cell Genet 15 (3), 146-152 (1975)
   PUBMED   172293
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513322.18 and AL607122.20.
            
            On Sep 21, 2018 this sequence version replaced NM_016308.2.
            
            Summary: This gene encodes one of the enzymes required for cellular
            nucleic acid biosynthesis. This enzyme catalyzes the transfer of a
            phosphate group from ATP to CMP, UMP, or dCMP, to form the
            corresponding diphosphate nucleotide. Alternate splicing results in
            both coding and non-coding transcript variants. [provided by
            RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1331711.1, AF070416.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371873.10/ ENSP00000360939.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               AL513322.18        57840-58166
            328-474             AL607122.20        26469-26615
            475-627             AL607122.20        30955-31107
            628-704             AL607122.20        32909-32985
            705-801             AL607122.20        33197-33293
            802-2937            AL607122.20        34704-36839
FEATURES             Location/Qualifiers
     source          1..2937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..2937
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
                     /note="cytidine/uridine monophosphate kinase 1"
                     /db_xref="GeneID:51727"
                     /db_xref="HGNC:HGNC:18170"
                     /db_xref="MIM:191710"
     exon            1..327
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..843
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
                     /EC_number="2.7.4.6"
                     /EC_number="2.7.4.14"
                     /note="isoform a is encoded by transcript variant 1;
                     cytidylate kinase; UMP/CMP kinase; deoxycytidylate kinase;
                     uridine monophosphate kinase; uridine
                     monophosphate/cytidine monophosphate kinase; dCMP kinase;
                     nucleoside-diphosphate kinase; cytidine monophosphate
                     (UMP-CMP) kinase 1, cytosolic"
                     /codon_start=1
                     /product="UMP-CMP kinase isoform a"
                     /protein_id="NP_057392.1"
                     /db_xref="CCDS:CCDS549.1"
                     /db_xref="GeneID:51727"
                     /db_xref="HGNC:HGNC:18170"
                     /db_xref="MIM:191710"
                     /translation="MLSRCRSGLLHVLGLSFLLQTRRPILLCSPRLMKPLVVFVLGGP
                     GAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPVEITIS
                     LLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICI
                     ERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKSVDEVFD
                     EVVQIFDKEG"
     exon            328..474
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
                     /inference="alignment:Splign:2.1.0"
     exon            475..627
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
                     /inference="alignment:Splign:2.1.0"
     exon            628..704
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
                     /inference="alignment:Splign:2.1.0"
     exon            705..801
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
                     /inference="alignment:Splign:2.1.0"
     exon            802..2937
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
                     /note="hexamer: AATAAA"
     polyA_site      1874
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
     regulatory      2910..2915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
                     /note="hexamer: AATAAA"
     polyA_site      2937
                     /gene="CMPK1"
                     /gene_synonym="CK; CMK; CMPK; UMK; UMP-CMPK; UMPK"
                     /note="major polyA site"
ORIGIN      
        1 cccttccgac agggccgcgg acgcccgggc agccacggcg gcggggccgc ggcgggcgcc
       61 ggctcagccc gcccctttct cccgccgcct ccccgccccg ccccgcgccg cgccggccgc
      121 tgtcagctcc ctcagcgtcc ggccgaggcg cggtgtatgc tgagccgctg ccgcagcggg
      181 ctgctccacg tcctgggcct tagcttcctg ctgcagaccc gccggccgat tctcctctgc
      241 tctccacgtc tcatgaagcc gctggtcgtg ttcgtcctcg gcggccccgg cgccggcaag
      301 gggacccagt gcgcccgcat cgtcgagaaa tatggctaca cacacctttc tgcaggagag
      361 ctgcttcgtg atgaaaggaa gaacccagat tcacagtatg gtgaacttat tgaaaagtac
      421 attaaagaag gaaagattgt accagttgag ataaccatca gtttattaaa gagggaaatg
      481 gatcagacaa tggctgccaa tgctcagaag aataaattct tgattgatgg gtttccaaga
      541 aatcaagaca accttcaagg atggaacaag accatggatg ggaaggcaga tgtatctttc
      601 gttctctttt ttgactgtaa taatgagatt tgtattgaac gatgtcttga gaggggaaag
      661 agtagtggta ggagtgatga caacagagag agcttggaaa agagaattca gacctacctt
      721 cagtcaacaa agccaattat tgacttatat gaagaaatgg ggaaagtcaa gaaaatagat
      781 gcttctaaat ctgttgatga agtttttgat gaagttgtgc agatttttga caaggaaggc
      841 taattctaaa cctgaaggca tccttgaaat catgcttgaa tattgctttg atagctgcta
      901 tcatgacccc tttttaaggc aattctaatc tttcataact acatctcaat tagtggctgg
      961 aaagtacatg gtaaaacaaa gtaaattttt ttatgttctt ttttttggtc acaggagtag
     1021 acagtgaatt caggtttaac ttcaccttag ttatggtgct caccaaacga agggtatcag
     1081 ctattttttt taaaattcaa aaagaatatc ccttttatag tttgtgcctt ctgtgagcaa
     1141 aactttttag tacgcgtata tatccctcta gtaatcacaa cattttagga tttagggata
     1201 cccgcttcct ctttttcttg caagttttaa atttccaacc ttaagtgaat ttgtggacca
     1261 aatttcaaag gaactttttg tgtagtcagt tcttgcacaa tgtgtttggt aaacaaactc
     1321 aaaatggatt cttaggagca ttttagtgtt tattaaataa ctgaccattt gctgtagaaa
     1381 gatgagaaaa cttaagcttt gttttactac aacttgtaca aagttgtatg acagggcata
     1441 ttctttgctt ccaagatttg ggttgggggc actaggggtt cagagcctgg cagaattgtc
     1501 agctttagtc tgacataatc taagggtatg gggcaaggat cacatctaat gcttgtgttc
     1561 cttatactct attatatagt gttattcatg attcagctga tcttaacaaa attcgtagca
     1621 gtggaacctt gaaatgcatg tggctagatt tatgctaaaa tgattctcag ttagcatttt
     1681 agtaacactt caaaggtttt tttttgtttg ttttctagac ttaataaaag cttaggatta
     1741 attagaagaa gcaatctagt taaatttccc atttgtattt tattttcttg aatacttttt
     1801 tcatagttat ttgtttaaaa agatttaaaa atcattgcac tttggtcaga aaaataataa
     1861 atatatctta taaatgtttg attcccttcc ttgctatttt tattcagtag atttttgttt
     1921 ggcatcatgt tgaagcaccg aaagataaat gatttttaaa aggctataga gtccaaagga
     1981 atattctttt acaccaattc ttcctttaaa aatctctgag gaatttgttt tcgccttact
     2041 tttttttctt ctgtcacaat gctaagtggt atccgaggtt cttaatatga gatttaaaat
     2101 cttaaaatgt ttcttatttt cagcacttac atcatttggt acacagggtc aaatagggca
     2161 aataattttg tctttgtata atagatttga tatttaaagt cactggaaat aggacaagtt
     2221 aatggatgtt tttatatttt aatagaatca tttatttcta tgtgttatga aattcactta
     2281 atgataaatt tttcaacata cttgccatta gaaaacaaag tattgctaag tactataaca
     2341 tattggccac taaaattcat attgagatta tcttggtttc ttggaagaga taggaatgag
     2401 ttcttatcta gtgttgcagg ccagcaaata cagaggtggt ttaatcaaac agctctagta
     2461 tgaagcaaga gtaaagacta aggtttcgag agcattccta ctcacataag tgaagaaatc
     2521 tgtcagatag gaatctaaat atttatagtg agattgtgaa agcaacctta aagttttgaa
     2581 gaagactgat gagactaggt gctttgcttc ctttcatcag gtatctttct gtggcatttg
     2641 agaacagaaa ccaagaaaca tggtaattac taaattatga ggctttgctt tttgtttgct
     2701 tttaagtaga aaaacatgtt ggcaacattg agttttggag ttgattgaga taatatgact
     2761 taactagttt tgtcattcca tttgttaaag atacagtcac caagaatgtt ttgagttttt
     2821 tgaaagaccc caatttaagc cttgcttatt tttaaattat ttccattcag tgatgttgga
     2881 tgtatatcag ttatttagta aataatctca ataaattttg tgctgtggcc tttgcta
//
