LOCUS       NM_001389445            2025 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens chemerin chemokine-like receptor 2 (CMKLR2),
            transcript variant 7, mRNA.
ACCESSION   NM_001389445
VERSION     NM_001389445.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2025)
  AUTHORS   Liu,A., Liu,Y., Chen,G., Lyu,W., Ye,F., Wang,J., Liao,Q., Zhu,L.,
            Du,Y. and Ye,R.D.
  TITLE     Structure of G protein-coupled receptor GPR1 bound to full-length
            chemerin adipokine reveals a chemokine-like reverse binding mode
  JOURNAL   PLoS Biol 22 (10), e3002838 (2024)
   PUBMED   39466725
  REMARK    GeneRIF: Structure of G protein-coupled receptor GPR1 bound to
            full-length chemerin adipokine reveals a chemokine-like reverse
            binding mode.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2025)
  AUTHORS   Degroot,G.N., Lepage,V., Parmentier,M. and Springael,J.Y.
  TITLE     The Atypical Chemerin Receptor GPR1 Displays Different Modes of
            Interaction with beta-Arrestins in Humans and Mice with Important
            Consequences on Subcellular Localization and Trafficking
  JOURNAL   Cells 11 (6), 1037 (2022)
   PUBMED   35326488
  REMARK    GeneRIF: The Atypical Chemerin Receptor GPR1 Displays Different
            Modes of Interaction with beta-Arrestins in Humans and Mice with
            Important Consequences on Subcellular Localization and Trafficking.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2025)
  AUTHORS   Zhu,L., Huang,J., Wang,Y., Yang,Z. and Chen,X.
  TITLE     Chemerin causes lipid metabolic imbalance and induces passive lipid
            accumulation in human hepatoma cell line via the receptor GPR1
  JOURNAL   Life Sci 278, 119530 (2021)
   PUBMED   33887347
  REMARK    GeneRIF: Chemerin causes lipid metabolic imbalance and induces
            passive lipid accumulation in human hepatoma cell line via the
            receptor GPR1.
REFERENCE   4  (bases 1 to 2025)
  AUTHORS   Feder,S., Bruckmann,A., McMullen,N., Sinal,C.J. and Buechler,C.
  TITLE     Chemerin Isoform-Specific Effects on Hepatocyte Migration and
            Immune Cell Inflammation
  JOURNAL   Int J Mol Sci 21 (19), 7205 (2020)
   PUBMED   33003572
  REMARK    GeneRIF: Chemerin Isoform-Specific Effects on Hepatocyte Migration
            and Immune Cell Inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2025)
  AUTHORS   Treeck,O., Buechler,C. and Ortmann,O.
  TITLE     Chemerin and Cancer
  JOURNAL   Int J Mol Sci 20 (15), 3750 (2019)
   PUBMED   31370263
  REMARK    GeneRIF: The majority of presented data report down-regulation of
            chemerin in cancer tissue and suggest a tumor-suppressing role of
            chemerin in most cancer types, being mediated by recruiting innate
            immune defenses and by growth-inhibitory downstream signaling by
            chemerin receptors CMKLR1 and GPR1. (Review)
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2025)
  AUTHORS   Hiura,H., Sugawara,A., Ogawa,H., John,R.M., Miyauchi,N.,
            Miyanari,Y., Horiike,T., Li,Y., Yaegashi,N., Sasaki,H., Kono,T. and
            Arima,T.
  TITLE     A tripartite paternally methylated region within the Gpr1-Zdbf2
            imprinted domain on mouse chromosome 1 identified by meDIP-on-chip
  JOURNAL   Nucleic Acids Res 38 (15), 4929-4945 (2010)
   PUBMED   20385583
  REMARK    GeneRIF: GPR1 gene is imprinted and paternally expressed in human
            and mouse.
REFERENCE   7  (bases 1 to 2025)
  AUTHORS   Jinno-Oue,A., Shimizu,N., Soda,Y., Tanaka,A., Ohtsuki,T.,
            Kurosaki,D., Suzuki,Y. and Hoshino,H.
  TITLE     The synthetic peptide derived from the NH2-terminal extracellular
            region of an orphan G protein-coupled receptor, GPR1,
            preferentially inhibits infection of X4 HIV-1
  JOURNAL   J Biol Chem 280 (35), 30924-30934 (2005)
   PUBMED   15919664
  REMARK    GeneRIF: Data report that a synthetic peptide derived from the
            NH2-terminal extracellular region of an orphan GPCR, GPR1,
            inhibited infection of not only an HIV-1 variant that uses GPR1 as
            a co-receptor, but also X4, R5, and R5X4 viruses.
REFERENCE   8  (bases 1 to 2025)
  AUTHORS   Kang,M.K., Kameta,A., Shin,K.H., Baluda,M.A., Kim,H.R. and
            Park,N.H.
  TITLE     Senescence-associated genes in normal human oral keratinocytes
  JOURNAL   Exp Cell Res 287 (2), 272-281 (2003)
   PUBMED   12837283
  REMARK    GeneRIF: GPR1 is a senescence-associated gene in normal human oral
            keratinocytes.
REFERENCE   9  (bases 1 to 2025)
  AUTHORS   Shimizu,N., Soda,Y., Kanbe,K., Liu,H.Y., Jinno,A., Kitamura,T. and
            Hoshino,H.
  TITLE     An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to
            allow replication of human immunodeficiency virus types 1 and 2 in
            brain-derived cells
  JOURNAL   J Virol 73 (6), 5231-5239 (1999)
   PUBMED   10233994
REFERENCE   10 (bases 1 to 2025)
  AUTHORS   Marchese,A., Docherty,J.M., Nguyen,T., Heiber,M., Cheng,R.,
            Heng,H.H., Tsui,L.C., Shi,X., George,S.R. and O'Dowd,B.F.
  TITLE     Cloning of human genes encoding novel G protein-coupled receptors
  JOURNAL   Genomics 23 (3), 609-618 (1994)
   PUBMED   7851889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075130.1 and AC007383.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075130.1, BC058005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 20385583
            MANE Ensembl match     :: ENST00000621141.5/ ENSP00000483003.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-623               AK075130.1         1-623
            624-1199            AC007383.4         115132-115707       c
            1200-2025           AK075130.1         1200-2025
FEATURES             Location/Qualifiers
     source          1..2025
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.3"
     gene            1..2025
                     /gene="CMKLR2"
                     /gene_synonym="GPR1"
                     /note="chemerin chemokine-like receptor 2"
                     /db_xref="GeneID:2825"
                     /db_xref="HGNC:HGNC:4463"
                     /db_xref="MIM:600239"
     exon            1..65
                     /gene="CMKLR2"
                     /gene_synonym="GPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            66..2025
                     /gene="CMKLR2"
                     /gene_synonym="GPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1161
                     /gene="CMKLR2"
                     /gene_synonym="GPR1"
                     /note="probable G-protein coupled receptor 1; G
                     protein-coupled receptor 1; chemokine-like receptor 2"
                     /codon_start=1
                     /product="chemerin-like receptor 2"
                     /protein_id="NP_001376374.1"
                     /db_xref="CCDS:CCDS2368.1"
                     /db_xref="GeneID:2825"
                     /db_xref="HGNC:HGNC:4463"
                     /db_xref="MIM:600239"
                     /translation="MEDLEETLFEEFENYSYDLDYYSLESDLEEKVQLGVVHWVSLVL
                     YCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFH
                     WPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIF
                     IWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLIRHHVLTWVKFIIGYLFP
                     LLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNS
                     YSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVSCSG
                     TVSEQLRNSETKNLCLLETAQ"
     regulatory      1998..2003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMKLR2"
                     /gene_synonym="GPR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2025
                     /gene="CMKLR2"
                     /gene_synonym="GPR1"
                     /note="major polyA site"
ORIGIN      
        1 attctggaac cgggaaggta cacccaggca tgacaatagc ttctctcctc acagaaattt
       61 aactgatttc ttcattctcc atttagcaag gtcatggaag atttggagga aacattattt
      121 gaagaatttg aaaactattc ctatgaccta gactattact ctctggagtc tgatttggag
      181 gagaaagtcc agctgggagt tgttcactgg gtctccctgg tgttatattg tttggctttt
      241 gttctgggaa ttccaggaaa tgccatcgtc atttggttca cggggttcaa gtggaagaag
      301 acagtcacca ctctgtggtt cctcaatcta gccattgcgg atttcatttt tcttctcttt
      361 ctgcccctgt acatctccta tgtggccatg aatttccact ggccctttgg catctggctg
      421 tgcaaagcca attccttcac tgcccagttg aacatgtttg ccagtgtttt tttcctgaca
      481 gtgatcagcc tggaccacta tatccacttg atccatcctg tcttatctca tcggcatcga
      541 accctcaaga actctctgat tgtcattata ttcatctggc ttttggcttc tctaattggc
      601 ggtcctgccc tgtacttccg ggacactgtg gagttcaata atcatactct ttgctataac
      661 aattttcaga agcatgatcc tgacctcact ttgatcaggc accatgttct gacttgggtg
      721 aaatttatca ttggctatct cttccctttg ctaacaatga gtatttgcta cttgtgtctc
      781 atcttcaagg tgaagaagcg aagcatcctg atctccagta ggcatttctg gacaattctg
      841 gttgtggttg tggcctttgt ggtttgctgg actccttatc acctgtttag catttgggag
      901 ctcaccattc accacaatag ctattcccac catgtgatgc aggctggaat ccccctctcc
      961 actggtttgg cattcctcaa tagttgcttg aaccccatcc tttatgtcct aattagtaag
     1021 aagttccaag ctcgcttccg gtcctcagtt gctgagatac tcaagtacac actgtgggaa
     1081 gtcagctgtt ctggcacagt gagtgaacag ctcaggaact cagaaaccaa gaatctgtgt
     1141 ctcctggaaa cagctcaata agttattact tttccacaaa tcagtatatg gctttttatg
     1201 tgggtcctct gactgatgct ttcagattaa aattgtttcc aagatagaga gccgactcca
     1261 ctttcatagt tattgtttct ggtcactata taggcatcac atttttgtgt ggatatgaaa
     1321 cttaggaagg atcctcttga ctccttgtga tgtggcaata aatttttttt aaaaaactga
     1381 aaatacttag gaaggatccg cataattttt ttctgcaact taaatgaaat gcatcattct
     1441 tgttaattat accatggtga attaatcact tttgaagcaa tatcagttat tttttgaata
     1501 ataacttttc taaagcctta agtcttaata ttaaatatat gattagccag gcacggtggc
     1561 tgacacctgt aatcccagca ctttgggagg ccaaggtggg gggattaccc gaggtcagga
     1621 attcgagacc agcctgacca acatggagaa accccgtctc tactaaaaat acaaaattag
     1681 ccggtcatgg tggtgcatgt ctgcaaaccc agctactcgg gaggctgaag caggagaatc
     1741 acttgaacct gggaggcaga ggttgtggtg agccaacatc acaccattgc actccagcct
     1801 gggcaacaag agtaaaactc tgtctcaaaa ataaataaat aaaatagata aataaatata
     1861 tgattaacta attttaaaaa tgttaaaatg tattcttaaa ttcattttaa ttttgtacaa
     1921 taacctgcta gacacatttt taaaatgcaa catgtgtact taatttcttt atgtaatcta
     1981 tgtatataca tttatgaatt aaagtaattg ttggttatct taaaa
//
