LOCUS       NM_001142343            5488 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens chemerin chemokine-like receptor 1 (CMKLR1),
            transcript variant 1, mRNA.
ACCESSION   NM_001142343
VERSION     NM_001142343.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5488)
  AUTHORS   Daneshfar,N., Falahi,S., Gorgin Karaji,A., Rezaiemanesh,A.,
            Mortazavi,S.H.R., Akbari,B., Eivazi,A. and Salari,F.
  TITLE     Association of Single Nucleotide Polymorphisms (SNPs) of
            Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to
            Allergic Rhinitis
  JOURNAL   Biochem Genet 62 (4), 2587-2605 (2024)
   PUBMED   37993706
  REMARK    GeneRIF: Association of Single Nucleotide Polymorphisms (SNPs) of
            Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to
            Allergic Rhinitis.
REFERENCE   2  (bases 1 to 5488)
  AUTHORS   Wang,D., Mahmud,I., Thakur,V.S., Tan,S.K., Isom,D.G., Lombard,D.B.,
            Gonzalgo,M.L., Kryvenko,O.N., Lorenzi,P.L., Tcheuyap,V.T.,
            Brugarolas,J. and Welford,S.M.
  TITLE     GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development
            of Clear Cell Renal Cell Carcinoma
  JOURNAL   Cancer Res 84 (13), 2141-2154 (2024)
   PUBMED   38640229
  REMARK    GeneRIF: GPR1 and CMKLR1 Control Lipid Metabolism to Support the
            Development of Clear Cell Renal Cell Carcinoma.
REFERENCE   3  (bases 1 to 5488)
  AUTHORS   Kretschmer,K., Zellmann,T., Morl,K. and Beck-Sickinger,A.G.
  TITLE     Stable Binding of Full-Length Chemerin Is Driven by Negative
            Charges in the CMKLR1 N Terminus
  JOURNAL   Chembiochem 24 (18), e202300280 (2023)
   PUBMED   37186779
  REMARK    GeneRIF: Stable Binding of Full-Length Chemerin Is Driven by
            Negative Charges in the CMKLR1 N Terminus.
REFERENCE   4  (bases 1 to 5488)
  AUTHORS   Lavy,M., Gauttier,V., Dumont,A., Chocteau,F., Deshayes,S.,
            Fresquet,J., Dehame,V., Girault,I., Trilleaud,C., Neyton,S.,
            Mary,C., Juin,P., Poirier,N., Barille-Nion,S. and Blanquart,C.
  TITLE     ChemR23 activation reprograms macrophages toward a less
            inflammatory phenotype and dampens carcinoma progression
  JOURNAL   Front Immunol 14, 1196731 (2023)
   PUBMED   37539056
  REMARK    GeneRIF: ChemR23 activation reprograms macrophages toward a less
            inflammatory phenotype and dampens carcinoma progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5488)
  AUTHORS   Hu,X.Y., Wang,N., Zhang,X.Y., Yang,Q., Gao,F., Xiang,F.G. and
            Feng,Y.Y.
  TITLE     [Chemerin mediated neutrophil infiltration in oral squamous cell
            carcinoma and predicted poor prognosis]
  JOURNAL   Shanghai Kou Qiang Yi Xue 32 (2), 158-165 (2023)
   PUBMED   37153997
  REMARK    GeneRIF: [Chemerin mediated neutrophil infiltration in oral
            squamous cell carcinoma and predicted poor prognosis].
REFERENCE   6  (bases 1 to 5488)
  AUTHORS   Wittamer,V., Franssen,J.D., Vulcano,M., Mirjolet,J.F., Le Poul,E.,
            Migeotte,I., Brezillon,S., Tyldesley,R., Blanpain,C., Detheux,M.,
            Mantovani,A., Sozzani,S., Vassart,G., Parmentier,M. and Communi,D.
  TITLE     Specific recruitment of antigen-presenting cells by chemerin, a
            novel processed ligand from human inflammatory fluids
  JOURNAL   J Exp Med 198 (7), 977-985 (2003)
   PUBMED   14530373
REFERENCE   7  (bases 1 to 5488)
  AUTHORS   Samson,M., Edinger,A.L., Stordeur,P., Rucker,J., Verhasselt,V.,
            Sharron,M., Govaerts,C., Mollereau,C., Vassart,G., Doms,R.W. and
            Parmentier,M.
  TITLE     ChemR23, a putative chemoattractant receptor, is expressed in
            monocyte-derived dendritic cells and macrophages and is a
            coreceptor for SIV and some primary HIV-1 strains
  JOURNAL   Eur J Immunol 28 (5), 1689-1700 (1998)
   PUBMED   9603476
REFERENCE   8  (bases 1 to 5488)
  AUTHORS   Owman,C., Lolait,S.J., Santen,S. and Olde,B.
  TITLE     Molecular cloning and tissue distribution of cDNA encoding a novel
            chemoattractant-like receptor
  JOURNAL   Biochem Biophys Res Commun 241 (2), 390-394 (1997)
   PUBMED   9425281
REFERENCE   9  (bases 1 to 5488)
  AUTHORS   Methner,A., Hermey,G., Schinke,B. and Hermans-Borgmeyer,I.
  TITLE     A novel G protein-coupled receptor with homology to neuropeptide
            and chemoattractant receptors expressed during bone development
  JOURNAL   Biochem Biophys Res Commun 233 (2), 336-342 (1997)
   PUBMED   9144535
REFERENCE   10 (bases 1 to 5488)
  AUTHORS   Gantz,I., Konda,Y., Yang,Y.K., Miller,D.E., Dierick,H.A. and
            Yamada,T.
  TITLE     Molecular cloning of a novel receptor (CMKLR1) with homology to the
            chemotactic factor receptors
  JOURNAL   Cytogenet Cell Genet 74 (4), 286-290 (1996)
   PUBMED   8976386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA466082.1, BC106927.2, AC063957.22 and AC009729.14.
            
            On Nov 22, 2018 this sequence version replaced NM_001142343.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1641446.1,
                                           SRR14038195.1398.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000550402.6/ ENSP00000449716.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               DA466082.1         7-186
            181-1863            BC106927.2         1-1683
            1864-1958           AC063957.22        2054-2148           c
            1959-5488           AC009729.14        163701-167230       c
FEATURES             Location/Qualifiers
     source          1..5488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..5488
                     /gene="CMKLR1"
                     /gene_synonym="CHEMERINR; ChemR23; DEZ; ERV1; RVER1"
                     /note="chemerin chemokine-like receptor 1"
                     /db_xref="GeneID:1240"
                     /db_xref="HGNC:HGNC:2121"
                     /db_xref="MIM:602351"
     exon            1..285
                     /gene="CMKLR1"
                     /gene_synonym="CHEMERINR; ChemR23; DEZ; ERV1; RVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..498
                     /gene="CMKLR1"
                     /gene_synonym="CHEMERINR; ChemR23; DEZ; ERV1; RVER1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..574
                     /gene="CMKLR1"
                     /gene_synonym="CHEMERINR; ChemR23; DEZ; ERV1; RVER1"
                     /inference="alignment:Splign:2.1.0"
     CDS             572..1693
                     /gene="CMKLR1"
                     /gene_synonym="CHEMERINR; ChemR23; DEZ; ERV1; RVER1"
                     /note="isoform a is encoded by transcript variant 1;
                     orphan G-protein coupled receptor, Dez; chemokine
                     receptor-like 1; G-protein coupled receptor DEZ; G-protein
                     coupled receptor ChemR23; chemerin receptor;
                     chemokine-like receptor 1; resolvin E1 receptor;
                     chemerin-like receptor 1"
                     /codon_start=1
                     /product="chemerin-like receptor 1 isoform a"
                     /protein_id="NP_001135815.1"
                     /db_xref="CCDS:CCDS44965.1"
                     /db_xref="GeneID:1240"
                     /db_xref="HGNC:HGNC:2121"
                     /db_xref="MIM:602351"
                     /translation="MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLV
                     VVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMD
                     YHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMAC
                     MVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHM
                     VVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPY
                     HTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRL
                     VNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML"
     exon            575..5488
                     /gene="CMKLR1"
                     /gene_synonym="CHEMERINR; ChemR23; DEZ; ERV1; RVER1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5470..5475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMKLR1"
                     /gene_synonym="CHEMERINR; ChemR23; DEZ; ERV1; RVER1"
                     /note="hexamer: AATAAA"
     polyA_site      5488
                     /gene="CMKLR1"
                     /gene_synonym="CHEMERINR; ChemR23; DEZ; ERV1; RVER1"
                     /note="major polyA site"
ORIGIN      
        1 attcagggaa gcagccccgg cggccagcag ggagctcagg acagagcagg ctccctggga
       61 agcctccggg tgataggggt gttccagctg cggcgctctg ggggttcaga gggggatctt
      121 gaatgaacaa atgaatgaac tgctttctgg gcaaacagcc acagccagag gagcctgtga
      181 ttggcagaaa gaagccaggg tgtgcaagtc tccccaacag cctcgagtgg cctgcagtca
      241 cagggaaccc tcaggaagac cttccgggca gagaccagag ggaagcccat ctctccagca
      301 gaactgcttg gatttttcta ccaggaggct cagggctctg caacaatgat agcagaagct
      361 gatggcatct agagatctag gctgggacta gcacagcatc acttctacca ctttctgttg
      421 gtcacagcaa ctcaccatgc cagtgcagat tcaaggggag gagaaataga gtccacttct
      481 tgatgggagg cgtgacatgt gtttctagct gtgtacaggg actgattggc tgaggactca
      541 cattggagag ctgcagacaa cataacggtg aatgagaatg gaggatgaag attacaacac
      601 ttccatcagt tacggtgatg aataccctga ttatttagac tccattgtgg ttttggagga
      661 cttatccccc ttggaagcca gggtgaccag gatcttcctg gtggtggtct acagcatcgt
      721 ctgcttcctc gggattctgg gcaatggtct ggtgatcatc attgccacct tcaagatgaa
      781 gaagacagtg aacatggtct ggttcctcaa cctggcagtg gcagatttcc tgttcaacgt
      841 cttcctccca atccatatca cctatgccgc catggactac cactgggttt tcgggacagc
      901 catgtgcaag atcagcaact tccttctcat ccacaacatg ttcaccagcg tcttcctgct
      961 gaccatcatc agctctgacc gctgcatctc tgtgctcctc cctgtctggt cccagaacca
     1021 ccgcagcgtt cgcctggctt acatggcctg catggtcatc tgggtcctgg ctttcttctt
     1081 gagttcccca tctctcgtct tccgggacac agccaacctg catgggaaaa tatcctgctt
     1141 caacaacttc agcctgtcca cacctgggtc ttcctcgtgg cccactcact cccaaatgga
     1201 ccctgtgggg tatagccggc acatggtggt gactgtcacc cgcttcctct gtggcttcct
     1261 ggtcccagtc ctcatcatca cagcttgcta cctcaccatc gtgtgcaaac tgcagcgcaa
     1321 ccgcctggcc aagaccaaga agcccttcaa gattattgtg accatcatca ttaccttctt
     1381 cctctgctgg tgcccctacc acacactcaa cctcctagag ctccaccaca ctgccatgcc
     1441 tggctctgtc ttcagcctgg gtttgcccct ggccactgcc cttgccattg ccaacagctg
     1501 catgaacccc attctgtatg ttttcatggg tcaggacttc aagaagttca aggtggccct
     1561 cttctctcgc ctggtcaatg ctctaagtga agatacaggc cactcttcct accccagcca
     1621 tagaagcttt accaagatgt catcaatgaa tgagaggact tctatgaatg agagggagac
     1681 cggcatgctt tgatcctcac tgtggaaccc ctcaatggac tctctcaacc cagggacacc
     1741 caaggatatg tcttctgaag atcaaggcaa gaacctcttt agcatccacc aattttcact
     1801 gcattttgca tgggatgaac agtgttttat gctgggaatc tagggcctgg aacccctttc
     1861 ttctagtgga cagaacatgc tgtgttccat acagccttgg actagcaatt tatgcttctt
     1921 gggaggccag ccttgactga ctcaaagcaa aaaaggaaga attctcaaaa gcattgccat
     1981 gaactgggat tggcataggg cggtgggatt aagctgccta ttgtgtgtgc cccagaaatg
     2041 acactctcca aggtccattc ctggtgtgag cagtgagggg gtcagagcaa acccagtgtg
     2101 atgcagatca cacttggccc ttgtatatat attatcagta gctggccaga aaaccctacc
     2161 ttcaagtcac tgctctgtgt taaagtatgt ggaaatgcat aggtgatctg ggagaggaag
     2221 gtgacatatc agcccatgaa ctccataggc catgaatttg gctttcggat cagctaggaa
     2281 gacagagaac tggtcctgag aggtcctgtg ggctctttgc aagggcaaga caagtgaggg
     2341 atgcaacgag gacttgagat ttggcaaaga aatgagaaag gagaaaagaa cctttaaagg
     2401 atgcaggcat ggagcagctc accctagaac atcgcaggct gatggtgctt taggctggag
     2461 ctatttgggg cgtcagggtg gtgccagccc ctgatctcac cttgcccctc ttacctgggg
     2521 gtggggttgt ggcaggcatc ttcaccagca gccctcaccc catcacaggg atttttttct
     2581 gcctttccta atccactcag ctctggctgg aggtgcttag aataaaacac tggtggtggg
     2641 gcttctcatt ctggttaatt tcctcaacgc ctttggagac aggtccaaaa tgcagctttg
     2701 ggaagcaact ccggagagtc ccctgggaag aagagtatgt ccgaggactc agtcacttga
     2761 gacagagtct ggagctggac tccttgaact gtgtttctga gctgcagaca ccaaatacct
     2821 cctggataca ggtgcctggc atggcttttc tcatctaata ctgacacgtc cctgtggcca
     2881 cagagtgtca tagccccatt tacaaatgac atagctgagg cccagatggg gaaagtaact
     2941 tgcccagcat cacacagcta atcagtggca gagttaagat ctgaacctgg ctccgtctgg
     3001 ctccagaaac tctgttcttc tatttggaat ttatctgtgg agattattct agtatattga
     3061 tagcctacat ttatttagca ctttttatat tatgcacttt acatatgttt tctcatttaa
     3121 tcattacagc aaccctgagt taggtatggt tataacttcc cttttacata ggaggaatct
     3181 gaggcttaga gaggttaagt aacttgccca aaggtaccca gctagtctct gccggagctt
     3241 ggatttgaac ttcagtttgc ctggctcaaa tgaggctgca gagttgggaa ggacttaaaa
     3301 agtttggaga tttttgccat aaatattgat ttttctgcaa atgaggatga acatcttaat
     3361 ggcctttaag aaactttgca aatagttttc aaaaatgatg caacatggca gagaaaatgc
     3421 acttggcttc cagctccctc aacagccatt aacagcctcc taccgtggct cccacctcct
     3481 atgtctccag agatcaaggc aatggggagg gaaagctggc aggaggcagt cccttgtggg
     3541 cctgaggccc tttggctcct aagtgtccac attctgttct cttccaagtc ccttcattgt
     3601 taagctgatt ctccaacaag atgcaatgaa cagatgcaat gtctaccccg cgctgggcga
     3661 gttcccgagg ccatgggctg tttggaatca cacttcatta agagacaaac tgttccttcc
     3721 cttattgtgc cttaatgctt atgacaaggc agctctgaat tgatcccaag ctggagcctc
     3781 tgaatgcttt aaagagtttg aatatagacg gtttgagagc aaaaagggag ctttaaatat
     3841 tgctcagtgg cccccatctc ccctcttccc acatttactg aggcacgaga tgggatggga
     3901 cctgtcccgg gtcacagcag cagtcgtcag cgccttggcc ctcctggctt gtaggatgct
     3961 gcttttcctg ggcttctggc agtccaggcc aggatggggg agccaggaat tcatgttgtc
     4021 attggaaaag ctgataaaca ggagcacaat tcaaaccggc tgttttcctc cttagagtct
     4081 ggcctccctc tttctggctg ctctgtgggt cttcctgttc tgacttaggt tcctgtcaag
     4141 tacttaaatg cagccttaac atcccataca gtcttgtccc cacagcttca tgtgaacatc
     4201 tccatgggtc atgcatatat cgtccctgca gtgtgcaaag tgtgctcacc tgcactgctg
     4261 cacaggcaac caacatactt agtgcccaga gccttctctc tgggcccagg actcagtgat
     4321 ggggccttac ttagccctgc ctcctgggtg gggtggggga gctgagggat cgtgaggaca
     4381 agaggtagag ggaaaagaaa agaagatggt gtttgaggat aggggaggga caggagaggg
     4441 gacagaaagg tcccagagca tgatgatgaa ggaaagggat ctggcattca tgaagcacct
     4501 acgatggttc aggcacaaac actgaaacct caaattggcc ctggcagaag gggaccatca
     4561 tagcaaggtg gggggggggt gcagaaagtg agtttctgtt tcaagaacag acttcactag
     4621 ttcagagttg cacagctagt gaggtatgga gctgggcttt gaatcaggtc agctgcctga
     4681 atgcccaact tcttcagccc ttggaaggag agggtgggga gaagaagaag gaaaagacaa
     4741 ggaagaaaga aagaagagag aaggggagag gaatggaagt ccaaagagtg ggaggaattt
     4801 gatttcagaa ccatctccag ctgacccttg agccagcaag gacagggaga agggaagagc
     4861 aagaacacga agggcctcaa gcaccgggat gcctttgcca gccttagata attcccagag
     4921 cgcacagagc cctgcaggtt cctgggtcct tctccagaga agaggcacag agattctggc
     4981 agcaaggttc agaaggggtg aggaaactgg gcactgacaa agggagggga ttggctcaaa
     5041 ttcgacccca gagtcagctc tggtggggtt gggagcctgg atgggtggga gaagatagaa
     5101 tccaatcgtg aaaaccataa gggaccttca aactcatctt gcccagatgt ctcccatttc
     5161 acagatgagg gaactgaggt tttgagagct tcccctgagg actctgcaaa acgaggtggt
     5221 gtctggtttg gatgaaagtg gtcggtgatt cctcaactcc tgccctgcct ccctctctcg
     5281 ttcctcccta acatgttatg ctcttgttgg ggctgggatg ccctaggccc aaggttacca
     5341 aatcctgggt ttggaaaatt gctgctgggg gtggtatcta ggaccagaga ggaatctact
     5401 atttctactg tgaaataatt cagcaggggg tcttcttact tcttcccttt gaggacaaag
     5461 tttctctcga ataaagagac tgaagcaa
//
