LOCUS       NM_198390               4719 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens c-Maf inducing protein (CMIP), transcript variant 1,
            mRNA.
ACCESSION   NM_198390
VERSION     NM_198390.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4719)
  AUTHORS   Lee,J., Song,J.H., Park,J.H., Chung,M.Y., Lee,S.H., Jeon,S.B.,
            Park,S.H., Hwang,J.T. and Choi,H.K.
  TITLE     Dnmt1/Tet2-mediated changes in Cmip methylation regulate the
            development of nonalcoholic fatty liver disease by controlling the
            Gbp2-Ppargamma-CD36 axis
  JOURNAL   Exp Mol Med 55 (1), 143-157 (2023)
   PUBMED   36609599
  REMARK    GeneRIF: Dnmt1/Tet2-mediated changes in Cmip methylation regulate
            the development of nonalcoholic fatty liver disease by controlling
            the Gbp2-Ppargamma-CD36 axis.
REFERENCE   2  (bases 1 to 4719)
  AUTHORS   Zhang,S.Y., Fan,Q., Moktefi,A., Ory,V., Audard,V., Pawlak,A.,
            Ollero,M., Sahali,D. and Henique,C.
  TITLE     CMIP interacts with WT1 and targets it on the proteasome
            degradation pathway
  JOURNAL   Clin Transl Med 11 (7), e460 (2021)
   PUBMED   34323419
  REMARK    GeneRIF: CMIP interacts with WT1 and targets it on the proteasome
            degradation pathway.
REFERENCE   3  (bases 1 to 4719)
  AUTHORS   Pan,L., Liao,Y.H., Mo,M.Q., Zhang,Q.H. and Yin,R.X.
  TITLE     CMIP SNPs and their haplotypes are associated with dyslipidaemia
            and clinicopathologic features of IgA nephropathy
  JOURNAL   Biosci Rep 40 (10) (2020)
   PUBMED   33112407
  REMARK    GeneRIF: CMIP SNPs and their haplotypes are associated with
            dyslipidaemia and clinicopathologic features of IgA nephropathy.
REFERENCE   4  (bases 1 to 4719)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4719)
  AUTHORS   Xiang,R., Han,X., Ding,K. and Wu,Z.
  TITLE     CMIP promotes Herceptin resistance of HER2 positive gastric cancer
            cells
  JOURNAL   Pathol Res Pract 216 (2), 152776 (2020)
   PUBMED   31822364
  REMARK    GeneRIF: CMIP promotes Herceptin resistance of HER2 positive
            gastric cancer cells.
REFERENCE   6  (bases 1 to 4719)
  AUTHORS   Newbury,D.F., Winchester,L., Addis,L., Paracchini,S.,
            Buckingham,L.L., Clark,A., Cohen,W., Cowie,H., Dworzynski,K.,
            Everitt,A., Goodyer,I.M., Hennessy,E., Kindley,A.D., Miller,L.L.,
            Nasir,J., O'Hare,A., Shaw,D., Simkin,Z., Simonoff,E., Slonims,V.,
            Watson,J., Ragoussis,J., Fisher,S.E., Seckl,J.R., Helms,P.J.,
            Bolton,P.F., Pickles,A., Conti-Ramsden,G., Baird,G., Bishop,D.V.
            and Monaco,A.P.
  TITLE     CMIP and ATP2C2 modulate phonological short-term memory in language
            impairment
  JOURNAL   Am J Hum Genet 85 (2), 264-272 (2009)
   PUBMED   19646677
  REMARK    GeneRIF: CMIP modulates phonological short-term memory in language
            impairment.
REFERENCE   7  (bases 1 to 4719)
  AUTHORS   Kamal,M., Valanciute,A., Dahan,K., Ory,V., Pawlak,A., Lang,P.,
            Guellaen,G. and Sahali,D.
  TITLE     C-mip interacts physically with RelA and inhibits nuclear factor
            kappa B activity
  JOURNAL   Mol Immunol 46 (5), 991-998 (2009)
   PUBMED   19019440
  REMARK    GeneRIF: c-mip inhibits the degradation of I-kappaBalpha and
            impedes the dissociation of the NF-kappaB/I-kappaBalpha complexes.
REFERENCE   8  (bases 1 to 4719)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 4719)
  AUTHORS   Grimbert,P., Valanciute,A., Audard,V., Lang,P., Guellaen,G. and
            Sahali,D.
  TITLE     The Filamin-A is a partner of Tc-mip, a new adapter protein
            involved in c-maf-dependent Th2 signaling pathway
  JOURNAL   Mol Immunol 40 (17), 1257-1261 (2004)
   PUBMED   15128042
  REMARK    GeneRIF: Filamin-A interacts with c-mip/Tc-mip in a new T-cell
            signaling pathway.
REFERENCE   10 (bases 1 to 4719)
  AUTHORS   Grimbert,P., Valanciute,A., Audard,V., Pawlak,A., Le gouvelo,S.,
            Lang,P., Niaudet,P., Bensman,A., Guellaen,G. and Sahali,D.
  TITLE     Truncation of C-mip (Tc-mip), a new proximal signaling protein,
            induces c-maf Th2 transcription factor and cytoskeleton
            reorganization
  JOURNAL   J Exp Med 198 (5), 797-807 (2003)
   PUBMED   12939343
  REMARK    GeneRIF: results suggest that Tc-mip plays a critical role in Th2
            signaling pathway and represents the first proximal signaling
            protein which links TCR-mediated signal to the activation of c-maf
            Th2 specific factor
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092139.5, CV570964.1,
            AB051481.1 and BM789770.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_198390.2.
            
            Summary: This gene encodes a c-Maf inducing protein that plays a
            role in T-cell signaling pathway. Alternatively spliced transcript
            variants encoding different isoforms have been described for this
            gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (C-Mip). This variant is
            predominantly expressed in fetal liver, kidney, and peripheral
            blood mononuclear cells (PBMCs), but weakly detected in PBMCs from
            minimal change nephrotic syndrome (MCNS) patients.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051481.1, AK096598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000537098.8/ ENSP00000446100.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               AC092139.5         97825-98186         c
            363-481             CV570964.1         1-119
            482-4448            AB051481.1         1-3967
            4449-4719           BM789770.1         144-414
FEATURES             Location/Qualifiers
     source          1..4719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.2-q23.3"
     gene            1..4719
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /note="c-Maf inducing protein"
                     /db_xref="GeneID:80790"
                     /db_xref="HGNC:HGNC:24319"
                     /db_xref="MIM:610112"
     exon            1..734
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..2756
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /note="isoform C-Mip is encoded by transcript variant 1;
                     tc-Mip; C-Maf-inducing protein"
                     /codon_start=1
                     /product="C-Maf-inducing protein isoform C-Mip"
                     /protein_id="NP_938204.2"
                     /db_xref="CCDS:CCDS54044.1"
                     /db_xref="GeneID:80790"
                     /db_xref="HGNC:HGNC:24319"
                     /db_xref="MIM:610112"
                     /translation="MDVTSSSGGGGDPRQIEETKPLLGGDVSAPEGTKMGAVPCRRAL
                     LLCNGMRYKLLQEGDIQVCVIRHPRTFLSKILTSKFLRRWEPHHLTLADNSLASATPT
                     GYMENSVSYSAIEDVQLLSWENAPKYCLQLTIPGGTVLLQAANSYLRDQWFHSLQWKK
                     KIYKYKKVLSNPSRWEVVLKEIRTLVDMALTSPLQDDSINQAPLEIVSKLLSENTNLT
                     TQEHENIIVAIAPLLENNHPPPDLCEFFCKHCRERPRSMVVIEVFTPVVQRILKHNMD
                     FGKCPRLRLFTQEYILALNELNAGMEVVKKFIQSMHGPTGHCPHPRVLPNLVAVCLAA
                     IYSCYEEFINSRDNSPSLKEIRNGCQQPCDRKPTLPLRLLHPSPDLVSQEATLSEARL
                     KSVVVASSEIHVEVERTSTAKPALTASAGNDSEPNLIDCLMVSPACSTMSIELGPQAD
                     RTLGCYVEILKLLSDYDDWRPSLASLLQPIPFPKEALAHEKFTKELKYVIQRFAEDPR
                     QEVHSCLLSVRAGKDGWFQLYSPGGVACDDDGELFASMVHILMGSCYKTKKFLLSLAE
                     NKLGPCMLLALRGNQTMVEILCLMLEYNIIDNNDTQLQIISTLESTDVGKRMYEQLCD
                     RQRELKELQRKGGPTRLTLPSKSTDADLARLLSSGSFGNLENLSLAFTNVTSACAEHL
                     IKLPSLKQLNLWSTQFGDAGLRLLSEHLTMLQVLNLCETPVTDAGLLALSSMKSLCSL
                     NMNSTKLSADTYEDLKAKLPNLKEVDVRYTEAW"
     exon            735..860
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            861..911
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1073
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1115
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1178
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1259
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1363
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1468
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1822
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1888
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1915
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..1964
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2072
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2189
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2330
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2378
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2525
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2631
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2702
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..4719
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4696..4701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /note="hexamer: AATAAA"
     polyA_site      4719
                     /gene="CMIP"
                     /gene_synonym="TCMIP"
                     /note="major polyA site"
ORIGIN      
        1 actctcgccc ggacggccgc gcggacacac gctctgtaca cacgcgcgcg gcggcgcggg
       61 gccccgagac acgcccgccc ccaccccgcc gcccccaccc cggcgcccgc cctccgcgcc
      121 tggccccggc ccgccctcgg cctcccccgc ccctccccgt cgcccgccga gcccggtcag
      181 ccgccgcgag catgcacccg acgagctagg aggaagcccg gagccccgca ggaagcgccg
      241 aggccggccc agcccgccgc acgcgccgcc ccccgcgggc agcgccccct cccctgcggg
      301 cgcccccagc cccacacccc cccaccttcc cggggggtgg gggggtgcgg gccgccggat
      361 ccgggggccc cgccgcccca gcagcccagg acagccccct ctccccgccc ccagccccct
      421 cccccggcgc ggccatggat gtgaccagca gctcgggcgg cggcggcgac ccccggcaga
      481 tcgaggagac caagccgctg ctggggggcg acgtgtcggc ccccgaaggc acgaagatgg
      541 gcgccgtgcc ctgccgccgg gctcttctgc tttgcaacgg gatgaggtac aaactgctgc
      601 aggagggcga cattcaggtc tgtgtcatcc ggcacccgcg gacctttctc agcaagatcc
      661 tcacctcgaa attcctgagg cgctgggagc cgcaccacct aacgctggcc gacaacagcc
      721 tggcgtccgc cacgccaact gggtacatgg aaaactcagt ctcctacagc gcaattgaag
      781 acgttcagct gctgtcctgg gagaatgccc cgaagtactg tttacagctc acgattcctg
      841 ggggaactgt cttactgcag gctgccaata gctacctgcg agaccagtgg ttccattctc
      901 tgcaatggaa gaaaaagatt tacaaatata agaaagtgct gagtaaccca agccgctggg
      961 aagttgtctt gaaagagatc cggaccctgg tggacatggc cctgacatcc cccctgcagg
     1021 atgactccat caaccaggcc ccactggaaa tcgtctcgaa actgctctca gagaacacaa
     1081 acttgaccac ccaggagcat gaaaacatca ttgtggcaat cgctcctttg ctggaaaaca
     1141 accacccacc accagatctc tgtgaattct tttgcaagca ctgcagagag cggccccggt
     1201 ccatggtggt catcgaggtg ttcacccccg tggtgcagcg aatcctcaag cataacatgg
     1261 actttgggaa gtgcccgcga ctgaggctgt ttactcagga gtacatcctt gccttgaacg
     1321 agctcaacgc ggggatggaa gtggtgaaga agttcattca gagcatgcac ggccccacag
     1381 ggcactgccc ccacccccgg gtcctgccca acctggtggc cgtgtgcctg gctgccatct
     1441 actcctgcta tgaagagttc atcaacagcc gcgacaattc cccaagcctg aaggaaatcc
     1501 ggaacggctg ccagcagccg tgcgaccgga agcccacttt acctctgcgc cttctgcacc
     1561 ccagcccgga cctggtgtct caggaagcca cgctgtctga ggcccggctc aagtcggtgg
     1621 tcgtggcctc cagtgagatc cacgtggagg tggaacgcac cagcactgcc aagccggcgc
     1681 tgacggccag cgcaggcaac gacagcgagc ccaacctcat cgactgcctc atggtcagcc
     1741 ccgcctgcag caccatgagc atcgagctgg gcccccaggc cgaccgcacg ctcggctgct
     1801 acgtggaaat cctcaagctg ctgtcagact atgatgactg gagaccgtct ctggccagtt
     1861 tgcttcaacc cattccattc cccaaagaag ctctcgcaca tgagaagttc accaaggaac
     1921 tgaagtacgt gattcagagg ttcgccgaag accccaggca agaggtccac tcatgcctgc
     1981 tgagcgtgcg ggccggcaaa gatggctggt tccagctcta cagccccgga ggggtggcct
     2041 gcgacgatga cggggagctg ttcgccagca tggtgcacat cctcatgggc tcctgttaca
     2101 agaccaaaaa attcctgctc tccctggcag aaaacaagct gggtccctgc atgctcctgg
     2161 cactgagggg gaaccagacc atggtggaga tcctgtgctt gatgctggaa tacaacatca
     2221 tcgacaacaa cgacacccaa ctgcagatca tctcaaccct ggagagcaca gacgtgggga
     2281 agcgcatgta cgagcagctg tgtgaccggc agcgggagct gaaggagctg caaaggaaag
     2341 gcgggcccac caggctaaca ctgccctcca agtccacaga cgctgacttg gctcgtttgc
     2401 tgagctccgg ctccttcgga aacctggaga acctcagttt ggccttcacc aatgtaacca
     2461 gtgcctgcgc cgagcacctc atcaaactgc cttcgctcaa gcagctgaac ctgtggtcca
     2521 ctcagtttgg agacgctggc cttcggctcc tgtcggaaca cctcaccatg ctccaggtgc
     2581 tgaacctgtg cgagaccccg gtcacagacg ctggcctgct ggccctgagc tccatgaaga
     2641 gtctctgcag tttaaacatg aacagcacca agctctcagc tgacacctac gaagatctga
     2701 aggccaagct tcccaatttg aaggaagtgg acgtccgcta caccgaagcc tggtgaagct
     2761 cccagctcaa ggcaggaaga cgtttgcaac cgcgacaaaa taactcttga ctaacagccg
     2821 cagagcagcc ggtcctgggg tcccaccctg gtgccctggc tgtgagatag atggggagtc
     2881 tttctggggg cggagggggg agggggtggg gagggggccc acaagcacgc ccagcccccg
     2941 ccgaattctt ttagcttcgt aattggaacc tttgacctga tctaaagtgg actttgtagc
     3001 aacaagagga gcatcagcgg gtcggggagg ggtttggggg tgggctgggg ggtgggggac
     3061 cctttgtgga ttttctttgc ctttgtgttt gatgccgtcg tgtgggaaaa gtcaactccg
     3121 atgccaccat tgcgggccgg acgaaggatg ctttcttcct agaggctccg agctgagctg
     3181 cgaactcgcc ccccgccctt gggacaagaa gacccagtca catcactgca cccgtcctgt
     3241 gtcctcacca ttgctatgca aagtgattct tgttgtacat aagatttaaa taatgcacct
     3301 atttaagaca tgttgacaaa ttgcgggtct gggacccgcc tcttatttat gaagtctttg
     3361 accgtccccc ccgcccgacc ccaccgccct cccgccccca cctggcgtgt agtactgtat
     3421 aaaccagtca gctgtcgggt tagtggtagt attattgtta tttttttaaa ggaaacaaac
     3481 agacaacaaa aagaagaaaa aaaaaaagaa cctccttgga aaaattaatt gctttttcgt
     3541 aatggattct ctatgctaat gctctctcgt ctgtctgtct gtctgcccac tcccccaccc
     3601 accactgtgc gtttctgatt tccaaatgtc tccaactccc tcacgaggtg gggctcaggc
     3661 tggaggagga gggattaaga tccccttgct ccactaaggc ccaagctctt tctctcggca
     3721 ccttttagac ttgaatggga ggctgctaac ccgccctctc cagtccaccc cggtaaaaga
     3781 gctgttcccc acccccaggg agctcctgtc cctgtcagcc tttgctgtcc cctgtcccca
     3841 acggagactc tgtcacccct gggctccccc tgccatcgtg tgcttcacgt ggccccatgc
     3901 atgcccgcct ctctgcatgg tctcttggga aaagagagat gtgtcgcctc cgccagtccg
     3961 actgccctcc ccaccccacc cccgccaccc cccacatgtg accactgcaa cgaagacact
     4021 ccttctgtcc ccacctgctc cgaagacaaa ccaacctccg tttcttttat aaacagtcgg
     4081 ctttttctta ataagccctc actgtacaga acagcccgtt gatggtttat ttggggtccc
     4141 cctctccccc cagccctttt ttctgttggt ttagcacaaa tacttccctc ctccggcacc
     4201 tccaaaccta ccccacagtc agtgtacttg ttttatatat atttaatctt attcaatgga
     4261 aaccatgctt ttgtcgtttt atactttgct aggtagactt tattaccccc ccactatgcc
     4321 ctcatttttt taaaaaagga aaaaaaaaag aaactgggtt ccagtcttaa ttcattttcc
     4381 gtgccaggtt ttatttcgtg tgtgtgtgag tgtgttctgt tttgtgtttt gttttttgtt
     4441 gttgttttta gttgtttggt tttcttttct ttcccccctc cggtcccata cttcacagca
     4501 ctctggtgcg ggaagaagca gaagcaaaaa aaataaaaat aaaaaaataa ataaaaataa
     4561 aaaaaataaa aaaggaaaaa aaaaaaagaa gaaacaagac atgccacctt tcccctcgca
     4621 ctgttgcttt tcctgatggt taatactact gtcacgtagc tgtgtacaaa gagatgtgaa
     4681 atactttcag gcaaaaataa actgtaagtg actcatcaa
//
