LOCUS       NM_001018024             881 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens C-X9-C motif containing 4 (CMC4), mRNA.
ACCESSION   NM_001018024
VERSION     NM_001018024.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 881)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 881)
  AUTHORS   Cavallaro,G.
  TITLE     Genome-wide analysis of eukaryotic twin CX9C proteins
  JOURNAL   Mol Biosyst 6 (12), 2459-2470 (2010)
   PUBMED   20922212
REFERENCE   3  (bases 1 to 881)
  AUTHORS   Barthe,P., Yang,Y.S., Chiche,L., Hoh,F., Strub,M.P., Guignard,L.,
            Soulier,J., Stern,M.H., van Tilbeurgh,H., Lhoste,J.M. and
            Roumestand,C.
  TITLE     Solution structure of human p8MTCP1, a cysteine-rich protein
            encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly
            motif
  JOURNAL   J Mol Biol 274 (5), 801-815 (1997)
   PUBMED   9405159
REFERENCE   4  (bases 1 to 881)
  AUTHORS   Madani,A., Soulier,J., Schmid,M., Plichtova,R., Lerme,F.,
            Gateau-Roesch,O., Garnier,J.P., Pla,M., Sigaux,F. and Stern,M.H.
  TITLE     The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial
            protein
  JOURNAL   Oncogene 10 (11), 2259-2262 (1995)
   PUBMED   7784073
REFERENCE   5  (bases 1 to 881)
  AUTHORS   Soulier,J., Madani,A., Cacheux,V., Rosenzwajg,M., Sigaux,F. and
            Stern,M.H.
  TITLE     The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein
            overexpressed in T cell leukemia bearing a t(X;14) translocation
  JOURNAL   Oncogene 9 (12), 3565-3570 (1994)
   PUBMED   7970717
REFERENCE   6  (bases 1 to 881)
  AUTHORS   Stern,M.H., Soulier,J., Rosenzwajg,M., Nakahara,K., Canki-Klain,N.,
            Aurias,A., Sigaux,F. and Kirsch,I.R.
  TITLE     MTCP-1: a novel gene on the human chromosome Xq28 translocated to
            the T cell receptor alpha/delta locus in mature T cell
            proliferations
  JOURNAL   Oncogene 8 (9), 2475-2483 (1993)
   PUBMED   8361760
REFERENCE   7  (bases 1 to 881)
  AUTHORS   Kenwrick,S., Levinson,B., Taylor,S., Shapiro,A. and Gitschier,J.
  TITLE     Isolation and sequence of two genes associated with a CpG island 5'
            of the factor VIII gene
  JOURNAL   Hum Mol Genet 1 (3), 179-186 (1992)
   PUBMED   1303175
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC002600.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001018024.2.
            
            Summary: This gene was identified by involvement in some t(X;14)
            translocations associated with mature T-cell proliferations. This
            region has a complex gene structure, with a common promoter and 5'
            exon spliced to two different sets of 3' exons that encode two
            different proteins. This gene represents the downstream 8 kDa
            protein that localizes to mitochondria.[provided by RefSeq, Mar
            2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002600.1, SRR5189655.194343.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267752 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000369484.8/
                                                  ENSP00000358496.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-881               BC002600.1         99-979
FEATURES             Location/Qualifiers
     source          1..881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..881
                     /gene="CMC4"
                     /gene_synonym="C6.1B; MTCP1; MTCP1B; MTCP1NB; p8; p8MTCP1"
                     /note="C-X9-C motif containing 4"
                     /db_xref="GeneID:100272147"
                     /db_xref="HGNC:HGNC:35428"
                     /db_xref="MIM:301088"
     exon            1..443
                     /gene="CMC4"
                     /gene_synonym="C6.1B; MTCP1; MTCP1B; MTCP1NB; p8; p8MTCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..511
                     /gene="CMC4"
                     /gene_synonym="C6.1B; MTCP1; MTCP1B; MTCP1NB; p8; p8MTCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..660
                     /gene="CMC4"
                     /gene_synonym="C6.1B; MTCP1; MTCP1B; MTCP1NB; p8; p8MTCP1"
                     /note="protein p8 MTCP-1; C-x(9)-C motif containing 4
                     homolog; mature T-cell proliferation 1 neighbor protein;
                     mature T-cell proliferation-1 type A; MTCP-1 type A"
                     /codon_start=1
                     /product="cx9C motif-containing protein 4"
                     /protein_id="NP_001018024.1"
                     /db_xref="CCDS:CCDS14764.1"
                     /db_xref="GeneID:100272147"
                     /db_xref="HGNC:HGNC:35428"
                     /db_xref="MIM:301088"
                     /translation="MPQKDPCQKQACEIQKCLQANSYMESKCQAVIQELRKCCAQYPK
                     GRSVVCSGFEKEEEENLTRKSASK"
     exon            512..881
                     /gene="CMC4"
                     /gene_synonym="C6.1B; MTCP1; MTCP1B; MTCP1NB; p8; p8MTCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      859..864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMC4"
                     /gene_synonym="C6.1B; MTCP1; MTCP1B; MTCP1NB; p8; p8MTCP1"
                     /note="hexamer: AATAAA"
     polyA_site      881
                     /gene="CMC4"
                     /gene_synonym="C6.1B; MTCP1; MTCP1B; MTCP1NB; p8; p8MTCP1"
                     /note="major polyA site"
ORIGIN      
        1 gtactctgtg agcggcgccc gggcgcctgg gcaggcgcct cccgagtacc ggcgcccatt
       61 ttgcccgccc gctaaggaga cccgtgcgcg gcctacacgc ttgggggaca gccctttaag
      121 acgacatctc cgcgaacgcc ggcctcttga gccaggggga cgctcttttg aaagtcagtc
      181 ccaaaacagt taaggtttta ttttattttg ttttatttcc aagtcacagc ccccgaatct
      241 cgtacaactc tccctggacc acttccggtt gccggcccgc gcctcataac ttcggttcga
      301 gtgacctcgg cccgggatgc ccctcggctc accccgggct cacgtcgcga tcctggcttg
      361 agtggcccag ggtgggagac ctggaagttt tagcctagct gttctcaagg cggattaatt
      421 agcccaagaa acattatatt catttttctg gatatgccgc agaaggatcc gtgccagaag
      481 caagcctgtg agatacagaa atgtttacaa gccaacagct acatggaatc aaagtgtcag
      541 gctgtcatcc aagaactgcg taagtgttgt gctcagtatc ccaagggaag atctgtcgtc
      601 tgttcaggat ttgaaaaaga agaggaagaa aacctaacac ggaagtctgc atcaaagtaa
      661 agttcttctg aagtgctgct ccatgtttcc accaaatgaa ttttttttat cctcctgact
      721 cttcaggcca ggtagcagca aatagcaaat gaaaaagtca gctacaaaag ttaatgaata
      781 tgccatctat gcagaacagg cagaaatata aacacattaa aagacaaata tgtagaatgt
      841 aatatactga gctgctaaaa taaacctgtt taagagaaaa a
//
