LOCUS       NM_020188              10072 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens C-X9-C motif containing 2 (CMC2), transcript variant
            1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_020188
VERSION     NM_020188.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10072)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 10072)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 10072)
  AUTHORS   Sehrawat,B., Sridharan,M., Ghosh,S., Robson,P., Cass,C.E.,
            Mackey,J.R., Greiner,R. and Damaraju,S.
  TITLE     Potential novel candidate polymorphisms identified in genome-wide
            association study for breast cancer susceptibility
  JOURNAL   Hum Genet 130 (4), 529-537 (2011)
   PUBMED   21424380
  REMARK    GeneRIF: Single nucleotide polymorphisms in C16orf61 gene is
            associated with breast cancer.
REFERENCE   4  (bases 1 to 10072)
  AUTHORS   Horn,D., Zhou,W., Trevisson,E., Al-Ali,H., Harris,T.K., Salviati,L.
            and Barrientos,A.
  TITLE     The conserved mitochondrial twin Cx9C protein Cmc2 Is a Cmc1
            homologue essential for cytochrome c oxidase biogenesis
  JOURNAL   J Biol Chem 285 (20), 15088-15099 (2010)
   PUBMED   20220131
REFERENCE   5  (bases 1 to 10072)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY000186.1, BC032631.1 and AC009079.4.
            
            On Jun 2, 2019 this sequence version replaced NM_020188.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG291426.1, SRR5189667.400730.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162841, SAMEA2163105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000219400.8/
                                                  ENSP00000219400.3
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 HY000186.1         35-35
            2-703               BC032631.1         18-719
            704-10072           AC009079.4         92890-102258        c
FEATURES             Location/Qualifiers
     source          1..10072
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.2"
     gene            1..10072
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
                     /note="C-X9-C motif containing 2"
                     /db_xref="GeneID:56942"
                     /db_xref="HGNC:HGNC:24447"
     exon            1..152
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
                     /inference="alignment:Splign:2.1.0"
     exon            153..268
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..427
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
                     /note="C-x(9)-C motif containing 2"
                     /codon_start=1
                     /product="COX assembly mitochondrial protein 2 homolog"
                     /protein_id="NP_064573.1"
                     /db_xref="CCDS:CCDS10930.1"
                     /db_xref="GeneID:56942"
                     /db_xref="HGNC:HGNC:24447"
                     /translation="MHPDLSPHLHTEECNVLINLLKECHKNHNILKFFGYCNDVDREL
                     RKCLKNEYVENRTKSREHGIAMRKKLFNPPEESEK"
     exon            269..340
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
                     /inference="alignment:Splign:2.1.0"
     exon            341..10072
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      700..705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
                     /note="hexamer: AATAAA"
     polyA_site      718
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
                     /note="major polyA site"
     regulatory      6489..6494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
                     /note="hexamer: AATAAA"
     polyA_site      6511
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
     regulatory      10049..10054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
                     /note="hexamer: ATTAAA"
     polyA_site      10072
                     /gene="CMC2"
                     /gene_synonym="2310061C15Rik; C16orf61; DC13"
ORIGIN      
        1 gagccgggag cacggtggag cggtggaggg cgtcactggg tttcggcgtc tggcaagcgg
       61 ttcagctgtc tgctccctag cagccggcct tcgggtcggg cgtctccgcc ggctactgcc
      121 gcttcagttc tcccggtgtg gccacgagtc gggttgcact gctgtgatcc atcctcatct
      181 cctaaagatg catcctgact tatctccaca cttgcacact gaagaatgca acgtcttgat
      241 taacttgctt aaggaatgtc acaaaaatca caacattctg aaattttttg gttattgtaa
      301 tgatgttgat cgggagttga gaaaatgcct gaagaatgag tacgtagaaa acaggaccaa
      361 gagcagggag catggcattg caatgcgaaa gaaacttttt aatcctccag aggaatccga
      421 aaaataaatt gtattttcac tcgatgcctt ggctgagaga agacctaaag actctgggtt
      481 gatacctgaa agaatcctgt cttatttggt ctccataatc ctttgaatgg aaagtgacct
      541 gtgagagatt gaaccatgga gaaatatgaa aaccctggat tctgagtatt tgttgggcag
      601 ggcgtttagt actgtctccc ctttaccagc aaacctgact tcaccatgtt tattcccttt
      661 gcctacaacc agttaatatc tgagtaactt atctccttca ataaaataat ttaaataatt
      721 tttttctcct ttctcttaga ttcttttggc attagaggaa aatgttgcca ttaggctttt
      781 tctttttgac aacatgatgt tgaagaattc tggggaaatc ccagcagtgt taactatttg
      841 aaaatgttgc aactttattg tttttaaaga gtgattttct aaatgattaa aaaaaatttt
      901 ttttttgaga catagtgtta ctttgctgcc caggctggag tgcagtggtg cgatctcagc
      961 ttactgtaac ctccacctcc cggattcaag tgattctcca gcctcagcct ctctagtagc
     1021 tggggctaca ggcgcaggct accatgcctg gctggttttt gtatttttgg tagagacaga
     1081 gttttgccat gttggccagg ctgatctcaa attcctgagc ttaggtgatc cgcccacttc
     1141 agcctcccaa agtgttggga ttacaagcgt gagccactgt gcccagacta aaagattaaa
     1201 tatttacact taacattgat aaaatttcat ctggttagga attgagtctt agcagacttt
     1261 gctttcccat ttggttgaat gtgtccactc gaggtgccag ttaactcctg gacattaacc
     1321 ttaggccagt gtgtctcctc tctgctgagt ataggactgt tcttcccgtg cccaattcta
     1381 gcagtcattt caccagtgtt ccttctgcca agtgtttctg agacctgtga caatctggaa
     1441 gtcagcagct tccagctgca gtcacagcag gggcttgatc ttgtcaggtg tcagggaaca
     1501 gactcagctg tgagctcctt ctagtggagt tctgtgtata atatccagca tgaggccttg
     1561 ttggtgttgg tgtttaataa gtgacttccc catcacagga ggtattcaag aagctggact
     1621 ttcgctcagt acgtcgatta cagagcataa cagacattca gtgaaaggat ggggaaagaa
     1681 ccagaattaa ttctgaagta ccttccaaga caaagtgtat gaatatttat tcagtccccc
     1741 tagtgtcagg cagtagaaat acagaaatga gacattttgc ctttagaatc ttgtagttaa
     1801 ctgaaaagtt gacttttagt cacctgtaat catcaaagtg ccatgattag gtagatgtca
     1861 tagaagacag aggactttca tgttcagtct tcatgaagaa ggagctattc caagaaagct
     1921 atttagcaaa gatgaccttt gacaaatgag tgaaaatggg atacattctg aggcgcactt
     1981 taaggcattt agcatgacta gaatatggga gcttagagtg gaggaagatc atagacagct
     2041 ttgaaatctg ttggaatttt attttcagtg ctgtgatgac cagttgcagg ttttaatatg
     2101 gtgattaggg atttgggtag aggagttagt tggaaggctg atatatttca atttgtattt
     2161 tagtaagttt ttttggttat agtttggggg ataaattgga ggggaaggaa gataacgccc
     2221 aaggagagca attaggtttt tgtgctaact tgagtgagaa atgagggcct ggatgaaaga
     2281 tgtggctttg gggattagga ggagtgacga ttcaagcatt gagtcagcat gactgactag
     2341 gtgtagggtt taaggaagtg tctaggatgt ctcaggcatt tgatttgtgc ctgcttggga
     2401 gggagtactg gggaggtgaa gtgtgtgtgg aggatccagc gggagagggc ttccgggttg
     2461 ctgctgggta tttaggtctg cagcttgtta gagtcacctg gattagaaca aaattgggag
     2521 atgtcagcat gcagatgcca gctaaggccc tgtaggccaa tgtcagtagc tgaccataag
     2581 agcaggatga aactttggaa gttcattctt aaaaatttta taagtaatat atgagtacgt
     2641 ttttatggga tattcaaacc acctactgtt tttaggtctt actctcttgt gttgcagctg
     2701 ttgctgatcc ctgtagagta aagtacacac tgaaggctat ggcaatgatc tacctttcca
     2761 gcttcctcta ggaagggagt ttgacaaata aaatgctagt gaactggagc acagtgagca
     2821 agggggaggg tggcatgagc tgaggacaca ggtgggcagg gccagaacac acaggccttg
     2881 gacatcacct cagggaactt gcatgttatt tggagcataa tggaaaacca ttagaaagtt
     2941 ttagggagtg gttatgattt catttattta tattttataa agatctttct ggttattcgg
     3001 tgaatagtta tggttaaacc agttcaaccc agtgacagta cctgtcacat agagttattg
     3061 tgaggattgg ttgagatgta tgtgatagat tatctggcac aaagtaaggg ccccctcaat
     3121 attgtttttc tctcaagtgc acccaaattg gggtattgga aacacttcct ccgtagtttg
     3181 gtagaaggca ccaaatcact agggctgata ccgtttgagt ggggccccag ctgatggggc
     3241 agggggtaaa ggggtgaggg gcttaatatg aggcagaagg aagggccagg cctctagaac
     3301 tcatcccaag ccggccccat tctctggctc cctgtacatc ctgcctttcc atagaggaag
     3361 ccagtcccag gggtggctgc atcttattcc atgctttaca tctcatcagc cttgctgact
     3421 ttccccagcc tgctgtagat cagagtgaaa tctgtttctc ctgtctagag caagcgcact
     3481 ttttcctgag gatttccaaa tattttgaat tcccatatgc agtggaagcc gaagaagctg
     3541 gagggagagt ggggttggga ggtgcagagg ttccatgtct tcttgccttt atgaagcttc
     3601 tggcattgtg ctgggtgcag gtgataccat ggaataagat ggatgtggtt ctagtgacgg
     3661 ttcacatcac gaaggaccat ctgtgtcctc ttagggagtc tggctttcct gctaagggca
     3721 acaggaaggc attgtagggt ctgtgcagga taccaagtga aggaagagat ttccttactg
     3781 tggacttgca gacgataagt aaacttttgg gtcataagag accatctctt ggaagctgaa
     3841 gaacttaggc caaggttttc ctgagaaatc tagttttgca gaatgttgtg aaccttgatg
     3901 ctctggtgac agtgaattaa tggtttattt taggaagcac tacacaattt tacttaagag
     3961 tgaggctaga aagttgagct gtttctcacc ttttataaat gaagtttaag atcagattaa
     4021 tctccatgga gtttttagct caaagcacaa ttagttttct atagaaaggg cttgggctga
     4081 accaaattat gccattgatc tgcctggtag acatacaaat cattctgttc ttagaaaaaa
     4141 acaaaaaaaa cgaaaaacaa aaaatcctca ctgtcccaag ggagttgctc ctttcactac
     4201 accctgatat tgaaaccctg atattgaaat ttgtgcccct taaatgatat catattcagg
     4261 gaaccagcta taccagaatc taccttaatc catagacatc cctgcctcct ctagagaggt
     4321 cactgaagga gataagtaca tagcagaaag tggtgaaggg aaagcaaagg gatgctttat
     4381 tgttaccagt ctcctgcctc tggtatcaga tggagcaggt ggcctgggct agaggcctgt
     4441 ggggccattt ctgtcctcta agctctagtc tgatctcacc ggcagctggt cacatgggag
     4501 gacaggagat ggagaacaag actgacagta gggaggggag agcagagaca ggtggctgag
     4561 tttctctcac ttagagaaaa gaaactggct gagtgtatac cacgtctgaa gtgagcaaaa
     4621 gggaagattg cccaaatcct gtaaaggacc ttttttgtgg tattaatgct attctttttt
     4681 atgacaaaat gtttcaggtt tacagaaaac tatacagact aatacgaaca ctcacatagc
     4741 tgctatctaa gtcatacttt taaaaaatac aggtttaaaa aaataataat acaaaagtgg
     4801 gtaaagcctc ctgtgtttgt caccccaagc ccgttccact tatttcttta ttggtggtaa
     4861 ctactaccct gactttgata tatttcattc tcatgcatga tttcatacat atatatatat
     4921 gcatgatttc atacatatat atatatatat atataaaatg tatgtatgtc agtatccata
     4981 gccatatttt attttgcatg tttagtcatt ttacttagga ggcgtcatga tgtgtgtagc
     5041 ctttggtagc gtaccttttt tttttaaaaa aaaaatacta tgttgataaa tgaggttctt
     5101 gtttatttgt tttgcctgct atatagcatt ttgttgtagg cctataccac ggtttatgta
     5161 tttccccgta gatggtcact tagatatcca gtctttgcta ttgtaaactt caatgaacgt
     5221 tcttacttac cttcttgtcc aatctgggag agtgttttta ggtataaacc taggatttta
     5281 attattgggc tgtaaggtat gcattttcaa acttactaga agttgctaaa ttacacccca
     5341 aatgttttta agattttatg atttgtattt ttgttgttgt tttttgagac agagtctcac
     5401 cctgtcaccc aggctggagt gcagtggtat gatctcagct cgctgcaact tccacctcct
     5461 ggcttcaagc aattctcgtg ccttagcctc ctgagtggct gggactacag gcatgtgcca
     5521 ccatgccctg ctaatttttg tattttttag tagagatagg gtttcaccat gtccaggctg
     5581 gaaaatttta tgatttttaa aatagtgttc ttatacatct tttgctagat ttgtgtctaa
     5641 ggggtatttt taaaattact tattctaata tctcttaaaa tttttttata aagcagggat
     5701 tataggcatg agcccctgca tccaatttat tctaatttcc tattactgat acattggagt
     5761 gtaattgact tctgtatatt tatcttacat tcagaaggct tgccaaactt tcttaataat
     5821 tctggggcct atagattatt ttagattttt ctatgtagac agtcacatca cttttgaata
     5881 gtaacagtaa tgaatcattt gtttctttcc aatgtttata cttccttatt ttattgtact
     5941 tagaacattc agtataatgt ttaatagata catcagactt ctcttgtgac tgatgttaaa
     6001 tccttacatt tcactgacaa gtagcaaatt tgtagtaggt ttttggaaga tgtctgttcc
     6061 tccctaagga agttcctttt ggtaattgta gatagacttg ctcaacctct actgcacctc
     6121 cttctagtgt gccttcccat atttgtgaaa ctcaaaagct aaatactgca ttttctccaa
     6181 ttcctttaca gttaggattc cagataggaa ttaatgtcca ttaatcggtg agatttggat
     6241 ttggaattga cttaaattga gagagagacg gtccatgaag catccatttt ctggtatgga
     6301 tcagagcaga aatggtgggg ttatagagcc tgcaactgta gccgcagttt tctctttttt
     6361 gctagacagc tttttaattg caatgtggct ctgaagtttc ttcatccctc ccaatggtca
     6421 ggtaagttat ttaaatacct gtctgtcatt gcttactaca ctgtcctttt aatcttcatt
     6481 atataaacaa taaagacata cttaatgctc accgctagtc ttgtgttaat atctccctag
     6541 tcattttggt tgtctgagcc tcattttcca gcagattcct aaggaagttc tcatgggaac
     6601 aatattccat gggttttttt cttttctaat tgagacggag tcttgctgtg tcacccaggc
     6661 tggggtgcag tggtgtgatc ttggctccct gcaaccttgc tgcctgggtt caagtgattc
     6721 ttgtgcctca gcctcccaag tagctgggat tacaggcatg caccatgatg cccggctaat
     6781 ttttttgtcc ttttagtaga gacggggttt caccatgttg cccaggctgg tcttgaactc
     6841 ccgacctcaa gtgatccacc tgcctcggcc tcctgaagtg ctgggattac aggcctgaac
     6901 caccgtgcct ggctctcttc atcacttctg ttgtccctat cctgttcaat tttttttctg
     6961 ctccctgcag ttcctcctca ctttggagtc ttgtcctggg agggaaccct acgggatcag
     7021 ttttgagagt tcattaatgc taaattgttc cagccccttc agaccttcct gtgggcccca
     7081 tttactgaag tgggcaagaa ccttcccagt accaattgct gttctcaaat tggccctccg
     7141 ggctttgcag tgaatatctg ttgttttggg ttcttcggtc cttagttggt tcaggtacct
     7201 tgtgcctccc tgtgctgctt tccacatcga tgctgagacc tcccaggact cctctggctc
     7261 ttgatgctct gtcctcacct cactcatttg tattttggga tatgagggtt acattttaac
     7321 ctaattttgt tgtaaatact gtctctcctc ctgccctttt tatatcataa aaaagatagt
     7381 tgcttccaca gtcacaacta tctttccaga atttcccacc agtaactttc tgacacacac
     7441 acttaactta ccaatgggaa acatattttt tctgctcaga gcccaaggtg agtcacactg
     7501 gccttactct tacctcccta tgctggcaag tgttatgttt tctagttaat gttttcttag
     7561 aggattacca tctcctggct ttatgtgata ttcttgtttc tcacaccatt cctcgtagag
     7621 actcagtatc ttccatcttt ttccattgtg tttatgaaaa cctcacttcc tggtacctgg
     7681 aactggtcta ggctgcatag catgtgctga tgcacttact ttctggttta cagttctctc
     7741 tgatttcaac ccccaaggat tttctttcct ttcttgtgag ctcaactaca cctttaaaaa
     7801 ctatatttga tatatgctat ctagtatttg tagatagctt tttagcagga gtgttttcag
     7861 attacctaat gagctatttt accagaaaca gatatcctgt acataaaatt ttaccttgga
     7921 aagactgccc cctaggaatg attatatttt caacagttag agaactaact cattcctaga
     7981 agatgggggg aggatgggag ttggggaggg catggcaaag agaggagtta taagagcatc
     8041 ttctgttcag agaccttcat cttcatctgc atttgggcca ttagactgtg gtccgtgggc
     8101 cagcagcttt agcgtaaccc gggaaagttt gttagcaacg cagaatctca gccgtgtggg
     8161 gtggcttgcg cctgtaatcc cagtactttc gaaggccgag gtgggagaat tgcttgaggc
     8221 cagggagttc aagaccagct tgggcaacat agtaagaccc tgtctctaca aaaataaaaa
     8281 taaaaaaaag aaatggagag ttttagaccc caccctgacc tactaactga gaatctgcat
     8341 tttaatgaaa tccccagatg atttgcatgc atataaaaat tggagaagca ttgacttaga
     8401 ctctttctga tgtaactgcc ttccataaaa tgcctacttc tttagggtta atgaccttca
     8461 tccactcttg tcatcacttc tagcttactc ttttttctgc atttaatttt taagcagttt
     8521 cctcaaataa cttttgtatt taagtttttg agaaaagttc ttattggtga tatattatgt
     8581 tgagaatgtg atttgaaaaa aaaataggaa gcgttaatat ggtatgttgt cattgaatat
     8641 gacagcaaaa tcttaagggc aaagctgtta cgaaattctc agggcattta ctttttcctc
     8701 aactctggcg agtagagggc taagaaagta aagcattctg caattctgca tacagaaatt
     8761 tagacctggc tatttttcac tggagtattt gcttacagag catccatatt tcctaaaatg
     8821 ctatgattgg attattgagc taatgattgg acttgctaca aatattgaaa agtacgagga
     8881 aggctgggcg aggtggctca cgcctgtaaa cccagcactt tgggaggccg aggcgggcgg
     8941 atcacgaggt caggagatcg agaccatcct ggctaacacg gtgaaacccc gtctctacta
     9001 aaaatacaaa aaattatccg ggcgtggtag tgggcgcctg tagtcccagc tacttgggag
     9061 gctgaggcgg gagaatggcg tgaacccggg aggcggagct tgcagtgagc cgagatcgtg
     9121 ccactgcact ccagcctggg cgacacggcg agctccgtct caaaaaacaa aacaaaacaa
     9181 aacaaaaaac gaggatatct tttcaaagca gatacaatta aaggaaaatt ctctagggat
     9241 agttcaagtt gctgtgatgg ctttatctgc taaaatttta gttaagctag cagataattt
     9301 atgagcaagt tcatgataca tggaattcag gttatgtgta gactgaaagc tctctgggct
     9361 gacacctctc tgggcagaca ccacattatt cctgtatctg cagctcttag gacagtggtt
     9421 aacacataat tggtattcaa taaatgcttt ttcactgaat gaatgaattt ttagtgaata
     9481 aagaataaat aaagtgttga agtagcccaa aggactttaa aatttacatt ttctttttct
     9541 gtagatcact tgataggtac attgttggat gtaattaaaa taagacgggc tctatatgtc
     9601 tacgaatagg acagtagtta aataaacaat gatgcattta cacaaaggta taccatgaat
     9661 ctatacaaag gaatgaagat ttcgtgtgtc tgtatgtatg actatatggt gattatataa
     9721 agaaaagaag aaattcctaa aacttgaaaa caagctgaaa caaataactc gagtacatgt
     9781 caagttgatt ttataaccac agaaaggaaa tgattataag tgttgttcaa atacaatatt
     9841 ttgactttac atctccagaa ggtgatacat cctgaagata aggagaactg caaaaaaagt
     9901 aaaactttat aataaaaata atattgtttt gaaattggta ttataaaata tcacgtttta
     9961 aagttatgat gttagtgtca gtagaaacca agattttcaa cctaagacca aaacaagata
    10021 caagtgtaaa attcaagtca aaacatgcat taaatttgaa ttggaaatag ta
//
