LOCUS       NM_001393344            1959 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens clusterin like 1 (CLUL1), transcript variant 6, mRNA.
ACCESSION   NM_001393344
VERSION     NM_001393344.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1959)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 1959)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1959)
  AUTHORS   Roni,V., Carpio,R. and Wissinger,B.
  TITLE     Mapping of transcription start sites of human retina expressed
            genes
  JOURNAL   BMC Genomics 8, 42 (2007)
   PUBMED   17286855
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1959)
  AUTHORS   Zhang,Q., Beltran,W.A., Mao,Z., Li,K., Johnson,J.L., Acland,G.M.
            and Aguirre,G.D.
  TITLE     Comparative analysis and expression of CLUL1, a cone
            photoreceptor-specific gene
  JOURNAL   Invest Ophthalmol Vis Sci 44 (10), 4542-4549 (2003)
   PUBMED   14507903
REFERENCE   5  (bases 1 to 1959)
  AUTHORS   Zhang,Q., Ray,K., Acland,G.M., Czarnecki,J.M. and Aguirre,G.D.
  TITLE     Molecular cloning, characterization and expression of a novel
            retinal clusterin-like protein cDNA
  JOURNAL   Gene 243 (1-2), 151-160 (2000)
   PUBMED   10675623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001178.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.22598.1,
                                           SRR1660805.163654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000692774.1/
                                                ENSP00000510271.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AP001178.4         24674-24815
            143-264             AP001178.4         34664-34785
            265-383             AP001178.4         45674-45792
            384-532             AP001178.4         46899-47047
            533-700             AP001178.4         52551-52718
            701-1133            AP001178.4         54783-55215
            1134-1271           AP001178.4         60984-61121
            1272-1486           AP001178.4         69013-69227
            1487-1674           AP001178.4         72596-72783
            1675-1959           AP001178.4         77584-77868
FEATURES             Location/Qualifiers
     source          1..1959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.32"
     gene            1..1959
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /note="clusterin like 1"
                     /db_xref="GeneID:27098"
                     /db_xref="HGNC:HGNC:2096"
                     /db_xref="MIM:616990"
     exon            1..142
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /inference="alignment:Splign:2.1.0"
     exon            143..264
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /inference="alignment:Splign:2.1.0"
     exon            265..383
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1678
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /note="clusterin-like protein 1; retinal-specific
                     clusterin-like protein; clusterin-like 1 (retinal);
                     retinal clusterin-like protein"
                     /codon_start=1
                     /product="clusterin-like protein 1 precursor"
                     /protein_id="NP_001380273.1"
                     /db_xref="CCDS:CCDS42405.1"
                     /db_xref="GeneID:27098"
                     /db_xref="HGNC:HGNC:2096"
                     /db_xref="MIM:616990"
                     /translation="MKPPLLVFIVCLLWLKDSHCAPTWKDKTAISENLKSFSEVGEID
                     ADEEVKKALTGIKQMKIMMERKEKEHTNLMSTLKKCREEKQEALKLLNEVQEHLEEEE
                     RLCRESLADSWGECRSCLENNCMRIYTTCQPSWSSVKNKIERFFRKIYQFLFPFHEDN
                     EKDLPISEKLIEEDAQLTQMEDVFSQLTVDVNSLFNRSFNVFRQMQQEFDQTFQSHFI
                     SDTDLTEPYFFPAFSKEPMTKADLEQCWDIPNFFQLFCNFSVSIYESVSETITKMLKA
                     IEDLPKQDKAPDHGGLISKMLPGQDRGLCGELDQNLSRCFKFHEKCQKCQAHLSEDCP
                     DVPALHTELDEAIRLVNVSNQQYGQILQMTRKHLEDTAYLVEKMRGQFGWVSELANQA
                     PETEIIFNSIQVVPRIHEGNISKQDETMMTDLSILPSSNFTLKIPLEESAESSNFIGY
                     VVAKALQHFKEHFKTW"
     exon            384..532
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /inference="alignment:Splign:2.1.0"
     exon            533..700
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /inference="alignment:Splign:2.1.0"
     exon            701..1133
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1271
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1486
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1674
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1959
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1942..1947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /note="hexamer: AATAAA"
     polyA_site      1959
                     /gene="CLUL1"
                     /gene_synonym="RA337M"
                     /note="major polyA site"
ORIGIN      
        1 accctgcgtc acctgcaggc ccgggccgcg gggttggttt ccaccctgga ggttgctgac
       61 accctgtgcc ctcggctgac ttccagccgg tggcacagac gcctccaggg ggcagcactc
      121 aagcgcatct taggaatgac agagttgcgt ccctctcggt tgccaggctg gagttcagtg
      181 gcatgttcat agctcactga agcctcaaat tcctgggttc aagtgaccct cctacctcag
      241 ccccatgagg acctgggact acagtaacag cgggaacatg aagccgccac tcttggtgtt
      301 tattgtgtgt ctgctgtggt tgaaagacag tcactgcgca cccacttgga aggacaaaac
      361 tgctatcagt gaaaacctga agagtttttc tgaggtgggg gagatagatg cagatgaaga
      421 ggtgaagaag gctttgactg gtattaagca aatgaaaatc atgatggaaa gaaaagagaa
      481 ggaacacacc aatctaatga gcaccctgaa gaaatgcaga gaagaaaagc aggaggccct
      541 gaaacttctg aatgaagttc aagaacatct ggaggaagaa gaaaggctat gccgggagtc
      601 tttggcagat tcctggggtg aatgcaggtc ttgcctggaa aataactgca tgagaattta
      661 tacaacctgc caacctagct ggtcctctgt gaaaaataag attgaacggt ttttcaggaa
      721 gatatatcaa tttctatttc ctttccatga agataatgaa aaagatctcc ccatcagtga
      781 aaagctcatt gaggaagatg cacaattgac ccaaatggag gatgtgttca gccagttgac
      841 tgtggatgtg aattctctct ttaacaggag ttttaacgtc ttcagacaga tgcagcaaga
      901 gtttgaccag acttttcaat cacatttcat atcagataca gacctaactg agccttactt
      961 ttttccagct ttctctaaag agccgatgac aaaagcagat cttgagcaat gttgggacat
     1021 tcccaacttc ttccagctgt tttgtaattt cagtgtctct atttatgaaa gtgtcagtga
     1081 aacaattact aagatgctga aggcaataga agatttacca aaacaagaca aagctcctga
     1141 ccacggaggc ctgatttcaa agatgttacc tgggcaggac agaggactgt gtggggaact
     1201 tgaccagaat ttgtcaagat gtttcaaatt tcatgaaaaa tgccaaaaat gtcaggctca
     1261 cctatctgaa gactgtcctg atgtacctgc tctgcacaca gaattagacg aggcgatcag
     1321 gttggtcaat gtatccaatc agcagtatgg ccagattctc cagatgaccc ggaagcactt
     1381 ggaggacacc gcctatctgg tggagaagat gagagggcaa tttggctggg tgtctgaact
     1441 ggcaaaccag gccccagaaa cagagatcat ctttaattca atacaggtag ttccaaggat
     1501 tcatgaagga aatatttcca aacaagatga aacaatgatg acagacttaa gcattctgcc
     1561 ttcctctaat ttcacactca agatccctct tgaagaaagt gctgagagtt ctaacttcat
     1621 tggctacgta gtggcaaaag ctctacagca ttttaaggaa cattttaaaa cctggtaaga
     1681 agatctaatg catcctatat ccagtaagta gaattatctc ttcatctggg acctggaaat
     1741 cctgaaataa aaaaggataa tgcaataaac acagttgcag gaaagtatgt tagctatata
     1801 ctatgaagta ctcttagttt acttatgttg aatggcttag ctattaatac tcaaattgag
     1861 ttaaaatgaa aattcctcct taaaaaatca aacgtaatat gtattacatt tcatggtaca
     1921 ttagtagttc tttgtatatt gaataaatac taaatcacc
//
