LOCUS       NM_001366661            5357 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens clustered mitochondria homolog (CLUH), transcript
            variant 1, mRNA.
ACCESSION   NM_001366661 XM_024450677
VERSION     NM_001366661.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5357)
  AUTHORS   Khan,S., Raj,D., Sahu,S., Naseer,A., Singh,N.C., Kumari,S.,
            Ishteyaque,S., Sharma,J., Lakra,P., Mugale,M.N., Trivedi,A.K.,
            Srivastava,M., Chandra,T., Bhosale,V., Barthwal,M.K., Gupta,S.K.,
            Mitra,K., Nazir,A., Ghoshal,U.C. and Lahiri,A.
  TITLE     CLUH functions as a negative regulator of inflammation in human
            macrophages and determines ulcerative colitis pathogenesis
  JOURNAL   JCI Insight 8 (11), e161096 (2023)
   PUBMED   37140992
  REMARK    GeneRIF: CLUH functions as a negative regulator of inflammation in
            human macrophages and determines ulcerative colitis pathogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5357)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 5357)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5357)
  AUTHORS   Pla-Martin,D., Schatton,D., Wiederstein,J.L., Marx,M.C., Khiati,S.,
            Kruger,M. and Rugarli,E.I.
  TITLE     CLUH granules coordinate translation of mitochondrial proteins with
            mTORC1 signaling and mitophagy
  JOURNAL   EMBO J 39 (9), e102731 (2020)
   PUBMED   32149416
  REMARK    GeneRIF: CLUH granules coordinate translation of mitochondrial
            proteins with mTORC1 signaling and mitophagy.
REFERENCE   5  (bases 1 to 5357)
  AUTHORS   Wakim,J., Goudenege,D., Perrot,R., Gueguen,N., Desquiret-Dumas,V.,
            Chao de la Barca,J.M., Dalla Rosa,I., Manero,F., Le Mao,M.,
            Chupin,S., Chevrollier,A., Procaccio,V., Bonneau,D., Logan,D.C.,
            Reynier,P., Lenaers,G. and Khiati,S.
  TITLE     CLUH couples mitochondrial distribution to the energetic and
            metabolic status
  JOURNAL   J Cell Sci 130 (11), 1940-1951 (2017)
   PUBMED   28424233
  REMARK    GeneRIF: CLUH couples mitochondrial distribution to the energetic
            and metabolic status.
REFERENCE   6  (bases 1 to 5357)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 5357)
  AUTHORS   Ando,T., Yamayoshi,S., Tomita,Y., Watanabe,S., Watanabe,T. and
            Kawaoka,Y.
  TITLE     The host protein CLUH participates in the subnuclear transport of
            influenza virus ribonucleoprotein complexes
  JOURNAL   Nat Microbiol 1 (8), 16062 (2016)
   PUBMED   27573102
  REMARK    GeneRIF: Here, the authors show that CLUH, a host protein whose
            cellular function is not well established, plays a key role in the
            subnuclear transport of influenza virus nucleoprotein.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5357)
  AUTHORS   Gao,J., Schatton,D., Martinelli,P., Hansen,H., Pla-Martin,D.,
            Barth,E., Becker,C., Altmueller,J., Frommolt,P., Sardiello,M. and
            Rugarli,E.I.
  TITLE     CLUH regulates mitochondrial biogenesis by binding mRNAs of
            nuclear-encoded mitochondrial proteins
  JOURNAL   J Cell Biol 207 (2), 213-223 (2014)
   PUBMED   25349259
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005696.1.
            
            On Oct 13, 2018 this sequence version replaced XM_024450677.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9304712.183301.1,
                                           SRR9304713.210662.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000651024.2/
                                                  ENSP00000498679.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC005696.1         86887-87089         c
            204-406             AC005696.1         79687-79889         c
            407-578             AC005696.1         78643-78814         c
            579-722             AC005696.1         77239-77382         c
            723-847             AC005696.1         76938-77062         c
            848-1002            AC005696.1         76691-76845         c
            1003-1128           AC005696.1         76465-76590         c
            1129-1276           AC005696.1         76003-76150         c
            1277-1369           AC005696.1         75707-75799         c
            1370-2064           AC005696.1         73221-73915         c
            2065-2288           AC005696.1         72044-72267         c
            2289-2393           AC005696.1         71759-71863         c
            2394-2494           AC005696.1         71484-71584         c
            2495-2647           AC005696.1         70699-70851         c
            2648-2710           AC005696.1         70543-70605         c
            2711-2955           AC005696.1         70182-70426         c
            2956-3040           AC005696.1         69805-69889         c
            3041-3194           AC005696.1         69448-69601         c
            3195-3334           AC005696.1         69225-69364         c
            3335-3415           AC005696.1         68105-68185         c
            3416-3541           AC005696.1         67896-68021         c
            3542-3663           AC005696.1         67686-67807         c
            3664-3757           AC005696.1         67329-67422         c
            3758-3892           AC005696.1         67086-67220         c
            3893-3966           AC005696.1         66934-67007         c
            3967-5357           AC005696.1         64712-66102         c
FEATURES             Location/Qualifiers
     source          1..5357
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..5357
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /note="clustered mitochondria homolog"
                     /db_xref="GeneID:23277"
                     /db_xref="HGNC:HGNC:29094"
                     /db_xref="MIM:616184"
     exon            1..203
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..4150
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     clustered mitochondria protein homolog; clustered
                     mitochondria (cluA/CLU1) homolog"
                     /codon_start=1
                     /product="clustered mitochondria protein homolog isoform
                     1"
                     /protein_id="NP_001353590.1"
                     /db_xref="CCDS:CCDS92221.1"
                     /db_xref="GeneID:23277"
                     /db_xref="HGNC:HGNC:29094"
                     /db_xref="MIM:616184"
                     /translation="MVIKTDELPAAAPADSAREHGSQAGGKGRPGAAELPSVMLLNGD
                     CPESLKKEAAAAEPPRENGLDEAGPGDETTGQEVIVIQDTGFSVKILAPGIEPFSLQV
                     SPQEMVQEIHQVLMDREDTCHRTCFSLHLDGNVLDHFSELRSVEGLQEGSVLRVVEEP
                     YTVREARIHVRHVRDLLKSLDPSDAFNGVDCNSLSFLSVFTDGDLGDSGKRKKGLEMD
                     PIDCTPPEYILPGSRERPLCPLQPQNRDWKPLQCLKVLTMSGWNPPPGNRKMHGDLMY
                     LFVITAEDRQVSITASTRGFYLNQSTAYHFNPKPASPRFLSHSLVELLNQISPTFKKN
                     FAVLQKKRVQRHPFERIATPFQVYSWTAPQAEHAMDCVRAEDAYTSRLGYEEHIPGQT
                     RDWNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVIDGNVMAINPSE
                     ETKMQMFIWNNIFFSLGFDVRDHYKDFGGDVAAYVAPTNDLNGVRTYNAVDVEGLYTL
                     GTVVVDYRGYRVTAQSIIPGILERDQEQSVIYGSIDFGKTVVSHPRYLELLERTSRPL
                     KILRHQVLNDRDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNFLPVPGEELPE
                     ECARAGFPRAHRHKLCCLRQELVDAFVEHRYLLFMKLAALQLMQQNASQLETPSSLEN
                     GGPSSLESKSEDPPGQEAGSEEEGSSASGLAKVKELAETIAADDGTADPRSREVIRNA
                     CKAVGSISSTAFDIRFNPDIFSPGVRFPESCQDEVRDQKQLLKDAAAFLLSCQIPGLV
                     KDCMEHAVLPVDGATLAEVMRQRGINMRYLGKVLELVLRSPARHQLDHVFKIGIGELI
                     TRSAKHIFKTYLQGVELSGLSAAISHFLNCFLSSYPNPVAHLPADELVSKKRNKRRKN
                     RPPGAADNTAWAVMTPQELWKNICQEAKNYFDFDLECETVDQAVETYGLQKITLLREI
                     SLKTGIQVLLKEYSFDSRHKPAFTEEDVLNIFPVVKHVNPKASDAFHFFQSGQAKVQQ
                     GFLKEGCELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLM
                     SERVMGTEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLD
                     NNIGLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALSHHLVARVYESKAEFRSA
                     LQHEKEGYTIYKTQLGEDHEKTKESSEYLKCLTQQAVALQRTMNEIYRNGSSANIPPL
                     KFTAPSMASVLEQLNVINGILFIPLSQKDLENLKAEVARRHQLQEASRNRDRAEEPMA
                     TEPAPAGAPGDLGSQPPAAKDPSPSVQG"
     exon            204..406
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..578
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..722
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..847
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1002
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1128
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1276
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1369
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..2064
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2288
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2393
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2494
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2647
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2710
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2955
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3040
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3194
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3334
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3415
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3541
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            3542..3663
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3757
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..3892
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..3966
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            3967..5357
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4344..4349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /note="hexamer: AATAGA"
     polyA_site      4380
                     /gene="CLUH"
                     /gene_synonym="CLU1"
     regulatory      5331..5336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /note="hexamer: AATAAA"
     polyA_site      5357
                     /gene="CLUH"
                     /gene_synonym="CLU1"
                     /note="major polyA site"
ORIGIN      
        1 ggtgactccg tccttccctc agcagccgcg gcgcgcaggg cacttgggtt agtggcgcgg
       61 cgggcggcgc ggacagccga ggcggacgcc cgctcccgcc accatggtta tcaagacgga
      121 cgagttgccg gcggccgccc cggccgacag cgcccgggaa cacggctcgc aggccggggg
      181 caaggggcgg ccgggcgcgg ccgagctgcc atcagtcatg ctcttaaacg gggactgccc
      241 agagagcctg aagaaggagg cggcggcggc cgagccaccc agggaaaatg ggcttgacga
      301 ggccggcccg ggagatgaga ccaccggcca ggaagtcatt gtcattcagg acacgggctt
      361 ttctgtgaag atcctcgccc ctgggatcga gcccttctcc ctgcaggtgt ccccccagga
      421 gatggtgcag gagattcacc aggtgctcat ggaccgggag gacacgtgtc accgcacctg
      481 cttctcactg cacctggatg gcaacgtgct ggaccacttc tcggagctgc gcagcgtcga
      541 ggggctgcag gagggctctg tgctgcgtgt ggtggaagag ccgtacacgg tgcgtgaggc
      601 ccgcatccac gtgcgccatg tccgagacct gctcaagagc ctggacccat ccgatgcctt
      661 caacggggtt gactgcaact ccttgtcctt cctgagtgtc ttcaccgacg gcgacctggg
      721 agacagcggg aagcggaaga agggcttgga gatggacccc atcgactgca caccacccga
      781 gtacatcctg ccagggagcc gggagcggcc actgtgtccc ctgcagcccc aaaaccgtga
      841 ctggaagccc ttgcagtgcc tgaaagtact caccatgagc ggatggaacc cgcccccggg
      901 gaaccggaag atgcacgggg acctcatgta cctgtttgtg atcacagccg aggaccggca
      961 agtcagcatc accgcgtcca cacggggctt ttacctgaat cagtccacag cttatcactt
     1021 caaccccaag cccgccagcc cccgcttcct aagccattcc ctagtggagc tgctcaacca
     1081 gatcagcccg accttcaaga agaacttcgc tgtgctgcag aagaaaaggg tccagcgcca
     1141 cccgttcgag aggatcgcca ccccattcca ggtgtacagc tggacagccc cccaggcgga
     1201 gcatgccatg gattgcgtgc gtgcagagga cgcctacacc tcgaggctgg gctatgagga
     1261 gcacattcct ggacagaccc gagactggaa tgaggagctg cagacgacga gggagctgcc
     1321 tcgcaagaac ctgcctgagc ggctgctccg agaaagggcc atattcaagg tgcacagcga
     1381 cttcaccgcg gcagccacca ggggcgccat ggccgtcatt gacggcaacg tgatggccat
     1441 caaccccagc gaggagacca agatgcagat gttcatctgg aacaacatct tcttcagcct
     1501 gggcttcgac gtccgagacc actacaagga cttcgggggg gacgtggcgg cctacgtggc
     1561 gcccaccaac gacctgaatg gcgtccgcac gtacaacgcg gtggacgtgg aggggctgta
     1621 cacgctgggc acggtggtgg tggattaccg cggctaccgg gtcacggccc agtccatcat
     1681 ccccggcatc ctggagcggg accaggagca gagcgtcatc tacggctcca tcgacttcgg
     1741 caagaccgtg gtgtcacacc cgcggtacct ggagctgctg gagcgcacga gtcggcccct
     1801 caagatcctg cggcaccagg tgctcaacga ccgtgacgag gaggtggagc tctgctcctc
     1861 ggtcgagtgc aagggcatca ttggcaacga cgggcgccac tacatcctcg acctgctgcg
     1921 caccttcccc ccggacctca acttcctgcc cgtgcctggc gaggagctgc ctgaggaatg
     1981 cgcccgcgcc ggcttccccc gcgcccaccg gcacaagctc tgctgcctgc gccaggagct
     2041 ggtggacgcc ttcgtggagc acaggtacct cctctttatg aagctggccg ccttgcagct
     2101 gatgcagcag aacgccagcc agctggagac cccctcctcc ctggaaaatg gtggtccttc
     2161 ctccttggag tccaagtctg aggatcctcc aggacaggag gcgggaagtg aggaggaggg
     2221 tagcagcgcc agcggcctgg ccaaggtgaa ggagctggca gagaccatcg ccgcagacga
     2281 cggcacagca gaccctcgga gccgggaggt gatccgcaac gcgtgcaagg cggtcggctc
     2341 catcagcagc accgccttcg acattcgctt caatcctgac atcttctcac caggggttcg
     2401 tttccctgag tcctgccagg atgaagttcg ggaccagaag cagctgctga aggacgcggc
     2461 tgccttcctg ctctcctgcc agatccctgg cttggtgaag gactgcatgg agcacgcggt
     2521 cctgcccgtg gacggggcaa cgctggcaga ggtgatgcgc cagcggggca tcaacatgcg
     2581 ctacctgggc aaggtgctgg agctggtgct gcggagcccg gcccgccacc agctggacca
     2641 cgtctttaaa atcggcattg gagaactcat cacccgctcg gccaagcaca tcttcaagac
     2701 gtacttacag ggagtcgagc tctccggcct ctcagccgcc atcagccact tcctgaactg
     2761 cttcctgagc tcctacccaa accccgtggc ccacctgccc gccgacgagc tggtctccaa
     2821 gaagcggaat aagaggagga aaaaccggcc cccgggggct gcagataaca cagcctgggc
     2881 tgtcatgacc ccccaggagc tctggaagaa catctgccag gaggccaaga actactttga
     2941 cttcgacctc gagtgtgaga ccgtggacca ggctgtggag acctacggcc tgcagaagat
     3001 aacgctcctg cgggagatct cgctgaaaac agggatccag gtcctgctga aggagtacag
     3061 cttcgacagt cgccacaagc ccgcgttcac cgaggaggac gtgctcaaca tcttccccgt
     3121 ggtcaagcac gtcaacccca aggcctcgga tgccttccat ttcttccaga gcgggcaggc
     3181 caaagtgcag cagggcttcc tgaaggaggg ctgtgagctc atcaatgagg ccctgaacct
     3241 gtttaacaac gtctacggag ccatgcacgt ggagacctgc gcctgcctgc gcctcctcgc
     3301 ccgcctccac tacatcatgg gcgactacgc agaggccctg agtaaccagc agaaggcggt
     3361 gctgatgagc gagcgggtga tgggcaccga gcaccccaac accatccagg aatacatgca
     3421 cctggccctg tactgcttcg ccagcagcca gctgtccacc gccctgagcc tgctgtaccg
     3481 cgcccgctac ctcatgctgc tggtgttcgg ggaagaccac cccgagatgg cgctgctgga
     3541 caacaacatc gggctggtgc tgcacggggt gatggagtac gacctgtcgc tgcgcttcct
     3601 ggagaacgcg ctggccgtca gcaccaagta ccacgggccc aaggccctca aggtggccct
     3661 cagccaccac cttgtcgccc gagtctacga gagcaaagct gagttccggt cggccctgca
     3721 gcacgagaag gagggttaca ccatctacaa gacgcagctg ggcgaggacc atgagaagac
     3781 caaggaaagc tccgagtacc tcaagtgcct gacccagcag gccgtggccc tgcagcgcac
     3841 catgaacgag atctaccgca acggctccag cgccaacatc ccgcccctca agttcacggc
     3901 ccccagcatg gccagcgtct tggagcagct gaacgtcatt aacggcatcc tcttcattcc
     3961 tctcagccaa aaagacctgg agaatctgaa agccgaggtg gcgcggcggc accagctcca
     4021 ggaggccagc agaaacaggg atagagccga ggagcccatg gctaccgagc ccgcgccagc
     4081 gggggcccca ggagacctgg gctcccagcc cccggctgcc aaggaccctt ctccgagcgt
     4141 gcagggatag agagggagcc agacggacag ccagccagcg gccccgtcac cagggagccc
     4201 gactgcggga gaagggggcg agcctgcggg cggaagagga agcaaggccc tcttcctcca
     4261 cgtctcaccc caccccaccc ccgtgtcctc ctgggagcct ggcctgcctg ccccgcagaa
     4321 ggtgtttttg cgctggttca atgaatagat gatgcagagg ccccattgga gacacgtgaa
     4381 tggcgtgtgc ggccatcagt tcccggctgg ggggcaggtg ttgcttcggc ccccgccgtc
     4441 cggccggcgt gtgcgagtgc gcccctggct gtgagtgttg accgttcctc tcccctgtac
     4501 atagcccgag ccagtcctga gtgggtgact cctgagtggg tgacgcgcag acgggatttc
     4561 tcaggtcatt tgtatggtcg acatgatggc tgctgctttg gctgccacca cccccgggcc
     4621 cagcctgtct gaaagttcag ggtttaggcc gaaaaacccg gtggggaggg gtggggagcc
     4681 ggagctctgt ggcggggctg gagggctggg gtgcacttta gtttggggcg ggacgggagc
     4741 cgccgttgtg actggcgtgg tctggctgct gctcccgaac ggaggggtcg gggttggctt
     4801 gctgggccct cagagcccag tgggtggctc tgactcggct ccctactccc tgcacccagc
     4861 tgggcgcagc cttggggcct gcggtctgaa tgtatccctc ccctcagttt taacctgagc
     4921 tgccgaacgc acagtgggcc gggggcgagg ctgggggaag cggggcccaa ttacggatcc
     4981 cgggagttac aggtgccgac gtgatgtcgc ttctctggtg cccagctccc ttcctggtct
     5041 gagactagct ctgggggtgg cgggggcccc cacacgctgc tcccgctcca ccctgcccgt
     5101 gctgctgctc tgtgcctgct gtcagagccc tggtggggga ggatgtggcc accctgagac
     5161 ccggaggaga cgggcgtctg cctgggtttg cggagagccg cttatgggtg tggtccgtcc
     5221 agacaccttg tttcaagggg gatgggcgtg agcgggcaag cagagcatcc ccaccgctga
     5281 gcaagaactt tttcttgttt ttaaaccatc acgtcctcat ttcacattgg aataaagtga
     5341 gtttttgaaa cctgcgg
//
