LOCUS       NM_015041               4083 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens clusterin associated protein 1 (CLUAP1), transcript
            variant 1, mRNA.
ACCESSION   NM_015041
VERSION     NM_015041.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4083)
  AUTHORS   Yu,J.H., Kim,J.H., Soung,N.K., Moon,E.Y. and Koo,J.H.
  TITLE     Identification of the primary ciliary proteins IFT38 and IFT144 to
            enhance serum-mediated YAP activation and cell proliferation
  JOURNAL   Biochem Biophys Res Commun 681, 186-193 (2023)
   PUBMED   37783116
  REMARK    GeneRIF: Identification of the primary ciliary proteins IFT38 and
            IFT144 to enhance serum-mediated YAP activation and cell
            proliferation.
REFERENCE   2  (bases 1 to 4083)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4083)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4083)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4083)
  AUTHORS   Soens,Z.T., Li,Y., Zhao,L., Eblimit,A., Dharmat,R., Li,Y., Chen,Y.,
            Naqeeb,M., Fajardo,N., Lopez,I., Sun,Z., Koenekoop,R.K. and Chen,R.
  TITLE     Hypomorphic mutations identified in the candidate Leber congenital
            amaurosis gene CLUAP1
  JOURNAL   Genet Med 18 (10), 1044-1051 (2016)
   PUBMED   26820066
  REMARK    GeneRIF: Consistent with the knowledge that CLUAP1 plays an
            important role in cilia function and that cilia are critical to
            photoreceptor function, our results indicate that hypomorphic
            mutations in CLUAP1 can result in dysfunctional photoreceptors
            without systemic abnormalities. This is the first report linking
            mutations in CLUAP1 to human disease and establishes CLUAP1 as a
            candidate Leber congenital amaurosis gene
REFERENCE   6  (bases 1 to 4083)
  AUTHORS   Raman,M., Sergeev,M., Garnaas,M., Lydeard,J.R., Huttlin,E.L.,
            Goessling,W., Shah,J.V. and Harper,J.W.
  TITLE     Systematic proteomics of the VCP-UBXD adaptor network identifies a
            role for UBXN10 in regulating ciliogenesis
  JOURNAL   Nat Cell Biol 17 (10), 1356-1369 (2015)
   PUBMED   26389662
  REMARK    Erratum:[Nat Cell Biol. 2016 Mar;18(3):347. doi: 10.1038/ncb3318..
            PMID: 26911913]
REFERENCE   7  (bases 1 to 4083)
  AUTHORS   Follit,J.A., Xu,F., Keady,B.T. and Pazour,G.J.
  TITLE     Characterization of mouse IFT complex B
  JOURNAL   Cell Motil Cytoskeleton 66 (8), 457-468 (2009)
   PUBMED   19253336
REFERENCE   8  (bases 1 to 4083)
  AUTHORS   Ishikura,H., Ikeda,H., Abe,H., Ohkuri,T., Hiraga,H., Isu,K.,
            Tsukahara,T., Sato,N., Kitamura,H., Iwasaki,N., Takeda,N.,
            Minami,A. and Nishimura,T.
  TITLE     Identification of CLUAP1 as a human osteosarcoma tumor-associated
            antigen recognized by the humoral immune system
  JOURNAL   Int J Oncol 30 (2), 461-467 (2007)
   PUBMED   17203229
  REMARK    GeneRIF: CLUAP1 (clusterin-associated protein 1) is highly
            expressed in osteosarcoma, ovarian, colon, and lung cancers
REFERENCE   9  (bases 1 to 4083)
  AUTHORS   Takahashi,M., Lin,Y.M., Nakamura,Y. and Furukawa,Y.
  TITLE     Isolation and characterization of a novel gene CLUAP1 whose
            expression is frequently upregulated in colon cancer
  JOURNAL   Oncogene 23 (57), 9289-9294 (2004)
   PUBMED   15480429
  REMARK    GeneRIF: inactivation of CLUAP1 may conceivably serve in the future
            as a novel therapeutic intervention for treatment of colon cancer
            Erratum:[Oncogene. 2005 Jun 16;24(26):4320]
REFERENCE   10 (bases 1 to 4083)
  AUTHORS   Kumaran,N., Pennesi,M.E., Yang,P., Trzupek,K.M., Schlechter,C.,
            Moore,A.T., Weleber,R.G. and Michaelides,M.
  TITLE     Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   30285347
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB089691.1, AK023319.1,
            T49451.1, AC004494.1 and BQ446386.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015041.2.
            
            Summary: The protein encoded by this gene contains a single
            coiled-coil region. Alternative splicing results in multiple
            transcript variants and protein isoforms. [provided by RefSeq, Jul
            2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.275535.1,
                                           SRR1660805.21016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000576634.6/ ENSP00000460850.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1620              AB089691.1         42-1661
            1621-2389           AK023319.1         896-1664
            2390-2750           AK023319.1         1666-2026
            2751-2751           T49451.1           285-285             c
            2752-3033           AK023319.1         2028-2309
            3034-4060           AC004494.1         7485-8511           c
            4061-4083           BQ446386.1         17-39               c
FEATURES             Location/Qualifiers
     source          1..4083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..4083
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /note="clusterin associated protein 1"
                     /db_xref="GeneID:23059"
                     /db_xref="HGNC:HGNC:19009"
                     /db_xref="MIM:616787"
     exon            1..86
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1306
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /note="isoform 1 is encoded by transcript variant 1;
                     flagellar associated protein 22, qilin-like protein,
                     homolog; cilia and flagella associated protein 22"
                     /codon_start=1
                     /product="clusterin-associated protein 1 isoform 1"
                     /protein_id="NP_055856.1"
                     /db_xref="CCDS:CCDS32381.1"
                     /db_xref="GeneID:23059"
                     /db_xref="HGNC:HGNC:19009"
                     /db_xref="MIM:616787"
                     /translation="MSFRDLRNFTEMMRALGYPRHISMENFRTPNFGLVSEVLLWLVK
                     RYEPQTDIPPDVDTEQDRVFFIKAIAQFMATKAHIKLNTKKLYQADGYAVKELLKITS
                     VLYNAMKTKGMEGSEIVEEDVNKFKFDLGSKIADLKAARQLASEITSKGASLYDLLGM
                     EVELREMRTEAIARPLEINETEKVMRIAIKEILTQVQKTKDLLNNVASDEANLEAKIE
                     KRKLELERNRKRLETLQSVRPCFMDEYEKTEEELQKQYDTYLEKFQNLTYLEQQLEDH
                     HRMEQERFEEAKNTLCLIQNKLKEEEKRLLKSGSNDDSDIDIQEDDESDSELEERRLP
                     KPQTAMEMLMQGRPGKRIVGTMQGGDSDDNEDSEESEIDMEDDDDEDDDLEDESISLS
                     PTKPNRRVRKSEPLDESDNDF"
     exon            87..198
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     exon            199..283
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     exon            284..463
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     exon            464..559
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     exon            560..643
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     exon            644..777
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     exon            778..919
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     exon            920..992
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1100
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1156
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..4083
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /note="hexamer: AAGAAA"
     polyA_site      1615
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /note="major polyA site"
     polyA_site      1781
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
     regulatory      1840..1845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /note="hexamer: ATTAAA"
     polyA_site      1863
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
     regulatory      3571..3576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /note="hexamer: AATAGA"
     polyA_site      3591
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
     regulatory      4056..4061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
                     /note="hexamer: AATACA"
     polyA_site      4059
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
     polyA_site      4083
                     /gene="CLUAP1"
                     /gene_synonym="CFAP22; FAP22; IFT38"
ORIGIN      
        1 gctgggcctg tgatcgctga ggggcgagca gttgcgaccc tgggctcctg gggacctgag
       61 cgttatgtct ttccgcgacc tccgcaattt cacagagatg atgagagccc tgggataccc
      121 tcgacatatt tctatggaaa atttccgtac acccaatttt ggacttgtat ctgaagtgct
      181 tctctggctt gtgaaaagat atgagcccca gactgacatc ccgcctgacg tggatactga
      241 acaggaccga gttttcttca ttaaggcaat tgcccagttc atggccacca aggcacatat
      301 aaaactcaac actaagaagc tttatcaagc agatgggtat gcggtaaaag agctgctgaa
      361 gatcacatct gtcctttata atgctatgaa gaccaagggg atggagggct ctgaaatagt
      421 agaggaagat gtcaacaagt tcaagtttga tcttggctca aagattgcag atttgaaggc
      481 agccaggcag cttgcgtctg aaatcacctc caaaggagca tctctgtatg acttgctcgg
      541 catggaagta gagttgaggg aaatgagaac agaagccatt gccagacctc tggaaataaa
      601 cgagactgaa aaagtgatga gaattgcaat aaaagagatt ttgacacagg ttcagaagac
      661 taaagacctg ctcaataatg tggcctctga tgaagctaat ttagaagcca aaatcgaaaa
      721 gagaaaatta gaactggaaa gaaatcggaa gcgactagag actctgcaga gtgtcaggcc
      781 atgttttatg gatgagtatg agaagactga ggaagaatta caaaagcagt atgacactta
      841 tctggagaaa tttcaaaatc tgacttatct ggaacaacag cttgaagacc atcataggat
      901 ggagcaagaa aggtttgagg aagctaaaaa cactctctgc ctgatacaga acaagctcaa
      961 ggaggaagag aagcgcctgc tcaagagtgg aagtaacgat gactcggaca tagacatcca
     1021 ggaggacgat gaatccgaca gtgagttgga agaaaggcgg ctgcccaagc cacagacagc
     1081 catggagatg ctcatgcaag gaagacctgg caaacgcatt gtgggcacga tgcaaggtgg
     1141 agactccgat gacaatgagg actcggagga gagtgaaatt gacatggaag atgatgatga
     1201 cgaggatgac gatttggaag acgagagcat ttctctctca ccaaccaagc ccaatcgaag
     1261 ggtccggaaa tctgaacccc tggatgagag tgacaatgac ttctgaccct tttgccaagg
     1321 gaccctggca gattaaaacc ctcagacttg taggtaaatg ggaacttaga aggttaggaa
     1381 ggtaacccct gttttgttta ctaagctggc tggactcatg atcactgaag caatacttat
     1441 ttctgcttta gcctcctatg tttgcattcc atgaagctta aataagaatt gaagcaaatc
     1501 cctaagattt atttttttcc accttattta tcttctaaaa cttgaggaat gcatgtgttc
     1561 ttagtgattc acatccacgg gacaaaaact caagaagaaa taagagctga cgccacacaa
     1621 gtcttggctg cttttgttac tatacatttt ctctgagact ccagcagagt tggggctgga
     1681 acttggcact ggggactcat gtttggaatc gtaggggaac atctggctgt taatcacttg
     1741 cacagttgag aacatttcct atacatcggc ttttaattct agctcttatt tcattttgta
     1801 atcttatttt ctttcgtctg catgttcaca ataccaagca ttaaatgtat tttaataact
     1861 aaacttttct gaaagaaggt tagctaaagt taaatgaaaa cttggtttct ttgaaaatca
     1921 ggcaatagag acaggctcca gatgaggaat cctccatttt ctgtccgaag ctgacattcc
     1981 tctggcagtc cagttcacct tggattacag ccaccttcat gtttccacgg ttggtactaa
     2041 atctggaaac tctggtgacc tgggctgccc tctcagaaac tccagactcc catggcaatg
     2101 acagccggga cacttttctt ccctccagcc agggtttctc taaaggagct ttgttttgtc
     2161 taaagtgtgg caagacatag tgcacaacac agggacaaag gcaggtttcc tgcagctcgc
     2221 tacctaagtg tttctgtagg ggaaggagcc aattaagaaa aagtgttggt acagattcat
     2281 gtttctgatt taaaaaaaca acaacacagg attgaattaa gtagagtaat agcactagaa
     2341 gaatttttct gttgtgaaat tagaagtgga gttggttttt ttcttttttc ttcttctttt
     2401 tttttaatat gaaaagtact tagctgggag tggtggcaag cgcccttggg tccagctact
     2461 caggaggcca aggtgggagg atcacttgag cccaggagtt ttagactagc ctggacaact
     2521 aagtgagact ccatctctac aaaaaattaa aaaattagcc aggtgtggag gggcatgcct
     2581 gtggtctcag ctattcagga ggctgaggca ggagaatcac ttgagaccag gaagttgagg
     2641 ctgcaatgag ccgtgatcat gccactgcac tccagcctgg gtgacagagt gagaccctgt
     2701 ctttaaaaaa aagaaaaaga aaagcacgct gcttgtaaaa agcgtacagt aggtcaggcg
     2761 tggtggctca tgcctgtaat cctagcactt tgagaggctg aggtgggtag atcacctgag
     2821 gtcaggggtt tgagaccagc ctggccaaca tggcgaaacc ccacctctac taaaaataca
     2881 aaaattagcc gggcgtggta gcgcatgcct gtaaccccag ctactgggga ggctgaggca
     2941 ggagaatcgc ttgaacctag gaggcggagg ttgcagtgag ccgagatggc gccactgcac
     3001 tccagcctgg gcagcagagt gagactccat ctcaaaaaaa aaaaaaaaaa aaaaagcata
     3061 cagtaaataa aaaagcacaa aacagttttc acttatttta caattaaaaa gtcagaagac
     3121 ttctgaagtt acttatcttt taatacatgt atttaacacc atacttcata ttattaaata
     3181 ggttttactt aaaaatataa ttattgtatt tgtacctgtc agatataaat acttattcag
     3241 gagttcacag gtacgaaaag atacacataa attttaggaa cttttgagtt atttctgtca
     3301 tttttgcttt tttctctttc ttttcctaaa ttttatgtat aagattaccc ctaaaaaaaa
     3361 aaaaacagcc agtattcagt gaattcacca gtaatttgaa atgcaccata ttgtaaatga
     3421 tccactgaca gggaagccag cgtgttggag ccatgccagc cacctcagac accgtggctc
     3481 taagatgcgg aagagtcact gcatcttctt gaatgttaca gatttggttt gcctgaatgt
     3541 gacttgactt ctgttttgaa aaaacatacg aatagagttc tattttcctt atgtgatgct
     3601 ttcttctaac acactttaac acagaagcct aacctagcta caaagagcct atccacagac
     3661 ataggcaaca gctccaaagg gtatttcatt gtgtcacctg cttctagatc atctgttagt
     3721 taactgactt tgtgcaaggt ctcaccatgt atagcactgc cttgcttgag cacggaagtt
     3781 tctgtcaaca gcaagcttta tgtgctctat catttttatt aaagtatttc agtcaatagt
     3841 gacccattgt agaatggatg caggattcac atgtgcaagt gctttgtgac ctggcaccat
     3901 ttggttttgg ccaagcagca gagcagacct caggacctaa cgaggatggt tgtgattagg
     3961 tcaaatagaa aactagcagg ccattgctga caatttttac tatataatta gaggacttcc
     4021 taaaatgctt taaaaaaaaa tgtgtatgga tggaaaatac aaaggaattt ttcaaatact
     4081 caa
//
