LOCUS       NM_007098               5518 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens clathrin heavy chain like 1 (CLTCL1), transcript
            variant 1, mRNA.
ACCESSION   NM_007098
VERSION     NM_007098.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5518)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 5518)
  AUTHORS   Gould,G.W., Brodsky,F.M. and Bryant,N.J.
  TITLE     Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch
  JOURNAL   Trends Cell Biol 30 (9), 705-719 (2020)
   PUBMED   32620516
  REMARK    GeneRIF: Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
            Review article
REFERENCE   3  (bases 1 to 5518)
  AUTHORS   Fumagalli,M., Camus,S.M., Diekmann,Y., Burke,A., Camus,M.D.,
            Norman,P.J., Joseph,A., Abi-Rached,L., Benazzo,A., Rasteiro,R.,
            Mathieson,I., Topf,M., Parham,P., Thomas,M.G. and Brodsky,F.M.
  TITLE     Genetic diversity of CHC22 clathrin impacts its function in glucose
            metabolism
  JOURNAL   Elife 8, e41517 (2019)
   PUBMED   31159924
  REMARK    GeneRIF: These analyses suggest that ancestral human dietary change
            influenced selection of allotypes that affect CHC22's role in
            metabolism and have potential to differentially influence the human
            insulin response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5518)
  AUTHORS   Nahorski,M.S., Borner,G.H.H., Shaikh,S.S., Davies,A.K.,
            Al-Gazali,L., Antrobus,R. and Woods,C.G.
  TITLE     Clathrin heavy chain 22 contributes to the control of neuropeptide
            degradation and secretion during neuronal development
  JOURNAL   Sci Rep 8 (1), 2340 (2018)
   PUBMED   29402896
  REMARK    GeneRIF: Clathrin heavy chain 22 contributes to the control of
            neuropeptide degradation and secretion during neuronal development.
            Study suggests This suggests that a reduction in CHC22 expression
            in sensory neural precursors may license a step in neuron precursor
            neurodevelopment; and that this step is mediated through control of
            a novel neuropeptide processing pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5518)
  AUTHORS   Dannhauser,P.N., Camus,S.M., Sakamoto,K., Sadacca,L.A.,
            Torres,J.A., Camus,M.D., Briant,K., Vassilopoulos,S., Rothnie,A.,
            Smith,C.J. and Brodsky,F.M.
  TITLE     CHC22 and CHC17 clathrins have distinct biochemical properties and
            display differential regulation and function
  JOURNAL   J Biol Chem 292 (51), 20834-20844 (2017)
   PUBMED   29097553
  REMARK    GeneRIF: Provide biochemical evidence for separate regulation and
            distinct functional niches for CHC17 and CHC22 in HeLa cells.
            Furthermore, the greater stability of the CHC22 coat relative to
            the CHC17 coat may be relevant to its excessive accumulation with
            GLUT4 during insulin resistance.
REFERENCE   6  (bases 1 to 5518)
  AUTHORS   Long,K.R., Trofatter,J.A., Ramesh,V., McCormick,M.K. and
            Buckler,A.J.
  TITLE     Cloning and characterization of a novel human clathrin heavy chain
            gene (CLTCL)
  JOURNAL   Genomics 35 (3), 466-472 (1996)
   PUBMED   8844170
REFERENCE   7  (bases 1 to 5518)
  AUTHORS   Gong,W., Emanuel,B.S., Collins,J., Kim,D.H., Wang,Z., Chen,F.,
            Zhang,G., Roe,B. and Budarf,M.L.
  TITLE     A transcription map of the DiGeorge and velo-cardio-facial syndrome
            minimal critical region on 22q11
  JOURNAL   Hum Mol Genet 5 (6), 789-800 (1996)
   PUBMED   8776594
REFERENCE   8  (bases 1 to 5518)
  AUTHORS   Kedra,D., Peyrard,M., Fransson,I., Collins,J.E., Dunham,I.,
            Roe,B.A. and Dumanski,J.P.
  TITLE     Characterization of a second human clathrin heavy chain polypeptide
            gene (CLH-22) from chromosome 22q11
  JOURNAL   Hum Mol Genet 5 (5), 625-631 (1996)
   PUBMED   8733129
REFERENCE   9  (bases 1 to 5518)
  AUTHORS   Sirotkin,H., Morrow,B., DasGupta,R., Goldberg,R., Patanjali,S.R.,
            Shi,G., Cannizzaro,L., Shprintzen,R., Weissman,S.M. and
            Kucherlapati,R.
  TITLE     Isolation of a new clathrin heavy chain gene with muscle-specific
            expression from the region commonly deleted in velo-cardio-facial
            syndrome
  JOURNAL   Hum Mol Genet 5 (5), 617-624 (1996)
   PUBMED   8733128
REFERENCE   10 (bases 1 to 5518)
  AUTHORS   Schon,K.R., Parker,A.P.J. and Woods,C.G.
  TITLE     Congenital Insensitivity to Pain Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29419974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC000085.5, BP281338.1,
            X95486.1, U41763.1 and AK302506.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007098.3.
            
            Summary: This gene is a member of the clathrin heavy chain family
            and encodes a major protein of the polyhedral coat of coated pits
            and vesicles. Chromosomal aberrations involving this gene are
            associated with meningioma, DiGeorge syndrome, and
            velo-cardio-facial syndrome. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U41763.1, X95486.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000427926.6/ ENSP00000441158.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC000085.5         32788-32790         c
            4-45                BP281338.1         1-42
            46-1036             X95486.1           1-991
            1037-1154           U41763.1           1056-1173
            1155-3266           X95486.1           1110-3221
            3267-3267           AK302506.1         3233-3233
            3268-5515           X95486.1           3223-5470
            5516-5518           U41763.1           5535-5537
FEATURES             Location/Qualifiers
     source          1..5518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..5518
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /note="clathrin heavy chain like 1"
                     /db_xref="GeneID:8218"
                     /db_xref="HGNC:HGNC:2093"
                     /db_xref="MIM:601273"
     exon            1..120
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..5001
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Clathrin, heavy polypeptide D; clathrin, heavy
                     polypeptide-like 1; clathrin heavy chain 2; CLH-22;
                     clathrin heavy chain on chromosome 22"
                     /codon_start=1
                     /product="clathrin heavy chain 2 isoform 1"
                     /protein_id="NP_009029.3"
                     /db_xref="CCDS:CCDS46662.2"
                     /db_xref="GeneID:8218"
                     /db_xref="HGNC:HGNC:2093"
                     /db_xref="MIM:601273"
                     /translation="MAQILPVRFQEHFQLQNLGINPANIGFSTLTMESDKFICIREKV
                     GEQAQVTIIDMSDPMAPIRRPISAESAIMNPASKVIALKAGKTLQIFNIEMKSKMKAH
                     TMAEEVIFWKWVSVNTVALVTETAVYHWSMEGDSQPMKMFDRHTSLVGCQVIHYRTDE
                     YQKWLLLVGISAQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCF
                     AVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLI
                     TKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNI
                     VNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGIL
                     RTRETVQKFQSIPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEK
                     WLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKV
                     GYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFL
                     LDALKNNRPAEGLLQTWLLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQ
                     QALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLC
                     VQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQ
                     IKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQR
                     YIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLK
                     LLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDP
                     HLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLID
                     QVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLIL
                     TAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEH
                     IGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASR
                     SNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDR
                     CYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMD
                     GQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGMFTEL
                     AILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTM
                     MSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTV
                     SFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNIS
                     LAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQK
                     LLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKV
                     DKLDALESLRKQEEHVTEPAPLVFDFDGHE"
     exon            121..328
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            329..597
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            598..759
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            760..873
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1047
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1245
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1446
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1599
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1722
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1860
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2025
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2206
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2370
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2496
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2639
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2874
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..2997
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3143
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3327
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3520
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3678
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3843
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..3951
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4119
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            4120..4269
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            4270..4401
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4512
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            4513..4683
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            4684..4905
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            4906..4981
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            4982..5021
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     exon            5022..5518
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5494..5499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /note="hexamer: ATTAAA"
     polyA_site      5518
                     /gene="CLTCL1"
                     /gene_synonym="CHC22; CLH22; CLTCL; CLTD"
                     /note="major polyA site"
ORIGIN      
        1 gccaccggtc agcccgcgcg aggggtcggc gttcattcct gccgctgccg ccgccgccgc
       61 cgaggtcccg caccagccat ggcgcagatc ctccctgttc gctttcagga gcacttccag
      121 ctccaaaacc ttggaattaa tccagctaac attggattca gcacactgac catggaatct
      181 gacaagttca tatgtatccg agagaaagtt ggtgagcagg cacaggtcac gatcattgac
      241 atgagtgacc caatggctcc gatccgacgg cctatctctg cagagagtgc catcatgaat
      301 ccagcctcta aggtgatagc tctgaaagct gggaagacac ttcagatctt taatattgag
      361 atgaagagta aaatgaaggc tcatactatg gcagaagaag tgattttctg gaaatgggtt
      421 tctgtgaaca ctgttgcctt ggtgaccgag accgcggtct accactggag catggaaggt
      481 gactcccagc ccatgaagat gtttgataga cataccagtc tggtgggctg ccaggtgatt
      541 cactaccgga ctgatgagta ccagaagtgg ctgctgctcg taggcatctc ggctcagcaa
      601 aaccgtgtgg ttggagcaat gcagctctac tctgtggata ggaaggtttc acaacccata
      661 gaaggccatg ctgcggcttt tgcagagttc aagatggagg ggaatgccaa gcctgccacc
      721 cttttctgct ttgctgtacg taatcccaca ggaggcaagt tgcacatcat tgaagttgga
      781 cagcctgcag cgggaaacca accttttgta aagaaagcag tagatgtgtt ttttcctcca
      841 gaggcacaga atgattttcc agtggctatg cagattggag ctaaacatgg tgttatttac
      901 ttgatcacaa agtatggcta tcttcatctg tacgacctag agtctggcgt gtgcatctgc
      961 atgaaccgta ttagtgctga cacaatattt gtcactgctc cacacaaacc aacctctgga
     1021 attattggtg tcaacaaaaa gggacaggta ctgtcagttt gtgttgagga agataacatt
     1081 gtgaattatg caaccaacgt gcttcagaat ccagaccttg gtctgcgttt ggccgttcgt
     1141 agtaacctgg ctggggcaga gaagttgttt gtgagaaaat tcaataccct ctttgcacag
     1201 ggcagctatg ctgaagccgc caaagttgca gcgtctgcac caaagggaat cctgcgtacc
     1261 agagagacgg tccagaaatt ccagagtata cccgctcagt ctggccaggc ttctccattg
     1321 ctgcagtact tcggaatcct gctcgaccag ggtcagctca ataaacttga atccttagaa
     1381 ctttgccatc tggttcttca gcaggggcgt aagcaactcc tagagaagtg gctgaaagaa
     1441 gataagctgg agtgctcaga ggagctcgga gacttggtca aaaccactga ccccatgctc
     1501 gctctgagtg tgtaccttcg ggcaaatgtg ccaagcaaag tgatccagtg ttttgcagaa
     1561 acaggccaat tccagaaaat tgtgctctat gccaaaaagg ttgggtacac cccagactgg
     1621 atctttctgc tgaggggtgt aatgaagatc agtccggaac agggcctgca gttttctcga
     1681 atgctagtgc aggacgagga gccgctggcc aacattagcc agattgtgga cattttcatg
     1741 gaaaacagtt taattcagca gtgtacttcc ttcttattgg atgccttgaa gaataatcgc
     1801 ccagctgagg gactcctgca gacatggctg ttggagatga accttgttca tgcaccccag
     1861 gttgcagatg ccatccttgg aaataaaatg tttactcatt acgaccgggc ccacattgcc
     1921 cagctctgtg agaaggcagg cctcctgcag caagcactgg agcactacac cgacctctat
     1981 gacatcaaga gggctgtggt ccacactcac ctcctcaatc ccgagtggct tgtcaatttc
     2041 tttggctcct tatcggtgga ggattctgtg gagtgtctgc atgccatgct gtctgctaac
     2101 atcagacaga accttcagct gtgtgtgcag gtggcctcta agtaccacga gcagctgggc
     2161 acgcaggccc tggtggagct ctttgaatcc ttcaagagtt acaaaggcct cttctacttc
     2221 ctgggctcaa tcgtgaactt cagccaagac ccagatgtgc atctgaaata cattcaggct
     2281 gcctgtaaga cagggcagat caaggaggtg gagaggatat gccgagagag cagctgctac
     2341 aacccagagc gtgtgaagaa cttcctgaag gaggccaagc tcacagacca gcttcccctc
     2401 atcatcgtgt gtgatcgttt tggctttgtc catgaccttg tcctatattt ataccgcaac
     2461 aacctgcaga ggtacattga gatctacgtg cagaaggtca accctagccg gaccccagct
     2521 gtgattggag ggctgcttga tgtggattgt tctgaggaag tgattaaaca cttaatcatg
     2581 gcagtgagag gacagttctc tactgatgag ttggtggctg aagtagaaaa aagaaatagg
     2641 ctcaagctgc tgcttccctg gctggagtcc cagattcagg aaggctgtga ggagcctgcc
     2701 actcacaatg cactggctaa aatctacatc gacagcaaca acagccccga gtgcttcctg
     2761 agagagaatg cctactatga cagcagcgtg gtgggccgct actgtgagaa gcgagacccc
     2821 catctggcct gtgttgccta tgagcggggg cagtgtgacc ttgagctcat caaggtgtgc
     2881 aatgagaatt ctctgttcaa aagcgaggcc cgctacctgg tatgcagaaa ggatccggag
     2941 ctctgggctc acgtccttga ggagaccaac ccatccagga gacagctaat tgaccaggtg
     3001 gtacagacag cattgtcaga aacacgggat cctgaagaga tttcggtcac tgtcaaagcc
     3061 tttatgacag ccgacctgcc taatgaactg attgaactgc tggagaagat agttctggat
     3121 aactctgtct tcagcgagca caggaatcta cagaatctgt tgatcctgac tgccatcaag
     3181 gcagaccgca cacgggtcat ggagtacatc agccgcctgg acaactatga cgcactggac
     3241 atcgcgagca tcgctgtcag cagcgcactg tatgaggagg ccttcaccgt tttccacaag
     3301 tttgatatga atgcctcagc aatccaggtc ctgatcgagc acattggaaa cctggaccgg
     3361 gcatatgagt ttgcggagag atgcaatgag cctgctgtgt ggagtcagct ggcccaagcc
     3421 cagctccaga aagatttggt gaaggaagcc atcaactcct atatcagagg ggacgaccct
     3481 tcctcttacc tggaagttgt tcagtcagcc agcaggagca acaactggga ggatctagtt
     3541 aaatttctgc agatggccag gaaaaagggc cgtgagtcct atatagagac tgaacttatt
     3601 tttgccttgg ctaaaaccag ccgtgtttct gagctagaag attttattaa tggacccaac
     3661 aatgcccaca tccagcaggt tggagaccgc tgttacgagg agggaatgta cgaggctgcc
     3721 aagctgctct atagcaatgt ttctaacttt gcccgcctgg cttccacctt ggttcacctc
     3781 ggtgagtatc aggcagcagt ggacaacagc cgcaaggcca gcagcacccg gacgtggaag
     3841 gaggtgtgct ttgcctgcat ggatggacaa gagttccgct tcgcacagct gtgtggtctt
     3901 cacatcgtca ttcatgcaga tgagctggag gagctgatgt gctattacca ggatcgtggc
     3961 tactttgagg agctgatctt gctgttggaa gcggccctgg gcctggagcg ggcccacatg
     4021 ggcatgttca ctgagctggc catcctctac tccaaattca agccacagaa gatgctggag
     4081 catctggagc ttttctggtc ccgtgtcaac atcccaaagg tgctgagggc tgcagagcag
     4141 gcacacctgt gggctgagct ggtgttcctc tatgacaagt acgaggagta tgacaatgct
     4201 gtgctcacca tgatgagcca ccccactgag gcctggaagg agggtcagtt caaggacatc
     4261 attaccaagg ttgccaacgt cgagctctgt tacagagccc tgcagttcta tttggattac
     4321 aaaccactgc tcatcaatga cctgctgctg gtgctttcac cccggctgga ccacacctgg
     4381 acagtcagtt tcttttcaaa ggcaggtcag ctgcccctgg tgaagcctta cctgcggtca
     4441 gtccagagcc acaacaacaa gagtgtgaat gaggcactca accacctgct gacagaggag
     4501 gaggactatc agggcttaag ggcatctatc gatgcctatg acaactttga caacatcagc
     4561 ctggctcagc agctggagaa gcatcagctg atggagttca ggtgcattgc ggcctatctg
     4621 tacaagggca ataactggtg ggcccagagc gtggagctct gcaagaagga tcatctctac
     4681 aaggatgcca tgcagcatgc tgcagagtcg cgggatgctg agctggccca gaagttgctg
     4741 cagtggttcc tggaggaagg caagagggag tgcttcgcag cttgtctctt cacctgctat
     4801 gacctgcttc gcccagacat ggtgcttgag ctggcctgga ggcacaacct cgtggacttg
     4861 gccatgccct acttcatcca ggtgatgagg gagtacctga gcaaggtgga caaactggat
     4921 gccttggaga gtctgcgcaa gcaagaggag catgtgacag agcctgcccc tctcgtgttt
     4981 gattttgatg ggcatgaatg agacccagct gattgcacta agccctgccg tgggcccagc
     5041 ccctgccagc ttcccctatg gatatgcctc tgctcccaac ttcgccagcc tccaatgtac
     5101 aacttccgcg tgtagtgggc gttgtcacca cccaccctac ctgcagagtt actaacttct
     5161 ccaaggagca tgtcactcca gcagcacagg ggacgcaatg ggaggcaggg acacctggac
     5221 aatatttatt tttgctgaaa cccaatgacg gcaacctctg agccatccca gagcctgggg
     5281 aggccagggt agaggctgac ggcgcaagac cagctttagc cgacaacaga gactggactg
     5341 tgggccctcc tgctggagcc aggccttcct cctgggcgcc tccgactggc tggagctgcc
     5401 ccctccaggc cagtttgaag actacatgaa cacgtcttgt ttggaggtac cggacctcat
     5461 aaaaggactc tcagcctctt ggcaatcata aatattaaag tcggtttatc caggcaaa
//
