LOCUS       NM_004859               8369 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens clathrin heavy chain (CLTC), transcript variant 1,
            mRNA.
ACCESSION   NM_004859
VERSION     NM_004859.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8369)
  AUTHORS   Crowley,H.M., Georgantzoglou,N., Tse,J.Y., Williams,E.A.,
            Mata,D.A., Martin,S.S., Guitart,J., Bridge,J.A. and Linos,K.
  TITLE     Expanding Our Knowledge of Molecular Pathogenesis in Histiocytoses:
            Solitary Soft Tissue Histiocytomas in Children With a Novel
            CLTC::SYK Fusion
  JOURNAL   Am J Surg Pathol 47 (10), 1108-1115 (2023)
   PUBMED   37522373
  REMARK    GeneRIF: Expanding Our Knowledge of Molecular Pathogenesis in
            Histiocytoses: Solitary Soft Tissue Histiocytomas in Children With
            a Novel CLTC::SYK Fusion.
REFERENCE   2  (bases 1 to 8369)
  AUTHORS   Liu,T., Li,J., Wang,X., Huang,T., Wu,W., Li,A., Li,C., Huang,X.,
            Wang,Q., Li,D., Wang,S. and Liang,M.
  TITLE     Knockout of CLTC gene reduces but not completely block SFTSV
            infection
  JOURNAL   PLoS One 18 (8), e0285673 (2023)
   PUBMED   37624798
  REMARK    GeneRIF: Knockout of CLTC gene reduces but not completely block
            SFTSV infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8369)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   4  (bases 1 to 8369)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8369)
  AUTHORS   Georgantzoglou,N., Green,D., Winnick,K.N., Sumegi,J.,
            Charville,G.W., Bridge,J.A. and Linos,K.
  TITLE     Molecular investigation of ALK-rearranged epithelioid fibrous
            histiocytomas identifies CLTC as a novel fusion partner and
            evidence of fusion-independent transcription activation
  JOURNAL   Genes Chromosomes Cancer 61 (8), 471-480 (2022)
   PUBMED   35289445
  REMARK    GeneRIF: Molecular investigation of ALK-rearranged epithelioid
            fibrous histiocytomas identifies CLTC as a novel fusion partner and
            evidence of fusion-independent transcription activation.
REFERENCE   6  (bases 1 to 8369)
  AUTHORS   Murphy,J.E. and Keen,J.H.
  TITLE     Recognition sites for clathrin-associated proteins AP-2 and AP-3 on
            clathrin triskelia
  JOURNAL   J Biol Chem 267 (15), 10850-10855 (1992)
   PUBMED   1587861
REFERENCE   7  (bases 1 to 8369)
  AUTHORS   Dodge,G.R., Kovalszky,I., McBride,O.W., Yi,H.F., Chu,M.L.,
            Saitta,B., Stokes,D.G. and Iozzo,R.V.
  TITLE     Human clathrin heavy chain (CLTC): partial molecular cloning,
            expression, and mapping of the gene to human chromosome 17q11-qter
  JOURNAL   Genomics 11 (1), 174-178 (1991)
   PUBMED   1765375
REFERENCE   8  (bases 1 to 8369)
  AUTHORS   Scarmato,P. and Kirchhausen,T.
  TITLE     Analysis of clathrin light chain-heavy chain interactions using
            truncated mutants of rat liver light chain LCB3
  JOURNAL   J Biol Chem 265 (7), 3661-3668 (1990)
   PUBMED   2406259
REFERENCE   9  (bases 1 to 8369)
  AUTHORS   Corvera,S.
  TITLE     Insulin stimulates the assembly of cytosolic clathrin onto
            adipocyte plasma membranes
  JOURNAL   J Biol Chem 265 (5), 2413-2416 (1990)
   PUBMED   2154445
REFERENCE   10 (bases 1 to 8369)
  AUTHORS   Brodsky,F.M.
  TITLE     Clathrin structure characterized with monoclonal antibodies. II.
            Identification of in vivo forms of clathrin
  JOURNAL   J Cell Biol 101 (6), 2055-2062 (1985)
   PUBMED   4066749
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091271.8 and BC054489.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004859.3.
            
            Summary:  Clathrin is a major protein component of the cytoplasmic
            face of intracellular organelles, called coated vesicles and coated
            pits. These specialized organelles are involved in the
            intracellular trafficking of receptors and endocytosis of a variety
            of macromolecules.  The basic subunit of the clathrin coat is
            composed of three heavy chains and three light chains. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.78622.1,
                                           SRR1803612.8414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269122.8/ ENSP00000269122.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AC091271.8         96314-96592         c
            280-5140            BC054489.1         270-5130
            5141-8369           AC091271.8         19531-22759         c
FEATURES             Location/Qualifiers
     source          1..8369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.1"
     gene            1..8369
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /note="clathrin heavy chain"
                     /db_xref="GeneID:1213"
                     /db_xref="HGNC:HGNC:2092"
                     /db_xref="MIM:118955"
     exon            1..279
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..5265
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /note="isoform 1 is encoded by transcript variant 1;
                     clathrin, heavy polypeptide-like 2; clathrin, heavy
                     polypeptide (Hc); clathrin heavy chain 1; clathrin heavy
                     chain on chromosome 17"
                     /codon_start=1
                     /product="clathrin heavy chain 1 isoform 1"
                     /protein_id="NP_004850.1"
                     /db_xref="CCDS:CCDS32696.1"
                     /db_xref="GeneID:1213"
                     /db_xref="HGNC:HGNC:2092"
                     /db_xref="MIM:118955"
                     /translation="MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKV
                     GEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAH
                     TMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDA
                     KQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCF
                     AVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLI
                     TKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENI
                     IPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGIL
                     RTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
                     WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKV
                     GYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFL
                     LDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQ
                     RALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQIC
                     VQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQ
                     IKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQK
                     YIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLK
                     LLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDP
                     HLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLID
                     QVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLIL
                     TAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEH
                     IGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANT
                     SGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDR
                     CYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVD
                     GKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTEL
                     AILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITM
                     MNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAV
                     NYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNIS
                     LAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEE
                     LLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKV
                     DKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQ
                     PGFGYSM"
     exon            280..487
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            488..756
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            757..918
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1032
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1206
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1404
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1605
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1758
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1881
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2019
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2184
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2365
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2529
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2655
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2798
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..3033
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3156
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3302
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3486
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3679
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3837
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..4002
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4110
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            4111..4278
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4428
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            4429..4560
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            4561..4671
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            4672..4842
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            4843..5064
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            5065..5140
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     exon            5141..8369
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6157..6162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /note="hexamer: AATAAA"
     polyA_site      6182
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /note="major polyA site"
     regulatory      6201..6206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /note="hexamer: ATTAAA"
     polyA_site      6223
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
     regulatory      6503..6508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /note="hexamer: AATAAA"
     regulatory      6508..6513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /note="hexamer: AATATA"
     polyA_site      6525
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
     polyA_site      6530
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
     regulatory      6553..6558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /note="hexamer: TATAAA"
     polyA_site      6596
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
     regulatory      7700..7705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /note="hexamer: ATTAAA"
     regulatory      7704..7709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
                     /note="hexamer: AATGAA"
     polyA_site      7719
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
     polyA_site      7723
                     /gene="CLTC"
                     /gene_synonym="CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56"
ORIGIN      
        1 agccgtttcc ggagtctgcg ctgcgcccgg ttccgccatt gcggctctcc tggcccctgg
       61 agcctccgcc cccgacccga gctctttcgt ctgcctgcca gtttcctgcg tccccggaga
      121 ggatcctgct gagcccagcc tcccccctcc ccttctcctc ctctcccttg gagagcccgg
      181 gcagccactg ccccgcagcc ccagtgacag gaggagacca taacccccga cagcgccatg
      241 gcccagattc tgccaattcg ttttcaggag catctccagc tccagaacct gggtatcaac
      301 ccagcaaaca ttggcttcag taccctgact atggagtctg acaaattcat ctgcattaga
      361 gaaaaagtag gagagcaggc ccaggtggta atcattgata tgaatgaccc aagtaatcca
      421 attcgaagac caatttcagc agacagcgcc atcatgaatc cagctagcaa agtaattgca
      481 ctgaaagctg ggaaaactct tcagattttt aacattgaaa tgaaaagtaa aatgaaggct
      541 cataccatga ctgatgatgt caccttttgg aaatggatct ctttgaatac ggttgctctt
      601 gttacggata atgcagttta tcactggagt atggaaggag agtctcagcc agtgaaaatg
      661 tttgatcgcc attctagcct tgcagggtgc cagattatca attaccgtac agatgcaaaa
      721 caaaagtggt tacttctgac tggtatatct gcacagcaaa atcgtgtggt gggagctatg
      781 cagctatatt ctgtagatag gaaagtgtct cagcccattg aaggacatgc agctagcttt
      841 gcacagttta agatggaagg aaatgcagaa gaatcaacgt tattttgttt tgcagttcgg
      901 ggccaagctg gagggaagtt acatattatt gaagttggca caccacctac agggaaccag
      961 ccctttccaa agaaggcagt ggatgtcttc tttcctccag aagcacaaaa tgattttcct
     1021 gttgcaatgc agatcagtga aaagcatgat gtggtgttct tgataaccaa gtatggttat
     1081 atccacctct atgatcttga gactggtacc tgcatctaca tgaatagaat cagtggagaa
     1141 acaatttttg ttactgcacc tcatgaagcc acagctggaa taattggagt aaacagaaag
     1201 ggacaagttc tgtcagtgtg tgtggaagaa gaaaacataa ttccttacat caccaatgtt
     1261 ctacaaaatc ctgatttggc tctgagaatg gctgtacgta ataacttagc cggtgctgaa
     1321 gaactctttg cccggaaatt taatgctctt tttgcccagg gaaattactc ggaggcagca
     1381 aaggtggctg ctaatgcacc aaagggaatt cttcgtactc cagacactat ccgtcggttc
     1441 cagagtgtcc cagcccagcc aggtcaaact tctcctctac ttcagtactt tggtatcctt
     1501 ttggaccagg gacagctcaa caaatacgaa tccttagagc tttgtaggcc tgtacttcag
     1561 caagggcgaa aacagctttt ggagaaatgg ttaaaagaag ataagctgga atgttctgaa
     1621 gaactgggtg atcttgtgaa atctgtggac cctacattgg cacttagtgt gtacctaagg
     1681 gctaacgtcc caaataaagt cattcagtgc tttgcagaaa caggtcaagt ccaaaagatt
     1741 gttttatatg ctaaaaaagt tggatacact ccagattgga tatttctgct gagaaatgta
     1801 atgcgaatca gtccagatca gggacagcag tttgcccaaa tgttagttca agatgaagag
     1861 cctcttgctg acatcacaca gattgtagat gtctttatgg aatacaatct aattcagcag
     1921 tgtactgcat tcttgcttga tgctctgaag aataatcgcc catctgaagg tcctttacag
     1981 acgcggttac ttgagatgaa ccttatgcat gcgcctcaag ttgcagatgc tattctaggc
     2041 aatcagatgt tcacacatta tgaccgggct catattgctc aactgtgtga aaaggctggc
     2101 ctactgcagc gtgcattaga acatttcact gatttatatg atataaaacg tgcagtggtt
     2161 cacacccatc ttcttaaccc tgagtggtta gtcaactact ttggttcctt atcagtagaa
     2221 gactccctag aatgtctcag agccatgctg tctgccaaca tccgtcagaa tctgcagatt
     2281 tgtgttcagg tggcttctaa atatcatgaa caactgtcaa ctcagtctct gattgaactt
     2341 tttgaatctt tcaagagttt tgaaggtctc ttttattttc tgggatccat tgttaacttt
     2401 agccaggacc cagatgtgca ctttaaatat attcaggcag cttgcaagac tgggcaaatc
     2461 aaagaagtag aaagaatctg tagagaaagc aactgctacg atcctgagcg agtcaagaat
     2521 tttcttaagg aagcaaaact aacagatcag ctaccactta tcattgtgtg tgatcgattt
     2581 gactttgtcc atgatttggt gctctattta tatagaaata atcttcaaaa gtatatagag
     2641 atatatgtac agaaggtgaa tccaagtcga cttcctgtag ttattggagg attacttgat
     2701 gttgactgtt ctgaagatgt cataaaaaac ttgattcttg ttgtaagagg tcaattctct
     2761 actgatgagc ttgttgctga ggttgaaaaa agaaacagat tgaaactgct tctgccttgg
     2821 ctagaggcca gaattcatga gggctgtgag gagcctgcta ctcacaatgc cttagccaaa
     2881 atctacatag acagtaataa caacccggag agatttcttc gtgaaaatcc ctactatgac
     2941 agtcgcgttg ttggaaagta ttgtgagaag agagatccac atctggcctg tgttgcttat
     3001 gaacgtggcc aatgtgatct ggaacttatt aatgtttgca atgagaattc cctcttcaaa
     3061 agtctttctc gctacctggt acgtcgaaag gatccagaat tgtggggcag cgtgctgctg
     3121 gaaagcaatc cttacaggag acccctaatt gaccaggttg tacaaacagc tttgtctgag
     3181 actcaggacc ctgaagaagt gtcagtaact gtaaaggctt tcatgactgc agaccttcct
     3241 aatgaactca ttgaactgct ggagaaaatt gtccttgata actctgtatt cagtgaacac
     3301 aggaatctgc aaaacctcct tatcctcact gcaattaagg ctgaccgtac acgtgttatg
     3361 gagtatatta accgcctgga taattatgat gccccagata ttgccaatat cgccatcagc
     3421 aatgagctgt ttgaagaagc atttgccatt ttccggaaat ttgatgtcaa tacttcagca
     3481 gttcaggtct taattgagca tattggaaac ttggatcggg catatgagtt tgctgaacgt
     3541 tgcaatgaac ctgcggtctg gagtcaactt gcaaaagccc agttgcagaa aggaatggtg
     3601 aaagaagcca ttgattctta tatcaaagca gatgatcctt cctcctacat ggaagttgtt
     3661 caggctgcca atactagtgg aaactgggaa gaactggtga agtacttgca gatggcccgt
     3721 aagaaggctc gagagtccta tgtggagaca gaactgatat tcgcactggc taaaacaaac
     3781 cgccttgcag agttagaaga atttatcaat ggaccaaata atgctcatat ccaacaagtt
     3841 ggtgaccgtt gttatgatga aaaaatgtat gatgctgcta agttgttgta caataatgtt
     3901 tccaattttg gacgtttggc atctaccctg gttcacctgg gtgaatatca ggcagctgtt
     3961 gatggggcta ggaaagctaa cagtactcga acatggaaag aggtctgctt cgcctgtgta
     4021 gatgggaaag aattccgtct tgctcagatg tgtggacttc atattgttgt acatgcagat
     4081 gaattagaag aacttatcaa ctactatcag gatcgtggct attttgaaga gctgatcacc
     4141 atgttggaag cagcactggg acttgagcga gctcacatgg gaatgtttac tgaattagct
     4201 attctatact ctaaatttaa gcctcagaaa atgagggagc acctggagct gttctggtct
     4261 agagtgaata ttcccaaggt gctaagagct gcagaacaag ctcatctttg ggcagaactg
     4321 gtgtttttgt atgacaagta tgaagaatat gataatgcca taattaccat gatgaatcat
     4381 ccaactgatg cctggaaaga agggcaattc aaagatatca ttaccaaggt tgccaatgtg
     4441 gaactatact acagagcaat acagttctac ttagaattca agcctctgtt gttaaatgat
     4501 ttgctgatgg tgctgtctcc acggttggat cacactcgtg cagtcaatta tttcagcaag
     4561 gttaaacagc taccactggt gaaaccgtat ttgcgttcag ttcagaacca taacaacaaa
     4621 tctgtgaatg aatcattgaa caatcttttt attacagaag aagattatca ggctctgcga
     4681 acatcaatag atgcttatga caactttgac aatatctcgc ttgctcagcg tttggaaaaa
     4741 catgaactca ttgagttcag gagaattgct gcttatctct tcaaaggcaa caatcgctgg
     4801 aaacagagtg tagagctgtg caagaaagac agcctttaca aggatgcaat gcagtatgct
     4861 tctgaatcta aagatactga attggctgaa gaactcctgc agtggttttt gcaggaagaa
     4921 aaaagagagt gctttggagc ttgtctgttt acctgttacg atcttttaag gccagatgtc
     4981 gtcctagaaa ctgcatggag gcacaatatc atggattttg ccatgcccta tttcatccag
     5041 gtcatgaagg agtacttgac aaaggtggat aaattagatg cttcagaatc actgagaaaa
     5101 gaagaagaac aagctacaga gacacaaccc attgtttatg gtcagcccca gttgatgctg
     5161 acagcaggac ccagtgttgc cgtccctccc caggcacctt ttggttatgg ttataccgca
     5221 ccaccgtatg gacagccaca gcctggcttt gggtacagca tgtgagatga agcgctgatc
     5281 ctgtagtcac ctattttcgt actgaaacat cgtctttacc cacttctcag tttataatgg
     5341 gggaaaacag gcaacgtgtt cttgtaacct ttatttcatg aaggacttct ttttgtttct
     5401 aactataaac ttggatcacc tatgttaaaa ccttatttca cattccacat cattttagaa
     5461 tttattttcg aaggggaata gtttcaatgt tttattcact tgggcttttt ttcttccccc
     5521 tctttcttta aagaactgct caatattcaa tctgttgtga agaacctgat ttgcactctg
     5581 tagtgtttaa agaaacaaag aaactctaat attgaatctc ttaaatttag tgtatgtaaa
     5641 cagcttacaa atacgtattg tctaaatgca tttaaatctg ttttattcaa agaaaagcta
     5701 aagcaaaaac actggcatat gaccatgcaa gactgtcagt gccaacaaag acaacactaa
     5761 tcagcacatc gtacactgga ttgcagtgct tcccagatta ttgaaaaatg ttacagacaa
     5821 cttgcctgat ttttaaatga gcgtaaaagg ccctctaacc tatgcaggtt tccccattat
     5881 gcatatagaa aatgctagta tgttttgctc acttcatatg taacaggtgc ccttatgttg
     5941 tgctgtatcc tgtgcttttt ctgtgggacc attccattca ggagcaaaga gcaccatgat
     6001 tccaatcttg tgtgtgttta ctaacccttc cctgaggttt gtgtatgttg gatattgtgg
     6061 tgttttagat cactgagtgt acagaagaga gaaattcaaa caaaatattg ctgttcttca
     6121 gttttgtttg tggaatttga aattactcaa atttaaaata aattactgga ctgtggaaat
     6181 aacatagaat tgaagtttta attaaatacc actcaaacga aaagaacagt agtttttgta
     6241 gttttatatt ggatactgag gcattaggga ggcatgaaag gaagaggaat gaggattgag
     6301 acatgtgaag acattgtgca ttatatcaat gtgcattcct gtagttcatt aacaaggtac
     6361 atgcaatagt ctaaagaacc agagtcacta ctatagtggc ttaacattta atctgtctcc
     6421 aatattttaa ccaagtgaca ccgaggtttt tatcgaagca tttcacttaa atgaacaaat
     6481 catggctgtt atattaactt gaaataaaat atatttaaac atgtagttaa catgctcttt
     6541 ctcatcatga attataaagg tgcccaaatt atgggtatct tgattttttt caaaaattgg
     6601 ttgtgtgaat ccagctcttg cttatggctg agaatgttcc taaagttcat ttcactatcc
     6661 cttaatcctc aatagctaca cataccccct tgcctagtta gtcttgcact gctttacaac
     6721 tctcttaggc aaattaccta acataagctc cacagaagag ttttttaaaa cttaaaatcc
     6781 ctgtcccacc aggtgtggtg gctcatgcct gtaatcccag cactttggga ggctgaggca
     6841 ggcggattgc ttgaggccag gagttcgaga caagcctgac caacatggtg actccatctc
     6901 tactaaaaat aaaaaatcag ccaggtgtga tggtggatgc ctataagatc ctagctgcta
     6961 ctcaggaggc aggaggctga ggcatgagaa tcacttgaac ctgtgaggca aaggttgtag
     7021 tgagccaaga tcacgtcact gcactccatc ctgggtgaca gaatgagact cttgtctcaa
     7081 aaaacaaaaa aacctattta gtttcatcca ggacattaag tgaaagtgtt taatgtgagt
     7141 gcaggtcagt gaagaataca atggtgcccc tgctttgatt tgtgggaggt gccatcagtt
     7201 ttccccacca ctgcttttgc accctcagtg caaatatcaa cacagagaaa aaaaaaataa
     7261 taatagtatt atgaaaacat tgactctgtg gagaccctgt gggttctgca gagtatactt
     7321 tgaaaactat aagattatga gttctataaa ataccaagta cagatgaact agaaaacaag
     7381 catatatcca caattaccag aattttcata gtattccttt tagtagatat gccatgacag
     7441 ttacttagcc accccatgcc atcctgttgg gaatgccact acctttgaat ttggagccat
     7501 cagtctatct gaggcaaacc tcagaaatta cctgagccag aatcatgcac ttagcactga
     7561 gttcaactca gtcttaacgt tgcattttgt tgcatcactt ttgcagccag taaacattct
     7621 gtttagaaat agttgctatt gtggcatcat tcacagttgc aatttttctc ctgtgctgtc
     7681 atatgcctgt gcgaagtgta ttaaatgaat caaatattag aaatttcaag gctgtcttta
     7741 gtgttctgcc cacaatactc caccaatgac cttagacctt gagatggtgc tataacgctg
     7801 cttatattgc agttaaccat agagaggtgg agccacttaa aatgggccta ttaccaaaat
     7861 tctccctggc atcattacag ttcttgggga tacactgatt ttagaaatta ctgtcagtat
     7921 cctcctaaaa gaaggcttaa atagtttcta acaagatgac tatcaggaag ctatgtggct
     7981 tggggagttg ggaccctctg cctcatattc tgggtaactg gtataacata gtaattatta
     8041 ggattgtatc aagtgtatct aaagatcaaa agggaaaaaa ggcaccctta attgtcaaag
     8101 ttagttctag gaaaaaatac tagcagggat gacaaactac gttcacttta cagttaccat
     8161 aaattcttac ttgggcccac ccatttccat ctgttaaggt ccataaggtt actcaagttt
     8221 cagtggcttc attgttacaa gaaagggggg aagtgagaaa ctttaatagg ctgtgattta
     8281 gaaccactgc tgattaacct ttggccagta tgggtcaggg aaggtgaaca tgaaacactg
     8341 cacagtaggt tgtatcaatg ctataaaac
//
