LOCUS       NM_001833               1078 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens clathrin light chain A (CLTA), transcript variant 1,
            mRNA.
ACCESSION   NM_001833
VERSION     NM_001833.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1078)
  AUTHORS   Xu,Y., Yao,Y., Yu,L., Fung,H.L., Tang,A.H.N., Ng,I.O., Wong,M.Y.M.,
            Che,C.M., Yun,J.P., Cui,Y. and Yam,J.W.P.
  TITLE     Clathrin light chain A facilitates small extracellular vesicle
            uptake to promote hepatocellular carcinoma progression
  JOURNAL   Hepatol Int 17 (6), 1490-1499 (2023)
   PUBMED   37354358
  REMARK    GeneRIF: Clathrin light chain A facilitates small extracellular
            vesicle uptake to promote hepatocellular carcinoma progression.
REFERENCE   2  (bases 1 to 1078)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1078)
  AUTHORS   Mukenhirn,M., Muraca,F., Bucher,D., Asberger,E., Cappio
            Barazzone,E., Cavalcanti-Adam,E.A. and Boulant,S.
  TITLE     Role of Clathrin Light Chains in Regulating Invadopodia Formation
  JOURNAL   Cells 10 (2), 451 (2021)
   PUBMED   33672612
  REMARK    GeneRIF: Role of Clathrin Light Chains in Regulating Invadopodia
            Formation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1078)
  AUTHORS   Zhang,X., Zheng,M. and Kim,K.M.
  TITLE     GRK2-mediated receptor phosphorylation and Mdm2-mediated
            beta-arrestin2 ubiquitination drive clathrin-mediated endocytosis
            of G protein-coupled receptors
  JOURNAL   Biochem Biophys Res Commun 533 (3), 383-390 (2020)
   PUBMED   32962859
  REMARK    GeneRIF: GRK2-mediated receptor phosphorylation and Mdm2-mediated
            beta-arrestin2 ubiquitination drive clathrin-mediated endocytosis
            of G protein-coupled receptors.
REFERENCE   5  (bases 1 to 1078)
  AUTHORS   Ponnambalam,S., Jackson,A.P., LeBeau,M.M., Pravtcheva,D.,
            Ruddle,F.H., Alibert,C. and Parham,P.
  TITLE     Chromosomal location and some structural features of human clathrin
            light-chain genes (CLTA and CLTB)
  JOURNAL   Genomics 24 (3), 440-444 (1994)
   PUBMED   7713494
REFERENCE   6  (bases 1 to 1078)
  AUTHORS   Nathke,I., Hill,B.L., Parham,P. and Brodsky,F.M.
  TITLE     The calcium-binding site of clathrin light chains
  JOURNAL   J Biol Chem 265 (30), 18621-18627 (1990)
   PUBMED   2211724
REFERENCE   7  (bases 1 to 1078)
  AUTHORS   DeLuca-Flaherty,C., McKay,D.B., Parham,P. and Hill,B.L.
  TITLE     Uncoating protein (hsc70) binds a conformationally labile domain of
            clathrin light chain LCa to stimulate ATP hydrolysis
  JOURNAL   Cell 62 (5), 875-887 (1990)
   PUBMED   1975516
REFERENCE   8  (bases 1 to 1078)
  AUTHORS   Wong,D.H., Ignatius,M.J., Parosky,G., Parham,P., Trojanowski,J.Q.
            and Brodsky,F.M.
  TITLE     Neuron-specific expression of high-molecular-weight clathrin light
            chain
  JOURNAL   J Neurosci 10 (9), 3025-3031 (1990)
   PUBMED   2204686
REFERENCE   9  (bases 1 to 1078)
  AUTHORS   Scarmato,P. and Kirchhausen,T.
  TITLE     Analysis of clathrin light chain-heavy chain interactions using
            truncated mutants of rat liver light chain LCB3
  JOURNAL   J Biol Chem 265 (7), 3661-3668 (1990)
   PUBMED   2406259
REFERENCE   10 (bases 1 to 1078)
  AUTHORS   Jackson,A.P. and Parham,P.
  TITLE     Structure of human clathrin light chains. Conservation of light
            chain polymorphism in three mammalian species
  JOURNAL   J Biol Chem 263 (32), 16688-16695 (1988)
   PUBMED   3267234
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DT220470.1 and BC009201.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001833.3.
            
            Summary: Clathrin is a large, soluble protein composed of heavy and
            light chains. It functions as the main structural component of the
            lattice-type cytoplasmic face of coated pits and vesicles which
            entrap specific macromolecules during receptor-mediated
            endocytosis. This gene encodes one of two clathrin light chain
            proteins which are believed to function as regulatory elements.
            Alternative splicing results in multiple transcript variants.
            Related pseudogenes have been identified on chromosomes 8 and 12.
            [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) lacks alternate in-frame exons
            compared to variant 2, resulting in a shorter protein (isoform a),
            compared to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.645379.1,
                                           SRR5189664.24360.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345519.10/ ENSP00000242284.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DT220470.1         66-81
            17-1078             BC009201.2         1-1062
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1078
                     /gene="CLTA"
                     /gene_synonym="LCA"
                     /note="clathrin light chain A"
                     /db_xref="GeneID:1211"
                     /db_xref="HGNC:HGNC:2090"
                     /db_xref="MIM:118960"
     exon            1..353
                     /gene="CLTA"
                     /gene_synonym="LCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..793
                     /gene="CLTA"
                     /gene_synonym="LCA"
                     /note="isoform a is encoded by transcript variant 1;
                     clathrin, light polypeptide (Lca)"
                     /codon_start=1
                     /product="clathrin light chain A isoform a"
                     /protein_id="NP_001824.1"
                     /db_xref="CCDS:CCDS6600.1"
                     /db_xref="GeneID:1211"
                     /db_xref="HGNC:HGNC:2090"
                     /db_xref="MIM:118960"
                     /translation="MAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIA
                     GIENDEAFAILDGGAPGPQPHGEPPGGPDAVDGVMNGEYYQESNGPTDSYAAISQVDR
                     LQSEPESIRKWREEQMERLEALDANSRKQEAEWKEKAIKELEEWYARQDEQLQKTKAN
                     NRAAEEAFVNDIDESSPGTEWERVARLCDFNPKSSKQAKDVSRMRSVLISLKQAPLVH
                     "
     exon            354..391
                     /gene="CLTA"
                     /gene_synonym="LCA"
                     /inference="alignment:Splign:2.1.0"
     exon            392..509
                     /gene="CLTA"
                     /gene_synonym="LCA"
                     /inference="alignment:Splign:2.1.0"
     exon            510..621
                     /gene="CLTA"
                     /gene_synonym="LCA"
                     /inference="alignment:Splign:2.1.0"
     exon            622..1078
                     /gene="CLTA"
                     /gene_synonym="LCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1055..1060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLTA"
                     /gene_synonym="LCA"
                     /note="hexamer: AATAAA"
     polyA_site      1078
                     /gene="CLTA"
                     /gene_synonym="LCA"
                     /note="major polyA site"
ORIGIN      
        1 ccgctttacc cgtctccctc ctggcgcttg tcctcctctc ccagtcggca ccacagcggt
       61 ggctgccggg cgtggtgtcg gtgggtcggt tggtttttgt ctcaccgttg gtgtccgtgc
      121 cgttcagttg cccgccatgg ctgagctgga tccgttcggc gcccctgccg gcgcccctgg
      181 cggtcccgcg ctggggaacg gagtggccgg cgccggcgaa gaagacccgg ctgcggcctt
      241 cttggcgcag caagagagcg agattgcggg catcgagaac gacgaggcct tcgccatcct
      301 ggacggcggc gcccccgggc cccagccgca cggcgagccg ccggggggtc cggatgctgt
      361 tgatggagta atgaatggtg aatactacca ggaaagtaat ggtccaacag acagttatgc
      421 agctatttca caagtggatc gattgcagtc agagcctgaa agtatccgta aatggagaga
      481 agaacaaatg gaacgcttgg aagcccttga tgccaattct cggaagcaag aagcagagtg
      541 gaaagaaaag gcaataaagg agctagaaga atggtatgca agacaggacg agcagctaca
      601 gaaaacaaaa gcaaacaaca gggcagcaga agaagccttt gtaaatgaca ttgacgagtc
      661 gtccccaggc actgagtggg aacgggtggc ccggctgtgt gactttaacc ccaagtctag
      721 caagcaggcc aaagatgtct cccgcatgcg ctcagtcctc atctccctca agcaggcccc
      781 gctggtgcac tgaagagcca ccctgtggaa acactacatc tgcaatatct taatcctact
      841 cagtgaagct cttcacagtc attggattaa ttatgttgag ttcttttgga ccaaaccttt
      901 ttgtctttag agttgttcat tgtttgtgat tgcatgtttc cttccttcaa ctgtgttctc
      961 cctggcattc agagaggagg gagaggagga agaggaaggg gagggaagct tcccaagagt
     1021 agcctcaacc tgtgcttctg tgcattattc tgagaataaa tttctgtttc aaactgta
//
