LOCUS       NM_014718               4013 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens calsyntenin 3 (CLSTN3), mRNA.
ACCESSION   NM_014718
VERSION     NM_014718.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4013)
  AUTHORS   Qian,K., Tol,M.J., Wu,J., Uchiyama,L.F., Xiao,X., Cui,L.,
            Bedard,A.H., Weston,T.A., Rajendran,P.S., Vergnes,L., Shimanaka,Y.,
            Yin,Y., Jami-Alahmadi,Y., Cohn,W., Bajar,B.T., Lin,C.H., Jin,B.,
            DeNardo,L.A., Black,D.L., Whitelegge,J.P., Wohlschlegel,J.A.,
            Reue,K., Shivkumar,K., Chen,F.J., Young,S.G., Li,P. and Tontonoz,P.
  TITLE     CLSTN3beta enforces adipocyte multilocularity to facilitate lipid
            utilization
  JOURNAL   Nature 613 (7942), 160-168 (2023)
   PUBMED   36477540
  REMARK    GeneRIF: CLSTN3beta enforces adipocyte multilocularity to
            facilitate lipid utilization.
REFERENCE   2  (bases 1 to 4013)
  AUTHORS   Bai,N., Lu,X., Jin,L., Alimujiang,M., Ma,J., Hu,F., Xu,Y., Sun,J.,
            Xu,J., Zhang,R., Han,J., Hu,C. and Yang,Y.
  TITLE     CLSTN3 gene variant associates with obesity risk and contributes to
            dysfunction in white adipose tissue
  JOURNAL   Mol Metab 63, 101531 (2022)
   PUBMED   35753632
  REMARK    GeneRIF: CLSTN3 gene variant associates with obesity risk and
            contributes to dysfunction in white adipose tissue.
REFERENCE   3  (bases 1 to 4013)
  AUTHORS   Subramanian,V.S., Teafatiller,T., Vidal,J., Gunaratne,G.S.,
            Rodriguez-Ortiz,C.J., Kitazawa,M. and Marchant,J.S.
  TITLE     Calsyntenin-3 interacts with the sodium-dependent vitamin C
            transporter-2 to regulate vitamin C uptake
  JOURNAL   Int J Biol Macromol 192, 1178-1184 (2021)
   PUBMED   34673103
REFERENCE   4  (bases 1 to 4013)
  AUTHORS   Plucinska,K., Jespersen,N.Z., Brown,E.L., Petersen,P.S., Rupar,K.,
            Nielsen,S., Scheele,C. and Emanuelli,B.
  TITLE     Calsyntenin 3beta Is Dynamically Regulated by Temperature in Murine
            Brown Adipose and Marks Human Multilocular Fat
  JOURNAL   Front Endocrinol (Lausanne) 11, 579785 (2020)
   PUBMED   33101212
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4013)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4013)
  AUTHORS   Lu,Z., Wang,Y., Chen,F., Tong,H., Reddy,M.V., Luo,L.,
            Seshadrinathan,S., Zhang,L., Holthauzen,L.M., Craig,A.M., Ren,G.
            and Rudenko,G.
  TITLE     Calsyntenin-3 molecular architecture and interaction with neurexin
            1alpha
  JOURNAL   J Biol Chem 289 (50), 34530-34542 (2014)
   PUBMED   25352602
  REMARK    GeneRIF: structure of Calsyntenin 3 and its interaction with
            neurexin 1alpha
REFERENCE   7  (bases 1 to 4013)
  AUTHORS   Uchida,Y., Gomi,F., Murayama,S. and Takahashi,H.
  TITLE     Calsyntenin-3 C-terminal fragment accumulates in dystrophic
            neurites surrounding abeta plaques in tg2576 mouse and Alzheimer
            disease brains: its neurotoxic role in mediating dystrophic neurite
            formation
  JOURNAL   Am J Pathol 182 (5), 1718-1726 (2013)
   PUBMED   23499467
  REMARK    GeneRIF: The C-terminal fragment but not full-length Cst-3
            accumulated in dystrophic neurites surrounding amyloidbeta plaques
            in Tg2576 mouse and Alzheimer disease brains.
REFERENCE   8  (bases 1 to 4013)
  AUTHORS   Araki,Y., Miyagi,N., Kato,N., Yoshida,T., Wada,S., Nishimura,M.,
            Komano,H., Yamamoto,T., De Strooper,B., Yamamoto,K. and Suzuki,T.
  TITLE     Coordinated metabolism of Alcadein and amyloid beta-protein
            precursor regulates FE65-dependent gene transactivation
  JOURNAL   J Biol Chem 279 (23), 24343-24354 (2004)
   PUBMED   15037614
  REMARK    GeneRIF: Alcadein and amyloid beta-protein precursor regulates
            FE65-dependent gene transactivation [alcalpha1, alcbeta, alcgamma]
REFERENCE   9  (bases 1 to 4013)
  AUTHORS   Araki,Y., Tomita,S., Yamaguchi,H., Miyagi,N., Sumioka,A., Kirino,Y.
            and Suzuki,T.
  TITLE     Novel cadherin-related membrane proteins, Alcadeins, enhance the
            X11-like protein-mediated stabilization of amyloid beta-protein
            precursor metabolism
  JOURNAL   J Biol Chem 278 (49), 49448-49458 (2003)
   PUBMED   12972431
REFERENCE   10 (bases 1 to 4013)
  AUTHORS   Hintsch,G., Zurlinden,A., Meskenaite,V., Steuble,M.,
            Fink-Widmer,K., Kinter,J. and Sonderegger,P.
  TITLE     The calsyntenins--a family of postsynaptic membrane proteins with
            distinct neuronal expression patterns
  JOURNAL   Mol Cell Neurosci 21 (3), 393-409 (2002)
   PUBMED   12498782
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA092023.1, AJ277460.1, AC018653.29 and AA864252.1.
            
            On May 17, 2019 this sequence version replaced NM_014718.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111491.1, AK316059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266546.11/ ENSP00000266546.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DA092023.1         1-3
            4-3190              AJ277460.1         1-3187
            3191-3999           AC018653.29        105915-106723       c
            4000-4013           AA864252.1         17-30               c
FEATURES             Location/Qualifiers
     source          1..4013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..4013
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /note="calsyntenin 3"
                     /db_xref="GeneID:9746"
                     /db_xref="HGNC:HGNC:18371"
                     /db_xref="MIM:611324"
     exon            1..342
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..3149
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /note="cadherin-related family member 14; alcadein beta;
                     alc-beta"
                     /codon_start=1
                     /product="calsyntenin-3 precursor"
                     /protein_id="NP_055533.2"
                     /db_xref="CCDS:CCDS8575.1"
                     /db_xref="GeneID:9746"
                     /db_xref="HGNC:HGNC:18371"
                     /db_xref="MIM:611324"
                     /translation="MTLLLLPLLLASLLASCSCNKANKHKPWIEAEYQGIVMENDNTV
                     LLNPPLFALDKDAPLRYAGEICGFRLHGSGVPFEAVILDKATGEGLIRAKEPVDCEAQ
                     KEHTFTIQAYDCGEGPDGANTKKSHKATVHVRVNDVNEFAPVFVERLYRAAVTEGKLY
                     DRILRVEAIDGDCSPQYSQICYYEILTPNTPFLIDNDGNIENTEKLQYSGERLYKFTV
                     TAYDCGKKRAADDAEVEIQVKPTCKPSWQGWNKRIEYAPGAGSLALFPGIRLETCDEP
                     LWNIQATIELQTSHVAKGCDRDNYSERALRKLCGAATGEVDLLPMPGPNANWTAGLSV
                     HYSQDSSLIYWFNGTQAVQVPLGGPSGLGSGPQDSLSDHFTLSFWMKHGVTPNKGKKE
                     EETIVCNTVQNEDGFSHYSLTVHGCRIAFLYWPLLESARPVKFLWKLEQVCDDEWHHY
                     ALNLEFPTVTLYTDGISFDPALIHDNGLIHPPRREPALMIGACWTEEKNKEKEKGDNS
                     TDTTQGDPLSIHHYFHGYLAGFSVRSGRLESREVIECLYACREGLDYRDFESLGKGMK
                     VHVNPSQSLLTLEGDDVETFNHALQHVAYMNTLRFATPGVRPLRLTTAVKCFSEESCV
                     SIPEVEGYVVVLQPDAPQILLSGTAHFARPAVDFEGTNGVPLFPDLQITCSISHQVEA
                     KKDESWQGTVTDTRMSDEIVHNLDGCEISLVGDDLDPERESLLLDTTSLQQRGLELTN
                     TSAYLTIAGVESITVYEEILRQARYRLRHGAALYTRKFRLSCSEMNGRYSSNEFIVEV
                     NVLHSMNRVAHPSHVLSSQQFLHRGHQPPPEMAGHSLASSHRNSMIPSAATLIIVVCV
                     GFLVLMVVLGLVRIHSLHRRVSGAGGPPGASSDPKDPDLFWDDSALTIIVNPMESYQN
                     RQSCVTGAVGGQQEDEDSSDSEVADSPSSDERRIIETPPHRY"
     exon            343..465
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            466..661
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            662..870
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1020
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1206
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1488
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1601
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1764
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1818
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1976
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2125
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2352
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2523
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2669
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2805
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..3008
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..4013
                     /gene="CLSTN3"
                     /gene_synonym="alcbeta; CDHR14; CSTN3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcctgcagt agcggggttg gggtgggagt gagagagtga ggacgctggg ctgggggaaa
       61 cgggaagccg ctgcaagtcc accgcctcag ctacccagat tgggatctgc ccaggcccgc
      121 tttatggact agtgtgggcg gcaggctcct ttccgtccct gccctgctgt accccgctcc
      181 ttggagaccc cctgtatccc tcccgcaagg tggaatccgc aggctggagg ctcccagggg
      241 aggcaaacgc ctggccctgc cctgccccac gccgcaccat gaccctcctg ctgctgcccc
      301 ttctgctggc ctctctgctc gcgtcctgct cctgtaacaa agccaacaag cacaagccat
      361 ggattgaggc agagtaccag ggcatcgtca tggagaatga caacacggtc ctactgaatc
      421 caccactctt tgccttggac aaggatgccc cgctgcgcta tgcaggtgag atctgcggct
      481 tccggctcca tgggtctggg gtgccctttg aggctgtgat ccttgacaag gcgacaggag
      541 aggggctgat ccgggccaag gagcctgtgg actgcgaggc ccagaaggaa cacaccttca
      601 ccatccaggc ctatgactgt ggcgagggcc ccgacggggc caacaccaag aagtcccaca
      661 aggccactgt gcatgtgcgg gtcaacgatg tgaacgagtt tgccccagtg tttgtggaac
      721 ggctgtatcg tgcggctgtg acagagggga agctgtacga tcgcatcctg cgggtggaag
      781 ccattgacgg tgactgctcc ccccagtaca gccagatctg ctactatgag attctcacac
      841 ccaacacccc tttcctcatt gacaatgacg ggaacattga gaacacagag aagctgcagt
      901 acagtggtga gaggctctat aagtttacag tgacagctta tgactgtggg aagaagcggg
      961 cagcagatga tgctgaggtg gagattcagg tgaagcccac ctgtaaaccc agctggcaag
     1021 gctggaacaa aaggatcgaa tatgcaccag gtgctgggag cttggctttg ttccctggta
     1081 tccgcctgga gacctgtgat gaaccactct ggaacattca ggccaccata gagctgcaga
     1141 ccagccatgt ggccaagggc tgtgaccgtg acaactactc agagcgggcg ctgcggaaac
     1201 tctgtggtgc tgccactggg gaggtggatc tgttgcccat gcctggcccc aatgccaact
     1261 ggacagcagg actctcggtg cactacagcc aggacagcag cctgatctac tggttcaatg
     1321 gcacccaggc tgtgcaggtg cccctgggtg gccccagtgg gctgggctct gggccccagg
     1381 acagcctcag tgaccacttc accctgtcct tctggatgaa gcatggcgta actcccaaca
     1441 agggcaagaa ggaagaggaa accatcgtat gtaacactgt ccagaatgag gacggcttct
     1501 ctcactactc gctgactgtc cacggctgta ggattgcctt cctctactgg cccctgcttg
     1561 agagtgcccg cccagtcaag ttcctctgga agctggagca ggtctgtgat gatgagtggc
     1621 accactacgc tctgaacctc gagttcccca cagtcacact ctataccgac ggcatctcct
     1681 tcgaccctgc cctcatccat gacaatggcc tcatccaccc accccgaagg gagcctgctc
     1741 tcatgattgg ggcctgctgg actgaggaga agaacaaaga gaaggaaaag ggagacaaca
     1801 gtacagacac cacccaagga gaccctttgt cgatccacca ctacttccat ggctacctgg
     1861 ctggtttcag cgtgcgctca ggtcgcctgg agagccgcga ggtcatcgag tgcctctatg
     1921 catgtcggga ggggctggac tatagggatt tcgagagcct gggcaaaggc atgaaggtcc
     1981 acgtgaaccc ctcacagtcc ctgctcaccc tggaggggga tgatgtggag accttcaacc
     2041 atgccctgca gcatgtggct tacatgaaca ctctgcgctt tgccacgccc ggcgtcaggc
     2101 ccctgcgcct caccactgct gtcaagtgct tcagcgaaga gtcctgcgtc tccatccctg
     2161 aagtggaggg ctacgtggtc gtccttcagc ctgacgcccc ccagatcctg ctgagtggca
     2221 ctgctcattt tgcccgccca gctgtggact ttgagggaac caacggcgtc cctttgttcc
     2281 ctgatcttca aatcacctgc tccatttctc accaggtgga ggccaaaaag gatgagagtt
     2341 ggcagggcac agtgacagac acacgcatgt cggatgagat tgtgcacaac ctggatggct
     2401 gtgaaatttc tctggtgggg gatgacctgg atcccgagcg ggaaagcctg ctcctggaca
     2461 caacctctct gcagcagcgg gggctggagc tcaccaacac atctgcctac ctcactattg
     2521 ctggggtgga gagcatcact gtgtatgaag agatcctgag gcaggctcgt tatcggctgc
     2581 gacacggagc tgccctctac accaggaagt tccggctttc ctgctcggaa atgaatggcc
     2641 gttactccag caatgaattc atcgtggagg tcaatgtcct gcacagcatg aaccgggttg
     2701 cccaccccag ccacgtgctc agctcccagc agttcctgca ccgtggtcac cagcccccgc
     2761 ctgagatggc tggacacagc ctagccagct cccacagaaa ctccatgata cccagcgccg
     2821 caaccctcat cattgtggtg tgcgtgggct tcctggtgct catggtcgtc ctgggcctgg
     2881 tgcgcatcca ttcccttcac cgccgcgtct caggggccgg cgggcctcca ggggcctcca
     2941 gtgaccccaa ggacccagac ctcttctggg atgactcagc tctcaccatc attgtgaacc
     3001 ccatggagtc ctaccagaat cggcagtcct gtgtgacggg ggctgttggg ggccagcagg
     3061 aggatgagga cagcagtgac tcggaggtgg ccgattcccc cagcagcgac gagagacgca
     3121 tcatcgagac ccccccacac cgctactaag gcctacacct ctccccacgc agagggggaa
     3181 ttctgccctg gtgaaacaga cactccagac atgggagaag gactttctgg gaacacagag
     3241 accaagaggg agagaggctt cagaaccagt cctcctttca tttcaaaacc ccagcgggcc
     3301 ctctggagtc cgccctgccc ctcccccggc cccccatccc tcacttctgg gctgtcatgc
     3361 tcctggtgtg ccccttgcac tggggctggc tgggttggaa agtgggctgg acttcagctg
     3421 cctttctacc cccaatggca gctgccccct tagcactcac tgtgttgggg agagggtgac
     3481 gattgcaatg gctggggctg gggctggggg tgggattgaa ggaaaccctc tcctctcccc
     3541 ttcccttctc tctcctgtcc atgggaagct tttccccctc tgcagggctc cctcagctgg
     3601 accatcgtcc ctgcttctct tatgatcgcc ccacctcatt tccatttcag tctggggacc
     3661 ccatttctcc ctcctttcca acttccttcc tttcttgtcc tgtttccctt cctgcccttg
     3721 cagtcctgag gtcctgcagc cccggcccct cctccgtgac ctggtgtggc caggctgcgg
     3781 ggacgggagg ggacgtgggg gccccgggtg tacatatata atgtatattt tttcaatgtt
     3841 gtcgtgagtg cagcccatgt tcctgcgtgc agctcacggc cttgtgtgta tgtgtgtgtg
     3901 tgtgtgtgtg tgaggcatcg tcatgtcctg gggcaggggc ggggggttgg gtgtggtgag
     3961 ggaggggaca tatcctaggg ttttcaaata aaacaatcag aaaaaaaaaa aaa
//
