LOCUS       NM_001009566            4760 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens calsyntenin 1 (CLSTN1), transcript variant 1, mRNA.
ACCESSION   NM_001009566 XM_937951
VERSION     NM_001009566.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4760)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4760)
  AUTHORS   Jensen,T.M.T., Albertsen,L., Bartling,C.R.O.,
            Haugaard-Kedstrom,L.M. and Stromgaard,K.
  TITLE     Probing the Mint2 Protein-Protein Interaction Network Relevant to
            the Pathophysiology of Alzheimer's Disease
  JOURNAL   Chembiochem (2018) In press
   PUBMED   29578633
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 4760)
  AUTHORS   Sobu,Y., Furukori,K., Chiba,K., Nairn,A.C., Kinjo,M., Hata,S. and
            Suzuki,T.
  TITLE     Phosphorylation of multiple sites within an acidic region of
            Alcadein alpha is required for kinesin-1 association and Golgi exit
            of Alcadein alpha cargo
  JOURNAL   Mol Biol Cell 28 (26), 3844-3856 (2017)
   PUBMED   29093024
  REMARK    GeneRIF: Results suggests that APP partially compensates for
            defective Alcalpha in anterograde transport by providing an
            alternative cargo receptor for kinesin-1.
            Erratum:[Mol Biol Cell. 2018 Feb 1;29(3):376. doi:
            10.1091/mbc.e16-05-0301-corr.. PMID: 29382807]
REFERENCE   4  (bases 1 to 4760)
  AUTHORS   Awan,Z., Tay,E.S.E., Eyre,N.S., Wu,L.E., Beard,M.R., Boo,I.,
            Drummer,H.E., George,J. and Douglas,M.W.
  TITLE     Calsyntenin-1 mediates hepatitis C virus replication
  JOURNAL   J Gen Virol 97 (8), 1877-1887 (2016)
   PUBMED   27221318
  REMARK    GeneRIF: Calsyntenin-1 contributes to the early stages of the
            hepatitis C virus replication cycle and the formation of the
            replication complex.
REFERENCE   5  (bases 1 to 4760)
  AUTHORS   Ponomareva,O.Y., Holmen,I.C., Sperry,A.J., Eliceiri,K.W. and
            Halloran,M.C.
  TITLE     Calsyntenin-1 regulates axon branching and endosomal trafficking
            during sensory neuron development in vivo
  JOURNAL   J Neurosci 34 (28), 9235-9248 (2014)
   PUBMED   25009257
REFERENCE   6  (bases 1 to 4760)
  AUTHORS   Araki,Y., Kawano,T., Taru,H., Saito,Y., Wada,S., Miyamoto,K.,
            Kobayashi,H., Ishikawa,H.O., Ohsugi,Y., Yamamoto,T., Matsuno,K.,
            Kinjo,M. and Suzuki,T.
  TITLE     The novel cargo Alcadein induces vesicle association of kinesin-1
            motor components and activates axonal transport
  JOURNAL   EMBO J 26 (6), 1475-1486 (2007)
   PUBMED   17332754
REFERENCE   7  (bases 1 to 4760)
  AUTHORS   Konecna,A., Frischknecht,R., Kinter,J., Ludwig,A., Steuble,M.,
            Meskenaite,V., Indermuhle,M., Engel,M., Cen,C., Mateos,J.M.,
            Streit,P. and Sonderegger,P.
  TITLE     Calsyntenin-1 docks vesicular cargo to kinesin-1
  JOURNAL   Mol Biol Cell 17 (8), 3651-3663 (2006)
   PUBMED   16760430
REFERENCE   8  (bases 1 to 4760)
  AUTHORS   Araki,Y., Miyagi,N., Kato,N., Yoshida,T., Wada,S., Nishimura,M.,
            Komano,H., Yamamoto,T., De Strooper,B., Yamamoto,K. and Suzuki,T.
  TITLE     Coordinated metabolism of Alcadein and amyloid beta-protein
            precursor regulates FE65-dependent gene transactivation
  JOURNAL   J Biol Chem 279 (23), 24343-24354 (2004)
   PUBMED   15037614
  REMARK    GeneRIF: Alcadein and amyloid beta-protein precursor regulates
            FE65-dependent gene transactivation [alcalpha1, alcbeta, alcgamma]
REFERENCE   9  (bases 1 to 4760)
  AUTHORS   Araki,Y., Tomita,S., Yamaguchi,H., Miyagi,N., Sumioka,A., Kirino,Y.
            and Suzuki,T.
  TITLE     Novel cadherin-related membrane proteins, Alcadeins, enhance the
            X11-like protein-mediated stabilization of amyloid beta-protein
            precursor metabolism
  JOURNAL   J Biol Chem 278 (49), 49448-49458 (2003)
   PUBMED   12972431
REFERENCE   10 (bases 1 to 4760)
  AUTHORS   Vogt,L., Schrimpf,S.P., Meskenaite,V., Frischknecht,R., Kinter,J.,
            Leone,D.P., Ziegler,U. and Sonderegger,P.
  TITLE     Calsyntenin-1, a proteolytically processed postsynaptic membrane
            protein with a cytoplasmic calcium-binding domain
  JOURNAL   Mol Cell Neurosci 17 (1), 151-166 (2001)
   PUBMED   11161476
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357140.33 and AL691449.21.
            
            On Jul 26, 2019 this sequence version replaced NM_001009566.2.
            
            Summary: This gene is a member of the calsyntenin family, a subset
            of the cadherin superfamily. The encoded transmembrane protein,
            also known as alcadein-alpha, is thought to bind to kinesin-1
            motors to mediate the axonal anterograde transport of certain types
            of vesicle. Amyloid precursor protein (APP) is trafficked via these
            vesicles and so this protein is being investigated to see how it
            might contribute to the mechanisms underlying Alzheimer's disease.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020718.1, SRR14038191.1850088.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377298.9/ ENSP00000366513.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AL357140.33        28510-28832         c
            324-446             AL691449.21        140073-140195       c
            447-476             AL691449.21        123282-123311       c
            477-672             AL691449.21        121915-122110       c
            673-881             AL691449.21        118274-118482       c
            882-1031            AL691449.21        116565-116714       c
            1032-1217           AL691449.21        116262-116447       c
            1218-1466           AL691449.21        111196-111444       c
            1467-1588           AL691449.21        110685-110806       c
            1589-1751           AL691449.21        107895-108057       c
            1752-1808           AL691449.21        104299-104355       c
            1809-1966           AL691449.21        102686-102843       c
            1967-2115           AL691449.21        102268-102416       c
            2116-2342           AL691449.21        101749-101975       c
            2343-2513           AL691449.21        100773-100943       c
            2514-2659           AL691449.21        100202-100347       c
            2660-2795           AL691449.21        98562-98697         c
            2796-2980           AL691449.21        98007-98191         c
            2981-4760           AL691449.21        95727-97506         c
FEATURES             Location/Qualifiers
     source          1..4760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..4760
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /note="calsyntenin 1"
                     /db_xref="GeneID:22883"
                     /db_xref="HGNC:HGNC:17447"
                     /db_xref="MIM:611321"
     exon            1..323
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..3178
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cadherin-related family member 12;
                     non-classical cadherin XB31alpha; alzheimer-related
                     cadherin-like protein; alcadein-alpha"
                     /codon_start=1
                     /product="calsyntenin-1 isoform 1 precursor"
                     /protein_id="NP_001009566.1"
                     /db_xref="CCDS:CCDS30580.1"
                     /db_xref="GeneID:22883"
                     /db_xref="HGNC:HGNC:17447"
                     /db_xref="MIM:611321"
                     /translation="MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHG
                     IVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVD
                     KSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY
                     APVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGY
                     IKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEP
                     GTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGT
                     AELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVWM
                     RHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPAEFHWKL
                     NQVCDEEWHHYVLNVEFPSVTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGACWQEF
                     SGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLD
                     LQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKIT
                     STIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPEL
                     RIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDM
                     ARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELN
                     GRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVV
                     PSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNP
                     METYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQL
                     EWDDSTLSY"
     exon            324..446
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            447..476
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            477..672
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            673..881
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1031
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1217
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1466
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1588
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1751
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1808
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1966
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2115
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2342
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2513
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2659
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2795
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2980
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..4760
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4638..4643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /note="hexamer: AATAAA"
     polyA_site      4660
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /note="major polyA site"
     regulatory      4740..4745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
                     /note="hexamer: CATAAA"
     polyA_site      4760
                     /gene="CLSTN1"
                     /gene_synonym="ALC-ALPHA; alcalpha1; alcalpha2; CDHR12;
                     CST-1; CSTN1; PIK3CD; XB31alpha"
ORIGIN      
        1 atcttagttg ctgccgctgc cttcagcaag acgctgctct gaggcgggga gggcgccgcg
       61 tcctgagcgc gcggcccagc gtcacggcgg cggcggcggc ggctcctcct tggacccccg
      121 gagctccccg cgccgcggag cagctagccc caggccccta gagccccgag agctccgaga
      181 gctccgctcg gcgtcccgcg cgcctccctg ccgctcccgc cccgggctgg cgatgctgcg
      241 ccgccccgct cccgcgctgg ccccggccgc ccggctgctg ctggccgggc tgctgtgcgg
      301 cggcggggtc tgggccgcgc gagttaacaa gcacaagccc tggctggagc ccacctacca
      361 cggcatagtc acagagaacg acaacaccgt gctcctcgac cccccactga tcgcgctgga
      421 taaagatgcg cctctgcgat ttgcagagag ttttgaggtg acagtcacca aagaaggtga
      481 gatttgtgga tttaaaattc acgggcagaa tgtccccttt gatgcagtgg tagtggataa
      541 atccactggt gagggagtca ttcgctccaa agagaaactg gactgtgagc tgcagaaaga
      601 ctattcattc accatccagg cctatgattg tgggaaggga cctgatggca ccaacgtgaa
      661 aaagtctcat aaagcaactg ttcatattca ggtgaacgac gtgaatgagt acgcgcccgt
      721 gttcaaggag aagtcctaca aagccacggt catcgagggg aagcagtacg acagcatttt
      781 gagggtggag gccgtggatg ccgactgctc ccctcagttc agccagattt gcagctacga
      841 aatcatcact ccagacgtgc cctttactgt tgacaaagat ggttatataa aaaacacaga
      901 gaaattaaac tacgggaaag aacatcaata taagctgacc gtcactgcct atgactgtgg
      961 gaagaaaaga gccacagaag atgttttggt gaagatcagc attaagccca cctgcacccc
     1021 tgggtggcaa ggatggaaca acaggattga gtatgagccg ggcaccggcg cgttggccgt
     1081 ctttccaaat atccacctgg agacatgtga cgagccagtc gcctcagtac aggccacagt
     1141 ggagctagaa accagccaca tagggaaagg ctgcgaccga gacacctact cagagaagtc
     1201 cctccaccgg ctctgtggtg cggccgcggg cactgccgag ctgctgccat ccccgagtgg
     1261 atccctcaac tggaccatgg gcctgcccac cgacaatggc cacgacagcg accaggtgtt
     1321 tgagttcaac ggcacccagg cagtgaggat cccggatggc gtcgtgtcgg tcagccccaa
     1381 agagccgttc accatctcgg tgtggatgag acatgggcca ttcggcagga agaaggagac
     1441 aattctttgc agttctgata aaacagatat gaatcggcac cactactccc tctatgtcca
     1501 cgggtgccgg ctgatcttcc tcttccgtca ggatccttct gaggagaaga aatacagacc
     1561 tgcagagttc cactggaagt tgaatcaggt ctgtgatgag gaatggcacc actacgtcct
     1621 caatgtagaa ttcccgagtg tgactctcta tgtggatggc acgtcccacg agcccttctc
     1681 tgtgactgag gattacccgc tccatccatc caagatagaa actcagctcg tggtgggggc
     1741 ttgctggcaa gagttttcag gagttgaaaa tgacaatgaa actgagcctg tgactgtggc
     1801 ctctgcaggt ggcgacctgc acatgaccca gtttttccga ggcaatctgg ctggcttaac
     1861 tctccgttcc gggaaactcg cggataagaa ggtgatcgac tgtctgtata cctgcaagga
     1921 ggggctggac ctgcaggtcc tcgaagacag tggcagaggc gtgcagatcc aagcacaccc
     1981 cagccagttg gtattgacct tggagggaga agacctcggg gaattggata aggccatgca
     2041 gcacatctcg tacctgaact cccggcagtt ccccacgccc ggaattcgca gactcaaaat
     2101 caccagcaca atcaagtgtt ttaacgaggc cacctgcatt tcggtccccc cggtagatgg
     2161 ctacgtgatg gttttacagc ccgaggagcc caagatcagc ctgagtggcg tccaccattt
     2221 tgcccgagca gcttctgaat ttgaaagctc agaaggggtg ttccttttcc ctgagcttcg
     2281 catcatcagc accatcacga gagaagtgga gcctgaaggg gacggggctg aggaccccac
     2341 agttcaagaa tcactggtgt ccgaggagat cgtgcacgac ctggatacct gtgaggtcac
     2401 ggtggaggga gaggagctga accacgagca ggagagcctg gaggtggaca tggcccgcct
     2461 gcagcagaag ggcattgaag tgagcagctc tgaactgggc atgaccttca caggcgtgga
     2521 caccatggcc agctacgagg aggttttgca cctgctgcgc tatcggaact ggcatgccag
     2581 gtccttgctt gaccggaagt ttaagctcat ctgctcagag ctgaatggcc gctacatcag
     2641 caacgaattt aaggtggagg tgaatgtaat ccacacggcc aaccccatgg aacacgccaa
     2701 ccacatggct gcccagccac agttcgtgca cccggaacac cgctcctttg ttgacctgtc
     2761 aggccacaac ctggccaacc cccacccgtt cgcagtcgtc cccagcactg cgacagttgt
     2821 gatcgtggtg tgcgtcagct tcctggtgtt catgattatc ctgggggtat ttcggatccg
     2881 ggccgcacat cggcggacca tgcgggatca ggacaccggg aaggagaacg agatggactg
     2941 ggacgactct gccctgacca tcaccgtcaa ccccatggag acctatgagg accagcacag
     3001 cagtgaggag gaggaggaag aggaagagga agaggaaagc gaggacggcg aagaagagga
     3061 tgacatcacc agcgccgagt cggagagcag cgaggaggag gagggggagc agggcgaccc
     3121 ccagaacgca acccggcagc agcagctgga gtgggatgac tccaccctca gctactgacc
     3181 cgtgcccccg gccacctcgg tttctgcttt cgaagactct gctgccatcc gttctcccag
     3241 tcccaagggt ccacgatgta caaagtcatt tcggccagta ggtgtgcaga cccctccccg
     3301 ccacgatcgt cgctgtgctt ggtgtgtagg accctaggct ccccgcccac cctctgcctg
     3361 gtcgcgctct tcagtcccac gaggagctga cacgtcctct ctggccgcca tccggctcgc
     3421 acaggggcct cccagcgcct caggccccgc gtttgtgtct ggagtctccc cccggggaga
     3481 ggacactggc ccctcgcact ccagaaaagc catgccagct gggctcgttg acaaagggta
     3541 aaacatgctc actcccaccc ggtaatcatt tttttctttt tttaaaaaaa gtttttattt
     3601 tttccaaact agtgcatgta taaataatgg caggatgggg ggtactgtgt agatgattaa
     3661 ctgacttttt aatattttgt aaataaatcg gattccttgt gtcctttgtg ctagtgtaac
     3721 ccgggactgg aatgtaaagt gaagttcgga gctctgagca cgggctcttc ccgccgggtc
     3781 ctccctcccc agaccccaga gggagaggcc caccccgccc agccccgccc cagcccctgc
     3841 tcaggtctga gtatggctgg gagtcggggg ccacaggcct ctagctgtgc tgctcaagag
     3901 actggatcag ggtagctaca agtggccggg ccttgccttt gggattctac ctgttcctaa
     3961 tttggtgtgg ggtgcggggt ccctggcccc ttttccacac tcctcctccg acagcagctc
     4021 cctgggcagt ggcctggtct caccgtgtgc agccttgtgg tttatgctta aatgtacatt
     4081 ttcctgctgg taaaaggaga aactgagagg tgtcctgcag accggctgac cactcctttt
     4141 ggagacggca ggaggcctga gcgatccgta ctcagaacgt ccaggagaga cgcatggccc
     4201 gaagtcaaag tgctggaatt ttccaaaaca gcctgttctc tcctctctcc tccccagagc
     4261 accccctgcc atcagggggg ttgaaatccc tctcccccag gagccctgct gctttgcttg
     4321 gtggtagggc aggagagcaa acaaacagtc atggtctaaa acccacatag cactttgctc
     4381 ttagttacat gtaaaatttt agatttctaa aacaggtggg caatcatttt gaatactgtt
     4441 ctgtgaccct gactgctagt tctgaggaca ctggtggctg tgctatgtgt ggccatcctc
     4501 catgtcccgt ccctgtagct gctctgttta gacagcggac agacgctcac gcccagggga
     4561 tgtcctcacg ctgtcgccgc gcggtttccc ttcgcagatg tgtatactca tgataggtca
     4621 gaaagtgtat ccgctacaat aaagttctgg ttctaactaa ctccagccgg agcggggttt
     4681 gtcttctctc ctgttttggt tttaaaccta cactcccttg tttctttttg agccgagaac
     4741 ataaaagaac ataaaaaggc
//
