LOCUS       NM_022111               8512 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens claspin (CLSPN), transcript variant 1, mRNA.
ACCESSION   NM_022111
VERSION     NM_022111.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8512)
  AUTHORS   Hsieh,M.J., Lo,Y.S., Ho,H.Y., Lin,C.C., Chuang,Y.C. and Chen,M.K.
  TITLE     The Interaction between CLSPN Gene Polymorphisms and Alcohol
            Consumption Contributes to Oral Cancer Progression
  JOURNAL   Int J Mol Sci 25 (2), 1098 (2024)
   PUBMED   38256171
  REMARK    GeneRIF: The Interaction between CLSPN Gene Polymorphisms and
            Alcohol Consumption Contributes to Oral Cancer Progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8512)
  AUTHORS   Jia,Y., Cheng,X., Liang,W., Lin,S., Li,P., Yan,Z., Zhang,M., Ma,W.,
            Hu,C., Wang,B. and Liu,Z.
  TITLE     CLSPN is a potential biomarker associated with poor prognosis in
            low-grade gliomas based on a multi-database analysis
  JOURNAL   Curr Res Transl Med 70 (4), 103345 (2022)
   PUBMED   35487167
  REMARK    GeneRIF: CLSPN is a potential biomarker associated with poor
            prognosis in low-grade gliomas based on a multi-database analysis.
REFERENCE   3  (bases 1 to 8512)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 8512)
  AUTHORS   Babasaki,T., Sentani,K., Sekino,Y., Kobayashi,G., Thang Pham,Q.,
            Katsuya,N., Akabane,S., Taniyama,D., Hayashi,T., Shiota,M., Oue,N.,
            Teishima,J., Matsubara,A. and Yasui,W.
  TITLE     Overexpression of claspin promotes docetaxel resistance and is
            associated with prostate-specific antigen recurrence in prostate
            cancer
  JOURNAL   Cancer Med 10 (16), 5574-5588 (2021)
   PUBMED   34240817
  REMARK    GeneRIF: Overexpression of claspin promotes docetaxel resistance
            and is associated with prostate-specific antigen recurrence in
            prostate cancer.
REFERENCE   5  (bases 1 to 8512)
  AUTHORS   Hu,T., Lei,D., Zhou,J. and Zhang,B.O.
  TITLE     circRNA derived from CLSPN (circCLSPN) is an oncogene in human
            glioblastoma multiforme by regulating cell growth, migration and
            invasion via ceRNA pathway
  JOURNAL   J Biosci 46 (2021)
   PUBMED   34269180
  REMARK    GeneRIF: circRNA derived from CLSPN (circCLSPN) is an oncogene in
            human glioblastoma multiforme by regulating cell growth, migration
            and invasion via ceRNA pathway.
REFERENCE   6  (bases 1 to 8512)
  AUTHORS   Lin,S.Y., Li,K., Stewart,G.S. and Elledge,S.J.
  TITLE     Human Claspin works with BRCA1 to both positively and negatively
            regulate cell proliferation
  JOURNAL   Proc Natl Acad Sci U S A 101 (17), 6484-6489 (2004)
   PUBMED   15096610
  REMARK    GeneRIF: determination of properties of both a tumor suppressor and
            an oncogene
REFERENCE   7  (bases 1 to 8512)
  AUTHORS   Chini,C.C. and Chen,J.
  TITLE     Human claspin is required for replication checkpoint control
  JOURNAL   J Biol Chem 278 (32), 30057-30062 (2003)
   PUBMED   12766152
  REMARK    GeneRIF: Claspin has a potentially critical role in replication
            checkpoint control in mammalian cells
REFERENCE   8  (bases 1 to 8512)
  AUTHORS   Zou,L. and Elledge,S.J.
  TITLE     Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
  JOURNAL   Science 300 (5625), 1542-1548 (2003)
   PUBMED   12791985
REFERENCE   9  (bases 1 to 8512)
  AUTHORS   Kumagai,A. and Dunphy,W.G.
  TITLE     Claspin, a novel protein required for the activation of Chk1 during
            a DNA replication checkpoint response in Xenopus egg extracts
  JOURNAL   Mol Cell 6 (4), 839-849 (2000)
   PUBMED   11090622
REFERENCE   10 (bases 1 to 8512)
  AUTHORS   Calderari,G.
  TITLE     [Inlays in the prosthetic rehabilitation of the periodontal
            patient]
  JOURNAL   Dent Cadmos 34 (11), 1509-1537 (1966)
   PUBMED   5226314
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354864.16, AF297866.1 and
            BC137279.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022111.3.
            
            Summary: The product of this gene is an essential upstream
            regulator of checkpoint kinase 1 and triggers a checkpoint arrest
            of the cell cycle in response to replicative stress or DNA damage.
            The protein is also required for efficient DNA replication during a
            normal S phase. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jun
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140789.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318121.8/ ENSP00000312995.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL354864.16        44272-44299
            29-49               AF297866.1         1-21
            50-4329             BC137279.1         1-4280
            4330-8512           AL354864.16        77956-82138
FEATURES             Location/Qualifiers
     source          1..8512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..8512
                     /gene="CLSPN"
                     /note="claspin"
                     /db_xref="GeneID:63967"
                     /db_xref="HGNC:HGNC:19715"
                     /db_xref="MIM:605434"
     exon            1..132
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..4128
                     /gene="CLSPN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     claspin homolog"
                     /codon_start=1
                     /product="claspin isoform 1"
                     /protein_id="NP_071394.2"
                     /db_xref="CCDS:CCDS396.1"
                     /db_xref="GeneID:63967"
                     /db_xref="HGNC:HGNC:19715"
                     /db_xref="MIM:605434"
                     /translation="MTGEVGSEVHLEINDPNVISQEEADSPSDSGQGSYETIGPLSEG
                     DSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKR
                     IYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEG
                     TAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETG
                     LEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKER
                     KAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALL
                     KSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITG
                     SDESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVA
                     FEPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKP
                     RLGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKE
                     ELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDN
                     EDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLL
                     SSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPT
                     EEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTS
                     FFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQDLYNASPEPKTLFLGA
                     GDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMDENAMDANMDELLDL
                     CTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSMGD
                     PMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHE
                     DDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVL
                     PSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDA
                     SQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDS
                     QFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQPKAV
                     LQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGPSFMTSPSPKHL
                     KTDDSTSGLTRSIFKYLES"
     exon            133..241
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            242..690
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            691..852
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            853..930
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1003
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1112
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1687
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1879
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2136
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2315
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2380
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2580
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2735
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2962
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3074
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3150
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3251
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3252..3416
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3538
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3666
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3772
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3855
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3856..4017
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     exon            4018..8512
                     /gene="CLSPN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6348..6353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLSPN"
                     /note="hexamer: AATAAA"
     polyA_site      6373
                     /gene="CLSPN"
                     /note="major polyA site"
     regulatory      8490..8495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLSPN"
                     /note="hexamer: AATAAA"
     polyA_site      8512
                     /gene="CLSPN"
ORIGIN      
        1 aaagcaagaa cagcactgct gggctggaga cggcgggagc cgctgctctc cggctgaggg
       61 aatcagagac agctccgtcc ctagtggagc gcaggggagg cagaagtcat gacaggcgag
      121 gtgggttctg aggttcacct agaaatcaat gacccaaacg tcatttcaca agaggaagca
      181 gatagtcctt cagatagtgg acagggcagc tatgaaacaa ttggaccctt gagtgaagga
      241 gattcagatg aagagatatt tgtaagtaag aagttgaaaa acaggaaggt tctacaagac
      301 agtgattccg aaacagagga cacaaatgcc tctccagaga aaactaccta tgacagtgcc
      361 gaggaggaaa ataaagagaa tttatatgct gggaaaaata caaaaatcaa aaggatttac
      421 aaaactgtgg cagacagtga tgaaagttac atggaaaagt ctttgtatca ggaaaatctt
      481 gaagcgcaag tgaaaccttg cttagagctg agtcttcagt ctggaaactc tacagacttt
      541 accactgaca gaaagagttc caaaaagcac atacatgata aagaaggaac tgcaggaaaa
      601 gcaaaagtaa aatcaaaaag aagacttgag aaagaggaga gaaaaatgga aaaaattaga
      661 cagctaaaaa agaaggaaac aaaaaaccag gaagatgatg tagaacagcc atttaatgac
      721 agtggctgtc ttcttgtgga taaagacctt tttgaaactg ggttggagga tgaaaataac
      781 tctccattgg aagatgaaga gtcattagaa tcaataagag cagctgtaaa aaacaaagta
      841 aaaaagcaca agaaaaaaga accatctttg gagagtgggg tccattcatt tgaggaagga
      901 agtgagttat caaaaggaac cacgaggaag gaaagaaagg cagccagatt aagtaaagaa
      961 gcattaaaac aactgcatag tgagactcag cgccttattc gagagtctgc actgaacctt
     1021 ccatatcata tgcctgagaa taaaaccatt catgatttct tcaaacgtaa accccggccc
     1081 acttgccacg gaaatgccat ggcactattg aagtcatcta aatatcagtc aagccatcac
     1141 aaagaaatca tagacactgc aaatactact gaaatgaaca gtgatcacca tagtaaaggt
     1201 tctgagcaga caacaggtgc agaaaatgaa gtggaaacta atgcactccc tgtagtttca
     1261 aaggaaaccc agatcattac tggatcagat gagtcttgca ggaaggattt ggtaaaaaat
     1321 gaagagctag aaattcagga gaaacagaag cagagtgaca ttagaccttc acctggggac
     1381 agctcagtgt tgcaacagga atccaacttc ctcgggaaca atcacagtga ggaatgtcag
     1441 gttggagggc ttgtagcatt tgaacctcat gccctggagg gtgaaggccc ccaaaatcca
     1501 gaagaaacag atgagaaagt ggaagagcct gagcagcaaa ataaatcatc agcagttggg
     1561 ccacctgaaa aagtgagacg gtttactctg gatagactta agcaactggg agtagatgtt
     1621 tccattaaac cacggctagg tgctgatgaa gattcctttg tgatacttga acctgaaacc
     1681 aacagagaac tggaagcctt gaagcagcgt ttctggaagc atgctaatcc agcagccaaa
     1741 cccagggctg gtcagacagt gaatgtgaac gtcatagtga aagacatggg cactgatgga
     1801 aaggaagagc taaaagcaga tgtggtacct gtgactttag cacctaagaa gttggatgga
     1861 gcaagccaca caaaaccagg tgaaaagctt caggtgttaa aagctaaact gcaagaagca
     1921 atgaaactcc gaaggtttga ggagcgccag aagcgccaag cactgtttaa attagataat
     1981 gaagatgggt ttgaggaaga ggaggaggaa gaggaagaaa tgacagatga gtctgaggaa
     2041 gatggagaag agaaggtaga gaaagaagag aaagaggaag aactagagga agaggaggag
     2101 aaagaagagg aggaggaaga agaaggaaat caggagactg cagaattcct tcttagtagt
     2161 gaagaaatag aaacaaaaga tgaaaaagaa atggataaag aaaataatga tggcagtagt
     2221 gaaattggca aggcagttgg cttcctctct gttcccaagt ctctctcatc agattctact
     2281 ttacttctgt ttaaggacag ctcttccaag atgggttact ttcctactga agaaaaatca
     2341 gaaacagatg aaaactcagg caagcagcct agcaaactgg atgaggatga ttcatgttca
     2401 ttgctaacaa aggagagcag ccacaatagc agctttgagc tgattggctc cacgattcca
     2461 tcctatcagc cttgcaacag acaaacaggc cgtgggacca gttttttccc tacagcagga
     2521 ggattcagat ctccttcccc tgggctattt cgagccagtt tggtcagctc agcttctaag
     2581 agttcaggga aactgtctga gccttcactt cccatagagg attcccagga tctgtataac
     2641 gcctccccag agcctaagac acttttccta ggagcaggag acttccagtt ctgtttagaa
     2701 gatgacactc agagccaact gttggatgca gatgggttct taaatgttag aaaccacagg
     2761 aatcagtacc aagctttgaa gcctcgattg ccattggcca gtatggatga gaatgccatg
     2821 gatgccaaca tggatgagct gttggatttg tgtactggaa agttcacatc tcaggctgaa
     2881 aaacatctac ccaggaagag tgacaagaaa gagaacatgg aggaacttct gaacctttgt
     2941 tcaggaaaat tcacttctca ggatgcctcc actccagcct catcagagtt aaataaacag
     3001 gagaaggaga gcagcatggg tgatccaatg gaagaagcac ttgctctttg ctcaggctct
     3061 tttcccacag acaaggaaga ggaagacgag gaggaggaat ttggagactt tcggcttgtt
     3121 tcaaatgata atgagtttga tagtgatgag gatgaacaca gtgactctgg taatgatctg
     3181 gcactggaag accatgaaga tgatgatgaa gaagaactcc tgaagcgatc tgagaagttg
     3241 aaaaggcaaa tgaggttgag gaaatacctg gaggatgagg cagaggtgtc aggaagtgat
     3301 gtgggaagcg aagatgagta tgatggggaa gaaattgatg aatatgaaga ggacgtaatt
     3361 gatgaagtac ttccttctga tgaggaactg cagagtcaaa tcaagaaaat acacatgaaa
     3421 actatgttgg atgatgataa gcgacagcta cgtttatacc aagagaggta ccttgctgat
     3481 ggggatctgc acagcgatgg tcctgggcga atgaggaagt ttcgatggaa aaacatagat
     3541 gatgcttccc agatggactt gttccacaga gactctgatg atgatcagac tgaagaacag
     3601 cttgatgagt cagaagccag gtggaggaag gagcgaattg aacgagagca gtggcttcgg
     3661 gacatggcac agcaggggaa aattacagct gaagaagaag aagaaattgg ggaggacagt
     3721 cagtttatga tactggccaa gaaagttaca gccaaagcac tgcagaagaa tgccagtcgc
     3781 cctatggtta ttcaggaatc aaagtctttg ctcagaaatc cttttgaagc catcagacca
     3841 ggaagtgctc aacaggtgaa gacaggctca ctgctaaacc agcccaaagc tgtgcttcag
     3901 aaactggctg ctctctctga ccataacccc agtgctcctc gaaattcaag aaactttgtc
     3961 tttcatacac tttctcctgt caaggctgag gcggcaaagg aatcgtctaa gtctcaggta
     4021 aagaaaaggg gtccatcttt catgacttct ccttcaccta agcacctcaa aacagatgat
     4081 agcacttcag gattgacgcg aagcatcttc aaatatttgg agagctaaca ccatcaaagg
     4141 tgccaaaatc tacattgaga ctgctttgag aagtttctag cactgaaagt tggaattgac
     4201 actccagcca atgatccttc cttctttcat aatcaatgca ataagattgc agacagaaat
     4261 tccagtgatt tctactgcac agctctggac atctcttttc ctagtattat tccctgaatt
     4321 ggccactgat ttcaattctg cagtatttac aacatcaaca actcatggaa tacttgggtg
     4381 aggtttcctt tttttttttt tttttaagat gggagtctca ctctgttgcc cagcttggag
     4441 tgcagtggcg tgatctcggc tcaccacaat ctctgcctcc caggttcaag cgattctcct
     4501 ccttcagcct cccgagtagc tgggattaca ggcatgtgcc aatacgccca gctaattttt
     4561 gtatttttag tagagacggg gtttcaccat gttggccagg ctggtcttga actcctgacc
     4621 tcaaatgatc catccacctc ggccccacaa agtgctggtc acatgcatga gtcactgcac
     4681 ctggccttgg gttaggtttc acttcctcca ttagacattt gacattttat tgtagcagct
     4741 ttctgggtta atatctcttt gtgattgata gaagtggttg gaagaggaag agtagggaaa
     4801 agtgtgacat tacagattaa acagtgaaaa tcagtaccat aatgactcct ttacacccat
     4861 gagatacgta ccatgatgac cagggctcgg tgaaagaaag atttcttttt ttttttttga
     4921 gatagtctca ctttgttgcc cagtctggag tgcagtggcg caatctcggc tcacggcaac
     4981 ctctgcctcc cgggttcaag tgattctcct gtctcagcct cccaagtagc tgggactaca
     5041 ggtgcatgcc accacacctg gctaattttt gtatttttag tggagacagg gagtcaccat
     5101 gttggccagg ctggtctcga tctcctgacc tcaagtgatc cagctgcctc agcctcccaa
     5161 agtgctgaga ttacaggcgt gagccactgt gcccagccaa aagaacgatt tcttagatgg
     5221 aggacctagg aaccaacaga tgggctgctg tattactctt acccctttca ttttcctgta
     5281 tgcttcttcc caaggcagca tcaaattttg aattaatttt tgctgcttaa taaggactta
     5341 aactggtacc caagtcagaa agactctgcc tctaattttc tggggcttgg ggatgaagat
     5401 aaagtgttac acccagtgtt tgtccaccac agtctgtggg gcagagagac ccttcctggg
     5461 actgaattct caatttgaag cactgttgtt caaagatctc ccttctgggt ctgacaagaa
     5521 gaaacataac ccttatttat tgcattcttc tggcttacat acattgccct cactaatcaa
     5581 tggacatttc agcatttcat tactaatttt gagagaaggc caccatggaa tttaataaaa
     5641 atattattga agagaattgc catcattctc cattttccct gaactaccac aagcttctca
     5701 gaattttaga caaatgtttt tcccctcaga actgagcatc agtgctgctt tggaaaaaca
     5761 ttccatgtga atactgtggt ttcagtgtca ggacctgtac ttgggcagtt ggaagagagt
     5821 gtgccagttt tttactggga gatgggaaca ccaatttaat tgatgcaatt aggttgtagg
     5881 ttttttacag tttttctttt cttttctttt tctttttctt ttcttttctt ttcttttttt
     5941 ttttttgaga cataggctgg ctctgtcacc taggctggaa tacaatggca tgatctcggc
     6001 ttactgcaac ctccgcctcc taggttcaag caattctgcc tcggcctccc aaatagcagg
     6061 gattacaggc acctgccacc actcccagct aattttttgt atttttatta gagatgaggt
     6121 ttcgccatgt tggccaggct ggtcttgaac tcctgacctg aggtgatcca cccgtctcgg
     6181 cctcccaaag tgctgggatt ataggcatga gccaccgcac ccggccggtt ttctacagtt
     6241 ttctaatact caagatgttg actttgacaa tacttatgtt tgtatacttg taatcttata
     6301 atggggaaaa tgtgtataaa gatgttttaa tatgtatgta gtttttcaat aaatcttaat
     6361 gccttgaagg gaagatttgc tgtccagctt gaatgctcat tcttgggtca gtgcctgtct
     6421 aaccttgagg agcatttcat tttcaggtta tctccatccc agggaaaccc tctgggtcta
     6481 aactgagaag ctgctgcaat tgtcccctca ctggcttctc agtcctagtg aattgatcaa
     6541 gttaacttac caagtggttt gggttcagct caggtgaaga ggataattga gtttacataa
     6601 atggtacctt ctattatagc tctttgttta aaaaacttat tttttagaga cagtctcatt
     6661 ctgttgccca ggttagagtg cagtggcaca atcatagctc actgtaccct tgaactcctg
     6721 ggcttcagca tcctccttcc tcaacctttg gaatagctgg gccacattac aggcatatgc
     6781 caccatgccc agctaattat tttattttag tagagacagg gtcttgctgt gttgccccag
     6841 ctgatcttga actcctggcc tcaagtaatc ctcccacctt ggcctcccaa aatgctgggg
     6901 tcacaggctc agccaccatg cccagcctgt tacagctttg attggccttt ctctttagct
     6961 aagtttgtat gtacttcatt ttatccatgg gttcaagata catgtttttg cctctttctt
     7021 tgaactctct aaacagttcc caaggcaaag tagcccttgc tgggcaaaag agaactgagc
     7081 aggaaggcta gatatttctt ccctcttgtt tccctacatg tcttttgagg agagatagaa
     7141 aagacaattg gaattgacaa ctgaggataa gaaaattcag ccaggtccgg tggctcacgc
     7201 cagcacttta ggagactgag gtgggtgcat tgcttgaact caggagttcg agaccagcct
     7261 gggaaacatg gtgaaatccc aactctaaaa aaaaaaaaaa aaagaaaaaa aaaagaaaat
     7321 tagtgcctga gaaatccagg gagaaaatgg tttctgggct gggcgtggtg gcttatgcct
     7381 gtaatctcag cactttggga ggctgaggca gctggatcac ctaaggtcag gagttggaga
     7441 ccagactgac caacaaggtg aaaccccgtc tctactaaaa atacaaaaat cagccaggct
     7501 tggtggtggc aggtgcctgt agtcccagct acttgggagg ctgagacaag agaattgctt
     7561 gaacctggga ggcagaggtt gcagtgagcc gagatcacgc cactgctctc cagcatgggc
     7621 gacagagtga gactccctct caaaaaaaaa aagaaagaaa gaaaatggtt tctgattgag
     7681 gctcctggga gaaagcactc tttggagaaa gaaaacttga gtcaaactct gggttacttt
     7741 tccttatgcc aggatggctg ctataaagta agctaagcct tgatcttggt aacaggattg
     7801 acatggacag tttcaatctg acccatatgc cctttgccca aagcactgag ccagcagcat
     7861 cagttatgtt ttaatgaaat tgaagcccca ggacctgcca ctatggctct gaggaggact
     7921 cagcttcact agcttggaaa ttacatattt ggagggatga gagcccatga gtgtgggaga
     7981 tagggtaggc tcagtgtcag tgtttttgtt tcttccttgt tccatacact tgagtaggga
     8041 tacatggtat taacctcttt aaacaggtct ctaatttcat ctcattaatt cacagttgca
     8101 cagccatact agggtctctt ccataaacca taagatttta ttcaccaaag ctctagagac
     8161 aaggtactca gatctctgtg gcatccctca ttttctcaac tgcttctcta caaacttctc
     8221 ctcactttga gagtttctaa tgctcaggct gggagacttt ttagggggtg tttttggttt
     8281 ttatctccta gggttatgtc taatcactct tgtggcatcc tgtcctggga tttgtgctcc
     8341 taaggataga ggagagtatt tctgggagga gtgttcccat gatactattt gattatgtca
     8401 tccttgagat ggtattgtat cttctaccct tatatcctac tcatcgcctg gcacacagct
     8461 tggaatgtag tggtgcctac cacagtttga ataaataaca ctacaccttt ca
//
