LOCUS       NM_207409                426 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens colipase like 2 (CLPSL2), transcript variant 2, mRNA.
ACCESSION   NM_207409
VERSION     NM_207409.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 426)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 426)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   3  (bases 1 to 426)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD513822.1, AL157823.9 and AW665167.1.
            
            On Nov 22, 2018 this sequence version replaced NM_207409.3.
            
            Transcript Variant: This variant (2) lacks an alternate exon that
            results in a frameshift in the 3' coding region, compared to
            variant 1. The encoded isoform (b) has a distinct C-terminus and is
            shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW665167.1, ERR3218370.415568.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153347, SAMEA2159931
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403376.4/ ENSP00000385898.3
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CD513822.1         32-47
            17-18               AL157823.9         77506-77507
            19-49               CD513822.1         50-80
            50-421              AW665167.1         9-380               c
            422-426             CD513822.1         555-559
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..426
                     /gene="CLPSL2"
                     /gene_synonym="AAAL3045; C6orf126; dJ510O8.5; UNQ3045"
                     /note="colipase like 2"
                     /db_xref="GeneID:389383"
                     /db_xref="HGNC:HGNC:21250"
     exon            1..105
                     /gene="CLPSL2"
                     /gene_synonym="AAAL3045; C6orf126; dJ510O8.5; UNQ3045"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..324
                     /gene="CLPSL2"
                     /gene_synonym="AAAL3045; C6orf126; dJ510O8.5; UNQ3045"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; colipase-like protein C6orf126; colipase-like
                     protein 2"
                     /codon_start=1
                     /product="colipase-like protein 2 isoform b precursor"
                     /protein_id="NP_997292.2"
                     /db_xref="CCDS:CCDS4810.2"
                     /db_xref="GeneID:389383"
                     /db_xref="HGNC:HGNC:21250"
                     /translation="MAAALALVAGVLSGAVLPLWSALPQYKKKITDRCFHHSECYSGC
                     CLMDLDSGGAFCAPRARITMICLPQTKGATNIICPCRMGLTCISKDLMCSRRCHMI"
     exon            106..228
                     /gene="CLPSL2"
                     /gene_synonym="AAAL3045; C6orf126; dJ510O8.5; UNQ3045"
                     /inference="alignment:Splign:2.1.0"
     exon            229..426
                     /gene="CLPSL2"
                     /gene_synonym="AAAL3045; C6orf126; dJ510O8.5; UNQ3045"
                     /inference="alignment:Splign:2.1.0"
     regulatory      408..413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLPSL2"
                     /gene_synonym="AAAL3045; C6orf126; dJ510O8.5; UNQ3045"
                     /note="hexamer: ATTAAA"
     polyA_site      426
                     /gene="CLPSL2"
                     /gene_synonym="AAAL3045; C6orf126; dJ510O8.5; UNQ3045"
                     /note="major polyA site"
ORIGIN      
        1 gctgctctgc cgcccaggcc catggccgca gccctggcgc tcgtggcggg ggtcctgtcg
       61 ggggcggtgc tgcccctctg gagcgcgctt ccgcaatata aaaagaaaat cacagacagg
      121 tgcttccacc actctgagtg ctacagtggc tgctgcctca tggacttgga ctccggtgga
      181 gccttctgtg cccccagggc cagaataacc atgatctgct tgccccagac caagggagct
      241 accaacatca tctgcccttg ccggatgggc ttgacgtgca tatccaagga cttgatgtgt
      301 tcccgccggt gccatatgat ttagaggaag atgcaggctg gtcactgctc ccttggggcc
      361 ataggccctg gttgccacca acttgctcca aatccagctc ctgagacatt aaagtcactt
      421 cctgtc
//
