LOCUS       NM_001832                538 bp    mRNA    linear   PRI 11-SEP-2020
DEFINITION  Homo sapiens colipase (CLPS), transcript variant 1, mRNA.
ACCESSION   NM_001832
VERSION     NM_001832.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 538)
  AUTHORS   Zhang G, He P, Tan H, Budhu A, Gaedcke J, Ghadimi BM, Ried T,
            Yfantis HG, Lee DH, Maitra A, Hanna N, Alexander HR and Hussain SP.
  TITLE     Integration of metabolomics and transcriptomics revealed a fatty
            acid network exerting growth inhibitory effects in human pancreatic
            cancer
  JOURNAL   Clin. Cancer Res. 19 (18), 4983-4993 (2013)
   PUBMED   23918603
  REMARK    GeneRIF: Low CLPS expression is associated with pancreatic cancer.
REFERENCE   2  (bases 1 to 538)
  AUTHORS   Xiao X, Ferguson MR, Magee KE, Hale PD, Wang Y and Lowe ME.
  TITLE     The Arg92Cys colipase polymorphism impairs function and secretion
            by increasing protein misfolding
  JOURNAL   J. Lipid Res. 54 (2), 514-521 (2013)
   PUBMED   23204298
  REMARK    GeneRIF: humans with the Arg92Cys substitution will secrete less
            functional colipase
REFERENCE   3  (bases 1 to 538)
  AUTHORS   Weyrich P, Albet S, Lammers R, Machicao F, Fritsche A, Stefan N and
            Haring HU.
  TITLE     Genetic variability of procolipase associates with altered insulin
            secretion in non-diabetic Caucasians
  JOURNAL   Exp. Clin. Endocrinol. Diabetes 117 (2), 83-87 (2009)
   PUBMED   18726866
  REMARK    GeneRIF: CLPS genetic variability associates with insulin secretory
            function in non-diabetic humans and may represent a novel candidate
            gene for development of type 2 diabetes
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 538)
  AUTHORS   Wermter AK, Scherag A, Holter K, Reichwald K, Lichtner P, Siegfried
            W, Blundell J, Lawton C, Whybrow S, Stubbs J, Arch JR, Meitinger T,
            Platzer M, Hinney A and Hebebrand J.
  TITLE     Procolipase gene: no association with early-onset obesity or fat
            intake
  JOURNAL   Obes Facts 2 (1), 40-44 (2009)
   PUBMED   20054203
  REMARK    GeneRIF: found no evidence for an association of pancreatic
            colipase(CLPS) single nucleotide polymorphisms rs2766597,
            rs41270082, rs3748050, and rs3748051 with obesity or percentage of
            dietary fat intake
            GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   5  (bases 1 to 538)
  AUTHORS   D'Silva S, Xiao X and Lowe ME.
  TITLE     A polymorphism in the gene encoding procolipase produces a
            colipase, Arg92Cys, with decreased function against long-chain
            triglycerides
  JOURNAL   J. Lipid Res. 48 (11), 2478-2484 (2007)
   PUBMED   17715423
  REMARK    GeneRIF: Our findings demonstrate that the Arg92Cys polymorphism
            decreases the function of Cys92 colipase. This change may
            contribute to the development of type 2 diabetes.
REFERENCE   6  (bases 1 to 538)
  AUTHORS   van Tilbeurgh H, Sarda L, Verger R and Cambillau C.
  TITLE     Structure of the pancreatic lipase-procolipase complex
  JOURNAL   Nature 359 (6391), 159-162 (1992)
   PUBMED   1522902
REFERENCE   7  (bases 1 to 538)
  AUTHORS   Sims HF and Lowe ME.
  TITLE     The human colipase gene: isolation, chromosomal location, and
            tissue-specific expression
  JOURNAL   Biochemistry 31 (31), 7120-7125 (1992)
   PUBMED   1643046
REFERENCE   8  (bases 1 to 538)
  AUTHORS   Davis RC, Xia YR, Mohandas T, Schotz MC and Lusis AJ.
  TITLE     Assignment of the human pancreatic colipase gene to chromosome
            6p21.1 to pter
  JOURNAL   Genomics 10 (1), 262-265 (1991)
   PUBMED   2045105
REFERENCE   9  (bases 1 to 538)
  AUTHORS   Lowe ME, Rosenblum JL, McEwen P and Strauss AW.
  TITLE     Cloning and characterization of the human colipase cDNA
  JOURNAL   Biochemistry 29 (3), 823-828 (1990)
   PUBMED   2337598
REFERENCE   10 (bases 1 to 538)
  AUTHORS   Sternby,B., Engstrom,A., Hellman,U., Vihert,A.M., Sternby,N.H. and
            Borgstrom,B.
  TITLE     The primary sequence of human pancreatic colipase
  JOURNAL   Biochim. Biophys. Acta 784 (1), 75-80 (1984)
   PUBMED   6691986
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP324927.1.
            
            On May 17, 2019 this sequence version replaced NM_001832.3.
            
            Summary: The protein encoded by this gene is a cofactor needed by
            pancreatic lipase for efficient dietary lipid hydrolysis. It binds
            to the C-terminal, non-catalytic domain of lipase, thereby
            stabilizing an active conformation and considerably increasing the
            overall hydrophobic binding site. The gene product allows lipase to
            anchor noncovalently to the surface of lipid micelles,
            counteracting the destabilizing influence of intestinal bile salts.
            This cofactor is only expressed in pancreatic acinar cells,
            suggesting regulation of expression by tissue-specific elements.
            Three transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP324927.1, BP322637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151405, SAMEA2153347
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259938.7/ ENSP00000259938.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-538               BP324927.1         1-538
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..538
                     /gene="CLPS"
                     /note="colipase"
                     /db_xref="GeneID:1208"
                     /db_xref="HGNC:HGNC:2085"
                     /db_xref="MIM:120105"
     exon            1..119
                     /gene="CLPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..374
                     /gene="CLPS"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; colipase, pancreatic; pancreatic colipase
                     preproprotein"
                     /codon_start=1
                     /product="colipase isoform 1 preproprotein"
                     /protein_id="NP_001823.1"
                     /db_xref="CCDS:CCDS4811.1"
                     /db_xref="GeneID:1208"
                     /db_xref="HGNC:HGNC:2085"
                     /db_xref="MIM:120105"
                     /translation="MEKILILLLVALSVAYAAPGPRGIIINLENGELCMNSAQCKSNC
                     CQHSSALGLARCTSMASENSECSVKTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFG
                     ICHDAGRSKQ"
     exon            120..242
                     /gene="CLPS"
                     /inference="alignment:Splign:2.1.0"
     exon            243..538
                     /gene="CLPS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcccgcc acccacacca gctgtcccac tcaccatgga gaagatcctg atcctcctgc
       61 ttgtcgccct ctctgtggcc tatgcagctc ctggcccccg ggggatcatt atcaacctgg
      121 agaacggtga gctctgcatg aatagtgccc agtgtaagag caattgctgc cagcattcaa
      181 gtgcgctggg cctggcccgc tgcacatcca tggccagcga gaacagcgag tgctctgtca
      241 agacgctcta tgggatttac tacaagtgtc cctgtgagcg tggcctgacc tgtgagggag
      301 acaagaccat cgtgggctcc atcaccaaca ccaactttgg catctgccat gacgctggac
      361 gctccaagca gtgagactgc ccacccactc ccacacctag cccagaatgc tgtaggccac
      421 taggcgcagg ggcatctctc ccctgctcca gcgcatctcc cgggctggcc acctccttga
      481 ccagcatatc tgttttctga ttgcgctctt cacaattaaa ggcctcctgc aaaccttt
//
