LOCUS       NM_052964               5502 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens cytokine dependent hematopoietic cell linker (CLNK),
            mRNA.
ACCESSION   NM_052964 XM_093920
VERSION     NM_052964.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5502)
  AUTHORS   Lan,B., Chen,P., Jiri,M., He,N., Feng,T., Liu,K., Jin,T. and
            Kang,L.
  TITLE     WDR1 and CLNK gene polymorphisms correlate with serum glucose and
            high-density lipoprotein levels in Tibetan gout patients
  JOURNAL   Rheumatol Int 36 (3), 405-412 (2016)
   PUBMED   26438387
  REMARK    GeneRIF: Identify positive correlations between WDR1 and CLNK gene
            polymorphisms in Chinese-Tibetan gout populations.
REFERENCE   2  (bases 1 to 5502)
  AUTHORS   Xu,M., Cai,C., Sun,X., Chen,W., Li,Q. and Zhou,H.
  TITLE     Clnk plays a role in TNF-alpha-induced cell death in murine
            fibrosarcoma cell line L929
  JOURNAL   Biochem Biophys Res Commun 463 (3), 275-279 (2015)
   PUBMED   26009488
REFERENCE   3  (bases 1 to 5502)
  AUTHORS   Jin,T.B., Ren,Y., Shi,X., Jiri,M., He,N., Feng,T., Yuan,D. and
            Kang,L.
  TITLE     Genetic variations in the CLNK gene and ZNF518B gene are associated
            with gout in case-control sample sets
  JOURNAL   Rheumatol Int 35 (7), 1141-1147 (2015)
   PUBMED   25591661
  REMARK    GeneRIF: CLNK and ZNF518B SNPs may have potential as diagnostic and
            prognostic marker for Chinese gout patients.
REFERENCE   4  (bases 1 to 5502)
  AUTHORS   Okada,Y., Wu,D., Trynka,G., Raj,T., Terao,C., Ikari,K., Kochi,Y.,
            Ohmura,K., Suzuki,A., Yoshida,S., Graham,R.R., Manoharan,A.,
            Ortmann,W., Bhangale,T., Denny,J.C., Carroll,R.J., Eyler,A.E.,
            Greenberg,J.D., Kremer,J.M., Pappas,D.A., Jiang,L., Yin,J., Ye,L.,
            Su,D.F., Yang,J., Xie,G., Keystone,E., Westra,H.J., Esko,T.,
            Metspalu,A., Zhou,X., Gupta,N., Mirel,D., Stahl,E.A., Diogo,D.,
            Cui,J., Liao,K., Guo,M.H., Myouzen,K., Kawaguchi,T., Coenen,M.J.,
            van Riel,P.L., van de Laar,M.A., Guchelaar,H.J., Huizinga,T.W.,
            Dieude,P., Mariette,X., Bridges,S.L. Jr., Zhernakova,A., Toes,R.E.,
            Tak,P.P., Miceli-Richard,C., Bang,S.Y., Lee,H.S., Martin,J.,
            Gonzalez-Gay,M.A., Rodriguez-Rodriguez,L., Rantapaa-Dahlqvist,S.,
            Arlestig,L., Choi,H.K., Kamatani,Y., Galan,P., Lathrop,M., Eyre,S.,
            Bowes,J., Barton,A., de Vries,N., Moreland,L.W., Criswell,L.A.,
            Karlson,E.W., Taniguchi,A., Yamada,R., Kubo,M., Liu,J.S., Bae,S.C.,
            Worthington,J., Padyukov,L., Klareskog,L., Gregersen,P.K.,
            Raychaudhuri,S., Stranger,B.E., De Jager,P.L., Franke,L.,
            Visscher,P.M., Brown,M.A., Yamanaka,H., Mimori,T., Takahashi,A.,
            Xu,H., Behrens,T.W., Siminovitch,K.A., Momohara,S., Matsuda,F.,
            Yamamoto,K. and Plenge,R.M.
  CONSRTM   RACI consortium; GARNET consortium
  TITLE     Genetics of rheumatoid arthritis contributes to biology and drug
            discovery
  JOURNAL   Nature 506 (7488), 376-381 (2014)
   PUBMED   24390342
REFERENCE   5  (bases 1 to 5502)
  AUTHORS   Jin,Y., Birlea,S.A., Fain,P.R., Ferrara,T.M., Ben,S.,
            Riccardi,S.L., Cole,J.B., Gowan,K., Holland,P.J., Bennett,D.C.,
            Luiten,R.M., Wolkerstorfer,A., van der Veen,J.P., Hartmann,A.,
            Eichner,S., Schuler,G., van Geel,N., Lambert,J., Kemp,E.H.,
            Gawkrodger,D.J., Weetman,A.P., Taieb,A., Jouary,T., Ezzedine,K.,
            Wallace,M.R., McCormack,W.T., Picardo,M., Leone,G., Overbeck,A.,
            Silverberg,N.B. and Spritz,R.A.
  TITLE     Genome-wide association analyses identify 13 new susceptibility
            loci for generalized vitiligo
  JOURNAL   Nat Genet 44 (6), 676-680 (2012)
   PUBMED   22561518
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5502)
  AUTHORS   Cronin,S., Tomik,B., Bradley,D.G., Slowik,A. and Hardiman,O.
  TITLE     Screening for replication of genome-wide SNP associations in
            sporadic ALS
  JOURNAL   Eur J Hum Genet 17 (2), 213-218 (2009)
   PUBMED   18987618
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 5502)
  AUTHORS   Jones,R.B., Gordus,A., Krall,J.A. and MacBeath,G.
  TITLE     A quantitative protein interaction network for the ErbB receptors
            using protein microarrays
  JOURNAL   Nature 439 (7073), 168-174 (2006)
   PUBMED   16273093
REFERENCE   8  (bases 1 to 5502)
  AUTHORS   Goitsuka,R., Tatsuno,A., Ishiai,M., Kurosaki,T. and Kitamura,D.
  TITLE     MIST functions through distinct domains in immunoreceptor signaling
            in the presence and absence of LAT
  JOURNAL   J Biol Chem 276 (38), 36043-36050 (2001)
   PUBMED   11463797
REFERENCE   9  (bases 1 to 5502)
  AUTHORS   Goitsuka,R., Kanazashi,H., Sasanuma,H., Fujimura,Y., Hidaka,Y.,
            Tatsuno,A., Ra,C., Hayashi,K. and Kitamura,D.
  TITLE     A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE
            receptor-mediated mast cell degranulation
  JOURNAL   Int Immunol 12 (4), 573-580 (2000)
   PUBMED   10744659
REFERENCE   10 (bases 1 to 5502)
  AUTHORS   Cao,M.Y., Davidson,D., Yu,J., Latour,S. and Veillette,A.
  TITLE     Clnk, a novel SLP-76-related adaptor molecule expressed in
            cytokine-stimulated hemopoietic cells
  JOURNAL   J Exp Med 190 (10), 1527-1534 (1999)
   PUBMED   10562326
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084048.5, AC005599.5 and AC110768.5.
            
            On Nov 23, 2018 this sequence version replaced NM_052964.3.
            
            Summary: MIST is a member of the SLP76 family of adaptors (see
            LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the
            regulation of immunoreceptor signaling, including PLC-gamma (PLCG1;
            MIM 172420)-mediated B cell antigen receptor (BCR) signaling and
            FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell
            degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al.,
            2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM,
            Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093001.1, AB110420.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2152719
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226951.11/ ENSP00000226951.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC084048.5         53022-53122         c
            102-154             AC084048.5         36213-36265         c
            155-226             AC005599.5         109505-109576       c
            227-255             AC005599.5         96454-96482         c
            256-293             AC005599.5         83268-83305         c
            294-435             AC005599.5         77536-77677         c
            436-542             AC005599.5         76198-76304         c
            543-588             AC005599.5         69934-69979         c
            589-614             AC005599.5         53782-53807         c
            615-634             AC005599.5         53549-53568         c
            635-745             AC005599.5         52021-52131         c
            746-773             AC005599.5         43783-43810         c
            774-792             AC005599.5         39603-39621         c
            793-874             AC005599.5         37368-37449         c
            875-915             AC005599.5         32318-32358         c
            916-1049            AC005599.5         24991-25124         c
            1050-1127           AC005599.5         19486-19563         c
            1128-1283           AC005599.5         12783-12938         c
            1284-3423           AC005599.5         1-2140              c
            3424-5502           AC110768.5         125633-127711       c
FEATURES             Location/Qualifiers
     source          1..5502
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..5502
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /note="cytokine dependent hematopoietic cell linker"
                     /db_xref="GeneID:116449"
                     /db_xref="HGNC:HGNC:17438"
                     /db_xref="MIM:611434"
     exon            1..101
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            102..154
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1430
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /note="mast cell immunoreceptor signal transducer"
                     /codon_start=1
                     /product="cytokine-dependent hematopoietic cell linker"
                     /protein_id="NP_443196.2"
                     /db_xref="CCDS:CCDS47024.1"
                     /db_xref="GeneID:116449"
                     /db_xref="HGNC:HGNC:17438"
                     /db_xref="MIM:611434"
                     /translation="MNRQGNRKTTKEGSNDLKFQNFSLPKNRSWPRINSATGQYQRMN
                     KPLLDWERNFAAVLDGAKGHSDDDYDDPELRMEETWQSIKILPARPIKESEYADTHYF
                     KVAMDTPLPLDTRTSISIGQPTWNTQTRLERVDKPISKDVRSQNIKGDASVRKNKIPL
                     PPPRPLITLPKKYQPLPPEPESSRPPLSQRHTFPEVQRMPSQISLRDLSEVLEAEKVP
                     HNQRKPESTHLLENQNTQEIPLAISSSSFTTSNHSVQNRDHRGGMQPCSPQRCQPPAS
                     CSPHENILPYKYTSWRPPFPKRSDRKDVQHNEWYIGEYSRQAVEEAFMKENKDGSFLV
                     RDCSTKSKEEPYVLAVFYENKVYNVKIRFLERNQQFALGTGLRGDEKFDSVEDIIEHY
                     KNFPIILIDGKDKTGVHRKQCHLTQPLPLTRHLLPL"
     exon            155..226
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            227..255
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            256..293
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            294..435
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            436..542
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            543..588
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            589..614
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            615..634
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            635..745
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            746..773
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            774..792
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            793..874
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            875..915
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1049
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1127
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1283
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..5502
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5474..5479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /note="hexamer: AATAAA"
     regulatory      5480..5485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /note="hexamer: AGTAAA"
     polyA_site      5492
                     /gene="CLNK"
                     /gene_synonym="MIST"
     polyA_site      5502
                     /gene="CLNK"
                     /gene_synonym="MIST"
                     /note="major polyA site"
ORIGIN      
        1 cttactaatt tccagtgccc caaggtctct gcactgccgc ccctcctcac aggagacgga
       61 cacctcagcc tagatccctt ggtgctctcc acgctgttca ggctgaattg aagatccctc
      121 ttacccgcca ggtgccaaga actatgaaca ggcagggcaa tagaaagaca actaaagaag
      181 gatccaacga tttgaaattc cagaacttca gtctgccaaa aaacaggtca tggcctcgca
      241 tcaatagtgc cacaggccag taccagagga tgaacaagcc tcttctagac tgggaaagaa
      301 actttgctgc agtcctggat ggagcaaaag gccacagtga tgatgactat gatgaccctg
      361 agcttcggat ggaagagaca tggcagtcga ttaaaatttt accagcccgg cctataaagg
      421 aatctgaata tgcagataca cactatttca aggttgcaat ggacactccc cttccgttag
      481 acaccaggac ctctatctcc attggacagc cgacctggaa cacacagacg aggttggaaa
      541 gagtggacaa acccatttcc aaggacgtca gaagccaaaa cattaaagga gatgcatccg
      601 taagaaagaa caagattcct ttaccacctc ctcggcctct cataacactt ccgaagaagt
      661 accaaccctt gccccctgag ccggagagca gcaggccacc tttatctcag agacacacct
      721 ttccagaagt ccagagaatg cccagtcaga taagcttaag ggacttaagt gaggtccttg
      781 aagcagaaaa agttcctcat aaccagagga agcctgaatc aactcatctg ttagaaaacc
      841 aaaatactca agagattcca cttgccatta gcagttcttc attcacgaca agcaaccaca
      901 gtgtgcaaaa cagagatcat agaggaggca tgcagccctg ttctcctcag agatgccagc
      961 ctccagccag ctgcagccct cacgaaaata tactgcccta taaatacaca agctggagac
     1021 cacctttccc caaaaggtct gatagaaagg atgtccagca caatgaatgg tacattggag
     1081 aatacagccg ccaggcagtg gaagaggcat tcatgaagga gaacaaggat ggtagtttct
     1141 tggtccgaga ttgttccaca aaatccaagg aagagcccta tgttttggct gtgttttatg
     1201 agaacaaagt ctacaatgta aaaatacgct tcctggagag gaatcagcag tttgccctgg
     1261 ggacaggact cagaggagat gagaagtttg attcagtaga agacatcatc gaacactaca
     1321 agaattttcc cattatacta attgatggga aagataaaac tggggtccac aggaaacagt
     1381 gtcacctcac tcagccactc cctctcacca gacacctctt gcctctgtag cctggtcttt
     1441 gtgttatctt tggtttactg gattcagcgc ttccattgtt ttcattgatt tcaaaagttt
     1501 attttctgtg ccttcaaggg acaacttttt taactttgga gaaaagaaaa acactctata
     1561 acagagagtg gaaaatcact cacggttttg aaagttcaaa ccacagagaa aatatttata
     1621 acatgcaaaa aataaaaaca ttctagtaac tggccactgg aaaataaata aaaataaaaa
     1681 ctagggtttt aaaagtatct tctaaaaaac aacaacaaaa aatactataa acatagccat
     1741 tatgctcatg atacaggcga gcagcaaagg gcaccagaag ctgttgctta aatgtttgca
     1801 gtcagtgcaa gacaagtcta tgggaaattc ccaaatctgt gctctttaca ggacactgcg
     1861 ctgcctttat gtcagttgtt gggccttaca tatatacaat gtgtggatga tttcttacac
     1921 taaagatgct gggctgggtg cggtgcctca tgcctgtaat cccagcactt tgggaggctg
     1981 aggtggacag atcacgaggt caggagatca agaccatcct ggctaacatg gtgaaacccc
     2041 atgtctacta aaaatacaaa aaatcagctg ggcgtggtgg tgggtgcctg tagtcccagc
     2101 tactcgggag gctgaggcag gagaatggtg tgaacccggg aggcggagct tgcagtgagc
     2161 cgaaatcgcg ccactgcact ccaatccagc ctggggacag agagactccg tctcaaaaaa
     2221 aaaaaaaggt gttgggttgg tgaatattag ctctctttta ttgtaatcct agaaattcaa
     2281 gtatagggaa gaaatgtggt atggaaaacc agcaattgtg aatgtcacct tgaagacaga
     2341 aactgaaaat cctctgacta gggtgtgaaa cggtcatggg accagcctcc agcatcatct
     2401 gcttcaagta gctttaagtc aaatggaatt aacacattca tagtacagag ctcagattat
     2461 atcctacact agccttcagg caagcatatg tctgagggaa actaaaaatt gtattaacaa
     2521 ttccaattat ggacttccat tcaaagacag agaaaaactg tcctcaaatt agtgctaatt
     2581 cttgcagtaa cgttgcacag gccatgatat tattccctgt agaggttaag aggatttaat
     2641 tttattattg ttttacaata aagatgagga aacagaggct cgaagtagct attgatctta
     2701 ctcaatatga gaagagagcc cagattgtaa tctgctttgc ctggctccat gcaagctcat
     2761 cttcccaggt acattctctg cgctgtgaca ttttacaatc aagttgaaaa gctaatttaa
     2821 aaaaaaagag agagagagag agaaagatag aaacaatttg aaaatacaga tttaccacct
     2881 taaaataaat aaactcttct agtgggaata agctttttta aaaaacatac tgtctgtcga
     2941 aaataacagt atatcatgat gtcaaatgct accaaagctt acaaaggaaa ttcatagagt
     3001 atttatgtaa ttgtagcatt gatgcagaaa gaaaaccaaa aataattaaa aggcaataga
     3061 agcaaatgaa aacaataaaa acaatgtgca ggattatctc ttttgtaaga cagcagacaa
     3121 tgagctctct gggaaaagct cttagcatct acccactatc caaatacctg ctcaggtgtt
     3181 ctcctttcac aaggtcaatg tgaagtgatg cctataagtt acatcaggag catttaatga
     3241 agaagctatt tgtaaagctg gaacttttga gacccagctg agcctatcgt agagtatgcc
     3301 tgcagaggat tacatagaac caagagacaa gagtgtttaa attggagctt ggatacgaaa
     3361 gaactcactg gtccggtcaa agctaaaagc tgtatggttg ctggtcattc tctactggaa
     3421 ttcaacaagc cagggacagt atggaaacaa ggactttaca gaagagctcc aggctcacat
     3481 taagaaggaa tctgaccctc accctaaaaa gctattggga gattactgat acctccaact
     3541 cactgattca ttgaggccat gccattcaat gctatgttct caagaaatgt ctatgagtcc
     3601 tctcaaccat tgctgttgat aaaataggtg aatgtcaagt gggggttagc atttgataag
     3661 gtgtacgttt gaaataatat tttatcgtct cttgttcaca aatacaacat ataattccaa
     3721 gaagaaaaaa gaagtagaaa ttcagcatcc ttaagatgac agcaagaatg aggggaaaag
     3781 gaagaaaaaa aagaaattaa acatcttgca ataaaaagct tacaatattt ttgtgtattt
     3841 gaacacttct gtaaaaaata taaaatggaa aatactgaca tgggctgctt ctggtgattg
     3901 gggtttgagg gattgggtgt cgggttttct agaactcaga caccaggaca aagttagaag
     3961 tgcaaacact gattggaggt taatgtttga gaaagataaa agggagaaga aacagaagta
     4021 tgggtatggg gtgggctttc aggctcccac ctgtgagagg gaagagggga ggtgtgggga
     4081 gtgaggagaa aaagcatgag attcagacac agctctggga gagttttggc cagctcatag
     4141 tgaggcccaa agcaaagttt gcccagagag gagacagtgt tatgctgggc agtaatgtct
     4201 gggtcttagt gccccatcct gttaagtcat tgtctggggc tatcctggga aaaagaaaaa
     4261 caacaaaaaa aaaagacctg caaatgctgt ggccaatcca gaaggcgcag ctggacgctg
     4321 tccactaact tgctggccag caagttattt caatggagac tcaagagacc cacctctggc
     4381 ctgccacagc aacatcctga attcactgtt ttcagtgttg attgtagtaa ggacaatcac
     4441 atttacattt tgcttgtaat ggatgattaa ataataagag tatataaatt cgattgtatt
     4501 tgtttcttac aacacttctg taaagaagag agggcagcta tttctaatgc attttataat
     4561 tgaggaaatt gtacctcatt ggccaaaatc tcacagtgac atagtcgcga ctggaaccaa
     4621 ggtctccata tgcaattatc ctattcatgg tctacctgct ttattagatc tgtaattgaa
     4681 tattcaatga tttggatttg gcatgcccaa attccagtgt tttaatccct tttcaaccat
     4741 tacctcacgt ttagtttaaa agtatcactt gatatctgat ttcaatagag taatagaatt
     4801 ttagctttat ccaattacag catttatgct ttccagatat tttttggact aaataattct
     4861 cattctgtat aaatgtgcat agccctcatc attagtcata tattgtgtta gcacctttgt
     4921 gtactgcatg tgtattcatt actaagcact attgtagatg ttgaaaatag agcagtgaat
     4981 aagagagata gatgacaaat aaatatacaa acaaataaga taatctaagt cagtttccca
     5041 ttactggatt ggatttctat tttaacactt atttctgagt acttgtgggg tgatgccaac
     5101 attaaatgtt ttgaggaagc tcctttgaga tggctttgaa aagtcctaag tgagaaaatt
     5161 taaaattttc ccaaacttat ttatgtgggg tgtgcatgtg tgtgcctgtg cctgtgtgcg
     5221 tgtgtgtgtg tgtgttttta agtaaccgca tcatggctgt aatcagttaa gtctcctgtt
     5281 ctaattacta cggaggaatc aaatgaaccc cattgtcgaa tgtagccaat tatgtatgtg
     5341 tgtacacaaa tacaaatttt tatgatagcc tatattgtat attagcatta tatttgtata
     5401 tcttttttat tctgagcaat atttgttcta gctaagcaca tttacattca taatttacag
     5461 ccttactaat gtaaataaaa gtaaatatgt aattgaatgt ta
//
