LOCUS       NM_024769               5032 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens CXADR like membrane protein (CLMP), mRNA.
ACCESSION   NM_024769
VERSION     NM_024769.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5032)
  AUTHORS   Luissint,A.C., Fan,S., Nishio,H., Lerario,A.M., Miranda,J.,
            Hilgarth,R.S., Cook,J., Nusrat,A. and Parkos,C.A.
  TITLE     CXADR-Like Membrane Protein Regulates Colonic Epithelial Cell
            Proliferation and Prevents Tumor Growth
  JOURNAL   Gastroenterology 166 (1), 103-116 (2024)
   PUBMED   37716376
  REMARK    GeneRIF: CXADR-Like Membrane Protein Regulates Colonic Epithelial
            Cell Proliferation and Prevents Tumor Growth.
REFERENCE   2  (bases 1 to 5032)
  AUTHORS   Fournier,A.P., Zandee,S., Charabati,M., Peelen,E., Tastet,O.,
            Alvarez,J.I., Kebir,H., Bourbonniere,L., Larouche,S., Lahav,B.,
            Klement,W., Tea,F., Bouthillier,A., Moumdjian,R., Cayrol,R.,
            Duquette,P., Girard,M., Larochelle,C., Arbour,N. and Prat,A.
  TITLE     CLMP Promotes Leukocyte Migration Across Brain Barriers in Multiple
            Sclerosis
  JOURNAL   Neurol Neuroimmunol Neuroinflamm 9 (6), e200022 (2022)
   PUBMED   36241608
  REMARK    GeneRIF: CLMP Promotes Leukocyte Migration Across Brain Barriers in
            Multiple Sclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5032)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5032)
  AUTHORS   Sharma,A., Xu,Y., Sung,B., Vincent,C.T., Worgall,T. and Worgall,S.
  TITLE     Regulation of the Coxsackie and adenovirus receptor expression is
            dependent on cystic fibrosis transmembrane regulator in airway
            epithelial cells
  JOURNAL   Cell Microbiol 19 (2) (2017)
   PUBMED   27527752
  REMARK    GeneRIF: Inhibition of CFTR or histone deacetylase (HDAC) enhanced
            CAR expression while CFTR overexpression or restoration of the
            diminished HDAC activity in cystic fibrosis cells reduced CAR
            expression.
REFERENCE   5  (bases 1 to 5032)
  AUTHORS   Gonnaud,L., Alves,M.M., Cremillieux,C., Billiemaz,K., Destombe,S.,
            Varlet,F., Lopez,M., Trapes,L., Touraine,R., Hofstra,R.M. and
            Patural,H.
  TITLE     Two new mutations of the CLMP gene identified in a newborn
            presenting congenital short-bowel syndrome
  JOURNAL   Clin Res Hepatol Gastroenterol 40 (6), e65-e67 (2016)
   PUBMED   27720179
  REMARK    GeneRIF: We describe a newborn presenting CSBS intestinal
            malrotation and chronic intestinal pseudo-obstruction syndrome
            (CIPS), compound heterozygous for two previously unreported
            heterozygous mutations in Coxsackie and adenovirus receptor-like
            membrane protein (CLMP) gene. We identified two heterozygous
            mutations in CLMP, one in intron 1 (c.28+1G>C) from the father, the
            other on exon 4 (c502C>T, p.R168X) from the mother.
REFERENCE   6  (bases 1 to 5032)
  AUTHORS   Eguchi,J., Wada,J., Hida,K., Zhang,H., Matsuoka,T., Baba,M.,
            Hashimoto,I., Shikata,K., Ogawa,N. and Makino,H.
  TITLE     Identification of adipocyte adhesion molecule (ACAM), a novel CTX
            gene family, implicated in adipocyte maturation and development of
            obesity
  JOURNAL   Biochem J 387 (Pt 2), 343-353 (2005)
   PUBMED   15563274
  REMARK    GeneRIF: We identified ACAM (adipocyte adhesion molecule), a novel
            homologue of the CTX (cortical thymocyte marker in Xenopus) gene
            family, which may be the critical adhesion molecule in adipocyte
            differentiation and development of obesity.
REFERENCE   7  (bases 1 to 5032)
  AUTHORS   Raschperger,E., Engstrom,U., Pettersson,R.F. and Fuxe,J.
  TITLE     CLMP, a novel member of the CTX family and a new component of
            epithelial tight junctions
  JOURNAL   J Biol Chem 279 (1), 796-804 (2004)
   PUBMED   14573622
  REMARK    GeneRIF: CLMP is a novel cell-cell adhesion molecule and a new
            component of epithelial tight junctions.
REFERENCE   8  (bases 1 to 5032)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 5032)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     IGSF11 gene, frequently up-regulated in intestinal-type gastric
            cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and
            ESAM
  JOURNAL   Int J Oncol 23 (2), 525-531 (2003)
   PUBMED   12851705
  REMARK    GeneRIF: ASAM, IGSF11, CXADR and ESAM are type I transmembrane
            proteins and members of the same IGSF superfamily.
REFERENCE   10 (bases 1 to 5032)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001970.3 and AP000926.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_024769.4.
            
            Summary: This gene encodes a type I transmembrane protein that is
            localized to junctional complexes between endothelial and
            epithelial cells and may have a role in cell-cell adhesion.
            Expression of this gene in white adipose tissue is implicated in
            adipocyte maturation and development of obesity. This gene is also
            essential for normal intestinal development and mutations in the
            gene are associated with congenital short bowel syndrome. [provided
            by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.831375.1,
                                           SRR1803617.85527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448775.4/ ENSP00000405577.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               AP001970.3         27306-27641         c
            337-494             AP000926.6         75706-75863         c
            495-696             AP000926.6         62423-62624         c
            697-864             AP000926.6         61591-61758         c
            865-987             AP000926.6         60996-61118         c
            988-1129            AP000926.6         52613-52754         c
            1130-5032           AP000926.6         47783-51685         c
FEATURES             Location/Qualifiers
     source          1..5032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..5032
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /note="CXADR like membrane protein"
                     /db_xref="GeneID:79827"
                     /db_xref="HGNC:HGNC:24039"
                     /db_xref="MIM:611693"
     exon            1..336
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1430
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /note="CAR-like membrane protein; adipocyte-specific
                     adhesion molecule; coxsackie- and adenovirus receptor-like
                     membrane protein"
                     /codon_start=1
                     /product="CXADR-like membrane protein precursor"
                     /protein_id="NP_079045.1"
                     /db_xref="CCDS:CCDS8441.1"
                     /db_xref="GeneID:79827"
                     /db_xref="HGNC:HGNC:24039"
                     /db_xref="MIM:611693"
                     /translation="MSLLLLLLLVSYYVGTLGTHTEIKRVAEEKVTLPCHHQLGLPEK
                     DTLDIEWLLTDNEGNQKVVITYSSRHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLK
                     PSDEGRYTCKVKNSGRYVWSHVILKVLVRPSKPKCELEGELTEGSDLTLQCESSSGTE
                     PIVYYWQRIREKEGEDERLPPKSRIDYNHPGRVLLQNLTMSYSGLYQCTAGNEAGKES
                     CVVRVTVQYVQSIGMVAGAVTGIVAGALLIFLLVWLLIRRKDKERYEEEERPNEIRED
                     AEAPKARLVKPSSSSSGSRSSRSGSSSTRSTANSASRSQRTLSTDAAPQPGLATQAYS
                     LVGPEVRGSEPKKVHHANLTKAETTPSMIPSQSRAFQTV"
     exon            337..494
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /inference="alignment:Splign:2.1.0"
     exon            495..696
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /inference="alignment:Splign:2.1.0"
     exon            697..864
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /inference="alignment:Splign:2.1.0"
     exon            865..987
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1129
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..5032
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4765..4770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /note="hexamer: AATAAA"
     regulatory      4774..4779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /note="hexamer: TATAAA"
     polyA_site      4784
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /note="major polyA site"
     polyA_site      4790
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
     regulatory      5014..5019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
                     /note="hexamer: AATAAA"
     polyA_site      5032
                     /gene="CLMP"
                     /gene_synonym="ACAM; ASAM; CSBM; CSBS"
ORIGIN      
        1 actccttttt ctttccaaac agggaaaagt gttccacgaa gcggtagcgc cttttcgcct
       61 cgcgttttcc tccctgaccc tggtcccggc tcccgtccgg gcgccagctg gtggggcgag
      121 cgccgggagc ccatctgccc ccaggggcac ggggcgcggg gccggctccc gcccggcaca
      181 tggctgcagc cacctcgcgc gcaccccgag gcgccgcgcc cagctcgccc gaggtccgtc
      241 ggaggcgccc ggccgccccg gagccaagca gcagctgagc ggggaagcgc ccgcgtccgg
      301 ggatcgggat gtccctcctc cttctcctct tgctagtttc ctactatgtt ggaaccttgg
      361 ggactcacac tgagatcaag agagtggcag aggaaaaggt cactttgccc tgccaccatc
      421 aactggggct tccagaaaaa gacactctgg atattgaatg gctgctcacc gataatgaag
      481 ggaaccaaaa agtggtgatc acttactcca gtcgtcatgt ctacaataac ttgactgagg
      541 aacagaaggg ccgagtggcc tttgcttcca atttcctggc aggagatgcc tccttgcaga
      601 ttgaacctct gaagcccagt gatgagggcc ggtacacctg taaggttaag aattcagggc
      661 gctacgtgtg gagccatgtc atcttaaaag tcttagtgag accatccaag cccaagtgtg
      721 agttggaagg agagctgaca gaaggaagtg acctgacttt gcagtgtgag tcatcctctg
      781 gcacagagcc cattgtgtat tactggcagc gaatccgaga gaaagaggga gaggatgaac
      841 gtctgcctcc caaatctagg attgactaca accaccctgg acgagttctg ctgcagaatc
      901 ttaccatgtc ctactctgga ctgtaccagt gcacagcagg caacgaagct gggaaggaaa
      961 gctgtgtggt gcgagtaact gtacagtatg tacaaagcat cggcatggtt gcaggagcag
     1021 tgacaggcat agtggctgga gccctgctga ttttcctctt ggtgtggctg ctaatccgaa
     1081 ggaaagacaa agaaagatat gaggaagaag agagacctaa tgaaattcga gaagatgctg
     1141 aagctccaaa agcccgtctt gtgaaaccca gctcctcttc ctcaggctct cggagctcac
     1201 gctctggttc ttcctccact cgctccacag caaatagtgc ctcacgcagc cagcggacac
     1261 tgtcaactga cgcagcaccc cagccagggc tggccaccca ggcatacagc ctagtggggc
     1321 cagaggtgag aggttctgaa ccaaagaaag tccaccatgc taatctgacc aaagcagaaa
     1381 ccacacccag catgatcccc agccagagca gagccttcca aacggtctga attacaatgg
     1441 acttgactcc cacgctttcc taggagtcag ggtctttgga ctcttctcgt cattggagct
     1501 caagtcacca gccacacaac cagatgagag gtcatctaag tagcagtgag cattgcacgg
     1561 aacagattca gatgagcatt ttccttatac aataccaaac aagcaaaagg atgtaagctg
     1621 attcatctgt aaaaaggcat cttattgtgc ctttagacca gagtaaggga aagcaggagt
     1681 ccaaatctat ttgttgacca ggacctgtgg tgagaaggtt ggggaaaggt gaggtgaata
     1741 tacctaaaac ttttaatgtg ggatattttg tatcagtgct ttgattcaca attttcaaga
     1801 ggaaatggga tgctgtttgt aaattttcta tgcatttctg caaacttatt ggattattag
     1861 ttattcagac agtcaagcag aacccacagc cttattacac ctgtctacac catgtactga
     1921 gctaaccact tctaagaaac tccaaaaaag gaaacatgtg tcttctattc tgacttaact
     1981 tcatttgtca taaggtttgg atattaattt caaggggagt tgaaatagtg ggagatggag
     2041 aagagtgaat gagtttctcc cactctatac taatctcact atttgtattg agcccaaaat
     2101 aactatgaaa ggagacaaaa atttgtgaca aaggattgtg aagagctttc catcttcatg
     2161 atgttatgag gattgttgac aaacattaga aatatataat ggagcaattg tggatttccc
     2221 ctcaaatcag atgcctctaa ggactttcct gctagatatt tctggaagga gaaaatacaa
     2281 catgtcattt atcaacgtcc ttagaaagaa ttcttctaga gaaaaaggga tctaggaatg
     2341 ctgaaagatt acccaacata ccattatagt ctcttctttc tgagaaaatg tgaaaccaga
     2401 attgcaagac tgggtggact agaaagggag attagatcag ttttctctta atatgtcaag
     2461 gaaggtagcc gggcatggtg ccaggcacct gtaggaaaat ccagcaggtg gaggttgcag
     2521 tgagccaaga ttatgccatt gcactccagc ctgggtgaca aagcaagact ccatctcaaa
     2581 aaaaaaaaaa aatcaaggaa ggataaaagg aagttcagta ttgtaccaca cttggaactt
     2641 cctccatttc ttccatttta gaaggatatg aacctggaac ttttgatgat tctaagcctt
     2701 aaactatcaa aaagatcagg gattgccaat gcttctaatg gcactgcaag tatatgccat
     2761 aaccgttccc tcctaaaagt gaaaaatgag agaaattcag tattttccca ggctcagcat
     2821 ccagaagtct agctctgggc tggaagaaaa gggtactaat atttagggaa gagatgagaa
     2881 taagtagtgg gtggcaggag agggctgagc tagtgcctgc taacatttta gttgtatctt
     2941 ggaaagattt agcaaaaata actcaccagg atagctgctg aagagttgat gaatgggaga
     3001 agaaagatgt ttgagaaata aagaaaacag cagcctgcaa tacaataact tgccttttta
     3061 atagttttga ttactcttga tacctacagc acaaatgctg gacctgaatc agctcttcaa
     3121 ggaccctagc acaaatgtca actgatcacc tctgggagag tagaaaactt tttttttttt
     3181 gagacgaagt ctcgctctgt tgcccaggct ggagtgcagt ggcaccatct cagctcactg
     3241 cagcgtccgc ctcttgggtt caagtgattc tcctgccttg tcctcctgag tcgctggtat
     3301 tacaggtgcc tgccatcaca cccagctaat ttttggagtt ctgatagaga cagggtttct
     3361 ccatgttggc caggcttgtc tcaagctcct gacctcaagt gacctaccca cccttggcct
     3421 cccacagtgc tggaagccac tgcacctggc tcagaatact tttttttttg agatgcagtc
     3481 ttgctctcat cacgcaggct ggagtgcagt ggcgtatctc ggctcactgc gacctccacc
     3541 tcccgagttc aagcgattct ccttcctcag tcccccaagt agcttggatt ataggtgtgc
     3601 gccaccacgt acagctaatt tttgtatttt tagtagagat ggggtttcgc catgttgacc
     3661 aggctggtct caaaacgcct gacctcaggt gatccaccca cctcggcccc acaaagtgct
     3721 aggattacag gtgtgagcca ccatgcccgg cccagaatac tttttaaaag aagagcaggt
     3781 tagaggaaag aaaaaaattg atgctgaatg tggtgatgaa agcatgtttc taaaatggga
     3841 agcagatgct taaagaggaa agactaatct gggattttgc cccatttctc tggtttttca
     3901 ctcctatatt taattctcac aatcgtgtcg tcacatagtg caaaaaacaa aattcttgta
     3961 aagtccccag gagtttatgc ttgggtgaaa gttttagcct gagtattttc ttcctctaaa
     4021 aaaggtggga aatgagacat tgaggaatta acatataaat gtctgctatg ggtttaagag
     4081 aactggcgta tttggaatgc ttcttacact aacactgtct cattgtaaaa tataaaaccc
     4141 cttactctaa ctacattttt attcctctgg tagtgtggta tccaggcaac atatcacttc
     4201 tgctatgtaa ttctaagaat tctcatttct agagtacctg agccaaacaa atacacaacg
     4261 gaagctgcag ctgtatcatc actagcaatt tgctcatcat tatttactac ctttgaacct
     4321 aaggtttcct gcctatgctt ttgaaagcaa aaatcagtct cctttgcatg aaaaagagcc
     4381 ttagattttt aaacatgtta gttaccagaa tgctaaaata ccagttgatt acccaaatta
     4441 ttttggaaat ctatccataa tggaagtcta caacaaacac ataaaacaga ttacactaag
     4501 agctgagaaa ttcaaaggaa ctgaagattc tgagagataa actgttcaag tcttagcaat
     4561 gatactgcac ttctctttga caggttctgg gcttaagtta gaggccctac tggttccaaa
     4621 ccatattcca ctgactttgc aagtaaaata aatttgattc tgaaatagga aacaaaaaaa
     4681 ggagaaataa ccgaatagta gaagaaaaac tgtttgtagg aagacgatgc agatggaatg
     4741 atgtggacat tgagtaacca tgtcaataaa atatataaac caaacttaaa tttgtgaaat
     4801 aaggaagttg gtacctttgt tgttacagtg tataaaaaca atttcggaac tgctgttgca
     4861 aaaagacata tatagttttg cttccttctg gtgttaagct gtttatattt cagtttcagt
     4921 tttaacttct aagttgcctt gtaattggga ctgtgtttca gcatcacaaa aaccaaatat
     4981 ttattatgga tgcatctgta tcagcaatta aaaaataaac aagtaaaagt ga
//
