LOCUS       NM_024734              12749 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens calmin (CLMN), mRNA.
ACCESSION   NM_024734
VERSION     NM_024734.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12749)
  AUTHORS   Sherva,R., Tripodis,Y., Bennett,D.A., Chibnik,L.B., Crane,P.K., de
            Jager,P.L., Farrer,L.A., Saykin,A.J., Shulman,J.M., Naj,A. and
            Green,R.C.
  CONSRTM   GENAROAD Consortium; Alzheimer's Disease Neuroimaging Initiative;
            Alzheimer's Disease Genetics Consortium
  TITLE     Genome-wide association study of the rate of cognitive decline in
            Alzheimer's disease
  JOURNAL   Alzheimers Dement 10 (1), 45-52 (2014)
   PUBMED   23535033
REFERENCE   2  (bases 1 to 12749)
  AUTHORS   Eriksson,N., Benton,G.M., Do,C.B., Kiefer,A.K., Mountain,J.L.,
            Hinds,D.A., Francke,U. and Tung,J.Y.
  TITLE     Genetic variants associated with breast size also influence breast
            cancer risk
  JOURNAL   BMC Med Genet 13, 53 (2012)
   PUBMED   22747683
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12749)
  AUTHORS   Adkins,D.E., Aberg,K., McClay,J.L., Bukszar,J., Zhao,Z., Jia,P.,
            Stroup,T.S., Perkins,D., McEvoy,J.P., Lieberman,J.A., Sullivan,P.F.
            and van den Oord,E.J.
  TITLE     Genomewide pharmacogenomic study of metabolic side effects to
            antipsychotic drugs
  JOURNAL   Mol Psychiatry 16 (3), 321-332 (2011)
   PUBMED   20195266
REFERENCE   4  (bases 1 to 12749)
  AUTHORS   Barber,M.J., Mangravite,L.M., Hyde,C.L., Chasman,D.I., Smith,J.D.,
            McCarty,C.A., Li,X., Wilke,R.A., Rieder,M.J., Williams,P.T.,
            Ridker,P.M., Chatterjee,A., Rotter,J.I., Nickerson,D.A.,
            Stephens,M. and Krauss,R.M.
  TITLE     Genome-wide association of lipid-lowering response to statins in
            combined study populations
  JOURNAL   PLoS One 5 (3), e9763 (2010)
   PUBMED   20339536
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12749)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 12749)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   7  (bases 1 to 12749)
  AUTHORS   Ishisaki,Z., Takaishi,M., Furuta,I. and Huh,N.
  TITLE     Calmin, a protein with calponin homology and transmembrane domains
            expressed in maturing spermatogenic cells
  JOURNAL   Genomics 74 (2), 172-179 (2001)
   PUBMED   11386753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB155696.1, BC068482.1, AB047979.1, AL356017.3 and AB007969.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024734.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314315.1, AB047979.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298912.9/ ENSP00000298912.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                CB155696.1         1-54
            55-506              BC068482.1         4-455
            507-3161            AB047979.1         464-3118
            3162-12602          AL356017.3         104842-114282       c
            12603-12749         AB007969.1         6430-6576
FEATURES             Location/Qualifiers
     source          1..12749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     gene            1..12749
                     /gene="CLMN"
                     /note="calmin"
                     /db_xref="GeneID:79789"
                     /db_xref="HGNC:HGNC:19972"
                     /db_xref="MIM:611121"
     exon            1..198
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..3125
                     /gene="CLMN"
                     /note="calponin-like transmembrane domain protein; calmin
                     (calponin-like, transmembrane)"
                     /codon_start=1
                     /product="calmin"
                     /protein_id="NP_079010.2"
                     /db_xref="CCDS:CCDS9933.1"
                     /db_xref="GeneID:79789"
                     /db_xref="HGNC:HGNC:19972"
                     /db_xref="MIM:611121"
                     /translation="MAAHEWDWFQREELIGQISDIRVQNLQVERENVQKRTFTRWINL
                     HLEKCNPPLEVKDLFVDIQDGKILMALLEVLSGRNLLHEYKSSSHRIFRLNNIAKALK
                     FLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILFFQIKELTGNLSRNSPSSSLSPGS
                     GGTDSDSSFPPTPTAERSVAISVKDQRKAIKALLAWVQRKTRKYGVAVQDFAGSWRSG
                     LAFLAVIKAIDPSLVDMKQALENSTRENLEKAFSIAQDALHIPRLLEPEDIMVDTPDE
                     QSIMTYVAQFLERFPELEAEDIFDSDKEVPIESTFVRIKETPSEQESKVFVLTENGER
                     TYTVNHETSHPPPSKVFVCDKPESMKEFRLDGVSSHALSDSSTEFMHQIIDQVLQGGP
                     GKTSDISEPSPESSILSSRKENGRSNSLPIKKTVHFEADTYKDPFCSKNLSLCFEGSP
                     RVAKESLRQDGHVLAVEVAEEKEQKQESSKIPESSSDKVAGDIFLVEGTNNNSQSSSC
                     NGALESTARHDEESHSLSPPGENTVMADSFQIKVNLMTVEALEEGDYFEAIPLKASKF
                     NSDLIDFASTSQAFNKVPSPHETKPDEDAEAFENHAEKLGKRSIKSAHKKKDSPEPQV
                     KMDKHEPHQDSGEEAEGCPSAPEETPVDKKPEVHEKAKRKSTRPHYEEEGEDDDLQGV
                     GEELSSSPPSSCVSLETLGSHSEEGLDFKPSPPLSKVSVIPHDLFYFPHYEVPLAAVL
                     EAYVEDPEDLKNEEMDLEEPEGYMPDLDSREEEADGSQSSSSSSVPGESLPSASDQVL
                     YLSRGGVGTTPASEPAPLAPHEDHQQRETKENDPMDSHQSQESPNLENIANPLEENVT
                     KESISSKKKEKRKHVDHVESSLFVAPGSVQSSDDLEEDSSDYSIPSRTSHSDSSIYLR
                     RHTHRSSESDHFSYVQLRNAADLDDRRNRILTRKANSSGEAMSLGSHSPQSDSLTQLV
                     QQPDMMYFILFLWLLVYCLLLFPQLDVSRL"
     exon            199..260
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     exon            261..356
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     exon            357..440
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     exon            441..533
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     exon            534..724
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     exon            725..918
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1001
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..2627
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2824
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2885
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2956
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..12749
                     /gene="CLMN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3141..3146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLMN"
                     /note="hexamer: AATAAA"
     polyA_site      3162
                     /gene="CLMN"
                     /note="major polyA site"
     regulatory      12731..12736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLMN"
                     /note="hexamer: TATAAA"
     polyA_site      12749
                     /gene="CLMN"
                     /note="major polyA site"
ORIGIN      
        1 gcgactccag ctccgcggcg ccctcgccgg gtgcgtgccg ctcgcgcgcc cgccagccag
       61 gctctccgcg cccgccgccc gcgccgcgct ggcccgggct ctcccgcccg cgcttcatgg
      121 ctgcacacga gtgggactgg ttccaacgcg aggagctcat cgggcagatt agcgacatcc
      181 gagtgcagaa cctgcaagtt gagagggaaa atgtgcagaa gaggaccttt acacgatgga
      241 taaatctaca tctagaaaag tgcaacccac ctctagaagt taaagattta ttcgtcgata
      301 tacaagatgg caaaatccta atggctttgt tagaagtcct gtctgggcgg aatctgctgc
      361 acgaatacaa atcctcgtcg catcgtattt ttcggttgaa caacatagcg aaagcactta
      421 agtttttgga agatagcaat gtaaaactgg ttagcattga tgcagcagaa atagcagatg
      481 gcaacccttc tttggttctt gggctgatat ggaacataat cctcttcttc cagattaagg
      541 agctcacagg caacctcagc agaaactctc catcttccag cttgtcccct ggctcagggg
      601 gcacagactc agactcatcc ttcccaccca cacccactgc agagaggagc gtggcaatat
      661 cggtgaaaga ccagaggaag gctatcaagg ccctgttggc gtgggtgcag aggaaaacga
      721 gaaagtatgg cgtggcggtg caggactttg cgggcagttg gaggagtggg ctggctttcc
      781 tggcggtgat caaggccatt gaccccagcc tggtggacat gaaacaggcc ctggaaaatt
      841 ccacacgaga aaatctagag aaggctttca gcatcgcaca ggatgccctg cacatcccca
      901 ggctcctgga gccagaagac atcatggttg acacaccaga cgagcagtct atcatgactt
      961 acgtggcaca gtttctagaa cgttttccgg agttggaagc cgaagatatt ttcgattcag
     1021 ataaagaagt tcctatcgaa tccacttttg ttcgcatcaa agaaactcct tctgaacagg
     1081 agagcaaagt cttcgttctg actgaaaatg gggagcgtac ctacactgtt aaccatgaaa
     1141 ccagccaccc accaccctcc aaagtctttg tctgtgacaa gcccgagagc atgaaggaat
     1201 tccgcctgga tggtgtttcc agccatgcgc tgtcagacag ctccaccgag ttcatgcacc
     1261 agattattga ccaggtcctg caagggggcc caggtaagac cagcgacatc agtgagccat
     1321 ctccagaatc ctccatttta tcatccagaa aggagaacgg gaggtccaac tctttgccga
     1381 tcaagaaaac agttcacttt gaggctgaca cctacaagga tcctttctgc agtaagaacc
     1441 tgtccctttg ctttgaaggg agcccaagag tggcaaagga atcattgagg caggatggac
     1501 atgtcttggc agttgaggtt gctgaggaaa aggaacagaa acaggaatcc tcgaagattc
     1561 cagaatcctc ctctgacaag gtcgctggtg acattttttt ggtggagggc acaaacaata
     1621 attctcagtc ttcttcctgt aatggtgctt tagagagtac agcccgccac gatgaagaaa
     1681 gtcactctct ttcaccccca ggagaaaata ctgtgatggc cgattccttc cagatcaagg
     1741 ttaacctgat gactgtagaa gctttagagg agggagacta ttttgaagcc atcccattaa
     1801 aagcctcaaa atttaacagc gacctaatag attttgcttc taccagccag gctttcaaca
     1861 aagttccttc acctcatgag acaaaacctg acgaggatgc tgaggctttt gagaatcatg
     1921 ctgaaaaact aggtaaaagg agtattaaat ctgctcacaa aaagaaggat tcgccagagc
     1981 ctcaagttaa gatggacaaa catgaacctc atcaggactc cggagaagaa gctgaaggct
     2041 gtccttcagc cccagaagag acaccagtgg ataaaaagcc agaggtgcat gaaaaggcca
     2101 agagaaagtc cacccgtcct cattatgagg aagagggaga agacgatgac ctccagggtg
     2161 tgggcgagga attatcttcc agccccccaa gcagctgtgt cagcttggag acccttggga
     2221 gtcacagcga agaaggcctg gatttcaagc cctccccacc cctctcaaag gtttccgtca
     2281 ttccccacga cctcttctat ttcccacact atgaggttcc cctggctgca gttttggagg
     2341 cttatgtaga agacccggag gatctaaaaa atgaagaaat ggatctcgaa gagccagagg
     2401 gctatatgcc agacctggac tccagggagg aggaggccga tggctctcag agcagctcca
     2461 gttcctcggt gccaggagag agcctcccca gtgccagcga ccaggtgctg tatctcagca
     2521 ggggtggtgt gggtaccaca ccagcctcag aacccgctcc actggccccc catgaggacc
     2581 accagcaaag ggagaccaaa gagaatgacc ccatggacag ccatcagtcc caggaatccc
     2641 caaacctgga aaacatagca aaccccctag aagaaaatgt aacgaaagaa tcaatcagta
     2701 gtaaaaaaaa ggaaaaaagg aaacatgtgg accacgtaga aagttcacta tttgtagcac
     2761 caggaagtgt tcaatcctca gatgacctag aagaagacag tagcgactac agcattcctt
     2821 ccaggactag tcacagtgac tccagcattt accttcgacg acatactcat aggtcttcgg
     2881 aatcggatca ttttagctat gttcagttga ggaacgcagc agatctggat gacagaagaa
     2941 accgaatatt aaccaggaag gccaacagct caggagaagc catgtcactg gggagccaca
     3001 gcccgcagag tgactccctg acacagcttg tccagcagcc ggatatgatg tattttattc
     3061 tcttcctgtg gctcctggtg tactgcttgc tgctcttccc acaactggat gttagcaggc
     3121 tctgatacgt gtgtctggat aataaaaaag acaggaccct gaccaggggc ggggttactt
     3181 cattttattt tgggttctgg gtggggcact tctacagaca gttgaggacc tccgaggaaa
     3241 cttagacccc ctttctcgct attgtggttt tttttttttt ttcaggtttc cttttttttc
     3301 tggacaacct gagcatgctt ttttctttgg ctgtgtactc aaaactcagg catgcagctg
     3361 gatccgtagg tggggttttg tccttgtgtg ccttgctggg ttggataggg agcattgtta
     3421 gtgatcatta gcccgcctgg atcttagcac accccacatt gcaggttcac acgctggatg
     3481 aacttgagtt tcttacctct cagatgaagg gctgcttaat gagaaagagg gtgggcaccc
     3541 caggccaagc cccagctggg gagagagctg ccacgttttc ctccaagcgt gggtgtttga
     3601 gagaaggtgc tggggtccat gcacctgtcg cagtccggta actggttgca ttcactaggg
     3661 gaaatccgag cagccagctc tgtgtaagca catccaggaa tggcagaatc cagggaggaa
     3721 ggtgaaagct gtgttgagag ccactgtgtg ctctttttca ccctgttttt tttgttgttt
     3781 ttttgttttg ttttttgttt gaggggagat aacacttgaa attcagtttt ccattgattg
     3841 gattgagata gaaccatgat tttcaaacca gatcgccagg gcccagcagg gccatataaa
     3901 agccatgagg agtggctggg ctggaatcag ctcccagcag tgctggagct gggtggtggg
     3961 gtagcttcct gcccactaaa gctttggtgc acacctccct cagaatgcat gtcttggaac
     4021 gggcattctt tgtggtcact tgtaatgggt ttcttgaaga ggctttctgg acagcactcc
     4081 gggagcaggc cagcacagga ggtttgtgaa agaagagagg catctctagc acccctgccc
     4141 ccagtcttcc tcagccccag gctccctctg ctctctcctc cctgccaaga ctcaggtccg
     4201 tggtgagtct ctgcattggt tcctcctccc cttgctctcc ccttcagaaa gcatgtacca
     4261 ggcaaccctt ataaaatcac aaatgagtca ggaggggact cagtgagcat cttgtctagc
     4321 tggacccaga gagacagagc agcttgacca agatcatata gccgaccagg ggcagacttg
     4381 cagtgagcac acaggcacct gatgccctgt ccagagctgt caccccttgt aggaaacttc
     4441 cactgggcac accaatgtcc tgagaaaaag ataaaatgac tagattaaaa tgtccacatt
     4501 caagcaaaac caaaaagttt agaccaacta tcgacatttg ttttgttctt gtatttttcc
     4561 catgaggaat tcttactcac cttcaagctc atccccaatt ccttctgaaa tacccttgac
     4621 agctgcaaca gcttgtcatt tgacatacca gcgtcgctct tactccagga atcacgtttc
     4681 tttctttgct agccaaggac ttgctcattt caagcagtgg gtttcaagtt tacagaattc
     4741 cagcatggcc agaagaattt acatagcaca tctgagtcga tgacagccaa aatctggcct
     4801 ctaaaccagt ctgattatag tctgtctccc ctcctgaaag aatttcagcc ttccaaccag
     4861 aaagctgctg ggagcttgga gtgattccat ctggaaggcc aagagcccca tggaaaatga
     4921 gctaattaat gagctccctg gcatcaatga aagctcaaag gtacagataa taaagattat
     4981 gtgatagttt ataactctgg gcaccatgca gtccttgcct aaattagatg ctcgaagagc
     5041 ctgggaagag ccaacccaaa tgtgaatcat ttcattttat gggtctagac cttgttcaga
     5101 aaaacctctg caagatactt ctctcaccta ttacaacttg taatattgtt taaaacatct
     5161 actggcaaga tgcctgaaag tcatttggtt caggttggca gtcaactgat attttgcaaa
     5221 ggaaaaaaaa atctcatttg agtataggct tctatggaag aagctggata tagaaaatgg
     5281 atgtggaagt ctgcaggaca aaccacccca ttgcttgtaa atttttttta aattaaaaga
     5341 aatacaataa ggcttttaac aagaactagc agtcccctaa gtctcgctgc ttagaagtaa
     5401 ccactttcaa ctctcttatg tttgcatttc tacataacgt gcttacactt tattttttaa
     5461 tttagaaaca tctactggct tgctgtcaca gtagaggagg atttcactct taccataccg
     5521 tgctttggtt ttccagtata gctagatcac atcatttagt acatttctat taggtgttga
     5581 cattacctgg agcacttaag gattgttgac tcccaagccc agcagtgtgt tatggttaca
     5641 tgtcctttct cctccaaatg tccccattaa tttgctattc tctctcttta cttttttttt
     5701 ttttttggtg tggcacattc tttaataact tcctgaggaa gagaacatgg gaagtaaata
     5761 tggttgtaaa tattttgaga tttttgcatg acttaagatg tctgtattct gcccttaaca
     5821 gaaatgtggc tgagcataga atgacaggtg gaaaataata ccctccccta gcccctccca
     5881 agcgtgctgg ttgagatttc tgatgccatt ctgattcccg tacctttata tgtgacttag
     5941 gtttttttat ccacccttcc tggaaacatt taagatctct ttattcttgg tgttctgaac
     6001 tgtcatgatg gtgttgtatc ccgggtgtta aaccttgtgc tgggccttca tgggaaattt
     6061 cttaaatttt cttgtgatta tttacattct ttctttctgg accacctatt atttcaatgt
     6121 tggaccctcc cctacaccca ggctgatgct ctaatatttt ttatcttttc tatttttcgt
     6181 ctatgtttct gatctgcttt caggaagaat tattcatttt tatcttccca atctgaatgt
     6241 tttattgaat ttttattttc caagttaata aaacctttgg ttattatcct gtctttgttt
     6301 tacagtgtcc tgctcttgat gcgtggatgc agattttgtc tctctgtgga cgttaatgat
     6361 tgtggtctga ggggaagtct tttctgctcc ctgtgttgcc ctcattttct ctgagttctc
     6421 tttattttgg tggtctcagt ctctatcttt cacgttgtga atttttctca aatatatggt
     6481 gatcctatgg atctgttcat gttttaagag tgaggcatcc aaaagctgat tggaagttgt
     6541 gtgtgccaac tggtgagctt ttccactagg gtcaccaggt gggcacctgg actcatcatt
     6601 ggagaacact gcctgtcagt atttgcacgt gttttctctg gggctcattc tgtttcttga
     6661 gagatattcc cactactctc cttcctggga aacgggcata cacagggctt ttagcctatg
     6721 ctgagtactc atgtggtttc aaaaatggtg tcccatctgg gcagaagtcc ccatgagcac
     6781 ttggcttgac tggcaaagga caccttttgc cccttcctcc agacataccc agctctgagc
     6841 ttggacaatg ctcgaggaac aatgaaaagg ctagatttta actcctaatt gccctcttta
     6901 gccaagtgcc tctgtgcaat gcacaactgt aggaccatat ccagagaccc tggtctatac
     6961 tcagtgtgcc cgagtcctga ccgctgagca ggcagcctca tcacccgtga gtatttagac
     7021 tttcattaag ttgcttcaac ctttgctgtg cctggtgtcc ctgagttgga gctgctctga
     7081 tttctccatg gagtaggagc acagtggtca tctggctgca tgggaaggac aggggacctc
     7141 agagccaata aatgccctgg tcttcagccc catgtctcac cccatccctc ctattccaat
     7201 ccccaagcct ctcctggagg ccacagggca tctctgctga ccactctgtg gcctcccctc
     7261 tgcaggcatg tggttttagg atccccctcc ctgctcactt ttccatcagt tccattcctg
     7321 cataaatagg ttgctagctc ttgcttactg ttctcttctg tattctgtgt tcatggttgt
     7381 attaatataa ctttcattcc tctgctccta ttttcatggg gtttcatgag ggaagaaaca
     7441 ggctcatgtg ttcagtatac catcttgatc cataaacccc atttgagtta tctcacaggt
     7501 tgcttagggg gcttgctgct ctgactggtt tgtgaacgtg ccctgagtcc agctgggact
     7561 gcagcaacat ccatcctgtt gagctgtggt ctgctaagtg attttgtgta atgctgtgcc
     7621 aagtgcagga gagggataca tagcatggct aagctctgct tgaatgccat gattagttat
     7681 taccttcctt ccttccccct ggttttgctg cctattgtca gtaaatgatc ttagatctcc
     7741 tgcctcccca aagatatagt ctatgtggtg gtctgggttc taggttttct ttaccaccct
     7801 tgcttcactt aagaaacaga aaactggcta ggcacagtag tggctcacac ctataatccc
     7861 agccctttgg gaggccaagg caggaggatc gcttgaggcc aggaattcaa gaccagcctg
     7921 cacaacatag caagactcca tctctacaaa aagttaaatt taaattagtg gtggcataca
     7981 cttatagtcc cagctactca ggaggatgag gcaggagaat tgtttgagcc catgactttg
     8041 aggttactgt gagctatgat cctgctattt tactccacct gagtgacaga gcgagacgct
     8101 gtctcaaaaa taaagaaaca agtagtccac acaggtgttt gccagcaaac aaacagcgcg
     8161 gattctctgt tgaacgtggc caacattgcc tcgtcgaagt ttgtatcttg ccatagttga
     8221 tgatcaggtg gtcggggctt cctggtcaga cctgaccttt gtggggagat gttctcccac
     8281 caaggctcag aagcaggaca ctcttgctgc ccctcgggca gccacccaga acatgggcgt
     8341 ctccatttct gaggttcagc atagttcccc ccaccctctt cccatgcagt gcatgcctgc
     8401 tctttatcag gatggaacag agggaaggca gaggcactgg gggcagcctg tgttgttgat
     8461 ctctgtaagt cacagactgt tcgaaaacct caggaattat gtaagcgttc agtgcctcat
     8521 ttaagagatg aaaaactgaa gattagaaag aggaaacgac tagtcgccct gctagttgat
     8581 gacctccaga tagccatctt cattcccagt taagtttact acaaaaccac agcctcagct
     8641 gctgaagcta acctccctac ccaccatcgc tagggactca gaacaccatg gagctcatct
     8701 ctccaacaaa agtcagaatt agcaagtaca gatgtgtctt acgaaaatgt cagaatccat
     8761 catggctgct ttggtgagga gctgttctcc ttccgtggtc atgccattgg aaggcagttg
     8821 tatgacaaga atgctttcac atgagctccg attttcttaa ctctccagaa ggacttcaga
     8881 agcctctgga gttttgagac acggcctctc tctcccttct gcttggagac accttcctgg
     8941 gggtctccac tgcattcccc gccggtattc ctctgtggag ccttgcgccc tcaggtccca
     9001 gaaatgggct gtgtgggagc ttccagtcag cctggtatct cgggaccttc tcagccagga
     9061 aatgagactg cacaaagccc tgtgaggccc agctgtgtta tttctccttc cccgacattg
     9121 cataatcact gctgacacag catttgggga agatttaacg tcttgggcca gcagctgcca
     9181 tctggaacca tcaccacata gcaggttgtt ctgtcccatc caactgatga gggggctgcc
     9241 ctaatgacaa ggtccaggac ctgggttggg tggtggaagg ctgggagctg gagtgggcat
     9301 tattgtgctt ctgtgctgaa aattgctatg gctcttttcc cctaacagcc agcgtgggag
     9361 aaccaaacat gagacacaag catccccttg agctccacag atcttgcgcc ttgctctcat
     9421 caggcatttc cttggaaaac agcagtcagc agctcatgga agtgagcccg gtgcacagac
     9481 tttgcatgga ctttgcacag gttccatttc catcgtgtgc agacacctgt atctttgggc
     9541 tccacgtgag cacctgccct cttcactctg attttttttt taagagacag catcttactc
     9601 tgtcaccgag gctggagtac agtggtgtga tcacagctca ctgcagcctg aaactcctgg
     9661 gctcaggcaa tcctcctgcc tcagcctccc aagtagctgg tagtacaggt gcatgccacc
     9721 acgcccacct aattttttta tcttttatag atacaggtct cactgttgct caggctggtc
     9781 tcgaactcct ggcctcaagt gatcctcctg ccttggccta ccaaaatgct gggattatag
     9841 gcatgaacca ctgtgcctgg ccttcactct gatttttctt aagagtccta caggaccttc
     9901 aggtcttgtc acttctctac cattgtgtgt gagacagggc atggggtgag cttggtcagg
     9961 tgtgggtcaa aagcctggag actcagagct gctggttccc caagagccca caaaagttat
    10021 cagagtttct gagctgagtg ttctgcagtt gccagacccc acaatgctgg gaatactggc
    10081 ttctttgtgt ttagaacttg ttctgagaac cttgatgaga acacatcaag caagcagttc
    10141 ctcccagcca gggctggagc aacatgccaa aaaacattct tgtctatggg aaaaagacaa
    10201 ccagtatttt gtactgtttg accaagttgt ttttaaatat acacatgcct caacaatcca
    10261 cggcctcaat cgcactgcta atttgtttaa atccctgaca ctcagatgtc aagaatagct
    10321 tcatctagca gtgttctctt taaaggaacc cttttttttg ttttcatttt aatcactgcc
    10381 ttcttctctg ggaggtattg tgggctagag aaagaagtca ggtttgggag tcagccagat
    10441 ttagattgga gtcccagctc tgtcaccaga tctctgggtg atcttggcaa actaacttct
    10501 gagcttctgt gcattatagg cattcagcac atatttgttg gatgaaaaat acttttcttg
    10561 aaagtttatg aagttgtagg atgcccagca gccccctttt ctctatttcc ttcctcttga
    10621 agcaagcgtt gactatacct ctttccctaa cccttagtgt accatagctt cttccaacct
    10681 ctctccaatc cattactttt ttctgagcta ccctgtctca aatctaactc aggccttttt
    10741 gcaagaggaa gtttaagcca ttgtttactc attaactcac ttgaccctta gaacaatcgt
    10801 gggaggtgtt tatttcggaa aggaagctaa agcacaggac agaaaaataa ggtcatagcg
    10861 tgaactagta agtagcagaa ctgggaacat aggactgtta ttttcaaaca ctctaaactt
    10921 cactgcagtt gcaaatttgc aaccaaaatg gccgccttga aagggtcttt tgcagtaaaa
    10981 tctcagtgtc caacatcaaa gacagttctt cagggcctcc aattaactat acatcctgcc
    11041 cccagctgct catctctgca cctctaacac gtacttcaca gagtaggaaa ttgggctttc
    11101 tccttcaaaa agaaaagtag agaaggcctg agggcagtgt aattaaaatg gagaagtaga
    11161 gaccacgaat tacttggatg aattcataac tggttggtct ctgaggcagg gattattatt
    11221 tttcctgtat tttaagctta aaagtagtga tttttgcatt gttacaaaaa acaaaatagc
    11281 aaaatatcat ttgatacttg tattctgttt gcaatagcta ccacttcctt tagccccagc
    11341 aaaaatcaat aggtgtgtat tctctacaag cccatgctgt gccagaatgc cagtattgct
    11401 aaatgtcatg caaggattta gacacttttt taaaggaaac tctgggagtg cctgttgtct
    11461 ggagagttga cattgtccaa agcaggccaa cactggtatg ggtatggaga acccacgtcc
    11521 tagctgtggc tcacctgcag atgccttgaa tttacctctc tgggttggaa gtgggaagac
    11581 ttcttttaaa agtcctttct aagtttaaaa atccaaaggt tacgaaggta gtttttattt
    11641 atctcaataa gtggcctatt tgcttaaagc aagtgtacct ctgtatatca gcccaaagct
    11701 tagggcagtg cttcttggct ttagtatctg agaaaggtgc ctttgggaag agtttggtca
    11761 gacagaaggt agtctgaatc ttaaaggttt cagatgaatg tttgaagtag aacctgggaa
    11821 atctgcttcc tagggctgtt agaaggaaat tggtctcctt aaattacgtc agcatctgag
    11881 gcagtttcct aagggaattt cttttaaatt caaaagttca actgcaggaa taaatagctg
    11941 tacaggacta gatcttccca tccctcatct tttccccttc cccgagtaac gactcaaaaa
    12001 ggcttctgaa attctactca gaatcggagc cgtttgcatt ccaacaagga tcccttaagc
    12061 caaatgctgg tgtgtttgtg tagaatgtcc ctggggtagg ggcggtagct gtggggaggg
    12121 aatgtggtgc aggggacacc tgccctctgc ccttgaaatt gcaccataag atgctgccta
    12181 tgtcactcac agtggtgctg atactatccg ccaaagacaa attgtgaaca cggaaaaatg
    12241 gtcgttccct actgtacatc ctcaggacag acttaactaa acttggagac aggagattgt
    12301 tcagaccata ttgtagtggg tggtgatcat tgttttattt tgggggagtc tggtctattg
    12361 agcagattga atgtttcctt attgtgcagg gcttaattga ctatgtctga aagtttttac
    12421 tgagagctct aagaaaacta ttgaggaaaa tgaaatgtta ttttgtagta caaggattat
    12481 ttttgtctat ttaggatata catagctgta gctttgtaaa aaaaaagatc tttataaaca
    12541 atatatgaat gtgccgtctt atttattgat tactgtaaat taagatataa atggctattt
    12601 gaataattta tacctgtggg aattaactgg agtatttgtt atttgactgt tttctattaa
    12661 ggaatattag gcttggtgct atgatgaatg atcttgtaaa atcatgtgta ttcttaagaa
    12721 aatttttgaa tataaatttc ttgaactga
//
