LOCUS       NM_001130028            1854 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens CDC like kinase 3 (CLK3), transcript variant 1, mRNA.
ACCESSION   NM_001130028
VERSION     NM_001130028.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Ma,Y., Gao,F. and Liu,Y.
  TITLE     CLK3 positively promoted colorectal cancer proliferation by
            activating IL-6/STAT3 signaling
  JOURNAL   Exp Cell Res 440 (1), 114132 (2024)
   PUBMED   38885806
  REMARK    GeneRIF: CLK3 positively promoted colorectal cancer proliferation
            by activating IL-6/STAT3 signaling.
REFERENCE   2  (bases 1 to 1854)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 1854)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1854)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 1854)
  AUTHORS   Zhou,Q., Lin,M., Feng,X., Ma,F., Zhu,Y., Liu,X., Qu,C., Sui,H.,
            Sun,B., Zhu,A., Zhang,H., Huang,H., Gao,Z., Zhao,Y., Sun,J.,
            Bai,Y., Jin,J., Hong,X., Zou,C. and Zhang,Z.
  TITLE     Targeting CLK3 inhibits the progression of cholangiocarcinoma by
            reprogramming nucleotide metabolism
  JOURNAL   J Exp Med 217 (8) (2020)
   PUBMED   32453420
  REMARK    GeneRIF: Targeting CLK3 inhibits the progression of
            cholangiocarcinoma by reprogramming nucleotide metabolism.
REFERENCE   6  (bases 1 to 1854)
  AUTHORS   Eisenreich,A., Bogdanov,V.Y., Zakrzewicz,A., Pries,A., Antoniak,S.,
            Poller,W., Schultheiss,H.P. and Rauch,U.
  TITLE     Cdc2-like kinases and DNA topoisomerase I regulate alternative
            splicing of tissue factor in human endothelial cells
  JOURNAL   Circ Res 104 (5), 589-599 (2009)
   PUBMED   19168442
  REMARK    GeneRIF: Cdc2-like kinases and DNA topoisomerase I regulate
            alternative splicing of tissue factor in human endothelial cells.
REFERENCE   7  (bases 1 to 1854)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   8  (bases 1 to 1854)
  AUTHORS   Talmadge,C.B., Finkernagel,S., Sumegi,J., Sciorra,L. and Rabinow,L.
  TITLE     Chromosomal mapping of three human LAMMER protein-kinase-encoding
            genes
  JOURNAL   Hum Genet 103 (4), 523-524 (1998)
   PUBMED   9856501
REFERENCE   9  (bases 1 to 1854)
  AUTHORS   Duncan,P.I., Stojdl,D.F., Marius,R.M., Scheit,K.H. and Bell,J.C.
  TITLE     The Clk2 and Clk3 dual-specificity protein kinases regulate the
            intranuclear distribution of SR proteins and influence pre-mRNA
            splicing
  JOURNAL   Exp Cell Res 241 (2), 300-308 (1998)
   PUBMED   9637771
REFERENCE   10 (bases 1 to 1854)
  AUTHORS   Hanes,J., von der Kammer,H., Klaudiny,J. and Scheit,K.H.
  TITLE     Characterization by cDNA cloning of two new human protein kinases.
            Evidence by sequence comparison of a new family of mammalian
            protein kinases
  JOURNAL   J Mol Biol 244 (5), 665-672 (1994)
   PUBMED   7990150
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100835.2.
            
            On Jun 15, 2020 this sequence version replaced NM_001130028.1.
            
            Summary: This gene encodes a protein belonging to the
            serine/threonine type protein kinase family. This protein is a
            nuclear dual-specificity kinase that regulates the intranuclear
            distribution of the serine/arginine-rich (SR) family of splicing
            factors. Two transcript variants encoding different isoforms have
            been found for this gene. Related pseudogenes are located on
            chromosomes 1 and 9. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002555.2, AK091692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395066.9/ ENSP00000378505.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC100835.2         91434-91496
            64-215              AC100835.2         94795-94946
            216-432             AC100835.2         95607-95823
            433-529             AC100835.2         97718-97814
            530-596             AC100835.2         98092-98158
            597-713             AC100835.2         100500-100616
            714-880             AC100835.2         101400-101566
            881-975             AC100835.2         102950-103044
            976-1105            AC100835.2         103137-103266
            1106-1188           AC100835.2         103568-103650
            1189-1268           AC100835.2         104202-104281
            1269-1359           AC100835.2         104540-104630
            1360-1854           AC100835.2         105305-105799
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..1854
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /note="CDC like kinase 3"
                     /db_xref="GeneID:1198"
                     /db_xref="HGNC:HGNC:2071"
                     /db_xref="MIM:602990"
     exon            1..63
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1536
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /EC_number="2.7.12.1"
                     /codon_start=1
                     /product="dual specificity protein kinase CLK3"
                     /protein_id="NP_001123500.2"
                     /db_xref="CCDS:CCDS10265.1"
                     /db_xref="GeneID:1198"
                     /db_xref="HGNC:HGNC:2071"
                     /db_xref="MIM:602990"
                     /translation="MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPP
                     RRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYR
                     TRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVG
                     NLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFL
                     CVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHE
                     NQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTI
                     VATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP
                     IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMR
                     RMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR"
     exon            64..215
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     exon            216..432
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     exon            433..529
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     exon            530..596
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     exon            597..713
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     exon            714..880
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     exon            881..975
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1105
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1188
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1268
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1359
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1854
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1746..1751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /note="hexamer: AATAAA"
     polyA_site      1771
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /note="major polyA site"
     regulatory      1831..1836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /note="hexamer: AATAAA"
     polyA_site      1854
                     /gene="CLK3"
                     /gene_synonym="PHCLK3; PHCLK3/152"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcggaa gaggcgctcg gagcggggag tggggcctag ctgcagccgg agcctgggag
       61 acgatgcatc actgtaagcg ataccgctcc cctgaaccag acccgtacct gagctaccga
      121 tggaagagga ggaggtccta cagtcgggaa catgaaggga gactgcgata cccgtcccga
      181 agggagcctc ccccacgaag atctcggtcc agaagccatg accgcctgcc ctaccagagg
      241 aggtaccggg agcgccgtga cagcgataca taccggtgtg aagagcggag cccatccttt
      301 ggagaggact actatggacc ttcacgttct cgtcatcgtc ggcgatcgcg ggagaggggg
      361 ccataccgga cccgcaagca tgcccaccac tgccacaaac gccgcaccag gtcttgtagc
      421 agcgcctcct cgagaagcca acagagcagt aagcgcagca gccggagtgt ggaagatgac
      481 aaggagggtc acctggtgtg ccggatcggc gattggctcc aagagcgata tgagattgtg
      541 gggaacctgg gtgaaggcac ctttggcaag gtggtggagt gcttggacca tgccagaggg
      601 aagtctcagg ttgccctgaa gatcatccgc aacgtgggca agtaccggga ggctgcccgg
      661 ctagaaatca acgtgctcaa aaaaatcaag gagaaggaca aagaaaacaa gttcctgtgt
      721 gtcttgatgt ctgactggtt caacttccac ggtcacatgt gcatcgcctt tgagctcctg
      781 ggcaagaaca cctttgagtt cctgaaggag aataacttcc agccttaccc cctaccacat
      841 gtccggcaca tggcctacca gctctgccac gcccttagat ttctgcatga gaatcagctg
      901 acccatacag acttgaaacc agagaacatc ctgtttgtga attctgagtt tgaaaccctc
      961 tacaatgagc acaagagctg tgaggagaag tcagtgaaga acaccagcat ccgagtggct
     1021 gactttggca gtgccacatt tgaccatgag caccacacca ccattgtggc cacccgtcac
     1081 tatcgcccgc ctgaggtgat ccttgagctg ggctgggcac agccctgtga cgtctggagc
     1141 attggctgca ttctctttga gtactaccgg ggcttcacac tcttccagac ccacgaaaac
     1201 cgagagcacc tggtgatgat ggagaagatc ctagggccca tcccatcaca catgatccac
     1261 cgtaccagga agcagaaata tttctacaaa gggggcctag tttgggatga gaacagctct
     1321 gacggccggt atgtgaagga gaactgcaaa cctctgaaga gttacatgct ccaagactcc
     1381 ctggagcacg tgcagctgtt tgacctgatg aggaggatgt tagaatttga ccctgcccag
     1441 cgcatcacac tggccgaggc cctgctgcac cccttctttg ctggcctgac ccctgaggag
     1501 cggtccttcc acaccagccg caacccaagc agatgacagg cacaggccac cgcatgagga
     1561 gatggagggc gggactgggc cgcccagccc cttgactcca gcctcgaccg ccaggcccca
     1621 ggccagagcc acccaatgaa cagtgcaatg tgaaggaagg caggagcctg caggggagca
     1681 gacttggtgc ccagctgcca gaaagcacag atttgaccca agctatttat atgttataaa
     1741 gttataataa agtgtttctt actgtttgta acccctggta ccagtgtgtc catctccagg
     1801 ctccttgcct tccccttacc tgaccttatt aataaagtct ttcttagcag ttca
//
