LOCUS       NM_024692               4299 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens CAP-Gly domain containing linker protein family member
            4 (CLIP4), transcript variant 1, mRNA.
ACCESSION   NM_024692
VERSION     NM_024692.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4299)
  AUTHORS   Peng,Z., Fang,C., Yuan,H., Zhu,Y., Ren,Z., Lu,M. and Hu,K.
  TITLE     miR-135b-5p promotes gastric carcinogenesis by targeting
            CLIP4-mediated JAK2/STAT3 signal pathway
  JOURNAL   Cell Signal 122, 111339 (2024)
   PUBMED   39121973
  REMARK    GeneRIF: miR-135b-5p promotes gastric carcinogenesis by targeting
            CLIP4-mediated JAK2/STAT3 signal pathway.
REFERENCE   2  (bases 1 to 4299)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   3  (bases 1 to 4299)
  AUTHORS   Gordon,D.E., Hiatt,J., Bouhaddou,M., Rezelj,V.V., Ulferts,S.,
            Braberg,H., Jureka,A.S., Obernier,K., Guo,J.Z., Batra,J.,
            Kaake,R.M., Weckstein,A.R., Owens,T.W., Gupta,M., Pourmal,S.,
            Titus,E.W., Cakir,M., Soucheray,M., McGregor,M., Cakir,Z., Jang,G.,
            O'Meara,M.J., Tummino,T.A., Zhang,Z., Foussard,H., Rojc,A.,
            Zhou,Y., Kuchenov,D., Huttenhain,R., Xu,J., Eckhardt,M.,
            Swaney,D.L., Fabius,J.M., Ummadi,M., Tutuncuoglu,B., Rathore,U.,
            Modak,M., Haas,P., Haas,K.M., Naing,Z.Z.C., Pulido,E.H., Shi,Y.,
            Barrio-Hernandez,I., Memon,D., Petsalaki,E., Dunham,A.,
            Marrero,M.C., Burke,D., Koh,C., Vallet,T., Silvas,J.A.,
            Azumaya,C.M., Billesbolle,C., Brilot,A.F., Campbell,M.G.,
            Diallo,A., Dickinson,M.S., Diwanji,D., Herrera,N., Hoppe,N.,
            Kratochvil,H.T., Liu,Y., Merz,G.E., Moritz,M., Nguyen,H.C.,
            Nowotny,C., Puchades,C., Rizo,A.N., Schulze-Gahmen,U., Smith,A.M.,
            Sun,M., Young,I.D., Zhao,J., Asarnow,D., Biel,J., Bowen,A.,
            Braxton,J.R., Chen,J., Chio,C.M., Chio,U.S., Deshpande,I., Doan,L.,
            Faust,B., Flores,S., Jin,M., Kim,K., Lam,V.L., Li,F., Li,J.,
            Li,Y.L., Li,Y., Liu,X., Lo,M., Lopez,K.E., Melo,A.A., Moss,F.R.
            3rd, Nguyen,P., Paulino,J., Pawar,K.I., Peters,J.K., Pospiech,T.H.
            Jr., Safari,M., Sangwan,S., Schaefer,K., Thomas,P.V., Thwin,A.C.,
            Trenker,R., Tse,E., Tsui,T.K.M., Wang,F., Whitis,N., Yu,Z.,
            Zhang,K., Zhang,Y., Zhou,F., Saltzberg,D., Hodder,A.J.,
            Shun-Shion,A.S., Williams,D.M., White,K.M., Rosales,R., Kehrer,T.,
            Miorin,L., Moreno,E., Patel,A.H., Rihn,S., Khalid,M.M.,
            Vallejo-Gracia,A., Fozouni,P., Simoneau,C.R., Roth,T.L., Wu,D.,
            Karim,M.A., Ghoussaini,M., Dunham,I., Berardi,F., Weigang,S.,
            Chazal,M., Park,J., Logue,J., McGrath,M., Weston,S., Haupt,R.,
            Hastie,C.J., Elliott,M., Brown,F., Burness,K.A., Reid,E.,
            Dorward,M., Johnson,C., Wilkinson,S.G., Geyer,A., Giesel,D.M.,
            Baillie,C., Raggett,S., Leech,H., Toth,R., Goodman,N., Keough,K.C.,
            Lind,A.L., Klesh,R.J., Hemphill,K.R., Carlson-Stevermer,J., Oki,J.,
            Holden,K., Maures,T., Pollard,K.S., Sali,A., Agard,D.A., Cheng,Y.,
            Fraser,J.S., Frost,A., Jura,N., Kortemme,T., Manglik,A.,
            Southworth,D.R., Stroud,R.M., Alessi,D.R., Davies,P., Frieman,M.B.,
            Ideker,T., Abate,C., Jouvenet,N., Kochs,G., Shoichet,B., Ott,M.,
            Palmarini,M., Shokat,K.M., Garcia-Sastre,A., Rassen,J.A.,
            Grosse,R., Rosenberg,O.S., Verba,K.A., Basler,C.F., Vignuzzi,M.,
            Peden,A.A., Beltrao,P. and Krogan,N.J.
  CONSRTM   QCRG Structural Biology Consortium; Zoonomia Consortium
  TITLE     Comparative host-coronavirus protein interaction networks reveal
            pan-viral disease mechanisms
  JOURNAL   Science 370 (6521) (2020)
   PUBMED   33060197
REFERENCE   4  (bases 1 to 4299)
  AUTHORS   Gordon,D.E., Jang,G.M., Bouhaddou,M., Xu,J., Obernier,K.,
            White,K.M., O'Meara,M.J., Rezelj,V.V., Guo,J.Z., Swaney,D.L.,
            Tummino,T.A., Huttenhain,R., Kaake,R.M., Richards,A.L.,
            Tutuncuoglu,B., Foussard,H., Batra,J., Haas,K., Modak,M., Kim,M.,
            Haas,P., Polacco,B.J., Braberg,H., Fabius,J.M., Eckhardt,M.,
            Soucheray,M., Bennett,M.J., Cakir,M., McGregor,M.J., Li,Q.,
            Meyer,B., Roesch,F., Vallet,T., Mac Kain,A., Miorin,L., Moreno,E.,
            Naing,Z.Z.C., Zhou,Y., Peng,S., Shi,Y., Zhang,Z., Shen,W.,
            Kirby,I.T., Melnyk,J.E., Chorba,J.S., Lou,K., Dai,S.A.,
            Barrio-Hernandez,I., Memon,D., Hernandez-Armenta,C., Lyu,J.,
            Mathy,C.J.P., Perica,T., Pilla,K.B., Ganesan,S.J., Saltzberg,D.J.,
            Rakesh,R., Liu,X., Rosenthal,S.B., Calviello,L., Venkataramanan,S.,
            Liboy-Lugo,J., Lin,Y., Huang,X.P., Liu,Y., Wankowicz,S.A., Bohn,M.,
            Safari,M., Ugur,F.S., Koh,C., Savar,N.S., Tran,Q.D., Shengjuler,D.,
            Fletcher,S.J., O'Neal,M.C., Cai,Y., Chang,J.C.J., Broadhurst,D.J.,
            Klippsten,S., Sharp,P.P., Wenzell,N.A., Kuzuoglu-Ozturk,D.,
            Wang,H.Y., Trenker,R., Young,J.M., Cavero,D.A., Hiatt,J.,
            Roth,T.L., Rathore,U., Subramanian,A., Noack,J., Hubert,M.,
            Stroud,R.M., Frankel,A.D., Rosenberg,O.S., Verba,K.A., Agard,D.A.,
            Ott,M., Emerman,M., Jura,N., von Zastrow,M., Verdin,E.,
            Ashworth,A., Schwartz,O., d'Enfert,C., Mukherjee,S., Jacobson,M.,
            Malik,H.S., Fujimori,D.G., Ideker,T., Craik,C.S., Floor,S.N.,
            Fraser,J.S., Gross,J.D., Sali,A., Roth,B.L., Ruggero,D.,
            Taunton,J., Kortemme,T., Beltrao,P., Vignuzzi,M., Garcia-Sastre,A.,
            Shokat,K.M., Shoichet,B.K. and Krogan,N.J.
  TITLE     A SARS-CoV-2 protein interaction map reveals targets for drug
            repurposing
  JOURNAL   Nature 583 (7816), 459-468 (2020)
   PUBMED   32353859
REFERENCE   5  (bases 1 to 4299)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4299)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4299)
  AUTHORS   Ahn,J., Han,K.S., Heo,J.H., Bang,D., Kang,Y.H., Jin,H.A.,
            Hong,S.J., Lee,J.H. and Ham,W.S.
  TITLE     FOXC2 and CLIP4 : a potential biomarker for synchronous metastasis
            of </=7-cm clear cell renal cell carcinomas
  JOURNAL   Oncotarget 7 (32), 51423-51434 (2016)
   PUBMED   27283491
  REMARK    GeneRIF: FOXC2 and CLIP4 activity correlates to the presence of
            </=7-cm clear cell renal cell carcinomas (ccRCCs) with synchronous
            metastasis and may be potential molecular predictors of synchronous
            metastasis of </=7-cm ccRCCs.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105398.3, BI600762.1, AL834443.1, AK304384.1 and AK023505.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024692.5.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834443.1, BC136331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320081.10/ ENSP00000327009.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC105398.3         152275-152290
            17-37               BI600762.1         13-33
            38-781              AL834443.1         1-744
            782-782             AK304384.1         597-597
            783-3113            AL834443.1         746-3076
            3114-3830           AK023505.1         631-1347
            3831-4299           AL834443.1         3795-4263
FEATURES             Location/Qualifiers
     source          1..4299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.2"
     gene            1..4299
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /note="CAP-Gly domain containing linker protein family
                     member 4"
                     /db_xref="GeneID:79745"
                     /db_xref="HGNC:HGNC:26108"
     exon            1..251
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            252..399
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..2384
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CAP-Gly domain-containing linker protein 4; restin-like
                     protein 2; CAP-GLY domain containing linker protein
                     family, member 4"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 4
                     isoform 1"
                     /protein_id="NP_078968.3"
                     /db_xref="CCDS:CCDS1770.1"
                     /db_xref="GeneID:79745"
                     /db_xref="HGNC:HGNC:26108"
                     /translation="MTIEDLPDFPLEGNPLFGRYPFIFSASDTPVIFSISAAPMPSDC
                     EFSFFDPNDASCQEILFDPKTSVSELFAILRQWVPQVQQNIDIIGNEILKRGCNVNDR
                     DGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYF
                     DVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRND
                     KGQIPADVVPDPVDMPLEMADAAATAKEIKQMLLDAVPLSCNISKAMLPNYDHVTGKA
                     MLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYF
                     KCAPKYGIFAPLSKISKAKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMT
                     SKKDSASESTLSLPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSN
                     KKTMSKSPSLSSRASAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTN
                     FAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISS
                     NKQNHSYPGFRRSFSTTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSVKLH
                     EGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHG
                     VLVRPSRVTYRGINGSKLVDENC"
     exon            400..539
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..633
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..795
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..914
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1151
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1287
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1431
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1521
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1665
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1800
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1924
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..1989
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2062
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..4299
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4270..4275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /note="hexamer: AATAAA"
     polyA_site      4299
                     /gene="CLIP4"
                     /gene_synonym="RSNL2"
                     /note="major polyA site"
ORIGIN      
        1 gtccccaccg agtccccagc gcgtgcgcgg ggccgtggcc gaggcctgcg cgccgcccgg
       61 ccgcctgcac tgcgcgcgcg cccaccccgc gtgggaggca gcgggagggg cccggagagg
      121 tgtggagcgg cgcggcggga ggctccgtgg gcggccacgg gagacagcgc cggcgggagc
      181 gcgcctctcg gcctttcctc cgcgcccccg cgtccccagc cggccgctcc gagaggaccc
      241 ggaggaggca ggtggctttc tagaagatga ccatagagga ccttccagat tttccattag
      301 aaggaaatcc tttgtttgga agatacccat ttatattttc tgcttctgat accccagtta
      361 tcttttccat ttctgcagca ccaatgcctt cagactgtga attttctttc tttgatccta
      421 atgatgcatc atgccaggaa attctttttg atcccaaaac ttcagtttca gaattatttg
      481 ccattttgag acagtgggtt cctcaggtcc aacaaaacat tgacattatt ggaaatgaga
      541 ttcttaagag aggttgcaat gtgaatgata gagatggatt gacagatatg actcttttac
      601 attatacctg caaatctgga gctcatggta ttggtgatgt ggaaacagct gtaaaatttg
      661 caactcagct tattgacctg ggagcagaca ttagtttgcg gagtcgctgg acaaacatga
      721 atgctttgca ttatgctgct tattttgatg tccctgaact tataagagtg attttgaaaa
      781 catcgaaacc aaaagatgtg gatgccactt gcagtgattt taattttgga acagctttgc
      841 atattgcagc atacaacttg tgtgcaggtg ctgtgaagtg cctcttggag cagggagcaa
      901 atcctgcatt taggaatgac aaaggacaga tccctgctga tgttgttcca gacccagtag
      961 atatgccgtt agagatggct gacgccgcag ccactgctaa ggaaatcaag cagatgcttc
     1021 tagatgcggt gcctctgtca tgtaacatct caaaggccat gctcccaaat tatgatcatg
     1081 tcactggcaa ggcaatgctt acgtcacttg gcctgaagtt gggggatcgt gttgttattg
     1141 caggacagaa ggttggtaca ttaagatttt gtggaacaac tgaatttgca agtgggcagt
     1201 gggctggcat tgaactggat gaaccagaag gaaaaaataa tggaagtgtt ggaaaagtcc
     1261 agtactttaa atgtgccccc aagtatggta tttttgcacc tctttcaaag ataagtaaag
     1321 caaaaggtcg aaggaagaat ataacacaca ctccttctac aaaagctgct gtacctctca
     1381 tcaggtccca gaaaattgac gtagctcatg tgacgtcaaa agtaaatact ggattaatga
     1441 catcaaaaaa agatagtgct tctgagtcaa cactttcatt gcctcctggt gaagaactta
     1501 aaactgtgac agagaaagat gttgccctgc ttggatctgt cagcagctgc tcctctacat
     1561 cttctttgga acacagacag agctacccca agaaacagaa tgcaatcagc agtaacaaga
     1621 agacaatgag caaaagccct tccctttcat ccagagccag tgctggtttg aattcctcag
     1681 caacatctac agcaaataat agccgttgcg agggggaact ccgcctcgga gagagagtgt
     1741 tagtggtagg acagagactg ggcaccatta ggttctttgg gacaacaaac ttcgctccag
     1801 gatattggta tggtatagag cttgaaaaac cccatggcaa gaatgatggt tcagttggag
     1861 gtgtgcagta ttttagctgt tctccaagat atggaatatt tgctccccca tccagggtgc
     1921 aaagagtaac agattccctg gatacccttt cagaaatttc ttcaaataaa cagaaccatt
     1981 cttatcctgg ttttaggaga agttttagca caacttctgc ttcttcccaa aaggagatta
     2041 acagaagaaa tgctttttcc aaatcgaaag ctgctttgcg tcgcagttgg agcagcaccc
     2101 ccaccgcagg tggcattgaa gggagcgtga agctgcacga ggggtctcag gtcctgctca
     2161 cgagctccaa tgagatgggt actgttaggt atgtgggccc cactgacttt gcttcaggta
     2221 tctggcttgg acttgagctc cgaagcgcca agggaaaaaa tgatgggtca gtgggtgaca
     2281 agcgctattt cacctgtaag ccgaaccatg gagtcttagt tcgaccgagc agagtgacct
     2341 atcggggaat taatgggtca aaacttgtgg atgagaattg ttaagcttct aaaatattaa
     2401 ataagctcaa atatatatat ttggtgtaaa taaagagtcc atggtaaatg gtttacttta
     2461 tttagccata ttaaaatttt gaaaatatag ttatcttctt aaaaaccatt ataacaattc
     2521 agagagagtt ctttacaaag ccatgaatat gaactatggg gaatcatggt tcttttaaag
     2581 caattttcaa aataagtacc aattaaagct ttaggttcca agaagattct gggactcagg
     2641 aagaaaaagt gccatcaggt gaccagctgt tgcatttctt gcttattctg ttttgttttt
     2701 gcacatcata atggattttt cttagtgccc taattgtgaa gggtttctct agctttggtt
     2761 atgtgtaatg ttcacgtgac ctttttttgt caatcatttt tggaattttt ctttctttct
     2821 gtgctttatt actaataagt ccaatgagtg agtagtagct agatgactag tatgtagttt
     2881 tatattttgg taaaattatt tgccctttca gaaatgcctc atctaaagat acatgataat
     2941 tttggagttg gaaggggcct tagaggctct ccagctctgc ttcttgccca ttgccaaata
     3001 ctgaaatgga agcccgtctt acctggggtc actaactggt tggttaactg agctaagaat
     3061 agactgtggg tctcctcact tgtggcccag tgctctttct gctatacaaa atgtctaatc
     3121 tcagattttt cttctgctgc ttgactgctt catctggatg aactacaaaa aacccatgat
     3181 taaggtttat gaattcaagt aataattaga ttttttttgc acagacttac ttaacttcct
     3241 tattggatat gtttgtaaca cataaacaca aagcactttt caaacatgat gcacttttat
     3301 ctttgtgaat aatttactgt cctttcctcc tgggatatga gaaacatttt aaaaaacgta
     3361 tttaacagaa gagagcaaat aaagatatat caggaaggat gtattagtta tttacttaaa
     3421 tgtttataat atctggattt tttttgtttt gttactcata gaactggtgt tgtttgctgt
     3481 ttttatttct ctaattgttg cagagttctg cctgttacaa agctacagaa ctgtattgtt
     3541 tttattttcc ttcttgagca catgttaaca aactaagctt cacattagag tgatgtcata
     3601 atgtaaaatg tttgcattgt ggttaggtat tgaagtttat gtcctgtctg tgtaaagatt
     3661 catcttttat tgtaaatatt tagactttac cacagaaata ttggaacagt ttgctttata
     3721 agattaaaaa gcatccttca gaatggagct tgccttgtgc ttagaaataa tatgttgaac
     3781 tattttgcaa tatactattt taaatctaaa ttctgtcact tcgctgcctt tttaaaatag
     3841 tgtggtattt caaatattgc tagagctatt ttcctgaaat acatttgcaa aataaggctg
     3901 ctttgtaatc aaggaatatt tttattgatt gaaggaaatg actgtactgc gattcaaaag
     3961 taaacttatt ttattataca gattatttct taaaaactct atttatacct taacatgaaa
     4021 tccatgacca caccaaactt ggttattcat aatttttcct gttaaatata aaacactgta
     4081 agttaaaaac agtaatgcca acattgaatt tatttttgag gtcaaagaac cagttgttct
     4141 ctttatattt agatgaggat gattgagtcc atatactatg tatgtttaca tatactatac
     4201 atgcacatta ggtgttttca tttgtgtttt gcttatgaaa tgtcatttaa agttcacttc
     4261 ttgagcatca ataaaaaggg aagctgtgtg gttttggaa
//
