LOCUS       NM_015526               3350 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens CAP-Gly domain containing linker protein 3 (CLIP3),
            transcript variant 2, mRNA.
ACCESSION   NM_015526
VERSION     NM_015526.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3350)
  AUTHORS   Kang,H., Lee,S., Kim,K., Jeon,J., Kang,S.G., Youn,H., Kim,H.Y. and
            Youn,B.
  TITLE     Downregulated CLIP3 induces radioresistance by enhancing stemness
            and glycolytic flux in glioblastoma
  JOURNAL   J Exp Clin Cancer Res 40 (1), 282 (2021)
   PUBMED   34488821
  REMARK    GeneRIF: Downregulated CLIP3 induces radioresistance by enhancing
            stemness and glycolytic flux in glioblastoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3350)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3350)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3350)
  AUTHORS   Yang,X., Tao,Z., Zhu,Z., Liao,H., Zhao,Y. and Fan,H.
  TITLE     MicroRNA-593-3p regulates insulin-promoted glucose consumption by
            targeting Slc38a1 and CLIP3
  JOURNAL   J Mol Endocrinol 57 (4), 211-222 (2016)
   PUBMED   27613819
  REMARK    GeneRIF: this study indicates that inhibition of miRNA-593-3p by
            insulin promotes glucose metabolism through the regulation of
            Slc38a1 and CLIP3 expression, and provides a new insight into the
            role and mechanism of insulin-induced glycolysis.
REFERENCE   5  (bases 1 to 3350)
  AUTHORS   Lemonidis,K., Sanchez-Perez,M.C. and Chamberlain,L.H.
  TITLE     Identification of a Novel Sequence Motif Recognized by the Ankyrin
            Repeat Domain of zDHHC17/13 S-Acyltransferases
  JOURNAL   J Biol Chem 290 (36), 21939-21950 (2015)
   PUBMED   26198635
REFERENCE   6  (bases 1 to 3350)
  AUTHORS   Fujikura,D., Ito,M., Chiba,S., Harada,T., Perez,F., Reed,J.C.,
            Uede,T. and Miyazaki,T.
  TITLE     CLIPR-59 regulates TNF-alpha-induced apoptosis by controlling
            ubiquitination of RIP1
  JOURNAL   Cell Death Dis 3 (2), e264 (2012)
   PUBMED   22297296
  REMARK    GeneRIF: CLIPR-59 modulates ubiquitination of RIP1, resulting in
            the formation of Complex-II and thus promoting Caspase-8 activation
            to induce apoptosis by TNF-alpha.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3350)
  AUTHORS   Sorice,M., Matarrese,P., Manganelli,V., Tinari,A.,
            Giammarioli,A.M., Mattei,V., Misasi,R., Garofalo,T. and Malorni,W.
  TITLE     Role of GD3-CLIPR-59 association in lymphoblastoid T cell apoptosis
            triggered by CD95/Fas
  JOURNAL   PLoS One 5 (1), e8567 (2010)
   PUBMED   20052288
  REMARK    GeneRIF: CLIPR-59 may act as a typical chaperone, allowing a prompt
            interaction between tubulin and the raft component GD3 during cell
            apoptosis triggered by CD95/Fas
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3350)
  AUTHORS   Ding,J. and Du,K.
  TITLE     ClipR-59 interacts with Akt and regulates Akt cellular
            compartmentalization
  JOURNAL   Mol Cell Biol 29 (6), 1459-1471 (2009)
   PUBMED   19139280
REFERENCE   9  (bases 1 to 3350)
  AUTHORS   Lallemand-Breitenbach,V., Quesnoit,M., Braun,V., El Marjou,A.,
            Pous,C., Goud,B. and Perez,F.
  TITLE     CLIPR-59 is a lipid raft-associated protein containing a
            cytoskeleton-associated protein glycine-rich domain (CAP-Gly) that
            perturbs microtubule dynamics
  JOURNAL   J Biol Chem 279 (39), 41168-41178 (2004)
   PUBMED   15262990
  REMARK    GeneRIF: CLIPR-59 prevents microtubule-raft interactions
REFERENCE   10 (bases 1 to 3350)
  AUTHORS   Perez,F., Pernet-Gallay,K., Nizak,C., Goodson,H.V., Kreis,T.E. and
            Goud,B.
  TITLE     CLIPR-59, a new trans-Golgi/TGN cytoplasmic linker protein
            belonging to the CLIP-170 family
  JOURNAL   J Cell Biol 156 (4), 631-642 (2002)
   PUBMED   11854307
  REMARK    GeneRIF: play an important role in membrane-microtubule
            interactions.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ427922.1 and AL117468.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015526.2.
            
            Summary: This gene encodes a member of the cytoplasmic linker
            protein 170 family. Members of this protein family contain a
            cytoskeleton-associated protein glycine-rich domain and mediate the
            interaction of microtubules with cellular organelles. The encoded
            protein plays a role in T cell apoptosis by facilitating the
            association of tubulin and the lipid raft ganglioside GD3. The
            encoded protein also functions as a scaffold protein mediating
            membrane localization of phosphorylated protein kinase B.
            Alternatively spliced transcript variants have been observed for
            this gene. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094738.1, SRR3476690.913460.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360535.9/ ENSP00000353732.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3349              AJ427922.1         1-3349
            3350-3350           AL117468.1         1984-1984
FEATURES             Location/Qualifiers
     source          1..3350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..3350
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /note="CAP-Gly domain containing linker protein 3"
                     /db_xref="GeneID:25999"
                     /db_xref="HGNC:HGNC:24314"
                     /db_xref="MIM:607382"
     exon            1..150
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..374
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1852
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /note="restin-like 1; CLIP-170-related 59 kDa protein;
                     cytoplasmic linker protein 170-related 59 kDa protein"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 3"
                     /protein_id="NP_056341.1"
                     /db_xref="CCDS:CCDS12486.1"
                     /db_xref="GeneID:25999"
                     /db_xref="HGNC:HGNC:24314"
                     /db_xref="MIM:607382"
                     /translation="MTKTDPAPMAPPPRGEEEEEEEEDEPVPEAPSPTQERRQKPVVH
                     PSAPAPLPKDYAFTFFDPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIGNE
                     ILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWT
                     NMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLL
                     EHGANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKELRTLLEEAVPLSCALPKVT
                     LPNYDNVPGNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGK
                     NDGSVGGVRYFICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDFSRVTGKGRRE
                     HKGKKKTPSSPSLGSLQQRDGAKAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIEL
                     DQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSVGAKKVHQVTMTQ
                     PKRTFTTVRTPKDIASENSISRLLFCCWFPWMLRAEMQS"
     exon            375..514
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..608
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..770
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..889
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1126
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1262
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1391
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1535
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1659
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1724
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1797
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..3350
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2257..2262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /note="hexamer: AATAAA"
     polyA_site      2281
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
     regulatory      3330..3335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /note="hexamer: AATAAA"
     polyA_site      3350
                     /gene="CLIP3"
                     /gene_synonym="CLIPR-59; CLIPR59; RSNL1"
                     /note="major polyA site"
ORIGIN      
        1 ctctccgccc ccaccccctg tcggcgtctg ggcctcgtcc ccttctctct gtctcccttg
       61 cctcccccat cacgtcccct gacaccgaca ccccattgct cccacagtct ccccagtctc
      121 cactttggtc cccagcgctg tctgcccgag gatttgcctg aaggctgccc ccaactctgc
      181 acccgccccc cgagggccac cgaggaccat gactaagaca gatcctgccc cgatggcccc
      241 gccaccccga ggagaggagg aagaagagga ggaggaggat gaacccgtcc ccgaggcccc
      301 cagccccacc caggagcgcc ggcagaagcc tgttgtgcac ccctcggcac ctgcccccct
      361 ccctaaggac tacgctttca ccttcttcga tcccaatgac ccggcgtgcc aggagatcct
      421 gtttgaccct cagaccacca tccccgagct gtttgccatt gtgcgccagt gggtgcccca
      481 agtccagcac aagatagacg tcatcggcaa tgagattctg cgccgaggct gccatgtgaa
      541 cgatcgtgac gggctgaccg acatgacact gctccactat gcgtgcaaag ctggggccca
      601 cggagtcggg gaccccgcgg cagccgtgcg cctctcgcag cagctgctgg cgctgggcgc
      661 agatgtgacg ctgcgcagcc gctggaccaa catgaacgcg cttcactacg cggcctattt
      721 tgatgtgccc gacctcgtgc gtgtgctgct gaagggtgcg aggccgcgag tggtgaactc
      781 cacgtgcagt gacttcaacc acggctcagc cctgcacatc gctgcttcca gcctgtgcct
      841 gggcgccgcc aaatgtttgc tggagcacgg cgccaaccct gcgctgagga atcgaaaagg
      901 acaggtgccg gcggaggtgg tcccagatcc tatggacatg tccctggaca aggcagaggc
      961 ggcactggtg gccaaggagc tgcggacgct tctggaagag gcagtgccac tatcttgcgc
     1021 cctccccaag gtcacgctac ccaactatga caacgtccca ggcaatctca tgcttagcgc
     1081 actgggcttg cgcctgggag accgcgtgct gctggatggc cagaagacgg gcacactgcg
     1141 gttctgtggg accacggagt ttgccagcgg ccagtgggtg ggcgtggagc tggacgaacc
     1201 tgagggcaag aacgatggca gcgttggggg cgttcggtac ttcatctgcc ctcccaagca
     1261 gggtctcttt gcctccgtgt ccaagatctc caaggcagtg gacgcacccc cctcctctgt
     1321 cacctccaca ccccggaccc cccggatgga cttctcccgt gtcaccggca aaggccgcag
     1381 ggaacacaaa ggcaagaaga agaccccatc atccccatct ctgggcagct tgcagcagcg
     1441 tgacggggcc aaggctgagg ttggagacca ggtccttgtc gcgggccaga agcaggggat
     1501 cgtgcgcttc tacgggaaga cagactttgc cccaggttac tggtatggca ttgagctgga
     1561 ccagcccaca ggcaagcatg atggctctgt cttcggtgtc cggtacttca cttgcccccc
     1621 gaggcatggg gtcttcgcac cagcatcccg tattcagagg attggcggat ccactgattc
     1681 ccccggggac agcgttggag ccaaaaaagt gcatcaagtg acaatgacgc agcccaaacg
     1741 caccttcacc acagtccgga ccccaaagga cattgcatca gagaactcca tttccaggtt
     1801 gctgttctgc tgctggttcc cctggatgct gagggcggag atgcagtctt agaggccctg
     1861 gacacctgac aaagagacag agtccccact agcatctcct gacacccgag gagccctgag
     1921 tcaccctgag atagagattc ccagtaacac atccagagta gagacccctg ttagccagcc
     1981 ctcgatcatt gaggccccat tattaacaga tactcccata ataaccccca aatacagacc
     2041 ccatgtcacc cagaaagaga ttccctgagt agcaccttca ggctagtccc tatccccaac
     2101 ccctcagagc agattcccag attaacagat ttccatatca ccccaaatga tggtgaccct
     2161 ctccacataa tgcattacaa cagaacattc ttgaatcacc caaccctgga tcagaaacct
     2221 ccccattaac aaacactgcc ccttaagtcc tcttgaaata aacataggtc acacccccaa
     2281 agcaaaagag taacagacat tcatgtcatt gttccccatt taacatcagt cctctcaaga
     2341 tgtcgtgacc ccatggtcac cctgaagccc ttagattcca acccctcaat cagagacttc
     2401 cttcattaac aaagaccctt gttcttatcc ctcaagaaga aacccaccat aaccagccca
     2461 ctgtcacccc taatttacag acaccaaaac agtcctggaa gtgctaatta caggaccccc
     2521 caagtcttcc taccctctgc accctcaaga aacccccagt gccttgtatg aagcccaccc
     2581 cacatggccc acagctcctg tgctggccag actcccagaa aattctctat tttttaagta
     2641 acgacttccc cctttggggg accccaaaat ttggaggccc cattctagga ctctggggat
     2701 cccaaaccct agagtacaca cgtcccaaac tcccctgtgc cctcaagtcc tacagcccct
     2761 agaagacccc aatgccgtaa ctcctaggac ccccaaatca tggaatccca aatccccagg
     2821 gaatcccaaa tttgaaaatc caatcccaag tccccaggaa acccaatcat gaggtccttg
     2881 tgcctggtat ggaggagact gcagtcagga tatgcattcc aggctcccag acacctcaag
     2941 ccctattcac aggcaccagg aaaccccaca caggaattcc catccctgga aactggagaa
     3001 tttcaatgcc ccgagtccat gggtttcaag acaccaaatt ccaagagccc cagccctaag
     3061 ggaaccccaa atcctaaagc ctccatctct aataaatgga aggccccaag gccctgaggg
     3121 gatctcaaat cctggaaccc cgatttcaat ctacgttcta gtcactggcc tcaaaggacc
     3181 ccacagcacc tgggccagac caacagctcg agggagaacc tgaaggccca gggggtccag
     3241 ggcggacctg gggccccgac caccaaggac agctcacgac tgccccttca ctgcatgtcc
     3301 ccaaactcag catgactcct gtcctcttca ataaagacgt ttctatggcc
//
