LOCUS       NM_032421               5518 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens CAP-Gly domain containing linker protein 2 (CLIP2),
            transcript variant 2, mRNA.
ACCESSION   NM_032421 NM_032719
VERSION     NM_032421.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5518)
  AUTHORS   Chapman,N., Greenwald,J., Suddock,J., Xu,D., Markowitz,A.,
            Humphrey,M., Cotter,J.A., Krieger,M.D., Hawes,D. and Ji,J.
  TITLE     Clinical, pathologic, and genomic characteristics of two pediatric
            glioneuronal tumors with a CLIP2::MET fusion
  JOURNAL   Acta Neuropathol Commun 12 (1), 63 (2024)
   PUBMED   38650040
  REMARK    GeneRIF: Clinical, pathologic, and genomic characteristics of two
            pediatric glioneuronal tumors with a CLIP2::MET fusion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5518)
  AUTHORS   Huang,Z., Xu,Z., Xu,R., Huang,L., Xu,X. and Lai,X.
  TITLE     Whole exome sequencing identifies three novel gene mutations in
            patients with the triad of diabetic ketoacidosis,
            hypertriglyceridemia, and acute pancreatitis
  JOURNAL   J Diabetes 13 (3), 200-210 (2021)
   PUBMED   32734598
  REMARK    GeneRIF: Whole exome sequencing identifies three novel gene
            mutations in patients with the triad of diabetic ketoacidosis,
            hypertriglyceridemia, and acute pancreatitis.
REFERENCE   3  (bases 1 to 5518)
  AUTHORS   Wu,T., Zhang,Q., Wu,S., Hu,W., Zhou,T., Li,K., Liu,D., Gu,H.F.,
            Zheng,H., Zhu,Z., Li,L. and Yang,G.
  TITLE     CILP-2 is a novel secreted protein and associated with insulin
            resistance
  JOURNAL   J Mol Cell Biol 11 (12), 1083-1094 (2019)
   PUBMED   30896018
  REMARK    GeneRIF: CILP-2 is a novel secreted protein and demonstrated that
            circulating CILP-2 levels were elevated in both IGT and nT2DM
            subjects and associated with IR. CILP-2 overexpression promoted
            hepatic IR in HFD-fed mice, increased PEPCK expression and
            suppressed insulin signaling in hepatocytes.
REFERENCE   4  (bases 1 to 5518)
  AUTHORS   Kaiser,J.C., Meckbach,R., Eidemuller,M., Selmansberger,M.,
            Unger,K., Shpak,V., Blettner,M., Zitzelsberger,H. and Jacob,P.
  TITLE     Integration of a radiation biomarker into modeling of thyroid
            carcinogenesis and post-Chernobyl risk assessment
  JOURNAL   Carcinogenesis 37 (12), 1152-1160 (2016)
   PUBMED   27729373
  REMARK    GeneRIF: Cross checking with epidemiological estimates and model
            validation suggests that CLIP2 is a marker of high precision. CLIP2
            leaves an imprint in the epidemiological incidence data which is
            typical for a driver gene.
REFERENCE   5  (bases 1 to 5518)
  AUTHORS   Selmansberger,M., Kaiser,J.C., Hess,J., Guthlin,D., Likhtarev,I.,
            Shpak,V., Tronko,M., Brenner,A., Abend,M., Blettner,M., Unger,K.,
            Jacob,P. and Zitzelsberger,H.
  TITLE     Dose-dependent expression of CLIP2 in post-Chernobyl papillary
            thyroid carcinomas
  JOURNAL   Carcinogenesis 36 (7), 748-756 (2015)
   PUBMED   25957251
  REMARK    GeneRIF: A clear radiation dose-response relationship for the CLIP2
            marker expression in post-Chernobyl papillary thyroid carcinomas
REFERENCE   6  (bases 1 to 5518)
  AUTHORS   Hoogenraad,C.C., Koekkoek,B., Akhmanova,A., Krugers,H.,
            Dortland,B., Miedema,M., van Alphen,A., Kistler,W.M., Jaegle,M.,
            Koutsourakis,M., Van Camp,N., Verhoye,M., van der Linden,A.,
            Kaverina,I., Grosveld,F., De Zeeuw,C.I. and Galjart,N.
  TITLE     Targeted mutation of Cyln2 in the Williams syndrome critical region
            links CLIP-115 haploinsufficiency to neurodevelopmental
            abnormalities in mice
  JOURNAL   Nat Genet 32 (1), 116-127 (2002)
   PUBMED   12195424
  REMARK    Erratum:[Nat Genet 2002 Oct;32(2):331]
REFERENCE   7  (bases 1 to 5518)
  AUTHORS   Akhmanova,A., Hoogenraad,C.C., Drabek,K., Stepanova,T.,
            Dortland,B., Verkerk,T., Vermeulen,W., Burgering,B.M., De
            Zeeuw,C.I., Grosveld,F. and Galjart,N.
  TITLE     Clasps are CLIP-115 and -170 associating proteins involved in the
            regional regulation of microtubule dynamics in motile fibroblasts
  JOURNAL   Cell 104 (6), 923-935 (2001)
   PUBMED   11290329
REFERENCE   8  (bases 1 to 5518)
  AUTHORS   Hoogenraad,C.C., Eussen,B.H., Langeveld,A., van Haperen,R.,
            Winterberg,S., Wouters,C.H., Grosveld,F., De Zeeuw,C.I. and
            Galjart,N.
  TITLE     The murine CYLN2 gene: genomic organization, chromosome
            localization, and comparison to the human gene that is located
            within the 7q11.23 Williams syndrome critical region
  JOURNAL   Genomics 53 (3), 348-358 (1998)
   PUBMED   9799601
REFERENCE   9  (bases 1 to 5518)
  AUTHORS   Ohara,O., Nagase,T., Ishikawa,K., Nakajima,D., Ohira,M., Seki,N.
            and Nomura,N.
  TITLE     Construction and characterization of human brain cDNA libraries
            suitable for analysis of cDNA clones encoding relatively large
            proteins
  JOURNAL   DNA Res 4 (1), 53-59 (1997)
   PUBMED   9179496
REFERENCE   10 (bases 1 to 5518)
  AUTHORS   Osborne,L.R., Martindale,D., Scherer,S.W., Shi,X.M., Huizenga,J.,
            Heng,H.H., Costa,T., Pober,B., Lew,L., Brinkman,J., Rommens,J.,
            Koop,B. and Tsui,L.C.
  TITLE     Identification of genes from a 500-kb region at 7q11.23 that is
            commonly deleted in Williams syndrome patients
  JOURNAL   Genomics 36 (2), 328-336 (1996)
   PUBMED   8812460
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005015.2.
            
            On Jun 2, 2019 this sequence version replaced NM_032421.2.
            
            Summary: The protein encoded by this gene belongs to the family of
            cytoplasmic linker proteins, which have been proposed to mediate
            the interaction between specific membranous organelles and
            microtubules. This protein was found to associate with both
            microtubules and an organelle called the dendritic lamellar body.
            This gene is hemizygously deleted in Williams syndrome, a
            multisystem developmental disorder caused by the deletion of
            contiguous genes at 7q11.23. Alternative splicing of this gene
            generates 2 transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an exon within the
            coding region, as compared to variant 1. Isoform 2 encoded by this
            variant is thus missing an internal aa fragment as compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006629.2, BC150332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               AC005015.2         217453-217780       c
            329-516             AC005015.2         189520-189707       c
            517-1073            AC005015.2         168183-168739       c
            1074-1198           AC005015.2         153183-153307       c
            1199-1412           AC005015.2         150564-150777       c
            1413-1610           AC005015.2         149710-149907       c
            1611-1714           AC005015.2         146909-147012       c
            1715-1775           AC005015.2         142872-142932       c
            1776-2711           AC005015.2         130365-131300       c
            2712-2769           AC005015.2         126324-126381       c
            2770-2853           AC005015.2         120583-120666       c
            2854-3010           AC005015.2         117928-118084       c
            3011-3170           AC005015.2         109954-110113       c
            3171-3356           AC005015.2         106632-106817       c
            3357-3419           AC005015.2         105620-105682       c
            3420-5518           AC005015.2         101252-103350       c
FEATURES             Location/Qualifiers
     source          1..5518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..5518
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /note="CAP-Gly domain containing linker protein 2"
                     /db_xref="GeneID:7461"
                     /db_xref="HGNC:HGNC:2586"
                     /db_xref="MIM:603432"
     exon            1..328
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..516
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..3431
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cytoplasmic linker 2; Williams-Beuren syndrome chromosome
                     region 3; Williams-Beuren syndrome chromosome region 4;
                     cytoplasmic linker protein 2; cytoplasmic linker protein
                     115; williams-Beuren syndrome chromosomal region 3
                     protein; williams-Beuren syndrome chromosomal region 4
                     protein; testicular tissue protein Li 40"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 2
                     isoform 2"
                     /protein_id="NP_115797.2"
                     /db_xref="CCDS:CCDS5570.1"
                     /db_xref="GeneID:7461"
                     /db_xref="HGNC:HGNC:2586"
                     /db_xref="MIM:603432"
                     /translation="MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPL
                     HKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQ
                     FAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHS
                     VESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKD
                     LRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKF
                     GLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRP
                     SRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEV
                     EKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVE
                     EESITKGDLELTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEIL
                     RLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQ
                     ATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKME
                     HQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLE
                     LQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQ
                     GKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLN
                     KRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDA
                     SGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDD
                     IRGLREKLTGLDKEKSLSDQRRYSLIDRSSAPELLRLQHQLMSTEDALRDALDQAQQV
                     EKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDKH"
     exon            517..1073
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1198
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1412
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1610
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1714
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1775
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..2711
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2769
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2853
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..3010
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3170
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3356
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3419
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..5518
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5494..5499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /note="hexamer: AATAAA"
     polyA_site      5518
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /note="major polyA site"
ORIGIN      
        1 ccttttgttc cctcccggag ccgggccgct ggctccgctg gctccgctgg ctccgcgggc
       61 gctcagctcg gctcggccgc ggggcgcgca ggcggctgct gggcggcctc ggtgcgcgcc
      121 tcccgccttc ccagagacgt ggcgcgaggc ccgggccctg agcacctatc gcggggatcc
      181 ccggcgccag gagggggtgc agccggtggg cagcgccgcg cagggagggg ccgcagcatc
      241 ctcgcccccc agcgcgcccg ggcccgagag gaggaggccg gggctctccg ggcctcccgc
      301 cgcttagcct gatgctggaa ggacgaaggt gagtgaagat ggcagagagg acgtgaccag
      361 cactcaccct tgtccacctg cccagtggca ccgccatgca gaagcccagc ggcctgaagc
      421 cccccggccg tggggggaag cactccagcc ccatgggccg gacatctact gggtcagctt
      481 catcctcggc ggcggtggcc gctagctcca aggaaggctc cccactgcac aaacagtcat
      541 ctggaccctc ctcctccccg gccgcagctg ctgcccccga gaagccgggc cccaaggcgg
      601 cggaagtggg ggatgacttc ctgggggact ttgtggtggg cgagcgggtg tgggtgaacg
      661 gcgtgaagcc aggcgtggtg cagtatctgg gagagacgca gttcgcaccg ggccagtggg
      721 ctggcgtggt gctggacgac ccggtgggca agaatgatgg cgcggtgggc ggcgtgcgct
      781 acttcgagtg cccggccctc cagggtatct tcacgcggcc ctccaagctg acccggcagc
      841 ccacggccga gggctcgggg agtgatgccc actccgtgga gtcgctgact gcccagaacc
      901 tgtcattgca ttcgggcacg gccacgcccc cgctgaccag ccgcgtcatc cccctgcggg
      961 agagcgtcct caacagctcc gtgaagactg gcaacgagtc gggatccaac ctctcagaca
     1021 gcggctctgt gaagcggggc gaaaaggacc tgcgcctggg ggaccgcgtg ctggttggcg
     1081 ggacgaagac tggcgtggtg cggtacgtgg gggagacaga ctttgccaag ggcgagtggt
     1141 gtggcgtgga gctggacgag ccccttggga agaatgatgg ggcggtggcg ggcaccaggt
     1201 acttccagtg cccacccaag tttggtctct tcgcgcccat ccacaaagtg atccgtatcg
     1261 gcttcccatc taccagccca gccaaggcca agaagaccaa gcgtatggcc atgggtgtgt
     1321 cagcactgac ccacagtccc agcagttcct ccatcagctc cgtcagctct gtggcctcct
     1381 ccgtgggggg tcggcccagc cgcagtggcc tgctcacgga gacctcttca cgctacgccc
     1441 gcaagatctc gggcaccacg gccttgcagg aggcactgaa ggagaagcag cagcacattg
     1501 agcagctgct ggctgaacga gacctggaac gggctgaggt ggccaaggcc acaagccaca
     1561 tctgcgaggt ggagaaggag attgccctgc tcaaggcaca gcatgagcag tatgttgcag
     1621 aagccgagga gaagctgcag cgagcccggc tgctcgtgga gagcgtgcgg aaagagaagg
     1681 tggacctgtc caaccagctg gaggaggaga ggaggaaggt ggaggatctg cagttccgcg
     1741 tggaggagga gtccatcacc aagggagacc tggagctgac cacagtggcc gagaagtcgc
     1801 gcgtgctgca gctggaggag gagctcaccc tgcgccgagg tgaaatcgag gagctccagc
     1861 agtgcctgtt gcactcgggt cccccacctc cggaccaccc agacgccgcc gagatcctgc
     1921 ggctacggga gcggctgctc tcggccagca aggaacacca gagggagagt ggggtgctgc
     1981 gggataaata cgagaaggcc ctgaaggcct accaggcgga ggtggacaag ctccgcgcgg
     2041 ccaacgagaa gtacgcacag gaggtggcgg gcctgaagga caaggttcag caggccacca
     2101 gcgagaacat ggggctaatg gacaactgga aatccaagct ggactcgctg gcctcggacc
     2161 accagaagtc cctggaggac ctcaaagcca ccctgaactc gggcccaggc gcccagcaga
     2221 aggagatcgg cgagctgaag gcagtgatgg agggcatcaa gatggagcac cagctggagc
     2281 tgggtaactt gcaggccaag catgacctgg agaccgccat gcacgtgaag gagaaggagg
     2341 ccctgcgaga gaagctgcag gaggcccagg aggagctggc tgggctgcag cggcactggc
     2401 gggcccagct ggaggtgcaa gccagccagc accggctgga gctgcaggag gcccaggacc
     2461 agcgccggga tgccgagctg cgtgtgcacg agctggaaaa actggacgtg gagtaccggg
     2521 gccaggcgca ggctatcgag ttcctcaagg agcagatctc gctggccgag aagaagatgt
     2581 tggactacga gcggctgcag cgggcagaag cccagggcaa acaggaggtc gagagtttgc
     2641 gggagaagct cctggtggct gagaacagac tccaggcggt cgaggccctg tgctcctccc
     2701 agcacaccca catgattgag tcgaatgaca tttcagagga gacgatcagg acgaaggaaa
     2761 ctgtggaggg cctgcaggac aagctgaaca agagggacaa agaggtgaca gccttgacct
     2821 cccagaccga gatgctcagg gcccaagtaa gtgcgctgga gagcaagtgt aagtcaggcg
     2881 agaagaaggt ggacgccctc ctgaaggaga agcggcgcct ggaggcagag ctggagaccg
     2941 tgtcccggaa gacccatgac gcctcgggcc agctagtcct catcagccag gagctgctgc
     3001 ggaaggagcg gagcctgaac gaactgcggg tgttgctgct ggaggccaat cgtcactccc
     3061 cagggccgga gagggacctg agccgtgagg tacacaaggc tgagtggcgg atcaaggagc
     3121 agaaactcaa ggatgacatc cggggcctgc gtgaaaagct gaccgggctg gacaaagaga
     3181 aatccctgtc ggatcagagg cgctactccc tcatcgaccg gtcctcggcg cccgagcttc
     3241 tgcggctgca gcaccagctg atgagcacgg aggacgccct gcgggatgcg ctggaccagg
     3301 ctcagcaggt ggagaagctg atggaggcca tgaggagctg ccctgacaag gcccagacca
     3361 tcggcaattc cggttctgca aacggcatcc accagcagga caaagctcag aaacaagagg
     3421 acaagcactg atcctgaggg gatactgtgg agcagcccag tccacaccag agccccacgc
     3481 ggctgcccgg cagtacctcc tccaggcagg agccgggact gtcactttgg agacaaaaca
     3541 gtgtttgtaa caataacgta ctcaccgccg cggacaatcc cccaccccga tccctcgcca
     3601 gaccaggacg cttcctcaag cccagccttc tacagagagt gtgaacggta cagccccggc
     3661 ctgacccggg gaccttcagc ctggacaccc ggcagcttct ggagtttgtc agtggaggca
     3721 gaggggatcc ggccaggccc ctctgtccag aaggagctgc cctgaggacc atcttagcgg
     3781 ccctgtcctc tttttccgcc cattctccct cgggtctccc cagaggggcc ggcgggggct
     3841 ggggaggggg taagtttatc catgcagaca ccaaggggga gcatccagtc tttaagagcc
     3901 aagtgggggc cccttttccg aagccacttc caggccaagg cagtcgccag ggcttcttgt
     3961 ccccaccttc tgaaccttct tcaaacagta gtacaagctc ccctcagcca gcctgcctgc
     4021 ccagcgaggc ccccaggttc aaggtgttgg cgggggcgga gggcagggga acgggatcct
     4081 tctcccgctg cccaccaaca ccaacacaca cacacctcta agctgctggc cgaagatgtc
     4141 accaaggcca aagacacagt attatgaagg tttggaaacc cctctcctca cctcccaccg
     4201 tgaccttggg caaaccctgg ctcggagccc agggcagagg cagctcagag tggaggctct
     4261 aggcaggttt gacaaaggtc agtaatacgg tttcccctgg ggttgaccag atgttccaaa
     4321 atatctgcat ccacctggag atgcagctaa gtgggtcctt atgtacacac cacgttcaca
     4381 cacacacaga gggaccacgt gtgcacgcat gaccgtgtgg gtggcggcgt ttgctgtgaa
     4441 ccacgctcag gccacacaga gacacatact tggtttctgg gactgagacc caggcctggc
     4501 aggaccgtgc ctacagatac tgcaaacgtt cctacagcct agaggtgcgt atacacaccc
     4561 aagtacacgc agccaggcat tcaggggtgt gtttgccaca tggagcatcc cttcctggtc
     4621 ttgccaggca cctgcacaga gcgtctccag ccccatctcc taacgggggc tgggggtaag
     4681 agaaatctaa ctgcgctccc ccaacccctc gccctgccat cttcccctca agcctgctaa
     4741 gttatcccag gcctgtgcgt ggtggaaaaa gccagccttg gccctgcagc ctccacctcg
     4801 ccgctggggg accaacaggt tgcttacagc tttgcacccc ggcatcagca caggggtccc
     4861 tgccccaccc tccggcagct cagggagtgt tttcctgtga ggcctccccc atcagtggac
     4921 cagagggaga agcccgatgc cccatcccgg ctttcccgta acgcacagga cacgtgtgca
     4981 attcatagga acggcccaga tcgccctcat gagtgccacc tggtacaggt aggtggcgct
     5041 cacgttcctg cccaaatgca gcccatcggg gagtcacagt cagtcccccc ggcccccctc
     5101 ccagtccctg ttggctttcg gtagctctcg catgcagttc tattaacagc cgtctagaag
     5161 cgatgcttta gtggcctaac ccagggtcaa atacagctct ttctagcaaa atcaggcagc
     5221 tctgccccat cggtaggggc accgattagt ctactaacag ccagaggtcc atctagcagg
     5281 gtgccgggag gagctgagcc cccggaggtg ggctcctggt gacgggtgtc caagaagcgg
     5341 tttccttggg agcttctgcc tccgtgggcc tctcagcccg ccccgtgtgg ccgcccgggt
     5401 gtggctcagc catgtcccct ccccaggtcc ttcattcacc cctcccctcc ccacagtgga
     5461 attgttgaag tgtggcgagt ctgtgctcgg gacaataaag cttgtgacag gtccagga
//
