LOCUS       NM_003388               5623 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens CAP-Gly domain containing linker protein 2 (CLIP2),
            transcript variant 1, mRNA.
ACCESSION   NM_003388
VERSION     NM_003388.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5623)
  AUTHORS   Chapman,N., Greenwald,J., Suddock,J., Xu,D., Markowitz,A.,
            Humphrey,M., Cotter,J.A., Krieger,M.D., Hawes,D. and Ji,J.
  TITLE     Clinical, pathologic, and genomic characteristics of two pediatric
            glioneuronal tumors with a CLIP2::MET fusion
  JOURNAL   Acta Neuropathol Commun 12 (1), 63 (2024)
   PUBMED   38650040
  REMARK    GeneRIF: Clinical, pathologic, and genomic characteristics of two
            pediatric glioneuronal tumors with a CLIP2::MET fusion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5623)
  AUTHORS   Huang,Z., Xu,Z., Xu,R., Huang,L., Xu,X. and Lai,X.
  TITLE     Whole exome sequencing identifies three novel gene mutations in
            patients with the triad of diabetic ketoacidosis,
            hypertriglyceridemia, and acute pancreatitis
  JOURNAL   J Diabetes 13 (3), 200-210 (2021)
   PUBMED   32734598
  REMARK    GeneRIF: Whole exome sequencing identifies three novel gene
            mutations in patients with the triad of diabetic ketoacidosis,
            hypertriglyceridemia, and acute pancreatitis.
REFERENCE   3  (bases 1 to 5623)
  AUTHORS   Wu,T., Zhang,Q., Wu,S., Hu,W., Zhou,T., Li,K., Liu,D., Gu,H.F.,
            Zheng,H., Zhu,Z., Li,L. and Yang,G.
  TITLE     CILP-2 is a novel secreted protein and associated with insulin
            resistance
  JOURNAL   J Mol Cell Biol 11 (12), 1083-1094 (2019)
   PUBMED   30896018
  REMARK    GeneRIF: CILP-2 is a novel secreted protein and demonstrated that
            circulating CILP-2 levels were elevated in both IGT and nT2DM
            subjects and associated with IR. CILP-2 overexpression promoted
            hepatic IR in HFD-fed mice, increased PEPCK expression and
            suppressed insulin signaling in hepatocytes.
REFERENCE   4  (bases 1 to 5623)
  AUTHORS   Kaiser,J.C., Meckbach,R., Eidemuller,M., Selmansberger,M.,
            Unger,K., Shpak,V., Blettner,M., Zitzelsberger,H. and Jacob,P.
  TITLE     Integration of a radiation biomarker into modeling of thyroid
            carcinogenesis and post-Chernobyl risk assessment
  JOURNAL   Carcinogenesis 37 (12), 1152-1160 (2016)
   PUBMED   27729373
  REMARK    GeneRIF: Cross checking with epidemiological estimates and model
            validation suggests that CLIP2 is a marker of high precision. CLIP2
            leaves an imprint in the epidemiological incidence data which is
            typical for a driver gene.
REFERENCE   5  (bases 1 to 5623)
  AUTHORS   Selmansberger,M., Kaiser,J.C., Hess,J., Guthlin,D., Likhtarev,I.,
            Shpak,V., Tronko,M., Brenner,A., Abend,M., Blettner,M., Unger,K.,
            Jacob,P. and Zitzelsberger,H.
  TITLE     Dose-dependent expression of CLIP2 in post-Chernobyl papillary
            thyroid carcinomas
  JOURNAL   Carcinogenesis 36 (7), 748-756 (2015)
   PUBMED   25957251
  REMARK    GeneRIF: A clear radiation dose-response relationship for the CLIP2
            marker expression in post-Chernobyl papillary thyroid carcinomas
REFERENCE   6  (bases 1 to 5623)
  AUTHORS   Hoogenraad,C.C., Koekkoek,B., Akhmanova,A., Krugers,H.,
            Dortland,B., Miedema,M., van Alphen,A., Kistler,W.M., Jaegle,M.,
            Koutsourakis,M., Van Camp,N., Verhoye,M., van der Linden,A.,
            Kaverina,I., Grosveld,F., De Zeeuw,C.I. and Galjart,N.
  TITLE     Targeted mutation of Cyln2 in the Williams syndrome critical region
            links CLIP-115 haploinsufficiency to neurodevelopmental
            abnormalities in mice
  JOURNAL   Nat Genet 32 (1), 116-127 (2002)
   PUBMED   12195424
  REMARK    Erratum:[Nat Genet 2002 Oct;32(2):331]
REFERENCE   7  (bases 1 to 5623)
  AUTHORS   Akhmanova,A., Hoogenraad,C.C., Drabek,K., Stepanova,T.,
            Dortland,B., Verkerk,T., Vermeulen,W., Burgering,B.M., De
            Zeeuw,C.I., Grosveld,F. and Galjart,N.
  TITLE     Clasps are CLIP-115 and -170 associating proteins involved in the
            regional regulation of microtubule dynamics in motile fibroblasts
  JOURNAL   Cell 104 (6), 923-935 (2001)
   PUBMED   11290329
REFERENCE   8  (bases 1 to 5623)
  AUTHORS   Hoogenraad,C.C., Eussen,B.H., Langeveld,A., van Haperen,R.,
            Winterberg,S., Wouters,C.H., Grosveld,F., De Zeeuw,C.I. and
            Galjart,N.
  TITLE     The murine CYLN2 gene: genomic organization, chromosome
            localization, and comparison to the human gene that is located
            within the 7q11.23 Williams syndrome critical region
  JOURNAL   Genomics 53 (3), 348-358 (1998)
   PUBMED   9799601
REFERENCE   9  (bases 1 to 5623)
  AUTHORS   Ohara,O., Nagase,T., Ishikawa,K., Nakajima,D., Ohira,M., Seki,N.
            and Nomura,N.
  TITLE     Construction and characterization of human brain cDNA libraries
            suitable for analysis of cDNA clones encoding relatively large
            proteins
  JOURNAL   DNA Res 4 (1), 53-59 (1997)
   PUBMED   9179496
REFERENCE   10 (bases 1 to 5623)
  AUTHORS   Osborne,L.R., Martindale,D., Scherer,S.W., Shi,X.M., Huizenga,J.,
            Heng,H.H., Costa,T., Pober,B., Lew,L., Brinkman,J., Rommens,J.,
            Koop,B. and Tsui,L.C.
  TITLE     Identification of genes from a 500-kb region at 7q11.23 that is
            commonly deleted in Williams syndrome patients
  JOURNAL   Genomics 36 (2), 328-336 (1996)
   PUBMED   8812460
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005015.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 1, 2019 this sequence version replaced NM_003388.4.
            
            Summary: The protein encoded by this gene belongs to the family of
            cytoplasmic linker proteins, which have been proposed to mediate
            the interaction between specific membranous organelles and
            microtubules. This protein was found to associate with both
            microtubules and an organelle called the dendritic lamellar body.
            This gene is hemizygously deleted in Williams syndrome, a
            multisystem developmental disorder caused by the deletion of
            contiguous genes at 7q11.23. Alternative splicing of this gene
            generates 2 transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2375446.1,
                                           SRR14038196.2287708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223398.11/ ENSP00000223398.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               AC005015.2         217453-217780       c
            329-516             AC005015.2         189520-189707       c
            517-1073            AC005015.2         168183-168739       c
            1074-1198           AC005015.2         153183-153307       c
            1199-1412           AC005015.2         150564-150777       c
            1413-1610           AC005015.2         149710-149907       c
            1611-1714           AC005015.2         146909-147012       c
            1715-1775           AC005015.2         142872-142932       c
            1776-1880           AC005015.2         134151-134255       c
            1881-2816           AC005015.2         130365-131300       c
            2817-2874           AC005015.2         126324-126381       c
            2875-2958           AC005015.2         120583-120666       c
            2959-3115           AC005015.2         117928-118084       c
            3116-3275           AC005015.2         109954-110113       c
            3276-3461           AC005015.2         106632-106817       c
            3462-3524           AC005015.2         105620-105682       c
            3525-5623           AC005015.2         101252-103350       c
FEATURES             Location/Qualifiers
     source          1..5623
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..5623
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /note="CAP-Gly domain containing linker protein 2"
                     /db_xref="GeneID:7461"
                     /db_xref="HGNC:HGNC:2586"
                     /db_xref="MIM:603432"
     exon            1..328
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..516
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..3536
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytoplasmic linker 2; Williams-Beuren syndrome chromosome
                     region 3; Williams-Beuren syndrome chromosome region 4;
                     cytoplasmic linker protein 2; cytoplasmic linker protein
                     115; williams-Beuren syndrome chromosomal region 3
                     protein; williams-Beuren syndrome chromosomal region 4
                     protein; testicular tissue protein Li 40"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 2
                     isoform 1"
                     /protein_id="NP_003379.4"
                     /db_xref="CCDS:CCDS5569.1"
                     /db_xref="GeneID:7461"
                     /db_xref="HGNC:HGNC:2586"
                     /db_xref="MIM:603432"
                     /translation="MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPL
                     HKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQ
                     FAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHS
                     VESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKD
                     LRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKF
                     GLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRP
                     SRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEV
                     EKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVE
                     EESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQL
                     EEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDK
                     YEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDH
                     QKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEK
                     EALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDV
                     EYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVE
                     ALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL
                     ESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRV
                     LLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRY
                     SLIDRSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSA
                     NGIHQQDKAQKQEDKH"
     exon            517..1073
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1198
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1412
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1610
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1714
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1775
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1880
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2816
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2874
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..2958
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3115
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3275
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3461
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3524
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..5623
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5599..5604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /note="hexamer: AATAAA"
     polyA_site      5623
                     /gene="CLIP2"
                     /gene_synonym="CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4;
                     WSCR3; WSCR4"
                     /note="major polyA site"
ORIGIN      
        1 ccttttgttc cctcccggag ccgggccgct ggctccgctg gctccgctgg ctccgcgggc
       61 gctcagctcg gctcggccgc ggggcgcgca ggcggctgct gggcggcctc ggtgcgcgcc
      121 tcccgccttc ccagagacgt ggcgcgaggc ccgggccctg agcacctatc gcggggatcc
      181 ccggcgccag gagggggtgc agccggtggg cagcgccgcg cagggagggg ccgcagcatc
      241 ctcgcccccc agcgcgcccg ggcccgagag gaggaggccg gggctctccg ggcctcccgc
      301 cgcttagcct gatgctggaa ggacgaaggt gagtgaagat ggcagagagg acgtgaccag
      361 cactcaccct tgtccacctg cccagtggca ccgccatgca gaagcccagc ggcctgaagc
      421 cccccggccg tggggggaag cactccagcc ccatgggccg gacatctact gggtcagctt
      481 catcctcggc ggcggtggcc gctagctcca aggaaggctc cccactgcac aaacagtcat
      541 ctggaccctc ctcctccccg gccgcagctg ctgcccccga gaagccgggc cccaaggcgg
      601 cggaagtggg ggatgacttc ctgggggact ttgtggtggg cgagcgggtg tgggtgaacg
      661 gcgtgaagcc aggcgtggtg cagtatctgg gagagacgca gttcgcaccg ggccagtggg
      721 ctggcgtggt gctggacgac ccggtgggca agaatgatgg cgcggtgggc ggcgtgcgct
      781 acttcgagtg cccggccctc cagggtatct tcacgcggcc ctccaagctg acccggcagc
      841 ccacggccga gggctcgggg agtgatgccc actccgtgga gtcgctgact gcccagaacc
      901 tgtcattgca ttcgggcacg gccacgcccc cgctgaccag ccgcgtcatc cccctgcggg
      961 agagcgtcct caacagctcc gtgaagactg gcaacgagtc gggatccaac ctctcagaca
     1021 gcggctctgt gaagcggggc gaaaaggacc tgcgcctggg ggaccgcgtg ctggttggcg
     1081 ggacgaagac tggcgtggtg cggtacgtgg gggagacaga ctttgccaag ggcgagtggt
     1141 gtggcgtgga gctggacgag ccccttggga agaatgatgg ggcggtggcg ggcaccaggt
     1201 acttccagtg cccacccaag tttggtctct tcgcgcccat ccacaaagtg atccgtatcg
     1261 gcttcccatc taccagccca gccaaggcca agaagaccaa gcgtatggcc atgggtgtgt
     1321 cagcactgac ccacagtccc agcagttcct ccatcagctc cgtcagctct gtggcctcct
     1381 ccgtgggggg tcggcccagc cgcagtggcc tgctcacgga gacctcttca cgctacgccc
     1441 gcaagatctc gggcaccacg gccttgcagg aggcactgaa ggagaagcag cagcacattg
     1501 agcagctgct ggctgaacga gacctggaac gggctgaggt ggccaaggcc acaagccaca
     1561 tctgcgaggt ggagaaggag attgccctgc tcaaggcaca gcatgagcag tatgttgcag
     1621 aagccgagga gaagctgcag cgagcccggc tgctcgtgga gagcgtgcgg aaagagaagg
     1681 tggacctgtc caaccagctg gaggaggaga ggaggaaggt ggaggatctg cagttccgcg
     1741 tggaggagga gtccatcacc aagggagacc tggagaccca gacgcagctg gagcacgcgc
     1801 gcattgggga gctggaacag agcctgctac tggagaaggc gcaggccgag cggctgctcc
     1861 gagaattagc ggacaacagg ctgaccacag tggccgagaa gtcgcgcgtg ctgcagctgg
     1921 aggaggagct caccctgcgc cgaggtgaaa tcgaggagct ccagcagtgc ctgttgcact
     1981 cgggtccccc acctccggac cacccagacg ccgccgagat cctgcggcta cgggagcggc
     2041 tgctctcggc cagcaaggaa caccagaggg agagtggggt gctgcgggat aaatacgaga
     2101 aggccctgaa ggcctaccag gcggaggtgg acaagctccg cgcggccaac gagaagtacg
     2161 cacaggaggt ggcgggcctg aaggacaagg ttcagcaggc caccagcgag aacatggggc
     2221 taatggacaa ctggaaatcc aagctggact cgctggcctc ggaccaccag aagtccctgg
     2281 aggacctcaa agccaccctg aactcgggcc caggcgccca gcagaaggag atcggcgagc
     2341 tgaaggcagt gatggagggc atcaagatgg agcaccagct ggagctgggt aacttgcagg
     2401 ccaagcatga cctggagacc gccatgcacg tgaaggagaa ggaggccctg cgagagaagc
     2461 tgcaggaggc ccaggaggag ctggctgggc tgcagcggca ctggcgggcc cagctggagg
     2521 tgcaagccag ccagcaccgg ctggagctgc aggaggccca ggaccagcgc cgggatgccg
     2581 agctgcgtgt gcacgagctg gaaaaactgg acgtggagta ccggggccag gcgcaggcta
     2641 tcgagttcct caaggagcag atctcgctgg ccgagaagaa gatgttggac tacgagcggc
     2701 tgcagcgggc agaagcccag ggcaaacagg aggtcgagag tttgcgggag aagctcctgg
     2761 tggctgagaa cagactccag gcggtcgagg ccctgtgctc ctcccagcac acccacatga
     2821 ttgagtcgaa tgacatttca gaggagacga tcaggacgaa ggaaactgtg gagggcctgc
     2881 aggacaagct gaacaagagg gacaaagagg tgacagcctt gacctcccag accgagatgc
     2941 tcagggccca agtaagtgcg ctggagagca agtgtaagtc aggcgagaag aaggtggacg
     3001 ccctcctgaa ggagaagcgg cgcctggagg cagagctgga gaccgtgtcc cggaagaccc
     3061 atgacgcctc gggccagcta gtcctcatca gccaggagct gctgcggaag gagcggagcc
     3121 tgaacgaact gcgggtgttg ctgctggagg ccaatcgtca ctccccaggg ccggagaggg
     3181 acctgagccg tgaggtacac aaggctgagt ggcggatcaa ggagcagaaa ctcaaggatg
     3241 acatccgggg cctgcgtgaa aagctgaccg ggctggacaa agagaaatcc ctgtcggatc
     3301 agaggcgcta ctccctcatc gaccggtcct cggcgcccga gcttctgcgg ctgcagcacc
     3361 agctgatgag cacggaggac gccctgcggg atgcgctgga ccaggctcag caggtggaga
     3421 agctgatgga ggccatgagg agctgccctg acaaggccca gaccatcggc aattccggtt
     3481 ctgcaaacgg catccaccag caggacaaag ctcagaaaca agaggacaag cactgatcct
     3541 gaggggatac tgtggagcag cccagtccac accagagccc cacgcggctg cccggcagta
     3601 cctcctccag gcaggagccg ggactgtcac tttggagaca aaacagtgtt tgtaacaata
     3661 acgtactcac cgccgcggac aatcccccac cccgatccct cgccagacca ggacgcttcc
     3721 tcaagcccag ccttctacag agagtgtgaa cggtacagcc ccggcctgac ccggggacct
     3781 tcagcctgga cacccggcag cttctggagt ttgtcagtgg aggcagaggg gatccggcca
     3841 ggcccctctg tccagaagga gctgccctga ggaccatctt agcggccctg tcctcttttt
     3901 ccgcccattc tccctcgggt ctccccagag gggccggcgg gggctgggga gggggtaagt
     3961 ttatccatgc agacaccaag ggggagcatc cagtctttaa gagccaagtg ggggcccctt
     4021 ttccgaagcc acttccaggc caaggcagtc gccagggctt cttgtcccca ccttctgaac
     4081 cttcttcaaa cagtagtaca agctcccctc agccagcctg cctgcccagc gaggccccca
     4141 ggttcaaggt gttggcgggg gcggagggca ggggaacggg atccttctcc cgctgcccac
     4201 caacaccaac acacacacac ctctaagctg ctggccgaag atgtcaccaa ggccaaagac
     4261 acagtattat gaaggtttgg aaacccctct cctcacctcc caccgtgacc ttgggcaaac
     4321 cctggctcgg agcccagggc agaggcagct cagagtggag gctctaggca ggtttgacaa
     4381 aggtcagtaa tacggtttcc cctggggttg accagatgtt ccaaaatatc tgcatccacc
     4441 tggagatgca gctaagtggg tccttatgta cacaccacgt tcacacacac acagagggac
     4501 cacgtgtgca cgcatgaccg tgtgggtggc ggcgtttgct gtgaaccacg ctcaggccac
     4561 acagagacac atacttggtt tctgggactg agacccaggc ctggcaggac cgtgcctaca
     4621 gatactgcaa acgttcctac agcctagagg tgcgtataca cacccaagta cacgcagcca
     4681 ggcattcagg ggtgtgtttg ccacatggag catcccttcc tggtcttgcc aggcacctgc
     4741 acagagcgtc tccagcccca tctcctaacg ggggctgggg gtaagagaaa tctaactgcg
     4801 ctcccccaac ccctcgccct gccatcttcc cctcaagcct gctaagttat cccaggcctg
     4861 tgcgtggtgg aaaaagccag ccttggccct gcagcctcca cctcgccgct gggggaccaa
     4921 caggttgctt acagctttgc accccggcat cagcacaggg gtccctgccc caccctccgg
     4981 cagctcaggg agtgttttcc tgtgaggcct cccccatcag tggaccagag ggagaagccc
     5041 gatgccccat cccggctttc ccgtaacgca caggacacgt gtgcaattca taggaacggc
     5101 ccagatcgcc ctcatgagtg ccacctggta caggtaggtg gcgctcacgt tcctgcccaa
     5161 atgcagccca tcggggagtc acagtcagtc cccccggccc ccctcccagt ccctgttggc
     5221 tttcggtagc tctcgcatgc agttctatta acagccgtct agaagcgatg ctttagtggc
     5281 ctaacccagg gtcaaataca gctctttcta gcaaaatcag gcagctctgc cccatcggta
     5341 ggggcaccga ttagtctact aacagccaga ggtccatcta gcagggtgcc gggaggagct
     5401 gagcccccgg aggtgggctc ctggtgacgg gtgtccaaga agcggtttcc ttgggagctt
     5461 ctgcctccgt gggcctctca gcccgccccg tgtggccgcc cgggtgtggc tcagccatgt
     5521 cccctcccca ggtccttcat tcacccctcc cctccccaca gtggaattgt tgaagtgtgg
     5581 cgagtctgtg ctcgggacaa taaagcttgt gacaggtcca gga
//
