LOCUS       NM_001247997            5978 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens CAP-Gly domain containing linker protein 1 (CLIP1),
            transcript variant 3, mRNA.
ACCESSION   NM_001247997
VERSION     NM_001247997.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5978)
  AUTHORS   Ma,B., Xu,Y., Gao,H., Yang,Y., Pan,Y. and You,C.
  TITLE     CLIP170 inhibits the metastasis and EMT of papillary thyroid cancer
            through the TGF-beta pathway
  JOURNAL   Med Oncol 41 (6), 137 (2024)
   PUBMED   38705933
  REMARK    GeneRIF: CLIP170 inhibits the metastasis and EMT of papillary
            thyroid cancer through the TGF-beta pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5978)
  AUTHORS   Nana,F.A., Lamberts,V., Hoton,D., Stanciu,C.P., Lecocq,M.,
            Carlier,F.M., Duplaquet,F., Pirard,L., Pilette,C., Bihin,B. and
            Ocak,S.
  TITLE     Restin protein expression in non-small cell lung cancer
  JOURNAL   Thorac Cancer 14 (23), 2302-2309 (2023)
   PUBMED   37365889
  REMARK    GeneRIF: Restin protein expression in non-small cell lung cancer.
REFERENCE   3  (bases 1 to 5978)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5978)
  AUTHORS   Thakkar,P.V., Kita,K., Castillo,U.D., Galletti,G., Madhukar,N.,
            Navarro,E.V., Barasoain,I., Goodson,H.V., Sackett,D., Diaz,J.F.,
            Lu,Y., RoyChoudhury,A., Molina,H., Elemento,O., Shah,M.A. and
            Giannakakou,P.
  TITLE     CLIP-170S is a microtubule +TIP variant that confers resistance to
            taxanes by impairing drug-target engagement
  JOURNAL   Dev Cell 56 (23), 3264-3275 (2021)
   PUBMED   34672971
  REMARK    GeneRIF: CLIP-170S is a microtubule +TIP variant that confers
            resistance to taxanes by impairing drug-target engagement.
REFERENCE   5  (bases 1 to 5978)
  AUTHORS   Izumi,H., Matsumoto,S., Liu,J., Tanaka,K., Mori,S., Hayashi,K.,
            Kumagai,S., Shibata,Y., Hayashida,T., Watanabe,K., Fukuhara,T.,
            Ikeda,T., Yoh,K., Kato,T., Nishino,K., Nakamura,A., Nakachi,I.,
            Kuyama,S., Furuya,N., Sakakibara-Konishi,J., Okamoto,I., Taima,K.,
            Ebi,N., Daga,H., Yamasaki,A., Kodani,M., Udagawa,H., Kirita,K.,
            Zenke,Y., Nosaki,K., Sugiyama,E., Sakai,T., Nakai,T., Ishii,G.,
            Niho,S., Ohtsu,A., Kobayashi,S.S. and Goto,K.
  TITLE     The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung
            cancer
  JOURNAL   Nature 600 (7888), 319-323 (2021)
   PUBMED   34819663
  REMARK    GeneRIF: The CLIP1-LTK fusion is an oncogenic driver in
            non-small-cell lung cancer.
REFERENCE   6  (bases 1 to 5978)
  AUTHORS   Griparic,L. and Keller,T.C.
  TITLE     Identification and expression of two novel CLIP-170/Restin isoforms
            expressed predominantly in muscle
  JOURNAL   Biochim Biophys Acta 1405 (1-3), 35-46 (1998)
   PUBMED   9784600
REFERENCE   7  (bases 1 to 5978)
  AUTHORS   Pierre,P., Pepperkok,R. and Kreis,T.E.
  TITLE     Molecular characterization of two functional domains of CLIP-170 in
            vivo
  JOURNAL   J Cell Sci 107 (Pt 7), 1909-1920 (1994)
   PUBMED   7983157
REFERENCE   8  (bases 1 to 5978)
  AUTHORS   Hilliker,C., Delabie,J., Speleman,F., Bilbe,G., Bruggen,J., Van
            Leuven,F. and Van den Berghe,H.
  TITLE     Localization of the gene (RSN) coding for restin, a marker for
            Reed-Sternberg cells in Hodgkin's disease, to human chromosome band
            12q24.3 and YAC cloning of the locus
  JOURNAL   Cytogenet Cell Genet 65 (3), 172-176 (1994)
   PUBMED   8222754
REFERENCE   9  (bases 1 to 5978)
  AUTHORS   Pierre,P., Scheel,J., Rickard,J.E. and Kreis,T.E.
  TITLE     CLIP-170 links endocytic vesicles to microtubules
  JOURNAL   Cell 70 (6), 887-900 (1992)
   PUBMED   1356075
REFERENCE   10 (bases 1 to 5978)
  AUTHORS   Bilbe,G., Delabie,J., Bruggen,J., Richener,H., Asselbergs,F.A.,
            Cerletti,N., Sorg,C., Odink,K., Tarcsay,L., Wiesendanger,W. et al.
  TITLE     Restin: a novel intermediate filament-associated protein highly
            expressed in the Reed-Sternberg cells of Hodgkin's disease
  JOURNAL   EMBO J 11 (6), 2103-2113 (1992)
   PUBMED   1600942
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127002.3, M97501.1,
            BC126305.1, AC048338.29 and CB305431.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001247997.1.
            
            Summary: The protein encoded by this gene links endocytic vesicles
            to microtubules. This gene is highly expressed in Reed-Sternberg
            cells of Hodgkin disease. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (c).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3039751.1,
                                           SRR1803617.201661.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620786.5/ ENSP00000479322.1
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC127002.3         3415-3514           c
            101-213             M97501.1           1-113
            214-4608            BC126305.1         1-4395
            4609-5972           AC048338.29        57694-59057
            5973-5978           CB305431.1         54-59               c
FEATURES             Location/Qualifiers
     source          1..5978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..5978
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /note="CAP-Gly domain containing linker protein 1"
                     /db_xref="GeneID:6249"
                     /db_xref="HGNC:HGNC:10461"
                     /db_xref="MIM:179838"
     exon            1..149
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            150..340
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..4572
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /note="isoform c is encoded by transcript variant 3;
                     restin (Reed-Steinberg cell-expressed intermediate
                     filament-associated protein); cytoplasmic linker protein
                     1; cytoplasmic linker protein 170 alpha-2; cytoplasmic
                     linker protein CLIP-170"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 1
                     isoform c"
                     /protein_id="NP_001234926.1"
                     /db_xref="CCDS:CCDS58285.1"
                     /db_xref="GeneID:6249"
                     /db_xref="HGNC:HGNC:10461"
                     /db_xref="MIM:179838"
                     /translation="MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASS
                     TPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGS
                     VAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSS
                     PSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRV
                     LVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVH
                     KVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTG
                     LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQEL
                     ALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESI
                     TKGDLEQKSQISEDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSE
                     KSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDH
                     QREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK
                     SKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQD
                     SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEI
                     KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE
                     AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQIL
                     KEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDE
                     REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENA
                     SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE
                     RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTA
                     EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTV
                     ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERS
                     VLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE
                     NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQE
                     SQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLF
                     CDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDE
                     TF"
     exon            341..912
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1037
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1260
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1458
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1562
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1623
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1656
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1761
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..2706
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2823
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2881
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2965
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3122
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3288
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..3504
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3621
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3728
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..3849
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            3850..3902
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            3903..4020
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4171
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            4172..4221
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            4222..4346
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     exon            4347..5978
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5958..5963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /note="hexamer: ATTAAA"
     polyA_site      5978
                     /gene="CLIP1"
                     /gene_synonym="CLIP; CLIP-170; CLIP170; CYLN1; RSN"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgcgcc cgcccggccc cgcggcggcg gcggcgcgtc acgctctccc ccgccccgag
       61 ccgacgagcc gggaggcggg aggcggcggc cgcggcggct gctgctgctg cagtgggaca
      121 ggtggcggcg accggcggcg tccgaggaga tttaatccag agactgactt cactatagaa
      181 cccacagttg tatcaatggt tggggaaaga tagtggcaac aggcaaagga gaaacagctc
      241 tgacatacaa agaaaatgag tatgctaaag ccaagtgggc ttaaggcccc caccaagatc
      301 ctgaagcctg gaagcacagc tctgaagaca cctacggctg ttgtagctcc agtagaaaaa
      361 accatatcca gtgaaaaagc atcaagcact ccatcatctg agactcagga ggaatttgtg
      421 gatgactttc gagttgggga gcgagtttgg gtgaatggaa ataagcctgg atttatccag
      481 tttcttggag aaacccagtt tgcaccaggc cagtgggctg gaattgtttt agatgaaccc
      541 ataggcaaga acgatggttc ggtggcagga gttcggtatt tccagtgtga acctttaaag
      601 ggcatattta cccgaccttc aaagttaaca aggaaggtgc aagcagaaga tgaagctaat
      661 ggcctgcaga caacgcccgc ctcccgagct acttcaccgc tgtgcacttc tacggccagc
      721 atggtgtctt cctccccctc caccccttca aacatccctc agaaaccatc acagccagca
      781 gcaaaggaac cttcagctac gcctccgatc agcaacctta caaaaactgc cagtgaatct
      841 atctccaacc tttcagaggc tggctcaatc aagaaaggag aaagagagct caaaatcgga
      901 gacagagtat tggttggtgg cactaaggct ggtgtagtcc ggtttcttgg ggagaccgac
      961 tttgccaagg gggagtggtg tggcgtggag ttagatgagc cacttgggaa gaatgatggc
     1021 gctgttgctg gaacaaggta ttttcagtgt caacccaaat atggcttgtt cgctcctgtc
     1081 cacaaagtta ccaagattgg cttcccttcc actacaccag ccaaagccaa ggccaacgca
     1141 gtgaggcgag tgatggcgac cacgtccgcc agcctgaagc gcagcccttc tgcctcttcc
     1201 ctcagctcca tgagctcagt ggcctcctct gtgagcagca ggcccagtcg gacaggacta
     1261 ttgactgaaa cctcctcccg ttacgccagg aagatctccg gtaccactgc cctccaggag
     1321 gccctgaagg agaagcagca gcacattgag cagctgctgg cggaacggga tctggagagg
     1381 gcggaggtgg ccaaggccac gagccacgtg ggggagatag agcaggagct agctctggcc
     1441 cgggacggac atgaccagca tgtcctggaa ttggaagcca aaatggacca gctgcgaaca
     1501 atggtggaag ctgctgacag ggagaaggtg gagcttctca accagcttga agaggagaaa
     1561 aggaaggttg aggaccttca gttccgggtt gaagaagaat caattaccaa aggtgatctt
     1621 gagcaaaaga gccagatttc tgaagatcct gagaatacgc agaccaaact ggagcatgcc
     1681 cgcattaagg agcttgaaca gagcctgctc tttgaaaaga ccaaagctga caaactccag
     1741 agggagttag aagacactag ggtggctaca gtttcagaaa agtcacgtat aatggaactg
     1801 gagaaagacc tagcattgag agtacaggaa gtagctgagc tccgaagaag gctagagtcc
     1861 aataagcctg ctggggatgt ggacatgtca ctttcccttt tgcaagagat aagctctttg
     1921 caagaaaagt tagaagtcac ccgtactgac caccagagag aaataacttc tctgaaggag
     1981 cattttggag cccgggaaga aactcatcag aaggagataa aggctctgta taccgccacg
     2041 gaaaagcttt ccaaagagaa cgagtcattg aaaagcaagc tggagcatgc caacaaagag
     2101 aactcagatg tgatagctct atggaagtcc aaactggaga ctgccatcgc atcccaccag
     2161 caggcgatgg aagaactgaa ggtatctttc agcaaagggc ttggaacaga gacggcagaa
     2221 tttgctgaac taaaaacaca aatagagaaa atgagactag attaccaaca cgaaatagaa
     2281 aatttgcaga atcaacaaga ctctgaacgg gctgcccatg ctaaagagat ggaagccttg
     2341 agggctaaac tgatgaaagt tattaaagaa aaggaaaaca gtctggaagc catcaggtcg
     2401 aaactggaca aagcagaaga ccagcatctc gtagaaatgg aagacacgtt aaacaaatta
     2461 caggaagctg aaataaaggt aaaggagcta gaggtactgc aagccaaatg caatgaacaa
     2521 accaaggtta ttgataattt tacatcacag ctcaaggcta ctgaagaaaa gctcttggat
     2581 cttgatgcac ttcggaaagc cagttccgaa ggtaaatcgg aaatgaagaa acttagacag
     2641 cagcttgagg cagctgagaa acagattaaa catttagaga ttgaaaagaa tgctgaaagt
     2701 agcaaggcta gtagcattac cagagagctc caggggagag agctaaagct tactaacctt
     2761 caggaaaatt tgagtgaagt cagtcaagtg aaagagactt tggaaaaaga acttcagatt
     2821 ttgaaagaaa agtttgctga agcttcagag gaggcagtct ctgttcagag aagtatgcaa
     2881 gaaactgtaa ataagttaca ccaaaaggag gaacagttta acatgctgtc ttctgacttg
     2941 gagaagctga gagaaaactt agcagatatg gaggcaaaat ttagagagaa agatgagaga
     3001 gaagagcagc tgataaaggc aaaggaaaaa ctggaaaatg acattgcaga aataatgaag
     3061 atgtcaggag ataactcttc tcagctgaca aaaatgaacg atgaattacg tctgaaagaa
     3121 agagatgtag aagaattaca gctaaaactt acaaaggcta atgaaaatgc aagttttctg
     3181 caaaaaagta ttgaggacat gactgtcaaa gctgaacaga gccagcaaga agcagctaaa
     3241 aagcatgagg aagaaaagaa agaattggag aggaaattgt cggacctgga aaagaaaatg
     3301 gaaacaagcc acaaccagtg tcaggagctg aaagccaggt atgagagagc cacttctgag
     3361 acaaaaacca agcatgaaga aatcctacag aacctccaga agacgctgct ggacacagag
     3421 gacaagctga agggcgcacg ggaggagaac agtggcttgc tgcaggagct ggaggagctg
     3481 agaaagcaag ccgacaaagc caaagctgct caaacagcgg aagatgccat gcagataatg
     3541 gaacagatga ccaaagagaa gactgagact ctggcctcct tggaggacac caagcaaaca
     3601 aatgcaaaac tacagaatga attggacaca cttaaagaaa acaacttgaa aaatgtggaa
     3661 gagctgaaca aatcaaaaga actcctgact gtagagaatc aaaaaatgga agaatttagg
     3721 aaagaaatag aaaccctaaa gcaggcagca gctcagaagt cccagcagct ttcagcgttg
     3781 caagaagaga acgttaaact tgctgaggag ctggggagaa gcagggacga agtcacaagt
     3841 catcaaaagc tggaagaaga aagatctgtg ctcaataatc agttgttaga aatgaaaaaa
     3901 agagaatcca agttcataaa agacgcagat gaagagaaag cttccttgca gaaatccatc
     3961 agtataacta gtgccttact cacagaaaag gatgccgagc tggagaaact gagaaatgag
     4021 gtcacagtgc tcaggggaga aaacgcctct gccaagtcct tgcattcagt tgttcagact
     4081 ctagagtctg ataaggtgaa gctcgagctc aaggtaaaga acttggagct tcaactcaaa
     4141 gaaaacaaga ggcagctcag cagctcctca ggtaatacag acactcaggc agacgaggat
     4201 gaaagagccc aggagagtca gattgatttc ctaaattcag taatagtgga ccttcaaagg
     4261 aagaatcaag acctcaagat gaaggtggag atgatgtcag aagcagccct gaatgggaac
     4321 ggggatgacc taaacaatta tgacagtgat gatcaggaga aacagtccaa gaagaaacct
     4381 cgcctcttct gtgacatttg tgactgcttt gatctccacg acacagagga ttgtcctacc
     4441 caggcacaga tgtcagagga ccctccccat tccacacacc atggcagtcg gggtgaggaa
     4501 cgcccatact gtgaaatctg tgagatgttt ggacactggg ccaccaactg caatgacgac
     4561 gaaaccttct gatgaagcct ccagtggaga actgggcttg ctcagacgca ctcgcattga
     4621 cacaacgtaa caccagcatt gtgtgtgcag acttcaggag aactcatgtt attttttaac
     4681 cccgtcaaca aatctaggaa aatattttga tcttcaacaa attgcccttt agtctccccg
     4741 tatgagttag aataataaat atttagtagg tgagttttca cctcgaattt tgttttcttg
     4801 atttttacgt ttgaagacat tgcaccagat gccattacat ttattggccc cccgaccttg
     4861 tagaaaaacc cctaccctca caatacctta tttaagtaac tttaaattat gccgttactt
     4921 ttcatatttg cactaagata tttccaggct gcatttgtat atttagattt tttggttaag
     4981 ctttgacact ggaatgagtt gaaaaaatgt gccattttgc attttcatct actcatttaa
     5041 agtattttat tcttattcaa agaaatatct gagctctttg cactacctgt tatcagtagt
     5101 gcctttactt caggcttgat aatacttagg tgtgattata aaatcatgaa gcaggtaaag
     5161 ggaggggcaa gcccccaaac tgctgtgggg acattttata atctatatgc tgcacccact
     5221 taatctactg tggtgttttg tttattagtt ttgcataatt tcagcttcta tatattgtat
     5281 gtatatattt tttaaaaatc tatattttgg gaaaaaaaca tacacaatgt gtctttcttt
     5341 ttggacattt acctttttga aaaagaaaac acttaaaatg atcattagga cataacagac
     5401 taggccagac atagcatctt gtggctttgc aaccattttc atttgtttgt tttcctttta
     5461 tttcttcacc agatttaaat aactggagga attttctcca attttttttt ccttctctgg
     5521 caggtatccc cagcagtcaa ttaacaataa gccagtataa aacacctaaa taaccaatct
     5581 acaatctccc ttcacaagtt tttttactgt ttttagatga atgtacgatg agaaattcaa
     5641 cgttaataat tctggatttt cttatcacaa aaaagaaaat gaaggacctc aaagcacctg
     5701 aacagtttat cgaccagttt gaatctattt atcttcattt gaatgtcttc tagaatatgt
     5761 aaaaagtcat aaaatgtatc ttccatgcta catgtacaat aagaacttct ataattgtat
     5821 atatgccttt gatgtatttt cccctcaaga ttatcaactg tgtgttcgac agtgaatatt
     5881 caatctggta ccagttgaaa tttttggtta taaatgtaat acgaattgtt tcacaaacag
     5941 aaaacatgta aagcagtatt aaaatttggc caaacaag
//
