LOCUS       NM_014666               3952 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens clathrin interactor 1 (CLINT1), transcript variant 2,
            mRNA.
ACCESSION   NM_014666 XM_001715730 XM_001723151 XM_001725023
VERSION     NM_014666.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3952)
  AUTHORS   Schor,S., Pu,S., Nicolaescu,V., Azari,S., Koivomagi,M., Karim,M.,
            Cassonnet,P., Saul,S., Neveu,G., Yueh,A., Demeret,C.,
            Skotheim,J.M., Jacob,Y., Randall,G. and Einav,S.
  TITLE     The cargo adapter protein CLINT1 is phosphorylated by the
            Numb-associated kinase BIKE and mediates dengue virus infection
  JOURNAL   J Biol Chem 298 (6), 101956 (2022)
   PUBMED   35452674
  REMARK    GeneRIF: The cargo adapter protein CLINT1 is phosphorylated by the
            Numb-associated kinase BIKE and mediates dengue virus infection.
REFERENCE   2  (bases 1 to 3952)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 3952)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3952)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3952)
  AUTHORS   Saint-Pol,A., Yelamos,B., Amessou,M., Mills,I.G., Dugast,M.,
            Tenza,D., Schu,P., Antony,C., McMahon,H.T., Lamaze,C. and
            Johannes,L.
  TITLE     Clathrin adaptor epsinR is required for retrograde sorting on early
            endosomal membranes
  JOURNAL   Dev Cell 6 (4), 525-538 (2004)
   PUBMED   15068792
  REMARK    GeneRIF: Our work reveals the existence of clathrin-independent and
            -dependent transport steps in the retrograde route, and establishes
            a function for clathrin and epsinR at the endosome-TGN interface.
REFERENCE   6  (bases 1 to 3952)
  AUTHORS   Wasiak,S., Denisov,A.Y., Han,Z., Leventis,P.A., de Heuvel,E.,
            Boulianne,G.L., Kay,B.K., Gehring,K. and McPherson,P.S.
  TITLE     Characterization of a gamma-adaptin ear-binding motif in
            enthoprotin
  JOURNAL   FEBS Lett 555 (3), 437-442 (2003)
   PUBMED   14675752
REFERENCE   7  (bases 1 to 3952)
  AUTHORS   Hirst,J., Motley,A., Harasaki,K., Peak Chew,S.Y. and Robinson,M.S.
  TITLE     EpsinR: an ENTH domain-containing protein that interacts with AP-1
  JOURNAL   Mol Biol Cell 14 (2), 625-641 (2003)
   PUBMED   12589059
  REMARK    GeneRIF: EpsinR is an ENTH domain-containing protein that interacts
            with AP-1
            Erratum:[Mol Biol Cell. 2003 Apr;14(4):following 1743]
REFERENCE   8  (bases 1 to 3952)
  AUTHORS   Mills,I.G., Praefcke,G.J., Vallis,Y., Peter,B.J., Olesen,L.E.,
            Gallop,J.L., Butler,P.J., Evans,P.R. and McMahon,H.T.
  TITLE     EpsinR: an AP1/clathrin interacting protein involved in vesicle
            trafficking
  JOURNAL   J Cell Biol 160 (2), 213-222 (2003)
   PUBMED   12538641
REFERENCE   9  (bases 1 to 3952)
  AUTHORS   Kalthoff,C., Groos,S., Kohl,R., Mahrhold,S. and Ungewickell,E.J.
  TITLE     Clint: a novel clathrin-binding ENTH-domain protein at the Golgi
  JOURNAL   Mol Biol Cell 13 (11), 4060-4073 (2002)
   PUBMED   12429846
  REMARK    GeneRIF: might participate in the formation of clathrin-coated
            vesicles at the level of the trans-Golgi network and remains
            associated with the vesicles longer than clathrin and adaptors
REFERENCE   10 (bases 1 to 3952)
  AUTHORS   Wasiak,S., Legendre-Guillemin,V., Puertollano,R., Blondeau,F.,
            Girard,M., de Heuvel,E., Boismenu,D., Bell,A.W., Bonifacino,J.S.
            and McPherson,P.S.
  TITLE     Enthoprotin: a novel clathrin-associated protein identified through
            subcellular proteomics
  JOURNAL   J Cell Biol 158 (5), 855-862 (2002)
   PUBMED   12213833
  REMARK    GeneRIF: a novel clathrin-associated protein identified through
            subcellular proteomics; data suggest a role in clathrin-mediated
            budding on internal membranes
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP246338.1, BK000414.1 and
            BC013091.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_014666.3.
            
            Summary: This gene encodes a protein with similarity to the epsin
            family of endocytic adapter proteins. The encoded protein interacts
            with clathrin, the adapter protein AP-1 and phosphoinositides. This
            protein may be involved in the formation of clathrin coated
            vesicles and trafficking between the trans-Golgi network and
            endosomes. Mutations in this gene are associated with a
            susceptibility to schizophrenia and psychotic disorders. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2010].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000414.1, D79993.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000411809.7/ ENSP00000388340.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BP246338.1         31-104
            75-3410             BK000414.1         1-3336
            3411-3952           BC013091.1         2307-2848
FEATURES             Location/Qualifiers
     source          1..3952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..3952
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /note="clathrin interactor 1"
                     /db_xref="GeneID:9685"
                     /db_xref="HGNC:HGNC:23186"
                     /db_xref="MIM:607265"
     exon            1..216
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..2053
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /note="isoform 2 is encoded by transcript variant 2;
                     epsin-related protein; clathrin interacting protein
                     localized in the trans-Golgi region; epsin 4; enthoprotin;
                     epsinR"
                     /codon_start=1
                     /product="clathrin interactor 1 isoform 2"
                     /protein_id="NP_055481.1"
                     /db_xref="CCDS:CCDS47330.1"
                     /db_xref="GeneID:9685"
                     /db_xref="HGNC:HGNC:23186"
                     /db_xref="MIM:607265"
                     /translation="MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLM
                     GEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAR
                     EHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYV
                     GVSSDSVGGFRYSERYDPEPKSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISK
                     FRRKDREDSPERCSDSDEEKKARRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHK
                     RTANPSKTIDLGAAAHYTGDKASPDQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTS
                     QSTGGSADLFGGFADFGSAAASGSFPSQVTATSGNGDFGDWSAFNQAPSGPVASSGEF
                     FGSASQPAVELVSGSQSALGPPPAASNSSDLFDLMGSSQATMTSSQSMNFSMMSTNTV
                     GLGLPMSRSQNTDMVQKSVSKTLPSTWSDPSVNISLDNLLPGMQPSKPQQPSLNTMIQ
                     QQNMQQPMNVMTQSFGAVNLSSPSNMLPVRPQTNALIGGPMPMSMPNVMTGTMGMAPL
                     GNTPMMNQSMMGMNMNIGMSAAGMGLTGTMGMGMPNIAMTSGTVQPKQDAFANFANFS
                     K"
     exon            217..321
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            322..418
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            419..527
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            528..692
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            693..870
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1117
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1187
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1262
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1555
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1706
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..3952
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2161..2166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /note="hexamer: AATAAA"
     polyA_site      2186
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
     regulatory      3390..3395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /note="hexamer: ATTAAA"
     regulatory      3402..3407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /note="hexamer: ATTAAA"
     polyA_site      3412
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /note="major polyA site"
     polyA_site      3424
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
     regulatory      3935..3940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
                     /note="hexamer: AGTAAA"
     polyA_site      3952
                     /gene="CLINT1"
                     /gene_synonym="CLINT; ENTH; EPN4; EPNR"
ORIGIN      
        1 gcgtctcgac gtgtcaccgg cggcgccgct gctgtggcaa aggaaggagc tgactggggg
       61 agttcgaggc ggcgggcggc ggtgaccccg gcctggaact gccccggtac ggaagtgttc
      121 cggggtccgt ggggagcagg agagggaggc ggcggaccgt cccgcgcggg gcacgatgtt
      181 gaacatgtgg aaggtgcgcg agctggtgga caaagccacc aatgttgtta tgaattattc
      241 agagatcgag tctaaggttc gagaggcaac gaacgatgat ccttggggac cttctgggca
      301 actcatggga gagattgcca aggctacatt tatgtatgaa caatttccag aacttatgaa
      361 catgctttgg tcacgaatgt taaaagacaa caaaaagaat tggagaagag tttataagtc
      421 gttgctgctc ctagcttacc tcataaggaa tggatcagag cgtgttgtta caagtgccag
      481 agaacacatt tatgatttac gatccctgga aaattaccac tttgtagatg agcatggtaa
      541 ggatcaaggt ataaatattc gacagaaggt gaaggaattg gttgaatttg cccaggatga
      601 cgacaggctt cgtgaagagc gaaagaaagc aaagaagaac aaagacaagt atgttggggt
      661 ttcctcagac agtgttggag gattcagata cagtgaaaga tatgatcctg agcccaaatc
      721 aaaatgggat gaggagtggg ataaaaacaa gagtgctttt ccattcagtg ataaattagg
      781 tgagctgagt gataaaattg gaagcacaat tgatgacacc atcagcaagt tccggaggaa
      841 agatagagaa gactctccag aaagatgcag cgacagcgat gaggaaaaga aagcgagaag
      901 aggcagatct cccaaaggtg aattcaaaga tgaagaggag actgtgacga caaagcatat
      961 tcatatcaca caggccacag agaccaccac aaccagacac aagcgcacag caaatccttc
     1021 caaaaccatt gatcttggag cagcagcaca ttacacaggg gacaaagcaa gtccagatca
     1081 gaatgcttca acccacacac ctcagtcttc agttaagact tcagtgccta gcagcaagtc
     1141 atctggtgac cttgttgatc tgtttgatgg caccagccag tcaacaggag gatcagctga
     1201 tttattcgga ggatttgctg actttggctc agctgctgca tcaggcagtt tcccttccca
     1261 agtaacagca acaagtggga atggagactt tggtgactgg agtgccttca accaagcccc
     1321 atcaggccct gttgcttcca gtggcgagtt ctttggcagt gcctcacagc cagcggtaga
     1381 acttgttagt ggctcacaat cagctctagg cccacctcct gctgcctcaa attcttcaga
     1441 cctgtttgat cttatgggct cgtcccaggc aaccatgaca tcttcccaga gtatgaattt
     1501 ctctatgatg agcactaaca ctgtgggact tggtttgcct atgtcaagat cacagaatac
     1561 agatatggtc cagaaatcag tcagcaaaac cttgccctct acttggtctg accccagtgt
     1621 aaacatcagc ctagacaact tactacctgg tatgcagcct tccaaacccc agcagccatc
     1681 actgaataca atgattcagc aacagaatat gcagcagcct atgaatgtga tgactcaaag
     1741 ttttggagct gtgaacctca gttctccatc gaacatgctt cctgtccggc cccaaactaa
     1801 tgctttgata gggggaccca tgcctatgag catgcccaat gtgatgactg gcaccatggg
     1861 aatggcccct cttggaaata ctccgatgat gaaccagagc atgatgggca tgaacatgaa
     1921 catagggatg tccgctgctg ggatgggctt gacaggcaca atgggaatgg gcatgcccaa
     1981 catagccatg acttctggaa ctgtgcaacc caagcaagat gcctttgcaa atttcgccaa
     2041 ttttagcaaa taagagattg taaaagaagc agattgaatg aagaattttt agctgtgcag
     2101 ataggtgatg ttgggatgga aaatgctaat caactaccct ttcttttatc aagtaattaa
     2161 aataaatcta cataaagaac caaaaaggct gttttataaa agtgaaatat ccagtatttc
     2221 agagggccag gcaagagcac ttcagatgag gcagtcaaaa tcattttttt ccagtgagga
     2281 tagaccacaa gtgggtggtg agaccattga aagcctttat caactgaaga gtccatttaa
     2341 cagcataatt tgtgggaaga ctggaatagg gctgaataaa tgtgtttgaa tctctaattt
     2401 tatactttct tttcctgagg aacttgattt ttctgtccct ggatcgcctt gtcataattg
     2461 ggtctgttcc ttttactacc actcttgagt ccatatatga aatcattaaa gttggatgat
     2521 cagtttttta taaaaatata tatttttgtc caagaaaaaa aaaagcatac atatgtgatt
     2581 atggctaaat caaaggtaac tggaatgtat atacttttgc taatgttcca gcaacactgc
     2641 tattatacta tccaaatttt tattgtaaca aaacctcttt aagcaattgg tgattgccat
     2701 gggacttttc ccatgtcttc tgctgtaatt atcctgtgca gaactaggaa gaaatttttt
     2761 tcaggactgc tctatggttt cctttaaaag aaaaaaactt ctgtttgttt ttagcagtca
     2821 ttatttacaa tttgcagtga ttaacttggc aaggcttcct tccgtgttta tccctgtagc
     2881 catcatttaa gtcaggaaca gtcagaaaaa tatttatttt attttttttt tgggtgtctg
     2941 caaaggtaaa aatccattaa aaccttaagt taaatataaa tgttacaact caatgtttgc
     3001 ttttagattt tatacagtat ttgttttgtt ttggttttga gtgtatataa tgcagcatta
     3061 gcaatatggt tccaatagag gagttaaata tatattgtta aaggagacct gtagcagtca
     3121 aagattttat tgatttaatg acaaaggaaa ttaatgaaaa tgtttttgtt tttctgctgt
     3181 aattctgcat taagctcaca tgaaaatcat gattctagag tttggaatgc aaaattaatt
     3241 gttttaccct caagctggga atatttttca aaataaatac tataatatag atatcaaatt
     3301 attacctccc catgttatgt tgaaaatttt tttattaaat tgataaaact ttatttccat
     3361 tatattcata atgttctgtt atacataaca ttaaaatgtt cattaaaatc aatgttgaac
     3421 tgctttttct ttcgttctgt tagacatttg agaccatttg gggaaaaaat aattatagtt
     3481 tgggcaaagt aatttttata aataatttaa aattatttaa tgacttctct attctttcct
     3541 atcagactct actgttagga attaaaaatg aagcagcaaa gatatcctga cctgctccat
     3601 tcttgctaat gttccatcta caacatttct aattaggcag aaattcatgt acttcagcta
     3661 agtggtaatg aaaagtgatt catttgctga ataagagatg agagtgagtg taattagctg
     3721 actgcggttt ttaatctttc aacaattcaa tgtgtttaac ttagtttcaa agaataggag
     3781 ctttcaagtg ttgttacttc agagcaatca agccagcctc tggtggccgc atagtagaat
     3841 atggtccctg atatttaaaa ccgatcatct taagtaaatt ttttctttaa gaagtatatc
     3901 ttcactttct caaatatgta tggttcttag acgaagtaaa tgtttatctg aa
//
