LOCUS       NM_013943               4253 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens chloride intracellular channel 4 (CLIC4), mRNA.
ACCESSION   NM_013943
VERSION     NM_013943.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4253)
  AUTHORS   Zhang,W., Xu,Q., Shi,C., Chen,X., Shen,C., Zhang,Y., Zheng,B. and
            Zhu,H.
  TITLE     RNA-binding protein DND1 participates in migration, invasion, and
            EMT of prostate cancer cells by degrading CLIC4
  JOURNAL   Histol Histopathol 39 (10), 1343-1358 (2024)
   PUBMED   38390782
  REMARK    GeneRIF: RNA-binding protein DND1 participates in migration,
            invasion, and EMT of prostate cancer cells by degrading CLIC4.
REFERENCE   2  (bases 1 to 4253)
  AUTHORS   Luo,J., Wang,J., Liu,H., Jiang,W., Pan,L., Huang,W., Liu,C., Qu,X.,
            Liu,C., Qin,X. and Xiang,Y.
  TITLE     Chloride intracellular channel 4 participates in the regulation of
            lipopolysaccharide-induced inflammatory responses in human
            bronchial epithelial cells
  JOURNAL   Respir Physiol Neurobiol 327, 104303 (2024)
   PUBMED   39029565
  REMARK    GeneRIF: Chloride intracellular channel 4 participates in the
            regulation of lipopolysaccharide-induced inflammatory responses in
            human bronchial epithelial cells.
REFERENCE   3  (bases 1 to 4253)
  AUTHORS   Xerez,M.C., da Silva Barros,C.C., de Souto Medeiros,M.R.,
            Mafra,R.P., de Lucena,H.F., da Silveira,E.J.D. and de Lisboa Lopes
            Costa,A.
  TITLE     CLIC4 Function in the Epithelial-Mesenchymal Transition of
            Epithelial Odontogenic Lesions
  JOURNAL   Head Neck Pathol 18 (1), 40 (2024)
   PUBMED   38727794
  REMARK    GeneRIF: CLIC4 Function in the Epithelial-Mesenchymal Transition of
            Epithelial Odontogenic Lesions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4253)
  AUTHORS   Xerez,M.C., Barros,C.C., Queiroz,S.I., Silveira,E.J. and Costa,A.D.
  TITLE     The stromal immunoexpression of CLIC4 may be related to the
            difference in the biological behavior between oral squamous cell
            carcinoma and oral verrucous carcinoma
  JOURNAL   Med Oral Patol Oral Cir Bucal 28 (5), e418-e424 (2023)
   PUBMED   37026609
  REMARK    GeneRIF: The stromal immunoexpression of CLIC4 may be related to
            the difference in the biological behavior between oral squamous
            cell carcinoma and oral verrucous carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4253)
  AUTHORS   Kleinjan,M.L., Mao,Y., Naiche,L.A., Joshi,J.C., Gupta,A.,
            Jesse,J.J., Shaye,D.D., Mehta,D. and Kitajewski,J.
  TITLE     CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1
            Signaling via RhoA
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (8), 1441-1454 (2023)
   PUBMED   37317855
  REMARK    GeneRIF: CLIC4 Regulates Endothelial Barrier Control by Mediating
            PAR1 Signaling via RhoA.
REFERENCE   6  (bases 1 to 4253)
  AUTHORS   Kloeker,S. and Wadzinski,B.E.
  TITLE     Purification and identification of a novel subunit of protein
            serine/threonine phosphatase 4
  JOURNAL   J Biol Chem 274 (9), 5339-5347 (1999)
   PUBMED   10026142
REFERENCE   7  (bases 1 to 4253)
  AUTHORS   Qian,Z., Okuhara,D., Abe,M.K. and Rosner,M.R.
  TITLE     Molecular cloning and characterization of a mitogen-activated
            protein kinase-associated intracellular chloride channel
  JOURNAL   J Biol Chem 274 (3), 1621-1627 (1999)
   PUBMED   9880541
REFERENCE   8  (bases 1 to 4253)
  AUTHORS   Duncan,R.R., Westwood,P.K., Boyd,A. and Ashley,R.H.
  TITLE     Rat brain p64H1, expression of a new member of the p64 chloride
            channel protein family in endoplasmic reticulum
  JOURNAL   J Biol Chem 272 (38), 23880-23886 (1997)
   PUBMED   9295337
REFERENCE   9  (bases 1 to 4253)
  AUTHORS   Valenzuela,S.M., Martin,D.K., Por,S.B., Robbins,J.M., Warton,K.,
            Bootcov,M.R., Schofield,P.R., Campbell,T.J. and Breit,S.N.
  TITLE     Molecular cloning and expression of a chloride ion channel of cell
            nuclei
  JOURNAL   J Biol Chem 272 (19), 12575-12582 (1997)
   PUBMED   9139710
REFERENCE   10 (bases 1 to 4253)
  AUTHORS   Wick,M., Burger,C., Brusselbach,S., Lucibello,F.C. and Muller,R.
  TITLE     Identification of serum-inducible genes: different patterns of gene
            regulation during G0-->S and G1-->S progression
  JOURNAL   J Cell Sci 107 (Pt 1), 227-239 (1994)
   PUBMED   8175911
  REMARK    Erratum:[J Cell Sci. 1994 Mar;107 ( Pt 3):preceding table of
            contents.. PMID: 8006057]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC012444.1, AL662924.24,
            BQ929781.1 and BQ574968.1.
            
            On Nov 22, 2018 this sequence version replaced NM_013943.2.
            
            Summary: Chloride channels are a diverse group of proteins that
            regulate fundamental cellular processes including stabilization of
            cell membrane potential, transepithelial transport, maintenance of
            intracellular pH, and regulation of cell volume. Chloride
            intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene,
            is a member of the p64 family; the gene is expressed in many
            tissues and exhibits a intracellular vesicular pattern in Panc-1
            cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.62160.1,
                                           SRR1660807.56912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000374379.9/
                                                  ENSP00000363500.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-887               BC012444.1         44-930
            888-1945            AL662924.24        56937-57994
            1946-2545           BQ929781.1         226-825
            2546-3727           AL662924.24        58595-59776
            3728-4253           BQ574968.1         22-547              c
FEATURES             Location/Qualifiers
     source          1..4253
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..4253
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
                     /note="chloride intracellular channel 4"
                     /db_xref="GeneID:25932"
                     /db_xref="HGNC:HGNC:13518"
                     /db_xref="MIM:606536"
     exon            1..179
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..869
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
                     /note="chloride intracellular channel 4 like;
                     intracellular chloride ion channel protein p64H1;
                     epididymis secretory sperm binding protein;
                     glutaredoxin-like oxidoreductase CLIC4"
                     /codon_start=1
                     /product="chloride intracellular channel protein 4"
                     /protein_id="NP_039234.1"
                     /db_xref="CCDS:CCDS256.1"
                     /db_xref="GeneID:25932"
                     /db_xref="HGNC:HGNC:13518"
                     /db_xref="MIM:606536"
                     /translation="MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMI
                     LWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPP
                     KYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLP
                     DEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIW
                     RYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK"
     exon            180..289
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
                     /inference="alignment:Splign:2.1.0"
     exon            290..415
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..522
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..704
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..4253
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4178..4183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
                     /note="hexamer: AATAAA"
     polyA_site      4200
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
     regulatory      4230..4235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
                     /note="hexamer: AATAAA"
     polyA_site      4253
                     /gene="CLIC4"
                     /gene_synonym="CLIC4L; H1; huH1; MTCLIC; p64H1"
                     /note="major polyA site"
ORIGIN      
        1 agtccagcga gcagcacggc gggaaccggc agccggagca gtcccggagc agaagcagca
       61 gcagcagcag cagccctcgc cgttcgcgga gcgcagccga gccggccatg gcgttgtcga
      121 tgccgctgaa tgggctgaag gaggaggaca aagagcccct catcgagctc ttcgtcaagg
      181 ctggcagtga tggtgaaagc ataggaaact gccccttttc ccagaggctc ttcatgattc
      241 tttggctcaa aggagttgta tttagtgtga cgactgttga cctgaaaagg aagccagcag
      301 acctgcagaa cttggctccc gggacccacc caccatttat aactttcaac agtgaagtca
      361 aaacggatgt aaataagatt gaggaatttc ttgaagaagt cttatgccct cccaagtact
      421 taaagctttc accaaaacac ccagaatcaa atactgctgg aatggacatc tttgccaaat
      481 tctctgcata tatcaagaat tcaaggccag aggctaatga agcactggag aggggtctcc
      541 tgaaaaccct gcagaaactg gatgaatatc tgaattctcc tctccctgat gaaattgatg
      601 aaaatagtat ggaggacata aagttttcta cacgtaaatt tctggatggc aatgaaatga
      661 cattagctga ttgcaacctg ctgcccaaac tgcatattgt caaggtggtg gccaaaaaat
      721 atcgcaactt tgatattcca aaagaaatga ctggcatctg gagataccta actaatgcat
      781 acagtaggga cgagttcacc aatacctgtc ccagtgataa ggaggttgaa atagcatata
      841 gtgatgtagc caaaagactc accaagtaaa atcgcgtttg taaaagagat gtcttcatgt
      901 cttcccctaa gaatacgctt ttcctaacag gctactcctt cctgtagagc agaaattgta
      961 ttttgcacga acatgcagtt attgaagatt aggatcaagg atagacaagg tatagtagtt
     1021 atcttaaaat atacactcct aagcagtatt attttaaaat cctttaccct ggctacctcc
     1081 cctacccggg ttcccctctc tttaatttgg agacactcca ccacaaactt ttcactttag
     1141 aggtagcttg ccatctctca ggagccctca ccattgtgtc cattcactgt gtatagatgg
     1201 cagaactttt gaggtgcaat gtttaattgt taaaaatagt agccacgact ttatcaggca
     1261 gccccaaact ggtgcataat gcatggtaca agaaatattt atgtattttt tggaattttg
     1321 taatatttag taagagtata tgaaaggatt gctactgtat cagaaatatt gtttcaattt
     1381 agtctatcct ggatatgtac taacgaatat taccaccaga gaagagagct ttctacaaaa
     1441 gtcactacag attttgctat attgctttgt agatagattt ttacttttgc ctaaaagcat
     1501 ttatccttca taccaattgt aacatctgac accatgtaga agctaaaagt ttagagggag
     1561 tgagggtttt ctcaagacct tcctcaagca ttttatcttt agaagagaaa ctgatgggca
     1621 cctgatactc tgtctaaata cgtttgttat atgtgttttg ccctgtgcca ttcatttgga
     1681 actttattgc attctttatt ttaaaaagct tgtttttacg taatcataga gcttgctatt
     1741 tgtacatctg ttgagcaaca ctacataact gatttttagt tgacttagct atagcagtac
     1801 aatgattagt aatgtaaaaa ttaacacaga aattaaccta aggaatgaag ggtgggtttg
     1861 tcaaaatatc aagtaaattt ttgtttctaa agtacattta atgtagatga cctaaagaat
     1921 gcgttatcca tcctatataa aagaaagata aaacacaggt caccaatttt ctcatttcac
     1981 cccatttacc ttgtatagag gattgttcat tcctttggga ctaagttata gttatggtga
     2041 gtgtgtattt actgtagttt tgcctgatct cactcattgc acttcctgga gttaaatttt
     2101 ccaacagcca tgttgaggaa tagcactctg catgtttttg ttttgttttt cggggttttt
     2161 tttaattgaa gccctaaacc aggaattatt tgtgttctaa caggaggatg aacttgctga
     2221 aaataaaact ttgctatgta tttactcttt tttaaaagac aaaagcaaaa ccagactttc
     2281 tacgtactac tccaaagact gtgattgtga ctataataca tttttggtaa tttttttata
     2341 cctaatttgt ataggaagtg ctatttctca taggctgttt cttgaaattt taagtttatt
     2401 gctttaaaat ggcagtgttt ctcccacttt gatatgctaa catttagtaa gcactggctt
     2461 tatgaaagcg gctttttata agtatactgc attttttgag cctatcatta attagcttag
     2521 tatgaaagat aagaaaatct ccatgttgta tccatttggc tcaggaagat tctttgcctt
     2581 acctttctta gaactcttta ttgcttatca aaagtttgag tacccgcttg gttttttttt
     2641 ggtaattaaa tattgtatga tttatctggt tcaaggaaga tgcactattc agttatctat
     2701 tgagaaatta ttttgcagtg gttttagtgg gtgaaaatgt cccatctgca ccagtacaca
     2761 ggcaggcatt atcattcttc acctactttt taaatagtgg caacttggga ttcattctgg
     2821 tgattctgaa ccttgcctca tagcttaaag tataaaaaag attcaagagc agtgaggttt
     2881 gttctttcca gtgaatggtg gactgagtgg tgcgaggtgg agggctaaca agaggaaaga
     2941 actacattct tcagaataca gtgatgaaaa ttcattttga aactcaaata ttttcatttt
     3001 ggatattctc ctgtttttat taaaccagtg attacacctg gccatccctc taaatgttct
     3061 aggaaggcat gtctattgtg attttgatga agacagaatt atttttctct gtagaaacac
     3121 agataccact ttatcaggga agttagtcaa atgaaatgga aattggtaaa tggacaaaag
     3181 ctagctagta aaaaggacga cccagcaaca tgctttaacc ccattgtatg tttgtggaaa
     3241 gagcatagtt taacatcttg agaaatttgg gacataaagt tttcatggta gacagttcat
     3301 gcagtatatg aattgccata atggaaataa tctgatttta tttttacaac taacatccat
     3361 tccccttcat ttaaacacct tttgtgtttt acttcagtga ggagattgga gtctgaatgg
     3421 atctgttttc caagagattc tgagaaattt ttgtattcag cagttggaaa gctctctatt
     3481 ctagttgata aaacttccct tttttgatgt agatgcagat attctataca gttctgttgt
     3541 cttttactag gactgtaaac ttttgtgata aaattcaaat aagattttat ttcttggtaa
     3601 ttttggcttt cacaatttat ctttaaatcc ttgagcaatc tgtatacaat taagagattt
     3661 ctgacattta ttcttacact aaatggatca actctaggat ttaggcatgt taacttctgt
     3721 tgtgttttga atctctccag agttgcatgt agatagcatt tatttctgtg cccttaaacc
     3781 catttagaaa ataactacaa agtaaaaatg tagaggaaat agaaatgtat tttttcatga
     3841 acattttgat acaaatttca tcatttaatg attcaccaat ttcttgcatt aatttgaatt
     3901 taagcattta attcaaagag aggggagcat ccattattga tacatgtggg cttttaaaaa
     3961 ctccatcctt tataaatagt caaggtttgg gccacacaaa gtatattttt atcatggaaa
     4021 aatttcaact cctcaagccg taatgttgaa cagaattgga gtattttctt tataatttct
     4081 tgaacaggca aatgaaagct tattatagaa tgcatgtatt ttcttttatc tttggaacat
     4141 cagcaccagt atattgctgg cagctattgt attaaaaaat aaagtatatt ttcactatca
     4201 taaaggattc ttttttcccc cctcatgaaa ataaacaaca acttggggta aaa
//
