LOCUS       NM_004669                809 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens chloride intracellular channel 3 (CLIC3), mRNA.
ACCESSION   NM_004669
VERSION     NM_004669.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 809)
  AUTHORS   Shuai,Y., Zhang,H., Liu,C., Wang,J., Jiang,Y., Sun,J., Gao,X.,
            Bo,X., Xiao,X., Liao,X., Huang,C., Chen,H. and Jiang,G.
  TITLE     CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine
            modification of p21 mRNA and promote bladder cancer progression
  JOURNAL   Cell Death Dis 15 (1), 9 (2024)
   PUBMED   38182571
  REMARK    GeneRIF: CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine
            modification of p21 mRNA and promote bladder cancer progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 809)
  AUTHORS   Liang,J., Long,Z., Zhang,Y., Wang,J., Chen,X., Liu,X., Gu,Y.,
            Zhang,W., Zhang,T., Chen,Y., Zhang,G., Sun,W., Kuang,D., Gao,Z. and
            Zheng,Y.
  TITLE     Chloride intercellular channel 3 suppression-mediated macrophage
            polarization: a potential indicator of poor prognosis of hepatitis
            B virus-related acute-on-chronic liver failure
  JOURNAL   Immunol Cell Biol 100 (5), 323-337 (2022)
   PUBMED   35238065
  REMARK    GeneRIF: Chloride intercellular channel 3 suppression-mediated
            macrophage polarization: a potential indicator of poor prognosis of
            hepatitis B virus-related acute-on-chronic liver failure.
REFERENCE   3  (bases 1 to 809)
  AUTHORS   Huang,J.J., Lin,J., Chen,X. and Zhu,W.
  TITLE     Identification of chloride intracellular channels as prognostic
            factors correlated with immune infiltration in hepatocellular
            carcinoma using bioinformatics analysis
  JOURNAL   Medicine (Baltimore) 100 (45), e27739 (2021)
   PUBMED   34766585
  REMARK    GeneRIF: Identification of chloride intracellular channels as
            prognostic factors correlated with immune infiltration in
            hepatocellular carcinoma using bioinformatics analysis.
REFERENCE   4  (bases 1 to 809)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 809)
  AUTHORS   Kawai,S., Fujii,T., Shimizu,T., Sukegawa,K., Hashimoto,I.,
            Okumura,T., Nagata,T., Sakai,H. and Fujii,T.
  TITLE     Pathophysiological properties of CLIC3 chloride channel in human
            gastric cancer cells
  JOURNAL   J Physiol Sci 70 (1), 15 (2020)
   PUBMED   32066374
  REMARK    GeneRIF: Pathophysiological properties of CLIC3 chloride channel in
            human gastric cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 809)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 809)
  AUTHORS   Money,T.T., King,R.G., Wong,M.H., Stevenson,J.L., Kalionis,B.,
            Erwich,J.J., Huisman,M.A., Timmer,A., Hiden,U., Desoye,G. and
            Gude,N.M.
  TITLE     Expression and cellular localisation of chloride intracellular
            channel 3 in human placenta and fetal membranes
  JOURNAL   Placenta 28 (5-6), 429-436 (2007)
   PUBMED   17027078
  REMARK    GeneRIF: CLIC3 facilitates chloride ion movement and regulates
            cellular processes associated with the movement of chloride in
            placental and fetal membrane cells.
REFERENCE   8  (bases 1 to 809)
  AUTHORS   Suginta,W., Karoulias,N., Aitken,A. and Ashley,R.H.
  TITLE     Chloride intracellular channel protein CLIC4 (p64H1) binds directly
            to brain dynamin I in a complex containing actin, tubulin and
            14-3-3 isoforms
  JOURNAL   Biochem J 359 (Pt 1), 55-64 (2001)
   PUBMED   11563969
REFERENCE   9  (bases 1 to 809)
  AUTHORS   Qian,Z., Okuhara,D., Abe,M.K. and Rosner,M.R.
  TITLE     Molecular cloning and characterization of a mitogen-activated
            protein kinase-associated intracellular chloride channel
  JOURNAL   J Biol Chem 274 (3), 1621-1627 (1999)
   PUBMED   9880541
REFERENCE   10 (bases 1 to 809)
  AUTHORS   Valenzuela,S.M., Martin,D.K., Por,S.B., Robbins,J.M., Warton,K.,
            Bootcov,M.R., Schofield,P.R., Campbell,T.J. and Breit,S.N.
  TITLE     Molecular cloning and expression of a chloride ion channel of cell
            nuclei
  JOURNAL   J Biol Chem 272 (19), 12575-12582 (1997)
   PUBMED   9139710
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM043659.1, AF102166.1,
            AI741256.1 and BF439361.1.
            
            On May 17, 2019 this sequence version replaced NM_004669.2.
            
            Summary: Chloride channels are a diverse group of proteins that
            regulate fundamental cellular processes including stabilization of
            cell membrane potential, transepithelial transport, maintenance of
            intracellular pH, and regulation of cell volume. Chloride
            intracellular channel 3 is a member of the p64 family and is
            predominantly localized in the nucleus and stimulates chloride ion
            channel activity. In addition, this protein may participate in
            cellular growth control, based on its association with ERK7, a
            member of the MAP kinase family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007012.1, AF102166.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000494426.2/
                                                  ENSP00000419378.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               BM043659.1         236-529
            295-782             AF102166.1         259-746
            783-803             AI741256.1         1-21                c
            804-809             BF439361.1         4-9                 c
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..809
                     /gene="CLIC3"
                     /note="chloride intracellular channel 3"
                     /db_xref="GeneID:9022"
                     /db_xref="HGNC:HGNC:2064"
                     /db_xref="MIM:606533"
     exon            1..58
                     /gene="CLIC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..736
                     /gene="CLIC3"
                     /note="glutaredoxin-like oxidoreductase CLIC3"
                     /codon_start=1
                     /product="chloride intracellular channel protein 3"
                     /protein_id="NP_004660.2"
                     /db_xref="CCDS:CCDS7021.1"
                     /db_xref="GeneID:9022"
                     /db_xref="HGNC:HGNC:2064"
                     /db_xref="MIM:606533"
                     /translation="MAETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTV
                     DTRRSPDVLKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESN
                     TAGNDVFHKFSAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESR
                     RRFLDGDRLTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYT
                     CPHSAEILAAYRPAVHPR"
     exon            59..168
                     /gene="CLIC3"
                     /inference="alignment:Splign:2.1.0"
     exon            169..294
                     /gene="CLIC3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..401
                     /gene="CLIC3"
                     /inference="alignment:Splign:2.1.0"
     exon            402..577
                     /gene="CLIC3"
                     /inference="alignment:Splign:2.1.0"
     exon            578..809
                     /gene="CLIC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      761..766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLIC3"
                     /note="hexamer: AATAAA"
     polyA_site      782
                     /gene="CLIC3"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctgacc gcggcagctc ccaccatggc ggagaccaag ctccagctgt ttgtcaaggc
       61 gagtgaggac ggggagagcg tgggtcactg cccctcctgc cagcggctct tcatggtcct
      121 gctcctcaag ggcgtacctt tcaccctcac cacggtggac acgcgcaggt ccccggacgt
      181 gctgaaggac ttcgcccccg gctcgcagct gcccatcctg ctctatgaca gcgacgccaa
      241 gacagacacg ctgcagatcg aggactttct ggaggagacg ctggggccgc ccgacttccc
      301 cagcctggcg cctcgttaca gggagtccaa caccgccggc aacgacgttt tccacaagtt
      361 ctccgcgttc atcaagaacc cggtgcccgc gcaggacgaa gccctgtacc agcagctgct
      421 gcgcgccctc gccaggctgg acagctacct gcgcgcgccc ctggagcacg agctggcggg
      481 ggagccgcag ctgcgcgagt cccgccgccg cttcctggac ggcgacaggc tcacgctggc
      541 cgactgcagc ctcctgccca agctgcacat cgtcgacacg gtgtgcgcgc acttccgcca
      601 ggcgcccatc cccgcggagc tgcgcggcgt acgccgctac ctggacagcg cgatgcagga
      661 gaaagagttc aaatacacgt gtccgcacag cgccgagatc ctggcggcct accggcccgc
      721 cgtgcacccc cgctagcgcc ccaccccgcg tctgtcgccc aataaaggca tctttgtcgg
      781 gagtgagggt gtcctgacat ctgaagggc
//
