LOCUS       NM_001288               1199 bp    mRNA    linear   PRI 05-APR-2025
DEFINITION  Homo sapiens chloride intracellular channel 1 (CLIC1), transcript
            variant 2, mRNA.
ACCESSION   NM_001288
VERSION     NM_001288.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1199)
  AUTHORS   Zheng,J.H., Zhu,Y.H., Yang,J., Ji,P.X., Zhao,R.K., Duan,Z.H.,
            Yao,H.F., Jia,Q.Y., Yin,Y.F., Hu,L.P., Li,Q., Jiang,S.H., Huo,Y.M.,
            Liu,W., Sun,Y.W. and Liu,D.J.
  TITLE     A CLIC1 network coordinates matrix stiffness and the Warburg effect
            to promote tumor growth in pancreatic cancer
  JOURNAL   Cell Rep 43 (8), 114633 (2024)
   PUBMED   39154343
  REMARK    GeneRIF: A CLIC1 network coordinates matrix stiffness and the
            Warburg effect to promote tumor growth in pancreatic cancer.
REFERENCE   2  (bases 1 to 1199)
  AUTHORS   Rashid,M.U. and Coombs,K.M.
  TITLE     Chloride Intracellular Channel Protein 1 (CLIC1) Is a Critical Host
            Cellular Factor for Influenza A Virus Replication
  JOURNAL   Viruses 16 (1), 129 (2024)
   PUBMED   38257829
  REMARK    GeneRIF: Chloride Intracellular Channel Protein 1 (CLIC1) Is a
            Critical Host Cellular Factor for Influenza A Virus Replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1199)
  AUTHORS   Nong,Z.L., Zhao,K., Wang,Y., Yu,Z., Wang,C.J. and Chen,J.Q.
  TITLE     CLIC1-mediated autophagy confers resistance to DDP in gastric
            cancer
  JOURNAL   Anticancer Drugs 35 (1), 1-11 (2024)
   PUBMED   37104099
  REMARK    GeneRIF: CLIC1-mediated autophagy confers resistance to DDP in
            gastric cancer.
REFERENCE   4  (bases 1 to 1199)
  AUTHORS   Chen,Z., Chen,W., Huang,R., Chen,D., Li,Z., Qi,X., Sun,L., Lin,L.
            and Zhang,Z.
  TITLE     Comprehensive analysis of clinical prognosis and CLIC1 immune
            invasion in lung adenocarcinoma
  JOURNAL   Medicine (Baltimore) 101 (39), e30760 (2022)
   PUBMED   36181109
  REMARK    GeneRIF: Comprehensive analysis of clinical prognosis and CLIC1
            immune invasion in lung adenocarcinoma.
REFERENCE   5  (bases 1 to 1199)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1199)
  AUTHORS   Heiss,N.S. and Poustka,A.
  TITLE     Genomic structure of a novel chloride channel gene, CLIC2, in Xq28
  JOURNAL   Genomics 45 (1), 224-228 (1997)
   PUBMED   9339381
REFERENCE   7  (bases 1 to 1199)
  AUTHORS   Valenzuela,S.M., Martin,D.K., Por,S.B., Robbins,J.M., Warton,K.,
            Bootcov,M.R., Schofield,P.R., Campbell,T.J. and Breit,S.N.
  TITLE     Molecular cloning and expression of a chloride ion channel of cell
            nuclei
  JOURNAL   J Biol Chem 272 (19), 12575-12582 (1997)
   PUBMED   9139710
  REMARK    GeneRIF: NCC27 (CLIC1) is a 27 kDa intracellular ion channel
            localized to the nucleus and cytoplasm that exists in both a
            soluble and integral membrane form
REFERENCE   8  (bases 1 to 1199)
  AUTHORS   Frigerio,J.M., Berthezene,P., Garrido,P., Ortiz,E., Barthellemy,S.,
            Vasseur,S., Sastre,B., Seleznieff,I., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Analysis of 2166 clones from a human colorectal cancer cDNA library
            by partial sequencing
  JOURNAL   Hum Mol Genet 4 (1), 37-43 (1995)
   PUBMED   7711732
REFERENCE   9  (bases 1 to 1199)
  AUTHORS   Liew,C.C., Hwang,D.M., Fung,Y.W., Laurenssen,C., Cukerman,E.,
            Tsui,S. and Lee,C.Y.
  TITLE     A catalogue of genes in the cardiovascular system as identified by
            expressed sequence tags
  JOURNAL   Proc Natl Acad Sci U S A 91 (22), 10645-10649 (1994)
   PUBMED   7938007
REFERENCE   10 (bases 1 to 1199)
  AUTHORS   Okubo,K., Hori,N., Matoba,R., Niiyama,T., Fukushima,A., Kojima,Y.
            and Matsubara,K.
  TITLE     Large scale cDNA sequencing for analysis of quantitative and
            qualitative aspects of gene expression
  JOURNAL   Nat Genet 2 (3), 173-179 (1992)
   PUBMED   1345164
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662899.5.
            
            On Jun 17, 2021 this sequence version replaced NM_001288.5.
            
            Summary: Chloride channels are a diverse group of proteins that
            regulate fundamental cellular processes including stabilization of
            cell membrane potential, transepithelial transport, maintenance of
            intracellular pH, and regulation of cell volume. Chloride
            intracellular channel 1  is a member of the p64 family; the protein
            localizes principally to the cell nucleus and exhibits both nuclear
            and plasma membrane chloride ion channel activity. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) has an alternate exon in the
            5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM463767.1, BM927520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375784.8/ ENSP00000364940.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               AL662899.5         78603-78871         c
            270-379             AL662899.5         76495-76604         c
            380-505             AL662899.5         76177-76302         c
            506-612             AL662899.5         75907-76013         c
            613-794             AL662899.5         74558-74739         c
            795-1199            AL662899.5         72940-73344         c
FEATURES             Location/Qualifiers
     source          1..1199
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1199
                     /gene="CLIC1"
                     /gene_synonym="CL1C1; CLCNL1; G6; NCC27"
                     /note="chloride intracellular channel 1"
                     /db_xref="GeneID:1192"
                     /db_xref="HGNC:HGNC:2062"
                     /db_xref="MIM:602872"
     exon            1..269
                     /gene="CLIC1"
                     /gene_synonym="CL1C1; CLCNL1; G6; NCC27"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..956
                     /gene="CLIC1"
                     /gene_synonym="CL1C1; CLCNL1; G6; NCC27"
                     /EC_number="1.8.5.1"
                     /note="p64CLCP; chloride channel ABP; RNCC protein;
                     nuclear chloride ion channel protein; hRNCC; nuclear
                     chloride ion channel 27; regulatory nuclear chloride ion
                     channel protein; glutaredoxin-like oxidoreductase CLIC1;
                     glutathione-dependent dehydroascorbate reductase CLIC1"
                     /codon_start=1
                     /product="chloride intracellular channel protein 1"
                     /protein_id="NP_001279.2"
                     /db_xref="CCDS:CCDS4719.1"
                     /db_xref="GeneID:1192"
                     /db_xref="HGNC:HGNC:2062"
                     /db_xref="MIM:602872"
                     /translation="MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVT
                     TVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPE
                     SNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDE
                     GVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREE
                     FASTCPDDEEIELAYEQVAKALK"
     exon            270..379
                     /gene="CLIC1"
                     /gene_synonym="CL1C1; CLCNL1; G6; NCC27"
                     /inference="alignment:Splign:2.1.0"
     exon            380..505
                     /gene="CLIC1"
                     /gene_synonym="CL1C1; CLCNL1; G6; NCC27"
                     /inference="alignment:Splign:2.1.0"
     exon            506..612
                     /gene="CLIC1"
                     /gene_synonym="CL1C1; CLCNL1; G6; NCC27"
                     /inference="alignment:Splign:2.1.0"
     exon            613..794
                     /gene="CLIC1"
                     /gene_synonym="CL1C1; CLCNL1; G6; NCC27"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1199
                     /gene="CLIC1"
                     /gene_synonym="CL1C1; CLCNL1; G6; NCC27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1180..1185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLIC1"
                     /gene_synonym="CL1C1; CLCNL1; G6; NCC27"
                     /note="hexamer: AATAAA"
     polyA_site      1199
                     /gene="CLIC1"
                     /gene_synonym="CL1C1; CLCNL1; G6; NCC27"
                     /note="major polyA site"
ORIGIN      
        1 ctctgatcca gcccgggaga ggaccgagct ggaggagctg ggtgtggggt gcgttgggct
       61 ggtggggagg cctagtttgg gtgcaagtag gtctgattga gcttgtgttg tgctgaaggg
      121 acagccctgg gtctagggga gagagtccct gagtgtgaga cccgccttcc ccggtcccag
      181 cccctcccag ttcccccagg gacggccact tcctggtccc cgacgcaacc atggctgaag
      241 aacaaccgca ggtcgaattg ttcgtgaagg ctggcagtga tggggccaag attgggaact
      301 gcccattctc ccagagactg ttcatggtac tgtggctcaa gggagtcacc ttcaatgtta
      361 ccaccgttga caccaaaagg cggaccgaga cagtgcagaa gctgtgccca ggggggcagc
      421 tcccattcct gctgtatggc actgaagtgc acacagacac caacaagatt gaggaatttc
      481 tggaggcagt gctgtgccct cccaggtacc ccaagctggc agctctgaac cctgagtcca
      541 acacagctgg gctggacata tttgccaaat tttctgccta catcaagaat tcaaacccag
      601 cactcaatga caatctggag aagggactcc tgaaagccct gaaggtttta gacaattact
      661 taacatcccc cctcccagaa gaagtggatg aaaccagtgc tgaagatgaa ggtgtctctc
      721 agaggaagtt tttggatggc aacgagctca ccctggctga ctgcaacctg ttgccaaagt
      781 tacacatagt acaggtggtg tgtaagaagt accggggatt caccatcccc gaggccttcc
      841 ggggagtgca tcggtacttg agcaatgcct acgcccggga agaattcgct tccacctgtc
      901 cagatgatga ggagatcgag ctcgcctatg agcaagtggc aaaggccctc aaataagccc
      961 ctcctgggac tccctcaacc ccctccattt tctccacaaa ggccctggtg gtttccacat
     1021 tgctacccaa tggacacact ccaaaatggc cagtgggcag ggaatcctgg agcacttgtt
     1081 ccgggatggt gtggtggaag aggggatgag ggaaagaaat ggggggcctg ggtcagattt
     1141 ttattgtggg gtgggatgag taggacaaca tatttcagta ataaaataca gaataaaaa
//
