LOCUS       NM_152385               5330 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens clathrin heavy chain linker domain containing 1
            (CLHC1), transcript variant 1, mRNA.
ACCESSION   NM_152385
VERSION     NM_152385.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5330)
  AUTHORS   Winham,S.J., Cuellar-Barboza,A.B., Oliveros,A., McElroy,S.L.,
            Crow,S., Colby,C., Choi,D.S., Chauhan,M., Frye,M. and
            Biernacka,J.M.
  TITLE     Genome-wide association study of bipolar disorder accounting for
            effect of body mass index identifies a new risk allele in TCF7L2
  JOURNAL   Mol Psychiatry 19 (9), 1010-1016 (2014)
   PUBMED   24322204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB055534.1, DA713663.1, AK315683.1, BC029502.1, BM046729.1,
            DA249479.1, AC093165.5 and BM968338.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152385.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029502.1, AK315683.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401408.6/ ENSP00000384869.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                DB055534.1         75-130
            57-71               DA713663.1         12-26
            72-825              AK315683.1         50-803
            826-1601            BC029502.1         846-1621
            1602-1698           BM046729.1         528-624
            1699-2087           AK315683.1         1677-2065
            2088-2256           DA249479.1         403-571
            2257-5175           AC093165.5         138881-141799       c
            5176-5330           BM968338.1         11-165              c
FEATURES             Location/Qualifiers
     source          1..5330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.1"
     gene            1..5330
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /note="clathrin heavy chain linker domain containing 1"
                     /db_xref="GeneID:130162"
                     /db_xref="HGNC:HGNC:26453"
     exon            1..71
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            72..244
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            245..503
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..2087
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /note="isoform 1 is encoded by transcript variant 1;
                     clathrin heavy chain linker domain-containing protein 1"
                     /codon_start=1
                     /product="clathrin heavy chain linker domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_689598.2"
                     /db_xref="CCDS:CCDS33201.1"
                     /db_xref="GeneID:130162"
                     /db_xref="HGNC:HGNC:26453"
                     /translation="MSVHQIRKHAVLPPIICRSDKEFLESVQRYIITETERLGCSEEG
                     PADEYYIIYRNVFDKVIEHITAYKSILTSIKKEYDAFIETIKKDRRTTFCLHGKLKGL
                     AAEPTALVYYRKRTIQLEAKMRIIESNSSKIQSQIDHIKQCRAEYDTKEVKYCTFSKD
                     PSKPIPGMTLQESMNLDALTKYMKHLEDKYAEIKQAMLIKYVPAQRKADLDEEMIVLL
                     KRRDVAENLNKKLQFCHQRLQIISQALSSWVKSDMSSPFQDFVEQIQKTKYLQGDQGI
                     VEELMEDDPRRAKEAEIMLHYIERFNELISLGEYEKAACYAANSPRRILRNIGTMNTF
                     KAVGKIRGKPLPLLLFFEALFITSHAFPCPVDAALTLEGIKCGLSEKRLDLVTNWVTQ
                     ERLTFSEEAGDVICDYGEQDTYNKAKCLALAQIVYSECGLHKKAILCLCKQGQTHRVM
                     EYIQQLKDFTTDDLLQLLMSCPQVELIQCLTKELNEKQPSLSFGLAILHLFSADMKKV
                     GIKLLQEINKGGIDAVESLMINDSFCSIEKWQEVANICSQNGFDKLSNDITSILRSQA
                     AVTEISEEDDAVNLMEHVFW"
     exon            504..691
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            692..825
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1027
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1140
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1225
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1332
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1507
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1710
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1890
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..5330
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5309..5314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /note="hexamer: AATATA"
     polyA_site      5330
                     /gene="CLHC1"
                     /gene_synonym="C2orf63"
                     /note="major polyA site"
ORIGIN      
        1 agattcccta gttactatct ctaagcactg aagtcggtgt ttggagaaaa ggactcaggt
       61 gaggactgga gcctaacaga tgagacagaa tataaacagg aagtctctaa ggcagtgtgg
      121 tggaaggata ataccatgat ggaggaagtg cacagtatta tgggagaaca tagcagtggc
      181 atctgaccaa ttttaaggga atccaggaca gctttcctga agctgaagaa agagtaaaag
      241 ccaggcttat caaagttttg gctttgttgc aagagcaggt caagatttag ctgttcttca
      301 gtgaacaagt gtgcagattg tcaaatatgt cagttcatca aataagaaaa catgcagttc
      361 tcccacctat catttgtaga agtgacaagg aatttttgga aagtgtgcaa agatacataa
      421 ttacagaaac tgaaagactg ggctgtagtg aggaaggacc tgctgatgaa tattacatca
      481 tataccgaaa tgtttttgat aaggtaatag agcatatcac tgcatacaaa tccattctta
      541 cttcaatcaa aaaagaatat gatgccttta ttgagacaat aaagaaagac cgaagaacta
      601 cattttgtct tcatggaaaa cttaaaggtt tggcagcaga gcctacagct ttggtatatt
      661 acaggaaaag aacaatccaa cttgaagcaa aaatgaggat tatcgaaagt aattcctcga
      721 agattcaatc tcaaatagat cacatcaagc agtgtagggc agagtatgac acaaaagaag
      781 taaaatattg tactttctcc aaagatcctt caaaacctat tccaggcatg actcttcaag
      841 aatccatgaa tctagatgct ctcactaaat acatgaaaca tcttgaagat aaatatgcag
      901 aaattaaaca agctatgttg ataaaatatg tgccagctca gaggaaggct gatttagatg
      961 aagaaatgat tgtgttatta aaacggcgag atgtagctga aaatctgaac aaaaaattgc
     1021 agttttgtca tcaaagactg cagataattt cacaggcact tagttcatgg gtaaaatctg
     1081 atatgagcag cccatttcaa gactttgtgg agcaaattca gaaaaccaaa tatttacaag
     1141 gtgaccaagg cattgttgaa gaactaatgg aagatgatcc acgcagggca aaagaagctg
     1201 aaattatgct tcactacatt gaaaggttta atgagttaat ctcacttggt gaatatgaaa
     1261 aggcagcttg ttatgcagca aacagtccta gaagaattct tcgaaacatt ggtacaatga
     1321 atacatttaa ggctgttgga aaaattagag gaaagcctct tccattactc ttattttttg
     1381 aggccctctt tatcacaagt catgcttttc catgtcctgt tgatgcagct ctaaccctgg
     1441 aaggaatcaa atgtggatta tcagaaaaac ggttagattt agttaccaat tgggttacac
     1501 aggaaagact gacattttct gaggaggctg gggatgtgat ttgtgattat ggggagcagg
     1561 atacttataa caaggccaag tgcctggctt tagctcagat tgtctacagt gaatgtggcc
     1621 tgcacaagaa agctattctt tgcttgtgta aacagggtca gactcatagg gtcatggagt
     1681 acatacagca gttgaaggac tttactaccg atgacctgtt gcagctatta atgtcatgtc
     1741 cccaagttga attaattcag tgtctcacta aagagttgaa tgagaaacaa ccatctttat
     1801 cttttggtct tgctatactt catctgttct ctgcagacat gaaaaaagtt ggcattaagc
     1861 tacttcaaga aatcaataaa ggtgggatag atgcagtaga aagtcttatg ataaatgatt
     1921 ccttttgctc catagaaaag tggcaagaag tggcaaatat atgttcacag aatggctttg
     1981 acaaattatc taatgacatc acgtctattc ttcgatctca ggctgcagtt acagaaattt
     2041 ctgaagagga tgacgcagtc aacctaatgg aacatgtgtt ttggtagttc tatatcttaa
     2101 ccagctgagg gagcttgtac aacaccttat gtatgctggt tgggaaaaac tgattttaac
     2161 gtaactaact tataaataaa tctagagtaa gaagatctca gaaataaatc acacttttgt
     2221 tatgatgaca tttagatttg tctttgaaat atttatacta ttgcttcctt ttccccatat
     2281 ggtcatttct tatattgaat cttgataaaa tccaagatta taactttgtg tgaaacagtg
     2341 tagggcattt ttatctaagg acataagcta atgtccagat atattacttt ctggtgatgt
     2401 aatatgatag caagaactga ggaaggtgtg ggtagtatcc tgtgtgttag actgtcttcc
     2461 caaacatgaa atgctacaag cctgacttga ccagaaaagc aggaaatcat ttcaaggttg
     2521 gacttgctgg caaaaaccta gagtatagta attttgtact gctgatttaa agatgcgccc
     2581 catgctttga tatatataaa tatggcaaag cttaggcttc tagtataaaa gctgggactc
     2641 ttggcatgtt attacttaga gagaagacca gtcgaatttt gcatagaagt agacctgtga
     2701 tacctatagg tatggaaaat atgtcataag aagtggtttt ggattatttc aagtgtctga
     2761 ataagtattt gattgaaaac tctgaaagtt ctgtgccatg gacaggtgta atattaaaaa
     2821 tatttaatga ttagtatggc atgggcacaa atcaagcaga acagatacct aattaatcag
     2881 aacagccttt agcccttatg ccacaccaga gcttactagc taaatgtcat ccttgaccat
     2941 ggaacatggt taaaatgagc tgctggctgg gcaaggtagc tcatgtctgt aatcccagca
     3001 ctttgggagg tcgaggcagg aggatcgctt gagcccagga gtttgagacc agctaggtaa
     3061 cacagtgaga tcccgtctct gttattaaaa aaagaaaaaa aaatttcaag taaaaaatga
     3121 aaatgatctg ctattagaat aagagcaaag agcataactt ttcccatcct aaatttaaat
     3181 tgaatatgta tttttatgtt atagtggaaa gaagatgaac ggggagtcag acagcttcat
     3241 attaaaattc tggtcctacc tcttactcac ttataaaata tgggcagtct tccttaggct
     3301 tgttgtgagg attagtgata atgtatgtgt agtgtaagtg tataacatga tagaggaact
     3361 taggaaaaga tagctgtaat tcctttgtaa tcggccccag aaacacacat ttctctactt
     3421 agtttgtact tactaaatcc catatgtcta ctcatttgta tttatatgtt tatccttctt
     3481 taaagtattt gatatattgg tacaacttat tgctgagatt aagttatctg tccacacttg
     3541 tattagggtt gcctggctta tcttataaat tcagaagcat tcaagctgag tttttaattt
     3601 ttccatttgg tgctaaatag aatactggat aattataatt cagctttcta aaacgtagca
     3661 tttttaaagt aatacatgtg catagtttaa aaagcaattt attactaaaa gccttatcaa
     3721 aataatattt tgatttttgg ccttcataca ggctgttgaa aagagcagat aaaggatgga
     3781 aaaaaggaat ggaaagggag aggtatttcg gcagcactgg ttctttgtgt gccaacggct
     3841 taaaaccttt tttttttttt ttttcctttg agacctatat gattgataga aagctattat
     3901 gtgtccattg acagagctta gaaaaaaaaa tgtcttcatg aaagccagga ggataaagta
     3961 ggtatataaa tctagagaaa gcttaaacag cggttgttgt tgttattcta attttgcctt
     4021 gtttttcctt ttctcattat tactccttct cagttagcat tgcctttggc agctttccca
     4081 aggaaagtaa aagttgtcaa gtgaatataa attaaaatgc ctggtgatgg aaaatggagt
     4141 tgggaggaag agcaagatta caaagttaaa tgaggaagga gaaagaattg agttgtgagc
     4201 tacagagggc tttgaagcta taagagcctc catgtaagct acactgaagg aggtataatc
     4261 tgggcctcag cacagaaacc tgcattctag accagcccca ccactgtcta gctatgtgtc
     4321 cttttcctca tgcttaagat aaatttattt tgactagata cctcctcttg tcatttccaa
     4381 ctctaaaatt cagtaattct gaaaaggtac aaattatttc ccaatgcttc ttgaccttca
     4441 gcctaaattt caaatactac aattcaacat cagcatcaac aacatctacc gaatacctgt
     4501 tttgcacaca atttctgcta gcaagattac aaccttaatg gaaacacaca acgtatttta
     4561 aaagttacta ataataattc cttagcatta tctaatagcc agtccatatt caaatttcac
     4621 cagttgctaa aaatgccttt taacatttga attgttccaa tgaagattta accaacgttc
     4681 atgtgttcta ttaggtcttg ctgtcttgag cgtgtcttct ctcctttttt cctcttgcca
     4741 ttgattgctt tacatagcag ttgcaaagca agggtcatga tgaactaagt ttctctgatt
     4801 tcatattagg ttttctttct accataccag tgaggaaagg aagatatttc ttccaaggtc
     4861 tgaaagattt aattgtaact agttacattt ttgtttatta tagtcaagca tgtatcaaaa
     4921 tgaatttcta ttaaattcat tcatttggaa aggtttagag atgttgaaca gaagtctagt
     4981 ctaatgaaaa aaattttttt aatatttaga acttttccta aatcctgaat taactaagaa
     5041 atgaccatta aattaatcac ttttttaact ttaaaaggtg aaaacctgtt actttttagg
     5101 tgcctggaat tctgttggat tgctaaagca tatgttaagt caaaaatcat agcagaggcc
     5161 tttttttttt tttttaactt tgtacatttc atagaaagct catacatttc ttccattctt
     5221 tctcagaaaa aaatggcatt taacaaatgt tcggtgtata aagctgtcag tttgctagta
     5281 gttataattt gttgtgttct tgaataaaaa tatattgggt acataaaaaa
//
