LOCUS       NM_207345               1733 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens C-type lectin domain containing 9A (CLEC9A), mRNA.
ACCESSION   NM_207345
VERSION     NM_207345.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1733)
  AUTHORS   Yan,L., Wu,X., Wu,P., Su,B., Xiong,Y., Rao,Y., Chen,X., Huang,W.
            and Cui,T.
  TITLE     Increased expression of Clec9A on cDC1s associated with cytotoxic
            CD8+ T cell response in COPD
  JOURNAL   Clin Immunol 242, 109082 (2022)
   PUBMED   35901921
  REMARK    GeneRIF: Increased expression of Clec9A on cDC1s associated with
            cytotoxic CD8(+) T cell response in COPD.
            Review article
REFERENCE   2  (bases 1 to 1733)
  AUTHORS   Pena-Cardelles,J.F., Pozo-Kreilinger,J.J., Roncador,G.,
            Esteban-Hernandez,J., Cebrian-Carretero,J.L. and
            Moro-Rodriguez,J.E.
  TITLE     Expression of clec9a in the oral cancer microenvironment. A
            preliminary immunohistochemical pilot study
  JOURNAL   Med Oral Patol Oral Cir Bucal 26 (5), e651-e660 (2021)
   PUBMED   34415004
  REMARK    GeneRIF: Expression of clec9a in the oral cancer microenvironment.
            A preliminary immunohistochemical pilot study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1733)
  AUTHORS   Giampazolias,E., Schulz,O., Lim,K.H.J., Rogers,N.C.,
            Chakravarty,P., Srinivasan,N., Gordon,O., Cardoso,A., Buck,M.D.,
            Poirier,E.Z., Canton,J., Zelenay,S., Sammicheli,S., Moncaut,N.,
            Varsani-Brown,S., Rosewell,I. and Reis e Sousa,C.
  TITLE     Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and
            cancer immunity
  JOURNAL   Cell 184 (15), 4016-4031 (2021)
   PUBMED   34081922
  REMARK    GeneRIF: Secreted gelsolin inhibits DNGR-1-dependent
            cross-presentation and cancer immunity.
REFERENCE   4  (bases 1 to 1733)
  AUTHORS   Canton,J., Blees,H., Henry,C.M., Buck,M.D., Schulz,O., Rogers,N.C.,
            Childs,E., Zelenay,S., Rhys,H., Domart,M.C., Collinson,L.,
            Alloatti,A., Ellison,C.J., Amigorena,S., Papayannopoulos,V.,
            Thomas,D.C., Randow,F. and Reis e Sousa,C.
  TITLE     The receptor DNGR-1 signals for phagosomal rupture to promote
            cross-presentation of dead-cell-associated antigens
  JOURNAL   Nat Immunol 22 (2), 140-153 (2021)
   PUBMED   33349708
  REMARK    GeneRIF: The receptor DNGR-1 signals for phagosomal rupture to
            promote cross-presentation of dead-cell-associated antigens.
            Erratum:[Nat Immunol. 2021 Mar;22(3):391. doi:
            10.1038/s41590-021-00885-6.. PMID: 33531713]
REFERENCE   5  (bases 1 to 1733)
  AUTHORS   Cheng,A.C., Yang,K.Y., Chen,N.J., Hsu,T.L., Jou,R., Hsieh,S.L. and
            Tseng,P.H.
  TITLE     CLEC9A modulates macrophage-mediated neutrophil recruitment in
            response to heat-killed Mycobacterium tuberculosis H37Ra
  JOURNAL   PLoS One 12 (10), e0186780 (2017)
   PUBMED   29065139
  REMARK    GeneRIF: findings demonstrate that CLEC9A is a specialized receptor
            that modulates the innate immune response when there is a
            mycobacterial infection
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1733)
  AUTHORS   Sancho,D., Joffre,O.P., Keller,A.M., Rogers,N.C., Martinez,D.,
            Hernanz-Falcon,P., Rosewell,I. and Reis e Sousa,C.
  TITLE     Identification of a dendritic cell receptor that couples sensing of
            necrosis to immunity
  JOURNAL   Nature 458 (7240), 899-903 (2009)
   PUBMED   19219027
  REMARK    GeneRIF: CLEC9A functions as a SYK-coupled C-type lectin receptor
            to mediate sensing of necrosis by the principal dendritic-cell
            subset involved in regulating cross-priming to cell-associated
            antigens
REFERENCE   7  (bases 1 to 1733)
  AUTHORS   Caminschi,I., Proietto,A.I., Ahmet,F., Kitsoulis,S., Shin Teh,J.,
            Lo,J.C., Rizzitelli,A., Wu,L., Vremec,D., van Dommelen,S.L.,
            Campbell,I.K., Maraskovsky,E., Braley,H., Davey,G.M., Mottram,P.,
            van de Velde,N., Jensen,K., Lew,A.M., Wright,M.D., Heath,W.R.,
            Shortman,K. and Lahoud,M.H.
  TITLE     The dendritic cell subtype-restricted C-type lectin Clec9A is a
            target for vaccine enhancement
  JOURNAL   Blood 112 (8), 3264-3273 (2008)
   PUBMED   18669894
  REMARK    GeneRIF: analysis of differences between mouse and human Clec9A
REFERENCE   8  (bases 1 to 1733)
  AUTHORS   Huysamen,C., Willment,J.A., Dennehy,K.M. and Brown,G.D.
  TITLE     CLEC9A is a novel activation C-type lectin-like receptor expressed
            on BDCA3+ dendritic cells and a subset of monocytes
  JOURNAL   J Biol Chem 283 (24), 16693-16701 (2008)
   PUBMED   18408006
  REMARK    GeneRIF: CLEC9A functions as an activation receptor
REFERENCE   9  (bases 1 to 1733)
  AUTHORS   Sancho,D., Mourao-Sa,D., Joffre,O.P., Schulz,O., Rogers,N.C.,
            Pennington,D.J., Carlyle,J.R. and Reis e Sousa,C.
  TITLE     Tumor therapy in mice via antigen targeting to a novel,
            DC-restricted C-type lectin
  JOURNAL   J Clin Invest 118 (6), 2098-2110 (2008)
   PUBMED   18497879
  REMARK    GeneRIF: DC, NK lectin group receptor-1 (DNGR-1) is a C-type lectin
            of the NK cell receptor group
            GeneRIF: The paper cited (J Clin Invest. 2008 Jun;118(6):2098-110)
            is the first characterization of human and mouse CLEC9A (a.k.a
            DNGR-1)
REFERENCE   10 (bases 1 to 1733)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358265.1, DB090462.1, DB526089.1 and AC024224.33.
            
            On Nov 23, 2018 this sequence version replaced NM_207345.3.
            
            Summary: CLEC9A is a group V C-type lectin-like receptor (CTLR)
            that functions as an activation receptor and is expressed on
            myeloid lineage cells (Huysamen et al., 2008 [PubMed
            18408006]).[supplied by OMIM, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358265.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355819.6/ ENSP00000348074.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               AY358265.1         6-344
            340-340             DB090462.1         346-346
            341-1668            AY358265.1         346-1673
            1669-1732           DB526089.1         362-425
            1733-1733           AC024224.33        56608-56608
FEATURES             Location/Qualifiers
     source          1..1733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1733
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /note="C-type lectin domain containing 9A"
                     /db_xref="GeneID:283420"
                     /db_xref="HGNC:HGNC:26705"
                     /db_xref="MIM:612252"
     exon            1..291
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /inference="alignment:Splign:2.1.0"
     exon            292..446
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /inference="alignment:Splign:2.1.0"
     exon            447..550
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /inference="alignment:Splign:2.1.0"
     exon            551..699
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /inference="alignment:Splign:2.1.0"
     CDS             609..1334
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /note="HEEE9341"
                     /codon_start=1
                     /product="C-type lectin domain family 9 member A"
                     /protein_id="NP_997228.1"
                     /db_xref="CCDS:CCDS8611.1"
                     /db_xref="GeneID:283420"
                     /db_xref="HGNC:HGNC:26705"
                     /db_xref="MIM:612252"
                     /translation="MHEEEIYTSLQWDSPAPDTYQKCLSSNKCSGACCLVMVISCVFC
                     MGLLTASIFLGVKLLQVSTIAMQQQEKLIQQERALLNFTEWKRSCALQMKYCQAFMQN
                     SLSSAHNSSPCPNNWIQNRESCYYVSEIWSIWHTSQENCLKEGSTLLQIESKEEMDFI
                     TGSLRKIKGSYDYWVGLSQDGHSGRWLWQDGSSPSPGLLPAERSQSANQVCGYVKSNS
                     LLSSNCSTWKYFICEKYALRSSV"
     exon            700..780
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /inference="alignment:Splign:2.1.0"
     exon            781..927
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1079
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1201
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1733
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1710..1715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /note="hexamer: AATAAA"
     polyA_site      1733
                     /gene="CLEC9A"
                     /gene_synonym="CD370; DNGR-1; DNGR1; UNQ9341"
                     /note="major polyA site"
ORIGIN      
        1 gtacccggct gtggcaatct gtggtgaagt tgaaatgctt ttctgctaga ctggcaacat
       61 gttttgattc ttctcaaata actcgcaagc tcttgtgaag cacaacggcc taccttgtcc
      121 tgaagaaaac atactctaag gcccacagat gattaaaccc agccatttat gtgacaatag
      181 catttttatt tttcttatca agatctgggt atttgatcca cacaatggta aagattccca
      241 tgttagccaa gatctaaatg attcaaactg atgatactct ctgcagaaga ggtgactata
      301 aacgcagccc ctgtgatgcc aactggacat attatggaga tagctgctat gggttcttca
      361 aacacaactt gacatggaaa gagagtgagc agtactgcac tgacatgaag gctactctcc
      421 tgaagactga caaccagaac attctgtgga tagaagtcaa gggctccaat gtctcccaag
      481 acgaaagaat cccaagtctc atttggagga atgctatcac taactaggat tcctggagct
      541 aaaacattat aggagttact tgttccagcc tcctgtgtgg actgctttcc tatcaaagca
      601 ccttagacat gcacgaggaa gaaatataca cctctcttca gtgggatagc ccagcaccag
      661 acacttacca gaaatgtctg tcttccaaca aatgttcagg agcatgctgt cttgtgatgg
      721 tgatttcatg tgttttctgc atgggattat taacagcatc cattttcttg ggcgtcaagt
      781 tgttgcaggt gtccaccatt gcgatgcagc agcaagaaaa actcatccaa caagagaggg
      841 cactgctaaa ctttacagaa tggaagagaa gctgtgccct tcagatgaaa tattgccaag
      901 ccttcatgca aaactcatta agttcagccc ataacagcag tccttgtcca aacaattgga
      961 ttcagaacag agaaagttgt tactatgtct ctgaaatttg gagcatttgg cacaccagtc
     1021 aagagaattg tttaaaggaa ggttccacgc tgctacaaat agagagcaaa gaagaaatgg
     1081 attttatcac tggcagcttg aggaagatta aaggaagcta tgattactgg gtggggttgt
     1141 ctcaggatgg acacagcgga cgctggcttt ggcaagatgg ctcctctcct tctcctggcc
     1201 tgttgccagc agagagatcc cagtcagcta accaagtctg tggatacgtg aaaagcaatt
     1261 cccttctttc gtctaactgc agcacgtgga agtattttat ctgtgagaag tatgcgttga
     1321 gatcctctgt ctgaaagaaa ttgtgttcaa agtgttctat tacactgtta tttggagcat
     1381 gccattggaa aacccacccc caccccccct caaaaaaaca gaacagtaaa ccaaaatgtg
     1441 ggccatgaaa ttagcaacct gggactcaat aatacacttg ggaatattct tccacaccgt
     1501 ccagatttca tttgatgttg ttcacattgc aagagtaaaa cttatttaga gctacagaag
     1561 acaaaaccct gaagagttaa gaacaaacgc aaggaaataa tttttattgt ttaaagcccg
     1621 gaatgactgt aactttcaca caaggtacgc atctatgttt ttgggggagg tgatgtagtt
     1681 acagctgact aatattttta aaataaataa ataaatttgg cctttaaaac tca
//
