LOCUS       NM_197947               2542 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens C-type lectin domain containing 7A (CLEC7A),
            transcript variant 1, mRNA.
ACCESSION   NM_197947
VERSION     NM_197947.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2542)
  AUTHORS   Cufre,M., Pastorini,M., Martin,I., Failde,R., Palmero,D. and
            Aleman,M.
  TITLE     Variants of human DECTIN-1 rs16910526 are linked to differential
            reactive oxygen species production and susceptibility to
            tuberculosis
  JOURNAL   J Biomed Sci 31 (1), 77 (2024)
   PUBMED   39103844
  REMARK    GeneRIF: Variants of human DECTIN-1 rs16910526 are linked to
            differential reactive oxygen species production and susceptibility
            to tuberculosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2542)
  AUTHORS   Azizollah,N., Sharifinejad,N., Mozhgani,S.H., Mousavian,S.M.,
            Bakhtiyari,M. and Mahmoudi,E.
  TITLE     Possible role of intestinal fungal dysbiosis in dectin-1 and
            cytokines expression in patients with ulcerative colitis
  JOURNAL   Indian J Gastroenterol 43 (4), 832-840 (2024)
   PUBMED   38874868
  REMARK    GeneRIF: Possible role of intestinal fungal dysbiosis in dectin-1
            and cytokines expression in patients with ulcerative colitis.
REFERENCE   3  (bases 1 to 2542)
  AUTHORS   Wang,J., Li,X., Wang,K., Li,K., Gao,Y., Xu,J., Peng,R., Zhang,X.,
            Zhang,S., Zhou,Y., Xu,S. and Zhang,J.
  TITLE     CLEC7A regulates M2 macrophages to suppress the immune
            microenvironment and implies poorer prognosis of glioma
  JOURNAL   Front Immunol 15, 1361351 (2024)
   PUBMED   38846954
  REMARK    GeneRIF: CLEC7A regulates M2 macrophages to suppress the immune
            microenvironment and implies poorer prognosis of glioma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2542)
  AUTHORS   Cui,W., Liu,J., Kong,S., Huang,H., Liu,L., Cao,Y. and Gu,Z.
  TITLE     IL-17A and TNF-alpha-induced Dectin-1 expression may promote
            keratinocyte proliferation in psoriatic lesions
  JOURNAL   Eur J Dermatol 34 (2), 119-130 (2024)
   PUBMED   38907541
  REMARK    GeneRIF: IL-17A and TNF-alpha-induced Dectin-1 expression may
            promote keratinocyte proliferation in psoriatic lesions.
REFERENCE   5  (bases 1 to 2542)
  AUTHORS   Cai,R., Gong,X., Li,X., Jiang,Y., Deng,S., Tang,J., Ge,H., Wu,C.,
            Tang,H., Wang,G., Xie,L., Chen,X., Hu,X. and Feng,J.
  TITLE     Dectin-1 aggravates neutrophil inflammation through
            caspase-11/4-mediated macrophage pyroptosis in asthma
  JOURNAL   Respir Res 25 (1), 119 (2024)
   PUBMED   38459541
  REMARK    GeneRIF: Dectin-1 aggravates neutrophil inflammation through
            caspase-11/4-mediated macrophage pyroptosis in asthma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2542)
  AUTHORS   Yokota,K., Takashima,A., Bergstresser,P.R. and Ariizumi,K.
  TITLE     Identification of a human homologue of the dendritic
            cell-associated C-type lectin-1, dectin-1
  JOURNAL   Gene 272 (1-2), 51-60 (2001)
   PUBMED   11470510
REFERENCE   7  (bases 1 to 2542)
  AUTHORS   Hermanz-Falcon,P., Arce,I., Roda-Navarro,P. and Fernandez-Ruiz,E.
  TITLE     Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene
            expressed on dendritic cells
  JOURNAL   Immunogenetics 53 (4), 288-295 (2001)
   PUBMED   11491532
  REMARK    Erratum:[Immunogenetics 2001 Aug;53(6):518]
REFERENCE   8  (bases 1 to 2542)
  AUTHORS   Ariizumi,K., Shen,G.L., Shikano,S., Xu,S., Ritter,R. 3rd,
            Kumamoto,T., Edelbaum,D., Morita,A., Bergstresser,P.R. and
            Takashima,A.
  TITLE     Identification of a novel, dendritic cell-associated molecule,
            dectin-1, by subtractive cDNA cloning
  JOURNAL   J Biol Chem 275 (26), 20157-20167 (2000)
   PUBMED   10779524
REFERENCE   9  (bases 1 to 2542)
  AUTHORS   Drickamer,K.
  TITLE     C-type lectin-like domains
  JOURNAL   Curr Opin Struct Biol 9 (5), 585-590 (1999)
   PUBMED   10508765
  REMARK    Review article
REFERENCE   10 (bases 1 to 2542)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA193873.1, AF400595.1,
            AY359002.1, AY009090.2 and CR749536.1.
            
            On Aug 31, 2019 this sequence version replaced NM_197947.2.
            
            Summary: This gene encodes a member of the C-type lectin/C-type
            lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein
            is a small type II membrane receptor with an extracellular C-type
            lectin-like domain fold and a cytoplasmic domain with an
            immunoreceptor tyrosine-based activation motif. It functions as a
            pattern-recognition receptor that recognizes a variety of
            beta-1,3-linked and beta-1,6-linked glucans from fungi and plants,
            and in this way plays a role in innate immune response. Alternate
            transcriptional splice variants, encoding different isoforms, have
            been characterized. This gene is closely linked to other CTL/CTLD
            superfamily members on chromosome 12p13 in the natural killer gene
            complex region. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variant 1 has been
            alternatively referred to as variant 2 and isoform a has been
            alternatively referred to as alpha in the literature.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.951120.1,
                                           SRR14038194.3457642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304084.13/ ENSP00000302569.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               DA193873.1         71-187
            118-861             AF400595.1         1-744
            862-1788            AY359002.1         766-1692
            1789-2148           AY009090.2         1604-1963
            2149-2542           CR749536.1         3285-3678
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..2542
                     /gene="CLEC7A"
                     /gene_synonym="BGR; CANDF4; CD369; CLECSF12; DECTIN1;
                     SCARE2"
                     /note="C-type lectin domain containing 7A"
                     /db_xref="GeneID:64581"
                     /db_xref="HGNC:HGNC:14558"
                     /db_xref="MIM:606264"
     exon            1..220
                     /gene="CLEC7A"
                     /gene_synonym="BGR; CANDF4; CD369; CLECSF12; DECTIN1;
                     SCARE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..861
                     /gene="CLEC7A"
                     /gene_synonym="BGR; CANDF4; CD369; CLECSF12; DECTIN1;
                     SCARE2"
                     /note="isoform a is encoded by transcript variant 1;
                     beta-glucan receptor; C-type (calcium dependent,
                     carbohydrate-recognition domain) lectin, superfamily
                     member 12; lectin-like receptor 1; dectin-1; dendritic
                     cell-associated C-type lectin-1; DC-associated C-type
                     lectin 1; C-type lectin superfamily member 12; C-type
                     lectin domain family 7 member A"
                     /codon_start=1
                     /product="C-type lectin domain family 7 member A isoform
                     a"
                     /protein_id="NP_922938.1"
                     /db_xref="CCDS:CCDS41753.1"
                     /db_xref="GeneID:64581"
                     /db_xref="HGNC:HGNC:14558"
                     /db_xref="MIM:606264"
                     /translation="MEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWR
                     LIAVILGILCLVILVIAVVLGTMAIWRSNSGSNTLENGYFLSRNKENHSQPTQSSLED
                     SVTPTKAVKTTGVLSSPCPPNWIIYEKSCYLFSMSLNSWDGSKRQCWQLGSNLLKIDS
                     SNELGFIVKQVSSQPDNSFWIGLSRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSP
                     NCVWIHVSVIYDQLCSVPSYSICEKKFSM"
     exon            221..319
                     /gene="CLEC7A"
                     /gene_synonym="BGR; CANDF4; CD369; CLECSF12; DECTIN1;
                     SCARE2"
                     /inference="alignment:Splign:2.1.0"
     exon            320..457
                     /gene="CLEC7A"
                     /gene_synonym="BGR; CANDF4; CD369; CLECSF12; DECTIN1;
                     SCARE2"
                     /inference="alignment:Splign:2.1.0"
     exon            458..609
                     /gene="CLEC7A"
                     /gene_synonym="BGR; CANDF4; CD369; CLECSF12; DECTIN1;
                     SCARE2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..728
                     /gene="CLEC7A"
                     /gene_synonym="BGR; CANDF4; CD369; CLECSF12; DECTIN1;
                     SCARE2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..2542
                     /gene="CLEC7A"
                     /gene_synonym="BGR; CANDF4; CD369; CLECSF12; DECTIN1;
                     SCARE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2517..2522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC7A"
                     /gene_synonym="BGR; CANDF4; CD369; CLECSF12; DECTIN1;
                     SCARE2"
                     /note="hexamer: AATAAA"
     polyA_site      2542
                     /gene="CLEC7A"
                     /gene_synonym="BGR; CANDF4; CD369; CLECSF12; DECTIN1;
                     SCARE2"
                     /note="major polyA site"
ORIGIN      
        1 agtacctagc ccacatgatt tgactcagag attctctttt gtccacagac agtcatctca
       61 ggagcagaaa gaaaagagct cccaaatgct atatctattc aggggctctc aagaacaatg
      121 gaatatcatc ctgatttaga aaatttggat gaagatggat atactcaatt acacttcgac
      181 tctcaaagca ataccaggat agctgttgtt tcagagaaag gatcgtgtgc tgcatctcct
      241 ccttggcgcc tcattgctgt aattttggga atcctatgct tggtaatact ggtgatagct
      301 gtggtcctgg gtaccatggc tatttggaga tccaattcag gaagcaacac attggagaat
      361 ggctactttc tatcaagaaa taaagagaac cacagtcaac ccacacaatc atctttagaa
      421 gacagtgtga ctcctaccaa agctgtcaaa accacagggg ttctttccag cccttgtcct
      481 cctaattgga ttatatatga gaagagctgt tatctattca gcatgtcact aaattcctgg
      541 gatggaagta aaagacaatg ctggcaactg ggctctaatc tcctaaagat agacagctca
      601 aatgaattgg gatttatagt aaaacaagtg tcttcccaac ctgataattc attttggata
      661 ggcctttctc ggccccagac tgaggtacca tggctctggg aggatggatc aacattctct
      721 tctaacttat ttcagatcag aaccacagct acccaagaaa acccatctcc aaattgtgta
      781 tggattcacg tgtcagtcat ttatgaccaa ctgtgtagtg tgccctcata tagtatttgt
      841 gagaagaagt tttcaatgta agaggaaggg tggagaagga gagagaaata tgtgaggtag
      901 taaggaggac agaaaacaga acagaaaaga gtaacagctg aggtcaagat aaatgcagaa
      961 aatgtttaga gagcttggcc aactgtaatc ttaaccaaga aattgaaggg agaggctgtg
     1021 atttctgtat ttgtcgacct acaggtaggc tagtattatt tttctagtta gtagatccct
     1081 agacatggaa tcagggcagc caagcttgag tttttatttt ttatttattt atttttttga
     1141 gatagggtct cactttgtta cccaggctgg agtgcagtgg cacaatctcg actcactgca
     1201 gctatctctc gcctcagccc ctcaagtagc tgggactaca ggtgcatgcc accatgccag
     1261 gctaattttt ggtgtttttt gtagagactg ggttttgcca tgttgaccaa gctggtctct
     1321 aactcctggg cttaagtgat ctgcccgcct tggcctccca aagtgctggg attacagatg
     1381 tgagccacca cacctggccc caagcttgaa ttttcattct gccattgact tggcatttac
     1441 cttgggtaag ccataagcga atcttaattt ctggctctat cagagttgtt tcatgctcaa
     1501 caatgccatt gaagtgcacg gtgtgttgcc acgatttgac cctcaacttc tagcagtata
     1561 tcagttatga actgagggtg aaatatattt ctgaatagct aaatgaagaa atgggaaaaa
     1621 atcttcacca cagtcagagc aattttatta ttttcatcag tatgatcata attatgatta
     1681 tcatcttagt aaaaagcagg aactcctact ttttctttat caattaaata gctcagagag
     1741 tacatctgcc atatctctaa tagaatcttt tttttttttt ttttttttga gacagagttt
     1801 cgctcttgtt gcccaggctg gagtgcaacg gcacgatctc ggctcaccgc aacctccgcc
     1861 ccctgggttc aagcaattct cctgcctcag cctcccaagt agctgggatt acagtcaggc
     1921 accaccacac ccggctaatt ttgtattttt ttagtagaga cagggtttct ccatgtcggt
     1981 cagggtagtc ccgaactcct gacctcaagt gatctgcctg cctcggcctc ccaagtgctg
     2041 ggattacagg cgtgagccac tgcacccagc ctagaatctt gtataatatg taattgtagg
     2101 gaaactgctc tcataggaaa gttttctgct ttttaaatac aaaaatacat aaaaatacat
     2161 aaaatctgat gatgaatata aaaaagtaac caacctcatt ggaacaagta ttaacatttt
     2221 ggaatatgtt ttattagttt tgtgatgtac tgttttacaa tttttaccat ttttttcagt
     2281 aattactgta aaatggtatt attggaatga aactatattt cctcatgtgc tgatttgtct
     2341 tatttttttc atactttccc actggtgcta tttttatttc caatggatat ttctgtatta
     2401 ctagggaggc atttacagtc ctctaatgtt gattaatatg tgaaaagaaa ttgtaccaat
     2461 tttactaaat tatgcagttt aaaatggatg attttatgtt atgtggattt catttcaata
     2521 aaaaaaaact cttatcaaaa aa
//
