LOCUS       NM_001007033            1646 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens C-type lectin domain containing 6A (CLEC6A),
            transcript variant 1, mRNA.
ACCESSION   NM_001007033
VERSION     NM_001007033.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1646)
  AUTHORS   Li,J., Liu,X.G., Ge,R.L., Yin,Y.P., Liu,Y.D., Lu,W.P., Huang,M.,
            He,X.Y., Wang,J., Cai,G., Sun,S.H. and Yuan,J.H.
  TITLE     The ligation between ERMAP, galectin-9 and dectin-2 promotes
            Kupffer cell phagocytosis and antitumor immunity
  JOURNAL   Nat Immunol 24 (11), 1813-1824 (2023)
   PUBMED   37813965
  REMARK    GeneRIF: The ligation between ERMAP, galectin-9 and dectin-2
            promotes Kupffer cell phagocytosis and antitumor immunity.
REFERENCE   2  (bases 1 to 1646)
  AUTHORS   Haider,M.J.A., Albaqsumi,Z., Al-Mulla,F., Ahmad,R. and Al-Rashed,F.
  TITLE     SOCS3 Regulates Dectin-2-Induced Inflammation in PBMCs of Diabetic
            Patients
  JOURNAL   Cells 11 (17), 2670 (2022)
   PUBMED   36078084
  REMARK    GeneRIF: SOCS3 Regulates Dectin-2-Induced Inflammation in PBMCs of
            Diabetic Patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1646)
  AUTHORS   Thiem,K., Hoeke,G., Zhou,E., Hijmans,A., Houben,T., Boels,M.G.,
            Mol,I.M., Lutgens,E., Shiri-Sverdlov,R., Bussink,J.,
            Kanneganti,T.D., Boon,M.R., Stienstra,R., Tack,C.J., Rensen,P.C.,
            Netea,M.G., Berbee,J.F. and van Diepen,J.A.
  TITLE     Deletion of haematopoietic Dectin-2 or CARD9 does not protect from
            atherosclerosis development under hyperglycaemic conditions
  JOURNAL   Diab Vasc Dis Res 17 (1), 1479164119892140 (2020)
   PUBMED   31868000
  REMARK    GeneRIF: Deletion of haematopoietic Dectin-2 did not influence
            atherosclerosis development under hyperglycaemic conditions,
            despite some minor effects on inflammation.
REFERENCE   4  (bases 1 to 1646)
  AUTHORS   Roesner,L.M., Ernst,M., Chen,W., Begemann,G., Kienlin,P.,
            Raulf,M.K., Lepenies,B. and Werfel,T.
  TITLE     Human thioredoxin, a damage-associated molecular pattern and
            Malassezia-crossreactive autoallergen, modulates immune responses
            via the C-type lectin receptors Dectin-1 and Dectin-2
  JOURNAL   Sci Rep 9 (1), 11210 (2019)
   PUBMED   31371767
  REMARK    GeneRIF: Human thioredoxin, a damage-associated molecular pattern
            and Malassezia-crossreactive autoallergen, modulates immune
            responses via the C-type lectin receptors Dectin-1 and Dectin-2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1646)
  AUTHORS   Decout,A., Silva-Gomes,S., Drocourt,D., Blattes,E., Riviere,M.,
            Prandi,J., Larrouy-Maumus,G., Caminade,A.M., Hamasur,B.,
            Kallenius,G., Kaur,D., Dobos,K.M., Lucas,M., Sutcliffe,I.C.,
            Besra,G.S., Appelmelk,B.J., Gilleron,M., Jackson,M., Vercellone,A.,
            Tiraby,G. and Nigou,J.
  TITLE     Deciphering the molecular basis of mycobacteria and lipoglycan
            recognition by the C-type lectin Dectin-2
  JOURNAL   Sci Rep 8 (1), 16840 (2018)
   PUBMED   30443026
  REMARK    GeneRIF: dimannoside caps and multivalent interaction are required
            for ligand binding to and signaling via Dectin-2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1646)
  AUTHORS   McGreal,E.P., Rosas,M., Brown,G.D., Zamze,S., Wong,S.Y., Gordon,S.,
            Martinez-Pomares,L. and Taylor,P.R.
  TITLE     The carbohydrate-recognition domain of Dectin-2 is a C-type lectin
            with specificity for high mannose
  JOURNAL   Glycobiology 16 (5), 422-430 (2006)
   PUBMED   16423983
REFERENCE   7  (bases 1 to 1646)
  AUTHORS   Gavino,A.C., Chung,J.S., Sato,K., Ariizumi,K. and Cruz,P.D. Jr.
  TITLE     Identification and expression profiling of a human C-type lectin,
            structurally homologous to mouse dectin-2
  JOURNAL   Exp Dermatol 14 (4), 281-288 (2005)
   PUBMED   15810886
  REMARK    GeneRIF: human DECTIN-2 has a role in innate immunity
REFERENCE   8  (bases 1 to 1646)
  AUTHORS   Flornes,L.M., Bryceson,Y.T., Spurkland,A., Lorentzen,J.C.,
            Dissen,E. and Fossum,S.
  TITLE     Identification of lectin-like receptors expressed by antigen
            presenting cells and neutrophils and their mapping to a novel gene
            complex
  JOURNAL   Immunogenetics 56 (7), 506-517 (2004)
   PUBMED   15368084
REFERENCE   9  (bases 1 to 1646)
  AUTHORS   Kanazawa,N., Tashiro,K., Inaba,K., Lutz,M.B. and Miyachi,Y.
  TITLE     Molecular cloning of human dectin-2
  JOURNAL   J Invest Dermatol 122 (6), 1522-1524 (2004)
   PUBMED   15175046
REFERENCE   10 (bases 1 to 1646)
  AUTHORS   Kanazawa,N., Tashiro,K. and Miyachi,Y.
  TITLE     Signaling and immune regulatory role of the dendritic cell
            immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and
            BDCA-2
  JOURNAL   Immunobiology 209 (1-2), 179-190 (2004)
   PUBMED   15481152
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092865.10 and AC092746.9.
            
            On May 17, 2019 this sequence version replaced NM_001007033.1.
            
            Summary: The protein encoded by this gene is a type II membrane
            receptor with an extracellular C-type lectin-like domain fold. The
            extracellular portion binds structures with a high mannose content
            and has been shown to recognize several pathogens, including C.
            elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house
            dust mite. When stimulated, the encoded protein initiates
            signalling through the CARD9-Bcl10-Malt1 pathway, leading to the
            induction of cytokines. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY321309.1, BC132935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382073.4/ ENSP00000371505.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC092865.10        15250-15430         c
            182-271             AC092865.10        13405-13494         c
            272-373             AC092865.10        11694-11795         c
            374-519             AC092865.10        5763-5908           c
            520-635             AC092746.9         102468-102583       c
            636-1646            AC092746.9         100378-101388       c
FEATURES             Location/Qualifiers
     source          1..1646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1646
                     /gene="CLEC6A"
                     /gene_synonym="CLEC4N; CLECSF10; dectin-2; hDECTIN-2"
                     /note="C-type lectin domain containing 6A"
                     /db_xref="GeneID:93978"
                     /db_xref="HGNC:HGNC:14556"
                     /db_xref="MIM:613579"
     exon            1..181
                     /gene="CLEC6A"
                     /gene_synonym="CLEC4N; CLECSF10; dectin-2; hDECTIN-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..780
                     /gene="CLEC6A"
                     /gene_synonym="CLEC4N; CLECSF10; dectin-2; hDECTIN-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     C-type (calcium dependent, carbohydrate-recognition
                     domain) lectin, superfamily member 10; dectin 2;
                     DC-associated C-type lectin 2; C-type lectin superfamily
                     member 10; dendritic cell-associated C-type lectin 2;
                     C-type lectin domain family 6 member A"
                     /codon_start=1
                     /product="C-type lectin domain family 6 member A isoform
                     1"
                     /protein_id="NP_001007034.1"
                     /db_xref="CCDS:CCDS31739.1"
                     /db_xref="GeneID:93978"
                     /db_xref="HGNC:HGNC:14556"
                     /db_xref="MIM:613579"
                     /translation="MMQEQQPQSTEKRGWLSLRLWSVAGISIALLSACFIVSCVVTYH
                     FTYGETGKRLSELHSYHSSLTCFSEGTKVPAWGCCPASWKSFGSSCYFISSEEKVWSK
                     SEQNCVEMGAHLVVFNTEAEQNFIVQQLNESFSYFLGLSDPQGNNNWQWIDKTPYEKN
                     VRFWHLGEPNHSAEQCASIVFWKPTGWGWNDVICETRRNSICEMNKIYL"
     exon            182..271
                     /gene="CLEC6A"
                     /gene_synonym="CLEC4N; CLECSF10; dectin-2; hDECTIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..373
                     /gene="CLEC6A"
                     /gene_synonym="CLEC4N; CLECSF10; dectin-2; hDECTIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..519
                     /gene="CLEC6A"
                     /gene_synonym="CLEC4N; CLECSF10; dectin-2; hDECTIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..635
                     /gene="CLEC6A"
                     /gene_synonym="CLEC4N; CLECSF10; dectin-2; hDECTIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..1646
                     /gene="CLEC6A"
                     /gene_synonym="CLEC4N; CLECSF10; dectin-2; hDECTIN-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatgttggaa gtctcttagt cctataagag tgtgtagcag tttgtccctg agctctagct
       61 tctttaaatg aagctgagtc tctgggcaac atctttaggg agagaggtac aaaaggttcc
      121 tggaccttct caacacaggg agcctgcata atgatgcaag agcagcaacc tcaaagtaca
      181 gagaaaagag gctggttgtc cctgagactc tggtctgtgg ctgggatttc cattgcactc
      241 ctcagtgctt gcttcattgt gagctgtgta gtaacttacc attttacata tggtgaaact
      301 ggcaaaaggc tgtctgaact acactcatat cattcaagtc tcacctgctt cagtgaaggg
      361 acaaaggtgc cagcctgggg atgttgccca gcttcttgga agtcatttgg ttccagttgc
      421 tacttcattt ccagtgaaga gaaggtttgg tctaagagtg agcagaactg tgttgagatg
      481 ggagcacatt tggttgtgtt caacacagaa gcagagcaga atttcattgt ccagcagctg
      541 aatgagtcat tttcttattt tctggggctt tcagacccac aaggtaataa taattggcaa
      601 tggattgata agacacctta tgagaaaaat gtcagatttt ggcacctagg tgagcccaat
      661 cattctgcag agcaatgtgc ttcaatagtc ttctggaaac ctacaggatg gggctggaat
      721 gatgttatct gtgaaactag aaggaattca atatgtgaga tgaataagat ttacctatga
      781 gtagaagctt aattggaaag aagagaagaa ttactgacgt aattttttcc ctgacgtctt
      841 taaaattgaa ccctatcatg aaatgataat ttcttcctga atttacacat aatccttatg
      901 ttatagaggt tcacagaaat ggaaagatac ctgtttccct ttaatcaatc ttctcgtttc
      961 ctcttttcca ttaatgatag aatgcaccct tcctctcttt gttccattct ttcacttgtt
     1021 attcattttt ttctttcttc acacttcatt acacaaatat ttattgtttc agagactgta
     1081 ctattttgtt tgttagaaga tttataaggc agtatctttt gaaaattatg actttccttc
     1141 ctcaatatac cataaagaaa tctttttggt caagatggta gttggaacta caatcatctg
     1201 aaggcctgac aagagttgaa agacatgttt tctagatggc tcactcacat ggctggcaac
     1261 ttggtgttgg ctattaatgt aacctggaaa taaattttat tctgcagtta gggatttggc
     1321 attttatata tgttgattca atcaagtttg gcaagcaggg tgttcgatac tgctatatcc
     1381 tgtattcttg gtttatttgt tttatttctg agaaatatgt gttaagatct ctcgctgatt
     1441 gggaatttgt ctatttctca tttaaatttt gtcaaatctt tctttgcttg caagcatttc
     1501 ttgttaccca aatctaatct attcctgaaa atatgatggt tagcaaagtt tgagataact
     1561 agagcctgta atccatcatt ttaaatggca atgataatga cagtttattt ttatgttata
     1621 taaaaacctc aacaaatttt ccaaac
//
