LOCUS       NM_198492               1299 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens C-type lectin domain family 4 member G (CLEC4G),
            transcript variant 1, mRNA.
ACCESSION   NM_198492 XM_290871
VERSION     NM_198492.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Feng,X., Qi,F., Huang,Y., Zhang,G. and Deng,W.
  TITLE     Reduced Expression of CLEC4G in Neurons Is Associated with
            Alzheimer's Disease
  JOURNAL   Int J Mol Sci 25 (9), 4621 (2024)
   PUBMED   38731839
  REMARK    GeneRIF: Reduced Expression of CLEC4G in Neurons Is Associated with
            Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Chen,X., Li,S., Jiang,Z.M., Gu,M., Feng,B., Xie,Z.Q., Huang,M.Y.,
            Chen,Z. and Tang,M.L.
  TITLE     C-type Lectin Domain Family 4 Member G (CLEC4G) Is a Negative
            Marker for CD34 in the Evolution of Liver Pathogenesis
  JOURNAL   Ann Clin Lab Sci 53 (4), 516-528 (2023)
   PUBMED   37625828
  REMARK    GeneRIF: C-type Lectin Domain Family 4 Member G (CLEC4G) Is a
            Negative Marker for CD34 in the Evolution of Liver Pathogenesis.
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   Li,Q., Cheng,H., Liu,Y., Wang,X., He,F. and Tang,L.
  TITLE     Activation of mTORC1 by LSECtin in macrophages directs intestinal
            repair in inflammatory bowel disease
  JOURNAL   Cell Death Dis 11 (10), 918 (2020)
   PUBMED   33106485
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1299)
  AUTHORS   Qi,F., Qian,S., Zhang,S. and Zhang,Z.
  TITLE     Single cell RNA sequencing of 13 human tissues identify cell types
            and receptors of human coronaviruses
  JOURNAL   Biochem Biophys Res Commun 526 (1), 135-140 (2020)
   PUBMED   32199615
REFERENCE   5  (bases 1 to 1299)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1299)
  AUTHORS   Li,H., Tang,N.L., Chan,P.K., Wang,C.Y., Hui,D.S., Luk,C., Kwok,R.,
            Huang,W., Sung,J.J., Kong,Q.P. and Zhang,Y.P.
  TITLE     Polymorphisms in the C-type lectin genes cluster in chromosome 19
            and predisposition to severe acute respiratory syndrome coronavirus
            (SARS-CoV) infection
  JOURNAL   J Med Genet 45 (11), 752-758 (2008)
   PUBMED   18697825
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1299)
  AUTHORS   Gramberg,T., Soilleux,E., Fisch,T., Lalor,P.F., Hofmann,H.,
            Wheeldon,S., Cotterill,A., Wegele,A., Winkler,T., Adams,D.H. and
            Pohlmann,S.
  TITLE     Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands:
            Differential pH dependence, internalization and virion binding
  JOURNAL   Virology 373 (1), 189-201 (2008)
   PUBMED   18083206
  REMARK    GeneRIF: Our results reveal important differences between Ebola
            virus and HIV-1 capture by DC-SIGN/R and LSECtin and hint towards
            different biological functions of these lectins.
REFERENCE   8  (bases 1 to 1299)
  AUTHORS   Dominguez-Soto,A., Aragoneses-Fenoll,L., Martin-Gayo,E.,
            Martinez-Prats,L., Colmenares,M., Naranjo-Gomez,M., Borras,F.E.,
            Munoz,P., Zubiaur,M., Toribio,M.L., Delgado,R. and Corbi,A.L.
  TITLE     The DC-SIGN-related lectin LSECtin mediates antigen capture and
            pathogen binding by human myeloid cells
  JOURNAL   Blood 109 (12), 5337-5345 (2007)
   PUBMED   17339424
  REMARK    GeneRIF: LSECtin is a pathogen-associated molecular pattern
            receptor in human myeloid cells; results suggest that LSECtin
            participates in antigen uptake and internalization
REFERENCE   9  (bases 1 to 1299)
  AUTHORS   Gramberg,T., Hofmann,H., Moller,P., Lalor,P.F., Marzi,A., Geier,M.,
            Krumbiegel,M., Winkler,T., Kirchhoff,F., Adams,D.H., Becker,S.,
            Munch,J. and Pohlmann,S.
  TITLE     LSECtin interacts with filovirus glycoproteins and the spike
            protein of SARS coronavirus
  JOURNAL   Virology 340 (2), 224-236 (2005)
   PUBMED   16051304
REFERENCE   10 (bases 1 to 1299)
  AUTHORS   Liu,W., Tang,L., Zhang,G., Wei,H., Cui,Y., Guo,L., Gou,Z., Chen,X.,
            Jiang,D., Zhu,Y., Kang,G. and He,F.
  TITLE     Characterization of a novel C-type lectin-like gene, LSECtin:
            demonstration of carbohydrate binding and expression in sinusoidal
            endothelial cells of liver and lymph node
  JOURNAL   J Biol Chem 279 (18), 18748-18758 (2004)
   PUBMED   14711836
  REMARK    GeneRIF: results indicate that LSECtin is a novel member of a
            family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might
            function in vivo as a lectin receptor
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008763.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 4, 2021 this sequence version replaced NM_198492.3.
            
            Summary: This gene encodes a glycan-binding receptor and member of
            the C-type lectin family which plays a role in the immune response.
            C-type lectin receptors are pattern recognition receptors located
            on immune cells that play a role in the recognition and uptake of
            both self and non-self glycoproteins as well as mediating cell
            adhesion, glycoprotein clearance, and cell signaling functions.
            This gene's protein binds complex-type N-glycans of the viral
            envelope proteins of Ebola virus, West Nile filovirus, and SARS
            coronavirus, but not HIV or hepatitis C virus. In mouse, this
            protein has been shown to recognize activated T-cells and to
            negatively regulate T-cell receptor-mediated signalling. It also
            acts as a novel, liver-specific regulator of NK cell-mediated
            immunity in mouse. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Apr
            2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY203939.1, AY423706.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000328853.11/ ENSP00000327599.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC008763.9         162860-162922       c
            64-174              AC008763.9         162473-162583       c
            175-228             AC008763.9         162078-162131       c
            229-291             AC008763.9         161838-161900       c
            292-396             AC008763.9         161567-161671       c
            397-486             AC008763.9         161163-161252       c
            487-635             AC008763.9         160831-160979       c
            636-751             AC008763.9         160633-160748       c
            752-1299            AC008763.9         159769-160316       c
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1299
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /note="C-type lectin domain family 4 member G"
                     /db_xref="GeneID:339390"
                     /db_xref="HGNC:HGNC:24591"
                     /db_xref="MIM:616256"
     exon            1..63
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..890
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /note="isoform 1 is encoded by transcript variant 1; liver
                     and lymph node sinusoidal endothelial cell C-type lectin;
                     C-type lectin superfamily 4, member G"
                     /codon_start=1
                     /product="C-type lectin domain family 4 member G isoform
                     1"
                     /protein_id="NP_940894.1"
                     /db_xref="CCDS:CCDS12185.1"
                     /db_xref="GeneID:339390"
                     /db_xref="HGNC:HGNC:24591"
                     /db_xref="MIM:616256"
                     /translation="MDTTRYSKWGGSSEEVPGGPWGRWVHWSRRPLFLALAVLVTTVL
                     WAVILSILLSKASTERAALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQAQL
                     QTTRAELGEAQAKLMEQESALRELRERVTQGLAEAGRGREDVRTELFRALEAVRLQNN
                     SCEPCPTSWLSFEGSCYFFSVPKTTWAAAQDHCADASAHLVIVGGLDEQGFLTRNTRG
                     RGYWLGLRAVRHLGKVQGYQWVDGVSLSFSHWNQGEPNDAWGRENCVMMLHTGLWNDA
                     PCDSEKDGWICEKRHNC"
     exon            64..174
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /inference="alignment:Splign:2.1.0"
     exon            175..228
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /inference="alignment:Splign:2.1.0"
     exon            229..291
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /inference="alignment:Splign:2.1.0"
     exon            292..396
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /inference="alignment:Splign:2.1.0"
     exon            397..486
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /inference="alignment:Splign:2.1.0"
     exon            487..635
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /inference="alignment:Splign:2.1.0"
     exon            636..751
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1299
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1272..1277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /note="hexamer: AATAAA"
     polyA_site      1299
                     /gene="CLEC4G"
                     /gene_synonym="DTTR431; LP2698; LSECtin; UNQ431"
                     /note="major polyA site"
ORIGIN      
        1 gcatcgccat ggacaccacc aggtacagca agtggggcgg cagctccgag gaggtccccg
       61 gagggccctg gggacgctgg gtgcactgga gcaggagacc cctcttcttg gccctggctg
      121 tcctggtcac cacagtcctt tgggctgtga ttctgagtat cctattgtcc aaggcctcca
      181 cggagcgcgc ggcgctgctt gacggccacg acctgctgag gacaaacgcc tcgaagcaga
      241 cggcggcgct gggtgccctg aaggaggagg tcggagactg ccacagctgc tgctcgggga
      301 cgcaggcgca gctgcagacc acgcgcgcgg agcttgggga ggcgcaggcg aagctgatgg
      361 agcaggagag cgccctgcgg gaactgcgtg agcgcgtgac ccagggcttg gctgaagccg
      421 gcaggggccg tgaggacgtc cgcactgagc tgttccgggc gctggaggcc gtgaggctcc
      481 agaacaactc ctgcgagccg tgccccacgt cgtggctgtc cttcgagggc tcctgctact
      541 ttttctctgt gccaaagacg acgtgggcgg cggcgcagga tcactgcgca gatgccagcg
      601 cgcacctggt gatcgttggg ggcctggatg agcagggctt cctcactcgg aacacgcgtg
      661 gccgtggtta ctggctgggc ctgagggctg tgcgccatct gggcaaggtt cagggctacc
      721 agtgggtgga cggagtctct ctcagcttca gccactggaa ccagggagag cccaatgacg
      781 cttgggggcg cgagaactgt gtcatgatgc tgcacacggg gctgtggaac gacgcaccgt
      841 gtgacagcga gaaggacggc tggatctgtg agaaaaggca caactgctga ccccgcccag
      901 tgccctggag ccgcgcccat tgcagcatgt cgtatcctgg gggctgctca cctccctggc
      961 tcctggagct gattgccaaa gagttttttc ttcctcatcc accgctgctg agtctcagaa
     1021 acacttggcc caacatagcc ctgtccagcc cagtgcctgg gctctgggac ctccatgccg
     1081 acctcatcct aactccactc acgcagaccc aacctaacct ccactagctc caaaatccct
     1141 gctcctgcgt ccccgtgata tgcctccact tctctcccta accaaggtta ggtgactgag
     1201 gactggagct gtttggtttt ctcgcatttt ccaccaaact ggaagctgtt tttgcagcct
     1261 gaggaagcat caataaatat ttgagaaatg aatccagga
//
