LOCUS       NM_173535               2474 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens C-type lectin domain family 4 member F (CLEC4F),
            transcript variant 1, mRNA.
ACCESSION   NM_173535
VERSION     NM_173535.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2474)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2474)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   3  (bases 1 to 2474)
  AUTHORS   Hoyle,G.W. and Hill,R.L.
  TITLE     Structure of the gene for a carbohydrate-binding receptor unique to
            rat kupffer cells
  JOURNAL   J Biol Chem 266 (3), 1850-1857 (1991)
   PUBMED   1846367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096429.1, CD701685.1, AC007395.4 and BU740367.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173535.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272367.7/ ENSP00000272367.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AK096429.1         2-126
            126-344             CD701685.1         146-364
            345-1695            AK096429.1         346-1696
            1696-1696           AC007395.4         134258-134258       c
            1697-1766           AK096429.1         1698-1767
            1767-1767           AC007395.4         133831-133831       c
            1768-2166           AK096429.1         1769-2167
            2167-2474           BU740367.1         12-319              c
FEATURES             Location/Qualifiers
     source          1..2474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..2474
                     /gene="CLEC4F"
                     /gene_synonym="CLECSF13; KCLR; KCR"
                     /note="C-type lectin domain family 4 member F"
                     /db_xref="GeneID:165530"
                     /db_xref="HGNC:HGNC:25357"
                     /db_xref="MIM:620105"
     exon            1..137
                     /gene="CLEC4F"
                     /gene_synonym="CLECSF13; KCLR; KCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1846
                     /gene="CLEC4F"
                     /gene_synonym="CLECSF13; KCLR; KCR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     C-type (calcium dependent, carbohydrate-recognition
                     domain) lectin, superfamily member 13"
                     /codon_start=1
                     /product="C-type lectin domain family 4 member F isoform
                     1"
                     /protein_id="NP_775806.2"
                     /db_xref="CCDS:CCDS1910.1"
                     /db_xref="GeneID:165530"
                     /db_xref="HGNC:HGNC:25357"
                     /db_xref="MIM:620105"
                     /translation="MDGEAVRFCTDNQCVSLHPQEVDSVAMAPAAPKIPRLVQATPAF
                     MAVTLVFSLVTLFVVVQQQTRPVPKPVQAVILGDNITGHLPFEPNNHHHFGREAEMRE
                     LIQTFKGHMENSSAWVVEIQMLKCRVDNVNSQLQVLGDHLGNTNADIQMVKGVLKDAT
                     TLSLQTQMLRSSLEGTNAEIQRLKEDLEKADALTFQTLNFLKSSLENTSIELHVLSRG
                     LENANSEIQMLNASLETANTQAQLANSSLKNANAEIYVLRGHLDSVNDLRTQNQVLRN
                     SLEGANAEIQGLKENLQNTNALNSQTQAFIKSSFDNTSAEIQFLRGHLERAGDEIHVL
                     KRDLKMVTAQTQKANGRLDQTDTQIQVFKSEMENVNTLNAQIQVLNGHMKNASREIQT
                     LKQGMKNASALTSQTQMLDSNLQKASAEIQRLRGDLENTKALTMEIQQEQSRLKTLHV
                     VITSQEQLQRTQSQLLQMVLQGWKFNGGSLYYFSSVKKSWHEAEQFCVSQGAHLASVA
                     SKEEQAFLVEFTSKVYYWIGLTDRGTEGSWRWTDGTPFNAAQNKAPGSKGSCPLRKYI
                     IVNSGMGACSFIDTPPCPWILSN"
     exon            138..254
                     /gene="CLEC4F"
                     /gene_synonym="CLECSF13; KCLR; KCR"
                     /inference="alignment:Splign:2.1.0"
     exon            255..344
                     /gene="CLEC4F"
                     /gene_synonym="CLECSF13; KCLR; KCR"
                     /inference="alignment:Splign:2.1.0"
     exon            345..1463
                     /gene="CLEC4F"
                     /gene_synonym="CLECSF13; KCLR; KCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1615
                     /gene="CLEC4F"
                     /gene_synonym="CLECSF13; KCLR; KCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1734
                     /gene="CLEC4F"
                     /gene_synonym="CLECSF13; KCLR; KCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..2474
                     /gene="CLEC4F"
                     /gene_synonym="CLECSF13; KCLR; KCR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2449..2454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC4F"
                     /gene_synonym="CLECSF13; KCLR; KCR"
                     /note="hexamer: AATAAA"
     polyA_site      2474
                     /gene="CLEC4F"
                     /gene_synonym="CLECSF13; KCLR; KCR"
                     /note="major polyA site"
ORIGIN      
        1 actgccattg gtccacggga cggcccttcc aggagccagt ggctgggagc agtgctggag
       61 gatcaaggaa gcagagatgg acggtgaggc agtccgcttc tgcacagata accagtgtgt
      121 ctccctgcac ccccaagagg tggactctgt ggcaatggct cctgcagccc ccaagatacc
      181 gaggctcgtt caggctaccc cggcatttat ggctgtgacc ttggtcttct ctcttgtgac
      241 tctctttgta gtggttcaac agcagacaag acctgttccg aagcctgtgc aagccgtaat
      301 tctgggagac aacattactg ggcatttacc ttttgaaccc aacaatcatc accactttgg
      361 cagggaggca gaaatgcgag agcttatcca gacatttaaa ggccacatgg agaattccag
      421 tgcctgggta gtagaaatcc agatgttgaa gtgcagagtg gacaatgtca attcgcagct
      481 ccaggtgctc ggtgatcatc tgggaaacac caatgctgac atccagatgg taaaaggagt
      541 tctaaaggat gccactacat tgagtttgca gacacagatg ttaaggagtt ccctggaggg
      601 aaccaatgct gagatccaga ggctcaagga agaccttgaa aaggcagatg ctttaacttt
      661 ccagacgctg aatttcttaa aaagcagttt agaaaacacc agcattgagc tccacgtgct
      721 aagcagaggc ttagaaaatg caaactctga aattcagatg ttgaatgcca gtttggaaac
      781 ggcaaatacc caggctcagt tagccaatag cagtttaaag aacgctaatg ctgagatcta
      841 tgttttgaga ggccatctag atagtgtcaa tgacttgagg acccagaacc aggttttaag
      901 aaatagtttg gaaggagcca atgctgagat ccagggacta aaggaaaatt tgcagaacac
      961 aaatgcttta aactcccaga cccaggcctt tataaaaagc agttttgaca acactagtgc
     1021 tgagatccag ttcttaagag gtcatttgga aagagctggt gatgaaattc acgtgttaaa
     1081 aagggatttg aaaatggtca cagcccagac ccaaaaagca aatggccgtc tggaccagac
     1141 agatactcag attcaggtat tcaagtcaga gatggaaaat gtgaatacct taaatgccca
     1201 gattcaggtc ttaaatggtc atatgaaaaa tgccagcaga gagatacaga ccctaaaaca
     1261 aggaatgaag aatgcttcag ccttaacttc ccagacccag atgttagaca gcaatctgca
     1321 gaaggccagt gccgagatcc agaggttaag aggggatcta gagaacacca aagctctaac
     1381 catggaaatc cagcaggagc agagtcgcct gaagaccctc catgtggtca ttacttcaca
     1441 ggaacagcta caaagaaccc aaagtcagct tctccagatg gtcctgcaag gctggaagtt
     1501 caatggtgga agcttatatt atttttctag tgtcaagaag tcttggcatg aggctgagca
     1561 gttctgcgtg tcccagggag cccatctggc atctgtggcc tccaaggagg agcaggcatt
     1621 tctggtagag ttcacaagta aagtgtacta ctggatcggt ctcactgaca ggggcacaga
     1681 gggctcctgg cgctggacag atgggacacc attcaacgcc gcccagaaca aagcgcctgg
     1741 ttccaaggga tcctgcccac tcagaaagta tattattgtg aattctggga tgggagcttg
     1801 cagcttcata gacacccctc cctgtccctg gatcctcagt aactaagagc aacctgagca
     1861 cagacaccct cagggtactc cttctcccag ccctgtcctc atcctagggc cactagggga
     1921 tgaaggaccc atctcaagtc agctccctag actcatccca tgtcagctcc ctaggagcca
     1981 cagcaccagg aagggatgct gccttcatct aacagtataa agccctgttg tcttcgggtt
     2041 ttgggaaaag aatcagtctg acaactggcg gcacaagaat gggcagactg aagactgtgt
     2101 ccaaattcag cagaagtgga atgacatgac ctgtgacacc ccctatcagt gggtgtgcaa
     2161 gaagcccatg ggccagggtg tggcctgagg gcaggccaga gctgaggggc tgctcctgct
     2221 tgccaatact gaccctcctc ctcgatgcct tcggagcctc tgagctctgc ttgttctctg
     2281 ggaccttccg ttggccttgt ggacttcctg ccttgttctt tgattcagcc ctttcaaaca
     2341 tgcttacctc gagtgaccca gtgacatcag tggcttctca agggaagagc cttgctgtgc
     2401 ccctgtagcc tcagcaccca gcacaggcct gtcagacagc aggtcctcaa taaatactcg
     2461 ctggatcaac aaaa
//
