LOCUS       NM_001371390             882 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens C-type lectin domain family 4 member C (CLEC4C),
            transcript variant 3, mRNA.
ACCESSION   NM_001371390
VERSION     NM_001371390.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 882)
  AUTHORS   Zhong,Q., Lu,Y., Xu,W., Rong,Z., Chang,X., Qin,L., Chen,X. and
            Zhou,F.
  TITLE     The differentiation of new human CD303+ Plasmacytoid dendritic cell
            subpopulations expressing CD205 and/or CD103 regulated by
            Non-Small-Cell lung cancer cells
  JOURNAL   Int Immunopharmacol 99, 107983 (2021)
   PUBMED   34298400
  REMARK    GeneRIF: The differentiation of new human CD303(+) Plasmacytoid
            dendritic cell subpopulations expressing CD205 and/or CD103
            regulated by Non-Small-Cell lung cancer cells.
REFERENCE   2  (bases 1 to 882)
  AUTHORS   Bos,S., Poirier-Beaudouin,B., Seffer,V., Manich,M., Mardi,C.,
            Despres,P., Gadea,G. and Gougeon,M.L.
  TITLE     Zika Virus Inhibits IFN-alpha Response by Human Plasmacytoid
            Dendritic Cells and Induces NS1-Dependent Triggering of CD303
            (BDCA-2) Signaling
  JOURNAL   Front Immunol 11, 582061 (2020)
   PUBMED   33193389
  REMARK    GeneRIF: Zika Virus Inhibits IFN-alpha Response by Human
            Plasmacytoid Dendritic Cells and Induces NS1-Dependent Triggering
            of CD303 (BDCA-2) Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 882)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 882)
  AUTHORS   Chen,Y.L., Gomes,T., Hardman,C.S., Vieira Braga,F.A.,
            Gutowska-Owsiak,D., Salimi,M., Gray,N., Duncan,D.A., Reynolds,G.,
            Johnson,D., Salio,M., Cerundolo,V., Barlow,J.L., McKenzie,A.N.J.,
            Teichmann,S.A., Haniffa,M. and Ogg,G.
  TITLE     Re-evaluation of human BDCA-2+ DC during acute sterile skin
            inflammation
  JOURNAL   J Exp Med 217 (3) (2020)
   PUBMED   31845972
  REMARK    GeneRIF: Re-evaluation of human BDCA-2+ DC during acute sterile
            skin inflammation.
REFERENCE   5  (bases 1 to 882)
  AUTHORS   Gardet,A., Pellerin,A., McCarl,C.A., Diwanji,R., Wang,W.,
            Donaldson,D., Franchimont,N., Werth,V.P. and Rabah,D.
  TITLE     Effect of in vivo Hydroxychloroquine and ex vivo Anti-BDCA2 mAb
            Treatment on pDC IFNalpha Production From Patients Affected With
            Cutaneous Lupus Erythematosus
  JOURNAL   Front Immunol 10, 275 (2019)
   PUBMED   30846987
  REMARK    GeneRIF: 24F4A (BIIB059) is an antibody targeting BDCA2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 882)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 882)
  AUTHORS   Dzionek,A., Sohma,Y., Nagafune,J., Cella,M., Colonna,M.,
            Facchetti,F., Gunther,G., Johnston,I., Lanzavecchia,A.,
            Nagasaka,T., Okada,T., Vermi,W., Winkels,G., Yamamoto,T., Zysk,M.,
            Yamaguchi,Y. and Schmitz,J.
  TITLE     BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type
            lectin, mediates antigen capture and is a potent inhibitor of
            interferon alpha/beta induction
  JOURNAL   J Exp Med 194 (12), 1823-1834 (2001)
   PUBMED   11748283
REFERENCE   8  (bases 1 to 882)
  AUTHORS   Arce,I., Roda-Navarro,P., Montoya,M.C., Hernanz-Falcon,P.,
            Puig-Kroger,A. and Fernandez-Ruiz,E.
  TITLE     Molecular and genomic characterization of human DLEC, a novel
            member of the C-type lectin receptor gene family preferentially
            expressed on monocyte-derived dendritic cells
  JOURNAL   Eur J Immunol 31 (9), 2733-2740 (2001)
   PUBMED   11536172
REFERENCE   9  (bases 1 to 882)
  AUTHORS   Dzionek,A., Fuchs,A., Schmidt,P., Cremer,S., Zysk,M., Miltenyi,S.,
            Buck,D.W. and Schmitz,J.
  TITLE     BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of
            dendritic cells in human peripheral blood
  JOURNAL   J Immunol 165 (11), 6037-6046 (2000)
   PUBMED   11086035
REFERENCE   10 (bases 1 to 882)
  AUTHORS   Fernandes,M.J., Iscove,N.N., Gingras,G. and Calabretta,B.
  TITLE     Identification and characterization of the gene for a novel C-type
            lectin (CLECSF7) that maps near the natural killer gene complex on
            human chromosome 12
  JOURNAL   Genomics 69 (2), 263-270 (2000)
   PUBMED   11031109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358223.1 and AC006517.46.
            
            Summary: This gene encodes a member of the C-type lectin/C-type
            lectin-like domain (CTL/CTLD) superfamily. Members of this family
            share a common protein fold and have diverse functions, such as
            cell adhesion, cell-cell signalling, glycoprotein turnover, and
            roles in inflammation and immune response. The encoded type 2
            transmembrane protein may play a role in dendritic cell function.
            Two transcript variants encoding distinct isoforms have been
            identified for this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358223.1, AF325459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360345.8/ ENSP00000353500.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AY358223.1         131-352
            223-223             AC006517.46        124267-124267
            224-821             AY358223.1         354-951
            822-882             AC006517.46        136284-136344
FEATURES             Location/Qualifiers
     source          1..882
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..882
                     /gene="CLEC4C"
                     /gene_synonym="BDCA-2; BDCA2; CD303; CLECSF11; CLECSF7;
                     DLEC; HECL; PRO34150"
                     /note="C-type lectin domain family 4 member C"
                     /db_xref="GeneID:170482"
                     /db_xref="HGNC:HGNC:13258"
                     /db_xref="MIM:606677"
     exon            1..58
                     /gene="CLEC4C"
                     /gene_synonym="BDCA-2; BDCA2; CD303; CLECSF11; CLECSF7;
                     DLEC; HECL; PRO34150"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..669
                     /gene="CLEC4C"
                     /gene_synonym="BDCA-2; BDCA2; CD303; CLECSF11; CLECSF7;
                     DLEC; HECL; PRO34150"
                     /note="isoform 1 is encoded by transcript variant 3;
                     C-type (calcium dependent, carbohydrate-recognition
                     domain) lectin, superfamily member 11; C-type (calcium
                     dependent, carbohydrate-recognition domain) lectin,
                     superfamily member 7; blood dendritic cell antigen 2
                     protein; dendritic cell lectin b; dendritic lectin; C-type
                     lectin superfamily member 7"
                     /codon_start=1
                     /product="C-type lectin domain family 4 member C isoform
                     1"
                     /protein_id="NP_001358319.1"
                     /db_xref="CCDS:CCDS8583.1"
                     /db_xref="GeneID:170482"
                     /db_xref="HGNC:HGNC:13258"
                     /db_xref="MIM:606677"
                     /translation="MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVVPH
                     NFMYSKTVKRLSKLREYQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQ
                     SWTKSQKNCSVMGADLVVINTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTP
                     YNENVTFWHSGEPNNLDERCAIINFRSSEEWGWNDIHCHVPQKSICKMKKIYI"
     exon            59..151
                     /gene="CLEC4C"
                     /gene_synonym="BDCA-2; BDCA2; CD303; CLECSF11; CLECSF7;
                     DLEC; HECL; PRO34150"
                     /inference="alignment:Splign:2.1.0"
     exon            152..262
                     /gene="CLEC4C"
                     /gene_synonym="BDCA-2; BDCA2; CD303; CLECSF11; CLECSF7;
                     DLEC; HECL; PRO34150"
                     /inference="alignment:Splign:2.1.0"
     exon            263..408
                     /gene="CLEC4C"
                     /gene_synonym="BDCA-2; BDCA2; CD303; CLECSF11; CLECSF7;
                     DLEC; HECL; PRO34150"
                     /inference="alignment:Splign:2.1.0"
     exon            409..524
                     /gene="CLEC4C"
                     /gene_synonym="BDCA-2; BDCA2; CD303; CLECSF11; CLECSF7;
                     DLEC; HECL; PRO34150"
                     /inference="alignment:Splign:2.1.0"
     exon            525..882
                     /gene="CLEC4C"
                     /gene_synonym="BDCA-2; BDCA2; CD303; CLECSF11; CLECSF7;
                     DLEC; HECL; PRO34150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      799..804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC4C"
                     /gene_synonym="BDCA-2; BDCA2; CD303; CLECSF11; CLECSF7;
                     DLEC; HECL; PRO34150"
                     /note="hexamer: ATTACA"
     polyA_site      820
                     /gene="CLEC4C"
                     /gene_synonym="BDCA-2; BDCA2; CD303; CLECSF11; CLECSF7;
                     DLEC; HECL; PRO34150"
                     /note="major polyA site"
ORIGIN      
        1 gaagtccaaa gggtgtgcgc acacacaatg gtgcctgaag aagagcctca agaccgagag
       61 aaaggactct ggtggttcca gttgaaggtc tggtccatgg cagtcgtatc catcttgctc
      121 ctcagtgtct gtttcactgt gagttctgtg gtgcctcaca attttatgta tagcaaaact
      181 gtcaagaggc tgtccaagtt acgagagtat caacagtatc atccaagcct gacctgcgtc
      241 atggaaggaa aggacataga agattggagc tgctgcccaa ccccttggac ttcatttcag
      301 tctagttgct actttatttc tactgggatg caatcttgga ctaagagtca aaagaactgt
      361 tctgtgatgg gggctgatct ggtggtgatc aacaccaggg aagaacagga tttcatcatt
      421 cagaatctga aaagaaattc ttcttatttt ctggggctgt cagatccagg gggtcggcga
      481 cattggcaat gggttgacca gacaccatac aatgaaaatg tcacattctg gcactcaggt
      541 gaacccaata accttgatga gcgttgtgcg ataataaatt tccgttcttc agaagaatgg
      601 ggctggaatg acattcactg tcatgtacct cagaagtcaa tttgcaagat gaagaagatc
      661 tacatataaa tgaaatattc tccctggaaa tgtgtttggg ttggcatcca ccgttgtaga
      721 aagctaaatt gattttttaa tttatgtgta agttttgtac aaggaatgcc cctaaaatgt
      781 ttcagcaggc tgtcacctat tacacttatg atataatcca ttcacacatt catttattca
      841 tttattcatt tattcattca taaaatgagt gtttagtgaa ca
//
