LOCUS       NM_003278                816 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens C-type lectin domain family 3 member B (CLEC3B),
            transcript variant 1, mRNA.
ACCESSION   NM_003278
VERSION     NM_003278.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 816)
  AUTHORS   Kopeva,K.V., Grakova,E.V., Shilov,S.N., Berezikova,E.N.,
            Bobyleva,E.T. and Teplyakov,A.T.
  TITLE     Tetranectin as a potential novel prognostic biomarker in
            anthracycline-related cardiac dysfunction
  JOURNAL   Heart Vessels 38 (10), 1256-1266 (2023)
   PUBMED   37310463
  REMARK    GeneRIF: Tetranectin as a potential novel prognostic biomarker in
            anthracycline-related cardiac dysfunction.
REFERENCE   2  (bases 1 to 816)
  AUTHORS   Lu,X., Shen,J., Huang,S., Wang,H. and Liu,D.
  TITLE     Down-regulation of CLEC3B facilitates epithelial-mesenchymal
            transition, migration and invasion of lung adenocarcinoma cells
  JOURNAL   Tissue Cell 76, 101802 (2022)
   PUBMED   35500520
  REMARK    GeneRIF: Down-regulation of CLEC3B facilitates
            epithelial-mesenchymal transition, migration and invasion of lung
            adenocarcinoma cells.
REFERENCE   3  (bases 1 to 816)
  AUTHORS   Kolicheski,A., Walton,R.L., Soto-Beasley,A.I., Heckman,M.G.,
            Uitti,R.J., Parfitt,F., Graff-Radford,M.R., Wszolek,Z.K.,
            Graff-Radford,N.R. and Ross,O.A.
  TITLE     CLEC3B p.S106G Mutant in a Caucasian Population of Successful
            Neurological Aging
  JOURNAL   J Gerontol A Biol Sci Med Sci 75 (9), 1618-1623 (2020)
   PUBMED   31570938
  REMARK    GeneRIF: CLEC3B p.S106G Mutant in a Caucasian Population of
            Successful Neurological Aging.
REFERENCE   4  (bases 1 to 816)
  AUTHORS   Lv,F., Wang,Z., Huang,Y., Si,A. and Chen,Y.
  TITLE     CLEC3B protects H9c2 cardiomyocytes from apoptosis caused by
            hypoxia via the PI3K/Akt pathway
  JOURNAL   Braz J Med Biol Res 53 (9), e9693 (2020)
   PUBMED   32696821
  REMARK    GeneRIF: CLEC3B alleviated the injury of hypoxic H9c2
            cardiomyocytes via the PI3K/Akt pathway
REFERENCE   5  (bases 1 to 816)
  AUTHORS   Dai,W., Wang,Y., Yang,T., Wang,J., Wu,W. and Gu,J.
  TITLE     Downregulation of exosomal CLEC3B in hepatocellular carcinoma
            promotes metastasis and angiogenesis via AMPK and VEGF signals
  JOURNAL   Cell Commun Signal 17 (1), 113 (2019)
   PUBMED   31477130
  REMARK    GeneRIF: CLEC3B acts as a novel independent prognostic factor
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 816)
  AUTHORS   Berglund,L. and Petersen,T.E.
  TITLE     The gene structure of tetranectin, a plasminogen binding protein
  JOURNAL   FEBS Lett 309 (1), 15-19 (1992)
   PUBMED   1511740
REFERENCE   7  (bases 1 to 816)
  AUTHORS   Wewer,U.M. and Albrechtsen,R.
  TITLE     Tetranectin, a plasminogen kringle 4-binding protein. Cloning and
            gene expression pattern in human colon cancer
  JOURNAL   Lab Invest 67 (2), 253-262 (1992)
   PUBMED   1354271
REFERENCE   8  (bases 1 to 816)
  AUTHORS   Borregaard,N., Christensen,L., Bejerrum,O.W., Birgens,H.S. and
            Clemmensen,I.
  TITLE     Identification of a highly mobilizable subset of human neutrophil
            intracellular vesicles that contains tetranectin and latent
            alkaline phosphatase
  JOURNAL   J Clin Invest 85 (2), 408-416 (1990)
   PUBMED   2298916
REFERENCE   9  (bases 1 to 816)
  AUTHORS   Clemmensen,I.
  TITLE     Interaction of tetranectin with sulphated polysaccharides and
            trypan blue
  JOURNAL   Scand J Clin Lab Invest 49 (8), 719-725 (1989)
   PUBMED   2533389
REFERENCE   10 (bases 1 to 816)
  AUTHORS   Clemmensen,I., Petersen,L.C. and Kluft,C.
  TITLE     Purification and characterization of a novel, oligomeric,
            plasminogen kringle 4 binding protein from human plasma:
            tetranectin
  JOURNAL   Eur J Biochem 156 (2), 327-333 (1986)
   PUBMED   3009181
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI837909.1, BC011024.1 and AC104165.2.
            
            On Nov 23, 2018 this sequence version replaced NM_003278.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X64559.1, SRR5189655.218901.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296130.5/ ENSP00000296130.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BI837909.1         121-123
            4-375               BC011024.1         5-376
            376-815             AC104165.2         129472-129911
            816-816             BC011024.1         817-817
FEATURES             Location/Qualifiers
     source          1..816
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..816
                     /gene="CLEC3B"
                     /gene_synonym="MCDR4; TN; TNA"
                     /note="C-type lectin domain family 3 member B"
                     /db_xref="GeneID:7123"
                     /db_xref="HGNC:HGNC:11891"
                     /db_xref="MIM:187520"
     exon            1..169
                     /gene="CLEC3B"
                     /gene_synonym="MCDR4; TN; TNA"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..669
                     /gene="CLEC3B"
                     /gene_synonym="MCDR4; TN; TNA"
                     /note="isoform 1precursor is encoded by transcript variant
                     1; tetranectin (plasminogen-binding protein); plasminogen
                     kringle 4-binding protein"
                     /codon_start=1
                     /product="tetranectin isoform 1precursor"
                     /protein_id="NP_003269.2"
                     /db_xref="CCDS:CCDS2726.1"
                     /db_xref="GeneID:7123"
                     /db_xref="HGNC:HGNC:11891"
                     /db_xref="MIM:187520"
                     /translation="MELWGAYLLLCLFSLLTQVTTEPPTQKPKKIVNAKKDVVNTKMF
                     EELKSRLDTLAQEVALLKEQQALQTVCLKGTKVHMKCFLAFTQTKTFHEASEDCISRG
                     GTLGTPQTGSENDALYEYLRQSVGNEAEIWLGLNDMAAEGTWVDMTGARIAYKNWETE
                     ITAQPDGGKTENCAVLSGAANGKWFDKRCRDQLPYICQFGIV"
     exon            170..268
                     /gene="CLEC3B"
                     /gene_synonym="MCDR4; TN; TNA"
                     /inference="alignment:Splign:2.1.0"
     exon            269..816
                     /gene="CLEC3B"
                     /gene_synonym="MCDR4; TN; TNA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      787..792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC3B"
                     /gene_synonym="MCDR4; TN; TNA"
                     /note="hexamer: AATAAA"
     polyA_site      816
                     /gene="CLEC3B"
                     /gene_synonym="MCDR4; TN; TNA"
                     /note="major polyA site"
ORIGIN      
        1 gtcactgcgt tcggacccag acccgctgca ggcagcagca gcccccgccc gcgcagcagc
       61 atggagctct ggggggccta cctcctcctc tgcctcttct ccctcctgac ccaggtcacc
      121 accgagccac caacccagaa gcccaagaag attgtaaatg ccaagaaaga tgttgtgaac
      181 acaaagatgt ttgaggagct caagagccgt ctggacaccc tggcccagga ggtggccctg
      241 ctgaaggagc agcaggccct gcagacggtc tgcctgaagg ggaccaaggt gcacatgaaa
      301 tgctttctgg ccttcaccca gacgaagacc ttccacgagg ccagcgagga ctgcatctcg
      361 cgcgggggca ccctgggcac ccctcagact ggctcggaga acgacgccct gtatgagtac
      421 ctgcgccaga gcgtgggcaa cgaggccgag atctggctgg gcctcaacga catggcggcc
      481 gagggcacct gggtggacat gaccggcgcc cgcatcgcct acaagaactg ggagactgag
      541 atcaccgcgc aacccgatgg cggcaagacc gagaactgcg cggtcctgtc aggcgcggcc
      601 aacggcaagt ggttcgacaa gcgctgccgc gatcagctgc cctacatctg ccagttcggg
      661 atcgtgtagc cggcggggcg ggggccgtgg ggggcctgga ggagggcagg ggccgcggga
      721 ggccgggagg agggtgggga ccttgcagcc cccatcctct ccgtgcgctt ggagcctctt
      781 tttgcaaata aagttggtgc agcttcgcgg agagga
//
