LOCUS       NM_005752               1933 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens C-type lectin domain family 3 member A (CLEC3A), mRNA.
ACCESSION   NM_005752
VERSION     NM_005752.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1933)
  AUTHORS   Chen,X., Ji,Y., Feng,F., Liu,Z., Qian,L., Shen,H. and Lao,L.
  TITLE     C-type lectin domain-containing protein CLEC3A regulates
            proliferation, regeneration and maintenance of nucleus pulposus
            cells
  JOURNAL   Cell Mol Life Sci 79 (8), 435 (2022)
   PUBMED   35864364
  REMARK    GeneRIF: C-type lectin domain-containing protein CLEC3A regulates
            proliferation, regeneration and maintenance of nucleus pulposus
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1933)
  AUTHORS   Ren,C., Pan,R., Hou,L., Wu,H., Sun,J., Zhang,W., Tian,X. and
            Chen,H.
  TITLE     Suppression of CLEC3A inhibits osteosarcoma cell proliferation and
            promotes their chemosensitivity through the AKT1/mTOR/HIF1alpha
            signaling pathway
  JOURNAL   Mol Med Rep 21 (4), 1739-1748 (2020)
   PUBMED   32319617
  REMARK    GeneRIF: Suppression of CLEC3A inhibits osteosarcoma cell
            proliferation and promotes their chemosensitivity through the
            AKT1/mTOR/HIF1alpha signaling pathway.
REFERENCE   3  (bases 1 to 1933)
  AUTHORS   Miki,M., Oono,T., Fujimori,N., Takaoka,T., Kawabe,K., Miyasaka,Y.,
            Ohtsuka,T., Saito,D., Nakamura,M., Ohkawa,Y., Oda,Y., Suyama,M.,
            Ito,T. and Ogawa,Y.
  TITLE     CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence
            in resected G1 and G2 pancreatic neuroendocrine tumors
  JOURNAL   Cancer Med 8 (8), 3748-3760 (2019)
   PUBMED   31129920
  REMARK    GeneRIF: we demonstrated that the recurrence potential in PNETs is
            characterized by the upregulation of genes related to ECM
            organization and cell adhesion. This study identified three
            genes-CLEC3, MMP7, and LCN2-that contribute to the prediction of
            postoperative recurrence of PNETs in clinical practice.
REFERENCE   4  (bases 1 to 1933)
  AUTHORS   Simino,J., Sung,Y.J., Kume,R., Schwander,K. and Rao,D.C.
  TITLE     Gene-alcohol interactions identify several novel blood pressure
            loci including a promising locus near SLC16A9
  JOURNAL   Front Genet 4, 277 (2013)
   PUBMED   24376456
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1933)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1933)
  AUTHORS   Tsunezumi,J., Higashi,S. and Miyazaki,K.
  TITLE     Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A
            (CLEC3A) on tumor cell surface and modulates its cell adhesion
            activity
  JOURNAL   J Cell Biochem 106 (4), 693-702 (2009)
   PUBMED   19173304
  REMARK    GeneRIF: CLEC3A binds to heparan sulfate proteoglycans on cell
            surface, leading to the enhancement of cell adhesion to integrin
            ligands on ECM; cleavage of CLEC3A by MMP-7 weakens the stable
            adhesion of tumor cells to the matrix
REFERENCE   7  (bases 1 to 1933)
  AUTHORS   Neame,P.J., Tapp,H. and Grimm,D.R.
  TITLE     The cartilage-derived, C-type lectin (CLECSF1): structure of the
            gene and chromosomal location
  JOURNAL   Biochim Biophys Acta 1446 (3), 193-202 (1999)
   PUBMED   10524194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK313316.1, AY358376.1 and AC079414.6.
            
            On May 17, 2019 this sequence version replaced NM_005752.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358376.1, SRR1803614.198704.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000299642.10/
                                                ENSP00000299642.5
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AK313316.1         3-48
            47-667              AY358376.1         1-621
            668-1542            AC079414.6         131194-132068       c
            1543-1933           AY358376.1         1497-1887
FEATURES             Location/Qualifiers
     source          1..1933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..1933
                     /gene="CLEC3A"
                     /gene_synonym="CLECSF1"
                     /note="C-type lectin domain family 3 member A"
                     /db_xref="GeneID:10143"
                     /db_xref="HGNC:HGNC:2052"
                     /db_xref="MIM:613588"
     exon            1..194
                     /gene="CLEC3A"
                     /gene_synonym="CLECSF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..673
                     /gene="CLEC3A"
                     /gene_synonym="CLECSF1"
                     /note="C-type (calcium dependent, carbohydrate-recognition
                     domain) lectin, superfamily member 1 (cartilage-derived)"
                     /codon_start=1
                     /product="C-type lectin domain family 3 member A
                     precursor"
                     /protein_id="NP_005743.5"
                     /db_xref="CCDS:CCDS10927.3"
                     /db_xref="GeneID:10143"
                     /db_xref="HGNC:HGNC:2052"
                     /db_xref="MIM:613588"
                     /translation="MAKNGLVICILVITLLLDQTTSHTSRLKARKHSKRRVRDKDGDL
                     KTQIEKLWTEVNALKEIQALQTVCLRGTKVHKKCYLASEGLKHFHEANEDCISKGGIL
                     VIPRNSDEINALQDYGKRSLPGVNDFWLGINDMVTEGKFVDVNGIAISFLNWDRAQPN
                     GGKRENCVLFSQSAQGKWSDEACRSSKRYICEFTIPQ"
     exon            195..278
                     /gene="CLEC3A"
                     /gene_synonym="CLECSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..1933
                     /gene="CLEC3A"
                     /gene_synonym="CLECSF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1909..1914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC3A"
                     /gene_synonym="CLECSF1"
                     /note="hexamer: AATAAA"
     polyA_site      1933
                     /gene="CLEC3A"
                     /gene_synonym="CLECSF1"
                     /note="major polyA site"
ORIGIN      
        1 aagatgtagc tgtgtagtct ccttccatag ctgctctaag ggggctggca acatggctca
       61 gcaggcttgc cccagagcca tggcaaagaa tggacttgta atttgcatcc tggtgatcac
      121 cttactcctg gaccagacca ccagccacac atccagatta aaagccagga agcacagcaa
      181 acgtcgagtg agagacaagg atggagatct gaagactcaa attgaaaagc tctggacaga
      241 agtcaatgcc ttgaaggaaa ttcaagccct gcagacagtc tgtctccgag gcactaaagt
      301 tcacaagaaa tgctaccttg cttcagaagg tttgaagcat ttccatgagg ccaatgaaga
      361 ctgcatttcc aaaggaggaa tcctggttat ccccaggaac tccgacgaaa tcaacgccct
      421 ccaagactat ggtaaaagga gcctgccagg tgtcaatgac ttttggctgg gcatcaatga
      481 catggtcacg gaaggcaagt ttgttgacgt caacggaatc gctatctcct tcctcaactg
      541 ggaccgtgca cagcctaacg gtggcaagcg agaaaactgt gtcctgttct cccaatcagc
      601 tcagggcaag tggagtgatg aggcctgtcg cagcagcaag agatacatat gcgagttcac
      661 catccctcaa taggtctttc tccaatgtgt cctccaagca agattcatca taacttatag
      721 gttcatgatc tctaagatca agtaaaaatc ataattttta cttattaaaa aattgcaaca
      781 caagatcaat gtccatagca atatgatagc atcagccaat tttgctaaca catttctttg
      841 ggattttgcc cttcctgggg tataggggat cagaaatatt gatccatgtg cacgcagata
      901 aaatggcttc tgctaaacag actaaaatct ttctctctag tctttctcac ttgtacaaac
      961 ccagtttgtt ttcaaaaaat cacagtagca atgcaactca tcactctaga aaagcaagct
     1021 taggctacct gaaagatttt cccttggaag tttagcgtat gtttgactaa caaaaattcc
     1081 ctacatcaga gactctaggt gctatataat ccaaaaactt ttcagcctgt tgctcattct
     1141 gtcccatgct ggcaataata ccttgtcagc ccattaccct tattttgaat tgctccatct
     1201 cctggtggga cttgtatctt gtctgccata tcagaacaca aacccctgaa gaggttctga
     1261 tttgattttt tttttttctt catgcctacc ctttttttgg aagtttccag ccgcaatttg
     1321 aaatgaaatg acaaggtgta tatttgatca attttcattc ccaccattgc attacaacct
     1381 ctaacttaaa tgggtaaccc taaggcatat caaagaagca gattgcatga taaacggaaa
     1441 cagaaaaaaa gaacctacat ttattttgct ttagcatcct tactctcacc ttttatgaga
     1501 ttgagagtgg acttacattt ccttttttac attttcgtat acttattttt tttagccatc
     1561 attatatgtt taagtctatt atgggcaacc aatctttgga agctgaaaac tgaatttaaa
     1621 gaatgctatc ttggaaaatt gcatacgtct gtgcaatttt ttattctgcc tagtgctatt
     1681 ctgcttgttt aactagattg tacaaaataa cttcattgct taatatcaaa ttacaaagtt
     1741 tagacttgga gggaaatggg ctttttagaa gcaaacaatt ttaaatatat tttgttcttc
     1801 aaataaatag tgtttaaaca ttgaatgtgt tttgtgaaca atatcccact ttgcaaactt
     1861 taactacaca tgcttggaat taagttttag ctgttttcat tgctcaataa taaagcctga
     1921 attctgatca ata
//
